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The oral microbiota and periodontal health in orthodontic patients Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-20 Brandon W. Peterson, Geerten‐Has Tjakkes, Anne‐Marie Renkema, David J. Manton, Yijin Ren
The oral microbiota develops within the first 2 years of childhood and becomes distinct from the parents by 4 years‐of‐age. The oral microbiota plays an important role in the overall health/symbiosis of the individual. Deviations from the state of symbiosis leads to dysbiosis and an increased risk of pathogenicity. Deviations can occur not only from daily life activities but also from orthodontic interventions
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Realizing the clinical utility of saliva for monitoring oral diseases Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-16 Jeffrey L. Ebersole, Hatice Hasturk, Michaell Huber, Robert Gellibolian, Adam Markaryan, Xiaohua D. Zhang, Craig S. Miller
In the era of personalized/precision health care, additional effort is being expended to understand the biology and molecular mechanisms of disease processes. How these mechanisms are affected by individual genetics, environmental exposures, and behavioral choices will encompass an expanding role in the future of optimally preventing and treating diseases. Considering saliva as an important biological
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Utility of gingival crevicular fluid components for periodontal diagnosis Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-15 Nurcan Buduneli, Başak Bıyıkoğlu, Denis F. Kinane
Periodontal diseases are highly prevalent chronic diseases, and severe periodontitis creates functional and esthetic problems and decreases self‐esteem for a large percentage of the older population worldwide. In many cases of periodontitis, there is no distinct tell‐tale pain that motivates a patient to seek treatment, rather the signs become clinically detectable late, and typically when the disease
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Root surface biomodification in periodontal therapy: Biological rationale and clinical applications Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-09 Muhammad H. A. Saleh, Debora R. Dias, Andrea Ravida, Hom‐Lay Wang
Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination and enhancing tissue attachment by removing the smear layer
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Periodontal pathogens and cancer development Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-05 Yuxi Zhou, Joerg Meyle, Sabine Groeger
Increasing evidence suggests a significant association between periodontal disease and the occurrence of various cancers. The carcinogenic potential of several periodontal pathogens has been substantiated in vitro and in vivo. This review provides a comprehensive overview of the diverse mechanisms employed by different periodontal pathogens in the development of cancer. These mechanisms induce chronic
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Diagnostic measures for monitoring and follow‐up in periodontology and implant dentistry Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-02 Christoph A. Ramseier
This review discusses the role of diagnostic measures in the lifelong management of periodontal disease and peri‐implant complications. After active treatment, these conditions require regular monitoring of the supporting structures of teeth and dental implants to assess bone and soft tissue health over time. Several clinical measures have been developed for the routine assessment of periodontal and
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Nonionizing diagnostic imaging modalities for visualizing health and pathology of periodontal and peri‐implant tissues Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-02 Andy Wai Kan Yeung, Abeer AlHadidi, Rutvi Vyas, Michael M. Bornstein, Hiroshi Watanabe, Ray Tanaka
Radiographic examination has been an essential part of the diagnostic workflow in periodontology and implant dentistry. However, radiographic examination unavoidably involves ionizing radiation and its associated risks. Clinicians and researchers have invested considerable efforts in assessing the feasibility and capability of utilizing nonionizing imaging modalities to replace traditional radiographic
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Radiographic assessment of the peri‐implant site Periodontol. 2000 (IF 17.5) Pub Date : 2024-07-02 Philipp Sahrmann, Sebastian Kühl, Dorothea Dagassan‐Berndt, Michael M. Bornstein, Nicola U. Zitzmann
While peri‐implant mucositis relies solely on clinical parameters, radiological assessment becomes indispensable for diagnosing peri‐implantitis. Intraoral radiography, with its simplicity of application, low radiation exposure, and adequate representation of peri‐implant structures, stands out as the standard of care for both immediate and follow‐up assessments. Standardization by custom‐made radiologic
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The use of patient‐related outcomes (PRO) and experience (PRE) in assessing the periodontal and implant patient Periodontol. 2000 (IF 17.5) Pub Date : 2024-06-27 Sirikarn P. Arunyanak, Kajorn Kungsadalpipob, Kyle E. Wright, Keskanya Subbalekha, Irina Dragan, Nikos Mattheos
