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Adult-onset deletion of ATP13A2 in mice induces progressive nigrostriatal pathway dopaminergic degeneration and lysosomal abnormalities npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-07-20 Madalynn L. Erb, Kayla Sipple, Nathan Levine, Xi Chen, Darren J. Moore
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DBScope as a versatile computational toolbox for the visualization and analysis of sensing data from deep brain stimulation npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-07-15 Andreia M. Oliveira, Eduardo Carvalho, Beatriz Barros, Carolina Soares, Manuel J. Ferreira-Pinto, Rui Vaz, Paulo Aguiar
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Metabolic profiling reveals circulating biomarkers associated with incident and prevalent Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-07-09 Wenyi Hu, Wei Wang, Huan Liao, Gabriella Bulloch, Xiayin Zhang, Xianwen Shang, Yu Huang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu
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A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-07-04 Yaoyun Kuang, Hengxu Mao, Tingting Gan, Wenyuan Guo, Wei Dai, Weimeng Huang, Zhuohua Wu, Hongyan Li, Xiaoyun Huang, Xinling Yang, Ping-Yi Xu
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Identification of metabolites reproducibly associated with Parkinson’s Disease via meta-analysis and computational modelling npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-29 Xi Luo, Yanjun Liu, Alexander Balck, Christine Klein, Ronan M. T. Fleming
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Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-29 Erind Alushaj, Dimuthu Hemachandra, Hooman Ganjavi, Ken N. Seergobin, Manas Sharma, Alia Kashgari, Jennifer Barr, William Reisman, Ali R. Khan, Penny A. MacDonald
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Associations of cholinergic system integrity with cognitive decline in GBA1 and LRRK2 mutation carriers npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-29 Julia Schumacher, Nicola Ray, Stefan Teipel, Alexander Storch
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A retrospective study of the MDS criteria for prodromal Parkinson’s disease in the general population npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-26 Gijs W. de Klerk, Teus van Laar, Sanne K. Meles
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Interpretable video-based tracking and quantification of parkinsonism clinical motor states npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-25 Daniel Deng, Jill L. Ostrem, Vy Nguyen, Daniel D. Cummins, Julia Sun, Anupam Pathak, Simon Little, Reza Abbasi-Asl
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Analysis of striatal connectivity corresponding to striosomes and matrix in de novo Parkinson’s disease and isolated REM behavior disorder npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-25 S. Marecek, T. Krajca, R. Krupicka, P. Sojka, J. Nepozitek, Z. Varga, C. Mala, J. Keller, J. L. Waugh, D. Zogala, J. Trnka, K. Sonka, E. Ruzicka, P. Dusek
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Prediction of motor and non-motor Parkinson’s disease symptoms using serum lipidomics and machine learning: a 2-year study npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-25 Jasmin Galper, Giorgia Mori, Gordon McDonald, Diba Ahmadi Rastegar, Russell Pickford, Simon J. G. Lewis, Glenda M. Halliday, Woojin S. Kim, Nicolas Dzamko
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Enhancing mitochondrial proteolysis alleviates alpha-synuclein-mediated cellular toxicity npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-21 Xi Zhang, Linhao Ruan, Hu Wang, Jin Zhu, Taibo Li, Gordon Sun, Yi Dong, Yuhao Wang, Gil Berreby, Ashley Shay, Rong Chen, Sreekumar Ramachandran, Valina L. Dawson, Ted M. Dawson, Rong Li
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Understanding the role of cerebellum in early Parkinson’s disease: a structural and functional MRI study npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-19 S. Pietracupa, A. Ojha, D. Belvisi, C. Piervincenzi, S. Tommasin, N. Petsas, M. I. De Bartolo, M. Costanzo, A. Fabbrini, A. Conte, A. Berardelli, P. Pantano
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Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-17 Tiziano Balzano, Natalia López-González del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A. Pineda-Pardo, Inés Trigo-Damas, José A. Obeso, Javier Blesa
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Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-15 Xiaowei Liu, Jing Guang, Stefanie Glowinsky, Hodaya Abadi, David Arkadir, Eduard Linetsky, Muneer Abu Snineh, Juan F. León, Zvi Israel, Wei Wang, Hagai Bergman