The purpose of this review was to summarize the evidence with regard to behavioral and psychosocial assessment of the periodontitis patient, the candidate for implant therapy, and the peri‐implantitis patient. Periodontitis has an adverse effect on quality of life and its treatment can lead to significant improvements experienced by the patient. The latter is true for rehabilitation with dental implants
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Artificial intelligence and personalized diagnostics in periodontology: A narrative review Periodontol. 2000 (IF 17.5) Pub Date : 2024-06-27 Vinay Pitchika, Martha Büttner, Falk Schwendicke
Periodontal diseases pose a significant global health burden, requiring early detection and personalized treatment approaches. Traditional diagnostic approaches in periodontology often rely on a “one size fits all” approach, which may overlook the unique variations in disease progression and response to treatment among individuals. This narrative review explores the role of artificial intelligence
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How to explain the beneficial effects of leukocyte‐ and platelet‐rich fibrin Periodontol. 2000 (IF 17.5) Pub Date : 2024-06-25 Juan Blanco, Angel García Alonso, Lidia Hermida‐Nogueira, Ana B. Castro
The survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents, and inflammation. This process involving cell proliferation and differentiation is driven by several growth factors and is critically dependent on the organization of the extracellular matrix. Since autologous platelet concentrates (APCs) are fibrin matrices in which cells, growth factors, and cytokines
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Diagnostic methods/parameters to monitor peri‐implant conditions Periodontol. 2000 (IF 17.5) Pub Date : 2024-06-25 Alberto Monje, Giovanni E. Salvi
The diagnostic accuracy of clinical parameters, including visual inspection and probing to monitor peri‐implant conditions, has been regarded with skepticism. Scientific evidence pointed out that primary diagnostic tools (chairside) seem to be highly specific, while their sensitivity is lower compared with their use in monitoring periodontal stability. Nonetheless, given the association between pocket
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Instructions for the use of L‐PRF in different clinical indications Periodontol. 2000 (IF 17.5) Pub Date : 2024-05-28 M. Quirynen, J. Blanco, H.‐L. Wang, N. Donos, A. Temmerman, A. Castro, N. Pinto
Autologous platelet concentrates (APCs) have demonstrated clear benefits across various clinical applications, including alveolar ridge preservation, guided tissue regeneration, guided bone regeneration, sinus floor elevation (both lateral window approach and transcrestal technique), endodontic surgery, the treatment of medication‐related osteonecrosis of the jaw bones, and periodontal plastic surgery
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Microbial diagnostics in periodontal diseases Periodontol. 2000 (IF 17.5) Pub Date : 2024-05-27 Daniel Manoil, Ana Parga, Nagihan Bostanci, Georgios N. Belibasakis
Microbial analytical methods have been instrumental in elucidating the complex microbial etiology of periodontal diseases, by shaping our understanding of subgingival community dynamics. Certain pathobionts can orchestrate the establishment of dysbiotic communities that can subvert the host immune system, triggering inflammation and tissue destruction. Yet, diagnosis and management of periodontal conditions
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Essential principles for blood centrifugation Periodontol. 2000 (IF 17.5) Pub Date : 2024-05-23 Marc Quirynen, Sayed Ahmad Manoetjer Siawasch, Jize Yu, Richard J. Miron
Currently, autologous platelet concentrates (APCs) are frequently used for soft‐ and hard‐tissue regeneration, not only within the oral cavity, but also extra‐orally including chronic wounds, burns, joints, dermatological conditions, among others. The benefits of APCs are largely influenced by the treatment strategy but also their preparation. This paper therefore discusses in detail: the physical
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The value‐for money of preventing and managing periodontitis: Opportunities and challenges Periodontol. 2000 (IF 17.5) Pub Date : 2024-05-15 Madhuri Pattamatta, Iain Chapple, Stefan Listl
This article gives an overview of the societal and economic aspects of periodontitis and periodontal care. Despite its largely preventable nature, periodontitis is highly prevalent worldwide and imposes a substantial health and economic burden on individuals and society as a whole. The worldwide estimated direct treatment costs and productivity losses due to periodontitis (including for periodontitis‐related
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The economic and societal impact of periodontal and peri‐implant diseases Periodontol. 2000 (IF 17.5) Pub Date : 2024-05-02 Muhammad H. A. Saleh, Debora R. Dias, Purnima Kumar