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Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-15 Ilaria Linda Dellarole, Elena Vacchi, Inigo Ruiz-Barrio, Sandra Pinton, Andrea Raimondi, Stefania Rossi, Sara Morandi, Giovanni Bianco, Merve Begum Bacinoglu, Annalisa Lombardo, Luigi Celauro, Claudio Staedler, Salvatore Galati, Javier Pagonabarraga, Jaime Kulisevsky, Giuseppe Legname, Claudio Gobbi, Alain Kaelin-Lang, Fabio Moda, Giorgia Melli
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Using a smartwatch and smartphone to assess early Parkinson’s disease in the WATCH-PD study over 12 months npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-12 Jamie L. Adams, Tairmae Kangarloo, Yishu Gong, Vahe Khachadourian, Brian Tracey, Dmitri Volfson, Robert D. Latzman, Joshua Cosman, Jeremy Edgerton, David Anderson, Allen Best, Melissa A. Kostrzebski, Peggy Auinger, Peter Wilmot, Yvonne Pohlson, Stella Jensen-Roberts, Martijn L. T. M. Müller, Diane Stephenson, E. Ray Dorsey
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Acoustic assessment in mandarin-speaking Parkinson’s disease patients and disease progression monitoring and brain impairment within the speech subsystem npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-12 Yu Diao, Hutao Xie, Yanwen Wang, Baotian Zhao, Anchao Yang, Jan Hlavnicka, Jianguo Zhang
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Predictors of short-term anxiety outcome in subthalamic stimulation for Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-08 Anna Sauerbier, Johanna Herberg, Vasilija Stopic, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Stefanie T. Jost, Jan Niklas Petry-Schmelzer, Alexandra Gronostay, Christian Schneider, Veerle Visser-Vandewalle, Julian Evans, Christopher Nimsky, Gereon R. Fink, Angelo Antonini, Pablo Martinez-Martin, Monty Silverdale, Daniel Weintraub, Anette Schrag, K. Ray Chaudhuri, Lars Timmermann, Haidar
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Genome-wide determinants of mortality and motor progression in Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-07 Manuela M. X. Tan, Michael A. Lawton, Miriam I. Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A. Grosset, Nin Bajaj, Roger A. Barker, David J. Burn, Catherine Bresner, Thomas Foltynie, Nicholas W. Wood, Caroline H. Williams-Gray, Ole A. Andreassen
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Disease progression in proposed brain-first and body-first Parkinson’s disease subtypes npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-06-04 Zhiheng Xu, Tianyu Hu, Chenqin Xu, Xiaoniu Liang, Shiyu Li, Yimin Sun, Fengtao Liu, Jian Wang, Yilin Tang
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Digital outcome measures from smartwatch data relate to non-motor features of Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-29 Ann-Kathrin Schalkamp, Neil A. Harrison, Kathryn J. Peall, Cynthia Sandor
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Profiling complex repeat expansions in RFC1 in Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-24 Pilar Alvarez Jerez, Kensuke Daida, Abigail Miano-Burkhardt, Hirotaka Iwaki, Laksh Malik, Guillaume Cogan, Mary B. Makarious, Roisin Sullivan, Jana Vandrovcova, Jinhui Ding, J. Raphael Gibbs, Androo Markham, Mike A. Nalls, Rupesh K. Kesharwani, Fritz J. Sedlazeck, Bradford Casey, John Hardy, Henry Houlden, Cornelis Blauwendraat, Andrew B. Singleton, Kimberley J. Billingsley
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A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-21 Andrew J. White, Karis A. Clark, Kellianne D. Alexander, Nagendran Ramalingam, Tracy L. Young-Pearse, Ulf Dettmer, Dennis J. Selkoe, Gary P. H. Ho
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Neither alpha-synuclein fibril strain nor host murine genotype influences seeding efficacy npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-21 Sara Walton, Alexis Fenyi, Tyler Tittle, Ellen Sidransky, Gian Pal, Solji Choi, Ronald Melki, Bryan A. Killinger, Jeffrey H. Kordower
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Microstructure predicts non-motor outcomes following deep brain stimulation in Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-18 Philipp A. Loehrer, Miriam H. A. Bopp, Haidar S. Dafsari, Sieglinde Seltenreich, Susanne Knake, Christopher Nimsky, Lars Timmermann, David J. Pedrosa, Marcus Belke
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Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-18 Utkarsh Tripathi, Idan Rosh, Ran Ben Ezer, Ritu Nayak, Yara Hussein, Ashwani Choudhary, Jose Djamus, Andreea Manole, Henry Houlden, Fred H. Gage, Shani Stern
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Lysosomal and synaptic dysfunction markers in longitudinal cerebrospinal fluid of de novo Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-17 Michael Bartl, Johanna Nilsson, Mohammed Dakna, Sandrina Weber, Sebastian Schade, Mary Xylaki, Bárbara Fernandes Gomes, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudia Trenkwalder, Henrik Zetterberg, Ann Brinkmalm, Brit Mollenhauer
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Patient-centered development of clinical outcome assessments in early Parkinson disease: key priorities and advances npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-14 Tiago A. Mestre, Glenn T. Stebbins, Diane Stephenson, David Dexter, Karen K. Lee, Yuge Xiao, Tien Dam, Catherine M. Kopil, Tanya Simuni
Novel therapies with the ability to delay disease progression are a gap in the care of people living with Parkinson disease (PD) today. Clinical outcomes assessments (COAs) that are sensitive to the earliest clinical changes in PD are deemed essential for a successful therapeutic development. To understand the current landscape of COAs use in clinical trials in PD and define priorities for future research
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Untargeted serum metabolic profiling of diabetes mellitus among Parkinson’s disease patients npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-10 Shiwen Li, Yuyuan Lin, Dean Jones, Douglas I. Walker, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Keren Zhang, Adrienne M. Keener, Jeff Bronstein, Beate Ritz, Kimberly C. Paul
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Transcriptomic imputation of genetic risk variants uncovers novel whole-blood biomarkers of Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-08 Gabriel Chew, Aaron Shengting Mai, John F. Ouyang, Yueyue Qi, Yinxia Chao, Qing Wang, Enrico Petretto, Eng-King Tan
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Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-07 S. L. Schaffner, W. Casazza, F. Artaud, C. Konwar, S. M. Merrill, C. Domenighetti, J. M. Schulze-Hentrich, S. Lesage, A. Brice, J. C. Corvol, S. Mostafavi, J. K. Dennis, A. Elbaz, M. S. Kobor
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Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-03 Thomas F. Tropea, Whitney Hartstone, Noor Amari, Dylan Baum, Jacqueline Rick, Eunran Suh, Hanwen Zhang, Rachel A. Paul, Noah Han, Rebecca Zack, Eliza M. Brody, Isabela Albuja, Justin James, Meredith Spindler, Andres Deik, Whitley W. Aamodt, Nabila Dahodwala, Ali Hamedani, Aaron Lasker, Howard Hurtig, Matthew Stern, Daniel Weintraub, Pavan Vaswani, Allison W. Willis, Andrew Siderowf, Sharon X. Xie,
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Misfolded protein deposits in Parkinson’s disease and Parkinson’s disease-related cognitive impairment, a [11C]PBB3 study npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-03 Michele Matarazzo, Alexandra Pérez-Soriano, Nasim Vafai, Elham Shahinfard, Kevin Ju-Chieh Cheng, Jessamyn McKenzie, Nicole Neilson, Qing Miao, Paul Schaffer, Hitoshi Shinotoh, Jeffrey H. Kordower, Vesna Sossi, A. Jon Stoessl
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Progression subtypes in Parkinson’s disease identified by a data-driven multi cohort analysis npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-02 Tom Hähnel, Tamara Raschka, Stefano Sapienza, Jochen Klucken, Enrico Glaab, Jean-Christophe Corvol, Björn H. Falkenburger, Holger Fröhlich
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Structural underpinnings and long-term effects of resilience in Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-05-02 Verena Dzialas, Merle C. Hoenig, Stéphane Prange, Gérard N. Bischof, Alexander Drzezga, Thilo van Eimeren
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PARKIN is not required to sustain OXPHOS function in adult mammalian tissues npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-29 Roberta Filograna, Jule Gerlach, Hae-Na Choi, Giovanni Rigoni, Michela Barbaro, Mikael Oscarson, Seungmin Lee, Katarina Tiklova, Markus Ringnér, Camilla Koolmeister, Rolf Wibom, Sara Riggare, Inger Nennesmo, Thomas Perlmann, Anna Wredenberg, Anna Wedell, Elisa Motori, Per Svenningsson, Nils-Göran Larsson
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No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-26 Philipp Alexander Loehrer, Wibke Schumacher, Stefanie T. Jost, Monty Silverdale, Jan Niklas Petry-Schmelzer, Anna Sauerbier, Alexandra Gronostay, Veerle Visser-Vandewalle, Gereon R. Fink, Julian Evans, Max Krause, Alexandra Rizos, Angelo Antonini, Keyoumars Ashkan, Pablo Martinez-Martin, Christian Gaser, K. Ray Chaudhuri, Lars Timmermann, Juan Carlos Baldermann, Haidar S. Dafsari
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Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson’s disease brains npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-25 Florian Ermini, Victoria F. Low, Jennifer J. Song, Adelie Y. S. Tan, Richard L. M. Faull, Michael Dragunow, Maurice A. Curtis, Stephen S. Dominy