Periodontal and peri‐implant diseases result from a chronic inflammatory response to dysbiotic microbial communities and are characterized by inflammation in the soft tissue and the ensuing progressive destruction of supporting bone, resulting in tooth or implant loss. These diseases' high prevalence, multifactorial etiology, extensive treatment costs, and significant detriment to patients' quality‐of‐life
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Strategic approaches in oral squamous cell carcinoma diagnostics using liquid biopsy Periodontol. 2000 (IF 17.5) Pub Date : 2024-04-27 Denis F. Kinane, Joerg Gabert, George Xynopoulos, Esra Guzeldemir‐Akcakanat
Liquid biopsy is a noninvasive diagnostic technique used for monitoring cancer utilizing specific genetic biomarkers present in bodily fluids, such as blood, saliva, or urine. These analyses employ multiple biomolecular sources including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes (that contain DNA fragments) to detect genetic biomarkers that can predict, disclose, and/or
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Impact of autologous platelet concentrates on the osseointegration of dental implants Periodontol. 2000 (IF 17.5) Pub Date : 2024-04-22 Sašo Ivanovski, Ryan S. B. Lee, Tulio Fernandez‐Medina, Nelson Pinto, Catherine Andrade, Marc Quirynen
Osseointegration is defined as the direct deposition of bone onto biomaterial devices, most commonly composed from titanium, for the purpose of anchoring dental prostheses. The use of autologous platelet concentrates (APC) has the potential to enhance this process by modifying the interface between the host and the surface of the titanium implant. The rationale is to modify the implant surface and
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The role and impact of viruses on cancer development Periodontol. 2000 (IF 17.5) Pub Date : 2024-04-20 Adolfo Contreras, Sandra Amaya Sánchez, Carolina Rodríguez‐Medina, Javier Enrique Botero
This review focuses on three major aspects of oncoviruses' role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause 20% of all human cancers worldwide. Second, we investigate the primary carcinogenic mechanisms, looking at how these oncogenic viruses can induce cellular transformation, angiogenesis, and local and systemic inflammation. Finally
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The role of acquired host immunity in periodontal diseases Periodontol. 2000 (IF 17.5) Pub Date : 2024-04-20 Denis F. Kinane, David F. Lappin, Shauna Culshaw
The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease. While the contribution of European authors is the focus, global literature is
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How to explain the beneficial effects of platelet‐rich plasma Periodontol. 2000 (IF 17.5) Pub Date : 2024-04-11 Reinhard Gruber
Platelet‐rich plasma (PRP) is the platelet and leukocyte‐containing plasmatic fraction of anticoagulated autologous blood. While evidence supporting the clinical use of PRP in dentistry is low, PRP is widely used in sports medicine, orthopedics, and dermatology. Its beneficial activity is commonly attributed to the growth factors released from platelets accumulating in PRP; however, evidence is indirect
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Understanding exosomes: Part 2—Emerging leaders in regenerative medicine Periodontol. 2000 (IF 17.5) Pub Date : 2024-04-09 Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published
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Understanding exososmes: Part 3—therapeutic + diagnostic potential in dentistry Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-28 Richard J. Miron, Nathan E. Estrin, Anton Sculean, Yufeng Zhang
Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of various diseases. Over 5000 publications are currently being published
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Accuracy of cone‐beam computed tomography in imaging the components of the periodontal phenotype Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-28 Ralf Schulze, Emilio Couso‐Queiruga, Christos Katsaros
The components and dimensions of the periodontal and peri‐implant phenotype have a high relevance in contemporary dental research and should be taken into consideration in the decision‐making process in the management of a variety of clinical scenarios to optimize the outcomes of therapy. Various assessment methods for quantifying and classifying the phenotypical dimensions have emerged and developed
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Natural history of periodontal disease: The original Sri Lanka and Oslo studies Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-23 Niklaus P. Lang, Marc Schätzle, Christoph A. Ramseier
Susceptibility to periodontal disease depends on individual factors within the host response to the bacterial challenge. The study of these factors requires longitudinal studies of an undisturbed development of the disease process. On the basis of the original longitudinal studies on the natural histology of periodontal disease staged in Sri Lanka and Oslo/Norway, several analyses of periodontal parameters
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Bacteriome and mycobiome dysbiosis in oral mucosal dysplasia and oral cancer Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-19 Georgios N. Belibasakis, Chaminda Jayampath Senevirantne, Ruwan Duminda Jayasinghe, Phuc Thi‐Duy Vo, Nagihan Bostanci, Youngnim Choi
It has long been considered that the oral microbiome is tightly connected to oral health and that dysbiotic changes can be detrimental to the occurrence and progression of dysplastic oral mucosal lesions or oral cancer. Improved understanding of the concepts of microbial dysbiosis together with advances in high‐throughput molecular sequencing of these pathologies have charted in greater microbiological
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Systemic racism and racial inequities in periodontal health: The long journey from upstream determinants to downstream treatment Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-19 Eleanor Fleming, George W. Taylor, Harold Woody Neighbors
Racial disparities in the prevalence of periodontal disease are consistent and persistent. The epidemiology of periodontal disease demonstrates racial inequities: non‐Hispanic Black (14.7%), Mexican American (13.4%), and other Hispanic adults (7.8%) experience a higher prevalence of severe periodontal disease than non‐Hispanic White adults (5.9%). Epidemiologic and clinical research on periodontal
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Orthodontic retention: Rationale and periodontal implications Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-18 Padhraig S. Fleming, Nikolaos Pandis
Post‐treatment change in the form of true relapse and physiological and maturational effects is common following orthodontics. The unpredictable nature of these manifestations dictates a conservative, near‐universal approach to retention. Both fixed and removable forms of retention are popular with the latter constrained by variable levels of adherence particularly in the medium‐ to long‐term. Fixed
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Differences between first‐ and second‐generation autologous platelet concentrates Periodontol. 2000 (IF 17.5) Pub Date : 2024-03-15 Elena Calciolari, Marina Dourou, Aliye Akcali, Nikolaos Donos
AbstractAutologous platelet concentrates (APCs) applied alone or combined with other biomaterials are popular bioactive factors employed in regenerative medicine. The main biological rationale of using such products is to concentrate blood‐derived growth factors and cells into the wound microenvironment to enhance the body's natural healing capacity. First‐generation APC is represented by platelet‐rich
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The role of viruses in oral mucosal lesions Periodontol. 2000 (IF 17.5) Pub Date : 2024-02-27 Henrik Dommisch, Andrea Maria Schmidt‐Westhausen
The mucosa of the oral cavity is exposed to a large number of different microorganisms such as archaea, bacteria, fungi, parasites, and viruses. Among those, viruses cause specific infections, which can easily be transmitted from one person to another. The infectious route may not only include patients and their relatives but also the dental professional team. Thus, a wide knowledge regarding specific
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Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases Periodontol. 2000 (IF 17.5) Pub Date : 2024-02-27 Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw
Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent clinical studies are described that evaluate how the treatment
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APCs in sinus floor augmentation Periodontol. 2000 (IF 17.5) Pub Date : 2024-02-16 Pascal Valentini, Elena Calciolari, Sebastien Monlezun, Aliye Akcalı, Nikos Donos, Marc Quirynen
After tooth loss in the posterior area of the maxilla, sinus floor elevation is often required to compensate the vertical bone loss due to sinus pneumatization. This narrative review reports on the potential benefits of autologous platelet concentrates (APCs) during this procedure. As for transcrestal approach, APCs have been used as “sole” substitute/graft. However, because of the low number of clinical
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The role of programmed death receptor (PD-)1/PD-ligand (L)1 in periodontitis and cancer Periodontol. 2000 (IF 17.5) Pub Date : 2024-02-13 Sabine Groeger, Joerg Meyle
The programmed-death-ligand-1 (PD-L1) is an immune-modulating molecule that is constitutively expressed on various immune cells, different epithelial cells and a multitude of cancer cells. It is a costimulatory molecule that may impair T-cell mediated immune response. Ligation to the programmed-death-receptor (PD)-1, on activated T-cells and further triggering of the related signaling pathways can
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The development of non-resorbable bone allografts: Biological background and clinical perspectives Periodontol. 2000 (IF 17.5) Pub Date : 2024-02-07 Richard J. Miron, Masako Fujioka-Kobayashi, Michael A. Pikos, Toshiaki Nakamura, Takatomo Imafuji, Yufeng Zhang, Yukiya Shinohara, Anton Sculean, Yoshinori Shirakata