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Lysosomal genes contribute to Parkinson’s disease near agriculture with high intensity pesticide use npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-25 Kathie J. Ngo, Kimberly C. Paul, Darice Wong, Cynthia D. J. Kusters, Jeff M. Bronstein, Beate Ritz, Brent L. Fogel
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Diet and the gut microbiome in patients with Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-22 Dayoon Kwon, Keren Zhang, Kimberly C. Paul, Aline D. Folle, Irish Del Rosario, Jonathan P. Jacobs, Adrienne M. Keener, Jeff M. Bronstein, Beate Ritz
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Longitudinal cognitive decline characterizes the profile of non-PD-manifest GBA1 mutation carriers npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-22 Benjamin Roeben, Inga Liepelt-Scarfone, Stefanie Lerche, Milan Zimmermann, Isabel Wurster, Ulrike Sünkel, Claudia Schulte, Christian Deuschle, Gerhard W. Eschweiler, Walter Maetzler, Thomas Gasser, Daniela Berg, Kathrin Brockmann
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Resequencing the complete SNCA locus in Indian patients with Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-15 Asha Kishore, Marc Sturm, Kanchana Soman Pillai, Christopher Hakkaart, Divya Kalikavil Puthanveedu, Madhusoodanan Urulangodi, Syam Krishnan, Ashwin Ashok Kumar Sreelatha, Roopa Rajan, Pramod Kumar Pal, Ravi Yadav, Gangadhara Sarma, Nicolas Casadei, Thomas Gasser, Peter Bauer, Olaf Riess, Manu Sharma
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GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-13 Lara Cheslow, Matthew Byrne, Jessica S. Kopenhaver, Lorraine Iacovitti, Richard J. Smeyne, Adam E. Snook, Scott A. Waldman
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Grey matter networks in women and men with dementia with Lewy bodies npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-13 Annegret Habich, Javier Oltra, Christopher G. Schwarz, Scott A. Przybelski, Ketil Oppedal, Anna Inguanzo, Frédéric Blanc, Afina W. Lemstra, Jakub Hort, Eric Westman, Barbara Segura, Carme Junque, Val J. Lowe, Bradley F. Boeve, Dag Aarsland, Thomas Dierks, Kejal Kantarci, Daniel Ferreira
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Early deficits in an in vitro striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-12 Quyen B. Do, Humaira Noor, Ricardo Marquez-Gomez, Kaitlyn M. L. Cramb, Bryan Ng, Ajantha Abbey, Naroa Ibarra-Aizpurua, Maria Claudia Caiazza, Parnaz Sharifi, Charmaine Lang, Dayne Beccano-Kelly, Jimena Baleriola, Nora Bengoa-Vergniory, Richard Wade-Martins
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Predictors of stress resilience in Parkinson’s disease and associations with symptom progression npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-11 Anouk van der Heide, Lisanne J. Dommershuijsen, Lara M. C. Puhlmann, Raffael Kalisch, Bastiaan R. Bloem, Anne E. M. Speckens, Rick C. Helmich
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Elevated α-synuclein levels inhibit mitophagic flux npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-09 Inge Kinnart, Liselot Manders, Thibaut Heyninck, Dorien Imberechts, Roman Praschberger, Nils Schoovaerts, Catherine Verfaillie, Patrik Verstreken, Wim Vandenberghe
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Social isolation and the risk of Parkinson disease in the UK biobank study npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-08 Tingting Geng, Yaqi Li, Yinshun Peng, Xiao Chen, Xinming Xu, Jian Wang, Liang Sun, Xiang Gao
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Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-06 Velma T. E. Aho, Matthias Klee, Zied Landoulsi, Anna Heintz-Buschart, Lukas Pavelka, Anja K. Leist, Rejko Krüger, Patrick May, Paul Wilmes
Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition
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Modulation of subthalamic beta oscillations by movement, dopamine, and deep brain stimulation in Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-05 Varvara Mathiopoulou, Roxanne Lofredi, Lucia K. Feldmann, Jeroen Habets, Natasha Darcy, Wolf-Julian Neumann, Katharina Faust, Gerd-Helge Schneider, Andrea A. Kühn
Subthalamic beta band activity (13–35 Hz) is known as a real-time correlate of motor symptom severity in Parkinson’s disease (PD) and is currently explored as a feedback signal for closed-loop deep brain stimulation (DBS). Here, we investigate the interaction of movement, dopaminergic medication, and deep brain stimulation on subthalamic beta activity in PD patients implanted with sensing-enabled,
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Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-03 Elijah Mak, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R. Jack, Hoon Ki Min, Manoj K. Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Vijay K. Ramanan, Dennis W. Dickson, Neill R.
Dementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) may help elucidate the biological underpinnings of white matter injury in individuals with DLB. In this study, diffusion tensor imaging (DTI) and NODDI metrics were
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RedOx regulation of LRRK2 kinase activity by active site cysteines npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-04-03 Chiara R. Trilling, Jui-Hung Weng, Pallavi Kaila Sharma, Viktoria Nolte, Jian Wu, Wen Ma, Daniela Boassa, Susan S. Taylor, Friedrich W. Herberg
Mutations of the human leucine-rich repeat kinase 2 (LRRK2) have been associated with both, idiopathic and familial Parkinson’s disease (PD). Most of these pathogenic mutations are located in the kinase domain (KD) or GTPase domain of LRRK2. In this study we describe a mechanism in which protein kinase activity can be modulated by reversible oxidation or reduction, involving a unique pair of adjacent
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Investigating the aspect of asymmetry in brain-first versus body-first Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-30 S. S. Lövdal, G. Carli, B. Orso, M. Biehl, D. Arnaldi, P. Mattioli, A. Janzen, E. Sittig, S. Morbelli, J. Booij, W. H. Oertel, K. L. Leenders, S. K. Meles
Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons in the substantia nigra. Recent literature has proposed two subgroups of PD. The “body-first subtype” is associated with a prodrome of isolated REM-sleep Behavior Disorder (iRBD) and a relatively symmetric brain degeneration. The “brain-first subtype” is suggested to have a more asymmetric degeneration and a prodromal
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Efficacy of deep brain stimulation of the subthalamic nucleus versus globus pallidus internus on sensory complaints npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-29 Maria Gabriela S. Ghilardi, Ana Carolina P. Campos, Rubens G. Cury, Raquel C. R. Martinez, Rosana L. Pagano, Erich T. Fonoff
Pain control after deep brain stimulation (DBS) in Parkinson’s disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endorphin level. Pallidal GPi-DBS decreased bodily discomfort and beta-endorphin levels. Unexplained pain by other conditions and bodily discomfort were negatively correlated
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Genotype–phenotype correlation in PRKN-associated Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-29 Poornima Jayadev Menon, Sara Sambin, Baptiste Criniere-Boizet, Thomas Courtin, Christelle Tesson, Fanny Casse, Melanie Ferrien, Louise-Laure Mariani, Stephanie Carvalho, Francois-Xavier Lejeune, Sana Rebbah, Gaspard Martet, Marion Houot, Aymeric Lanore, Graziella Mangone, Emmanuel Roze, Marie Vidailhet, Jan Aasly, Ziv Gan Or, Eric Yu, Yves Dauvilliers, Alexander Zimprich, Volker Tomantschger, Walter
Bi-allelic pathogenic variants in PRKN are the most common cause of autosomal recessive Parkinson’s disease (PD). 647 patients with PRKN-PD were included in this international study. The pathogenic variants present were characterised and investigated for their effect on phenotype. Clinical features and progression of PRKN-PD was also assessed. Among 133 variants in index cases (n = 582), there were
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Altered perivascular spaces in subcortical white matter in Parkinson’s disease patients with levodopa-induced dyskinesia npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-28 Xingyue Cao, Caiting Gan, Heng Zhang, Yongsheng Yuan, Huimin Sun, Li Zhang, Lina Wang, Lian Zhang, Kezhong Zhang
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Association between irritable bowel syndrome and Parkinson’s disease by Cohort study and Mendelian randomization analysis npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-28 Zhi-yun Wang, Dong-rui Ma, Meng-jie Li, Yuan-yuan Liang, Zheng-wei Hu, Shuang-jie Li, Chun-yan Zuo, Chen-wei Hao, Yan-mei Feng, Meng-nan Guo, Xiao-yan Hao, Yuan-li Guo, Ke-ke Ma, Li-na Guo, Chan Zhang, Yu-ming Xu, Cheng-yuan Mao, Chang-he Shi
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A multi-site study on sex differences in cortical thickness in non-demented Parkinson’s disease npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-23 Javier Oltra, Barbara Segura, Antonio P. Strafella, Thilo van Eimeren, Naroa Ibarretxe-Bilbao, Maria Diez-Cirarda, Carsten Eggers, Olaia Lucas-Jiménez, Gemma C. Monté-Rubio, Natalia Ojeda, Javier Peña, Marina C. Ruppert, Roser Sala-Llonch, Hendrik Theis, Carme Uribe, Carme Junque
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Distinguishing features of Parkinson’s disease fallers based on wireless insole plantar pressure monitoring npj Parkinsons Dis. (IF 6.7) Pub Date : 2024-03-19 Cara Herbers, Raymond Zhang, Arthur Erdman, Matthew D. Johnson