Bone grafts are typically categorized into four categories: autografts, allografts, xenografts, and synthetic alloplasts. While it was originally thought that all bone grafts should be slowly resorbed and replaced with native bone over time, accumulating evidence has in fact suggested that the use of nonresorbable xenografts is favored for certain clinical indications. Thus, many clinicians take advantage
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Etiology, pathogenesis and treatment of peri-implantitis: A European perspective Periodontol. 2000 (IF 17.5) Pub Date : 2024-02-02 Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks
Peri-implantitis is a plaque-associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri-implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri-implantitis has become a major disease burden in dentistry. An understanding of the diagnosis, etiology and pathogenesis, epidemiology, and treatment of peri-implantitis
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The role of the epithelial sentinels, Langerhans cells and γδT cells, in oral squamous cell carcinoma Periodontol. 2000 (IF 17.5) Pub Date : 2024-01-25 Avi-Hai Hovav, Asaf Wilensky
Oral squamous cell carcinoma (OSCC) arises in the oral epithelium, a tissue in which immune surveillance is mediated by its primary resident leukocytes, Langerhans cells (LCs), and γδT cells. Under steady-state conditions, LCs and γδT cells play a critical role in maintaining oral mucosal homeostasis. As antigen-presenting cells of stratified epithelia, LCs respond to various challenges faced by the
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Role of innate host defense proteins in oral cancerogenesis Periodontol. 2000 (IF 17.5) Pub Date : 2024-01-24 Jochen Winter, Søren Jepsen
It is nowadays well accepted that chronic inflammation plays a pivotal role in tumor initiation and progression. Under this aspect, the oral cavity is predestined to examine this connection because periodontitis is a highly prevalent chronic inflammatory disease and oral squamous cell carcinomas are the most common oral malignant lesions. In this review, we describe how particular molecules of the
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Biological processes and factors involved in soft and hard tissue healing Periodontol. 2000 (IF 17.5) Pub Date : 2024-01-20 Mark Bartold, Saso Ivanovski
Wound healing is a complex and iterative process involving myriad cellular and biologic processes that are highly regulated to allow satisfactory repair and regeneration of damaged tissues. This review is intended to be an introductory chapter in a volume focusing on the use of platelet concentrates for tissue regeneration. In order to fully appreciate the clinical utility of these preparations, a
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Disparities and social determinants of periodontal diseases Periodontol. 2000 (IF 17.5) Pub Date : 2024-01-13 Jasim M. Albandar
Periodontal diseases are highly prevalent in populations worldwide and are a major global public health problem, with major negative impacts on individuals and communities. This study investigates evidence of disparities in periodontal diseases by age groups, gender, and socioeconomic factors. There is ample evidence that these diseases disproportionally affect poorer and marginalized groups and are
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Guided bone regeneration in implant dentistry: Basic principle, progress over 35 years, and recent research activities Periodontol. 2000 (IF 17.5) Pub Date : 2024-01-09 Daniel Buser, Istvan Urban, Alberto Monje, Marcel F. Kunrath, Christer Dahlin
Bone augmentation procedures are frequent today in implant patients, since an implant should be circumferentially anchored in bone at completion of bone healing to have a good long-term stability. The best documented surgical technique to achieve this goal is guided bone regeneration (GBR) utilizing barrier membranes in combination with bone fillers. This clinical review paper reflects 35 years of
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Fresh-frozen allogeneic bone blocks grafts for alveolar ridge augmentation: Biological and clinical aspects Periodontol. 2000 (IF 17.5) Pub Date : 2024-01-09 Andreas Stavropoulos, Camila Chierici Marcantonio, Vithor Xavier Resende de Oliveira, Élcio Marcantonio, Guilherme José Pimentel Lopes de Oliveira
The possibilities for oral bone regeneration procedures vary depending on the type of bone defect to be treated, which in turn dictate the type of graft to be used. Atrophic alveolar ridges are non-contained defects and pose a challenging defect morphology for bone regeneration/augmentation. Successful results are regularly obtained with the use of particulate grafts in combination with barrier membranes
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Mechanical plaque removal in step-1 of care Periodontol. 2000 (IF 17.5) Pub Date : 2023-12-26 G. A. (Fridus) Van der Weijden, Cor van Loveren
Maintaining a regular oral hygiene routine is essential for taking care of our mouths, ensuring healthy teeth, and achieving fresh breath. Patient education on oral hygiene is an important component of their overall treatment. Firstly, patients should be informed about the direct connection between bacteria in dental plaque and oral diseases. It is important for patients to understand that these conditions
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Periodontitis and risk of cancer: Mechanistic evidence Periodontol. 2000 (IF 17.5) Pub Date : 2023-12-15 Giacomo Baima, Margherita Minoli, Dominique S. Michaud, Mario Aimetti, Mariano Sanz, Bruno G. Loos, Mario Romandini
This review aims to critically analyze the pathways of interaction and the pathogenic mechanisms linking periodontitis and oral bacteria with the initiation/progression of cancer at different body compartments. A higher risk of head and neck cancer has been consistently associated with periodontitis. This relationship has been explained by the local promotion of dysbiosis, chronic inflammation, immune
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Biological biomarkers of oral cancer Periodontol. 2000 (IF 17.5) Pub Date : 2023-12-10 Allan Radaic, Pachiyappan Kamarajan, Alex Cho, Sandy Wang, Guo-Chin Hung, Fereshteh Najarzadegan, David T. Wong, Hung Ton-That, Cun-Yu Wang, Yvonne L. Kapila
The oral squamous cell carcinoma (OSCC) 5 year survival rate of 41% has marginally improved in the last few years, with less than a 1% improvement per year from 2005 to 2017, with higher survival rates when detected at early stages. Based on histopathological grading of oral dysplasia, it is estimated that severe dysplasia has a malignant transformation rate of 7%–50%. Despite these numbers, oral dysplasia
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Ten years of injectable platelet-rich fibrin Periodontol. 2000 (IF 17.5) Pub Date : 2023-11-30 Richard J. Miron, Reinhard Gruber, Nima Farshidfar, Anton Sculean, Yufeng Zhang
The use of platelet-rich fibrin (PRF) has seen widespread advantages over platelet-rich plasma (PRP) in many fields of medicine. However, until 2014, PRF remained clinically available only in its solid clotted form. Modifications to centrifugation protocols and tube technology have led to the development of a liquid injectable version of PRF (i-PRF). This narrative review takes a look back at the technological
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Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal Periodontol. 2000 (IF 17.5) Pub Date : 2023-11-23 Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard
In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds)). Cardiovascular diseases are a group
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Extended platelet-rich fibrin Periodontol. 2000 (IF 17.5) Pub Date : 2023-11-20 Richard J. Miron, Michael A. Pikos, Nathan E. Estrin, Masako Kobayashi-Fujioka, Alan Rene Espinoza, Hussein Basma, Yufeng Zhang
Platelet-rich fibrin (PRF) has been characterized as a regenerative biomaterial that is fully resorbed within a typical 2–3 week period. Very recently, however, a novel heating process was shown to extend the working properties of PRP/PRF from a standard 2–3 week period toward a duration of 4–6 months. Numerous clinicians have now utilized this extended-PRF (e-PRF) membrane as a substitute for collagen
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Indications and surgical technique for distraction osteogenesis of the alveolar bone for augmentation prior to insertion of dental implants Periodontol. 2000 (IF 17.5) Pub Date : 2023-11-08 Hans-Joachim Nickenig, Joachim E. Zöller, Matthias Kreppel
When bone is limited, short, ultra-short, or narrow implants help to restore oral rehabilitation with an acceptable long-term outcome. This becomes more difficult with severe vertical bone loss. Guided bone regeneration, onlay block transplantation, or sandwich osteotomy have been established to build up these defects. The alternative to the alveolar distraction osteogenesis (ADO) has only been established
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Emerging factors affecting peri-implant bone metabolism Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-30 Angel Insua, Pablo Galindo-Moreno, Richard J. Miron, Hom-Lay Wang, Alberto Monje
Implant dentistry has evolved to the point that standard implant osseointegration is predictable. This is attributed in part to the advancements in material sciences that have led toward improvements in implant surface technology and characteristics. Nonetheless, there remain several cases where implant therapy fails (specifically at early time points), most commonly attributed to factors affecting
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The natural history of periodontal disease—Part 2: In populations with access to dental care: The Studies of Health in Pomerania (SHIP) Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-25 Thomas Kocher, Peter Meisel, Reiner Biffar, Henry Völzke, Birte Holtfreter
In this descriptive analysis of the 21-year follow-up data from the SHIP-START cohort and the 7-year follow-up data from the SHIP-TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in SHIP-START and SHIP-TREND, respectively. At the final follow-up
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Membrane barriers for guided bone regeneration: An overview of available biomaterials Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-19 Gabriel Mizraji, Alon Davidzohn, Mervi Gursoy, Ulvi Gursoy, Lior Shapira, Asaf Wilensky
Dental implants revolutionized the treatment options for restoring form, function, and esthetics when one or more teeth are missing. At sites of insufficient bone, guided bone regeneration (GBR) is performed either prior to or in conjunction with implant placement to achieve a three-dimensional prosthetic-driven implant position. To date, GBR is well documented, widely used, and constitutes a predictable
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Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-16 Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto
Noncommunicable diseases (NCDs) are multifactorial, long-term, chronic conditions that represent a burden to health-care systems worldwide as they can only be controlled rather than cured; hence, they require long-term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is also rapidly rising. “Multimorbidity,” defined as the presence
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Do autologous platelet concentrates (APCs) have a role in intra-oral bone regeneration? A critical review of clinical guidelines on decision-making process Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-16 Marc Quirynen, Sam Siawasch, Andy Temmerman, Simone Cortellini, Rutger Dhondt, Wim Teughels, Anna B. Castro
In the past decades, personalized regenerative medicine has gained increased attention. Autologous platelet concentrates (APCs) such as PRP, PRGF, and L-PRF, all serving as a source of a large variety of cells and growth factors that participate in hard and soft tissue healing and regeneration, could play a significant role in regenerative periodontal procedures. This narrative review evaluated the
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Ion incorporation into bone grafting materials Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-12 Qin Zhao, Yueqi Ni, Hongjiang Wei, Yiling Duan, Jingqiu Chen, Qi Xiao, Jie Gao, Yiqian Yu, Yu Cui, Simin Ouyang, Richard J. Miron, Yufeng Zhang, Chengtie Wu
The use of biomaterials in regenerative medicine has expanded to treat various disorders caused by trauma or disease in orthopedics and dentistry. However, the treatment of large and complex bone defects presents a challenge, leading to a pressing need for optimized biomaterials for bone repair. Recent advances in chemical sciences have enabled the incorporation of therapeutic ions into bone grafts
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3D printing for bone regeneration: challenges and opportunities for achieving predictability Periodontol. 2000 (IF 17.5) Pub Date : 2023-10-12 Saso Ivanovski, Omar Breik, Danilo Carluccio, Jamil Alayan, Ruben Staples, Cedryck Vaquette
3D printing offers attractive opportunities for large-volume bone regeneration in the oro-dental and craniofacial regions. This is enabled by the development of CAD-CAM technologies that support the design and manufacturing of anatomically accurate meshes and scaffolds. This review describes the main 3D-printing technologies utilized for the fabrication of these patient-matched devices, and reports
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Less marginal bone loss around bone-level implants restored with long abutments: A systematic review and meta-analysis Periodontol. 2000 (IF 17.5) Pub Date : 2023-09-28 Péter Tajti, Eleonora Solyom, Szilárd Váncsa, Péter Mátrai, Péter Hegyi, Gábor Varga, Péter Hermann, Judit Borbély, Anton Sculean, Krisztina Mikulás
The aim of this study was to investigate the biological outcomes of bone-level implants restored with long vs. short abutments, with regard to the ‘one abutment at one time’ protocol. The systematic search was performed in five databases: MEDLINE (PubMed), EMBASE, Web of Science, Scopus, and CENTRAL for randomized controlled trials up to January 14, 2023. Data were collected for marginal bone loss
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Supra and subgingival application of antiseptics or antibiotics during periodontal therapy Periodontol. 2000 (IF 17.5) Pub Date : 2023-09-28 Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil
Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient's risk factors and the debridement of supra and subgingival
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Efficacy of biomaterials for lateral bone augmentation performed with guided bone regeneration. A network meta-analysis Periodontol. 2000 (IF 17.5) Pub Date : 2023-09-27 Elena Calciolari, Stefano Corbella, Nikolaos Gkranias, Marco Viganó, Anton Sculean, Nikolaos Donos
Bone regeneration is often required concomitant with implant placement to treat a bone fenestration, a dehiscence, and for contouring. This systematic review assessed the impact of different biomaterials employed for guided bone regeneration (GBR) simultaneous to implant placement on the stability of radiographic peri-implant bone levels at ≥12 months of follow-up (focused question 1), as well as on