![](https://scdn.x-mol.com/css/images/icon-new-link.png)
样式: 排序: IF: - GO 导出 标记为已读
-
Unique report of iliocaval endovascular reconstruction successfully enabling a kidney transplant Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-25 Henrique A. Almeida, Paulo Almeida, Duarte Rego, Sérgio Teixeira, Luís Loureiro, Henrique Rocha, Andreia Pinelo, Rui Machado
Patients with end-stage renal disease and iliocaval venous obstruction are normally nonviable recipients of kidney transplantation. We report a case of a 34-year-old male patient who has been receiving hemodialysis as renal replacement therapy for 6 years due to immunoglobulin A nephropathy. Past medical history included multiple central venous catheter infections and catheter-associated thrombosis
-
International multicenter study of ultralow graft-to-recipient weight ratio grafts in adult living donor liver transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-22 Mettu S. Reddy, Ashwin Rammohan, Subash Gupta, Mureo Kasahara, Tomoharu Yoshizumi, Ravi Mohanka, Gaurav Chaubal, Raghavendra Yelakanti, Viniyendra Pamecha, Abhideep Chaudhary, Abhishek Mathur, Hiroto Egawa, Ahmed Elsabbagh, Chao-Long Chen, Zhi-Jun Zhu, Abhinav Humar, Neerav Goyal, Surendran Sudhindran, Yaman Tokat, Jean Emond, Toru Ikegami, Mohamed Rela
Decreasing the graft size in living donor liver transplantation (LDLT) increases the risk of early allograft dysfunction. Graft-to-recipient weight ratio (GRWR) of 0.8 is considered the threshold. There is evidence that smaller volume grafts may also provide equally good outcomes, the cut-off of which remains unknown. In this retrospective multicenter study, 92 adult LDLTs with a final GRWR ≤0.6 performed
-
Letter to the editor: Liver machine perfusion technology in liver transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-22 Miho Akabane, Kazunari Sasaki
-
Effect of citizenship status on access to pediatric liver and kidney transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-20 Donna C. Koo, P. Nina Scalise, Megan Z. Chiu, Steven J. Staffa, Farokh R. Demehri, Alex G. Cuenca, Heung Bae Kim, Eliza J. Lee
Transplantation of non-US citizen residents remains controversial. We evaluate national trends in transplant activity among pediatric noncitizen residents (PNCR). Pediatric liver and kidney transplant data were obtained from the Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients. Data on transplanted organs, region, waitlist additions, procedures, and
-
Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-18 Sarah Kemme, Jennifer D. Canniff, Krystle M. Garth, Shaobing Li, Krupa Mysore, Adriana Weinberg, Amy G. Feldman
Infections preventable by live virus vaccines are surging in the setting of decreased herd immunity. Many children with chronic liver diseases (CLDs) are unimmunized and at increased risk for infection due to guidelines recommending against live vaccines within 4 weeks pretransplant. This prospective study of 21 children with CLD and 13 healthy controls defined the timing of measles virus and varicella-zoster
-
The emerging role of generative artificial intelligence in transplant medicine Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-18 Maya Deeb, Anirudh Gangadhar, Madhumitha Rabindranath, Khyathi Rao, Michael Brudno, Aman Sidhu, Bo Wang, Mamatha Bhat
Generative artificial intelligence (AI), a subset of machine learning that creates new content based on training data, has witnessed tremendous advances in recent years. Practical applications have been identified in health care in general, and there is significant opportunity in transplant medicine for generative AI to simplify tasks in research, medical education, and clinical practice. In addition
-
Integrating immune check inhibitors in liver transplantation for hepatocellular carcinoma: The right time and the right patient Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-18 Grainne O’Kane, Parissa Tabrizian, Laia Aceituno, Laura Kulik, Gonzalo Sapisochin
-
Dawn has arrived, illuminating thrilling opportunities and fresh challenges in a new era of United States transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-17 Mark J. Hobeika, Garrett R. Roll
-
Establishing targets for goal-directed anesthesia in renal transplantation: A cohort analysis of high-saliency surgical time courses Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-15 Rohit Malyala, Anna-Lisa Tam-Vi Nguyen, Erika Escamilla, Alex Ng, Lucie Hammond, Sasha Vozynuk, Alireza Habibi, Amirreza Habibi, Hana Mehdic, Christopher Nguan
Delayed graft function (DGF) increases morbidity and mortality in kidney transplant recipients. Operative parameters, including hemodynamic manipulation through vasopressors and fluids, can impact perfusion to the newly transplanted kidney and influence DGF incidence. We analyzed intraoperative time-series data in 5-minute intervals from kidney transplant recipient operations (N = 545) in conjunction
-
Consequences of low estimated glomerular filtration rate either before or early after kidney donation Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-14 Michael D. Evans, Erika S. Helgeson, Andrew D. Rule, David M. Vock, Arthur J. Matas
In the general population, decreases in glomerular filtration rate (GFR) are associated with subsequent development of chronic kidney disease (CKD), cardiovascular disease (CVD), and death. It is unknown if low estimated GFR (eGFR) before or early after kidney donation was also associated with these risks One thousand six hundred ninety-nine living donors who had both predonation and early (4-10 weeks)
-
Virus-specific T cell efficacy after solid organ transplantation: More questions than answers Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-13 Barbara C. Gärtner, Martina Sester
-
Cross-species metabolomic profiling reveals phosphocholine-mediated liver protection from cold and ischemia/reperfusion Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-13 Lele Zhang, Liang Chen, Yong Jiang, Guanghui Jin, Jinghong Yang, Haobin Sun, Jinliang Liang, Guo Lv, Qing Yang, Shuhong Yi, Guihua Chen, Wei Liu, Jingxing Ou, Yang Yang
Cold and ischemia/reperfusion (IR)-associated injuries are seemingly inevitable during liver transplantation and hepatectomy. Because Syrian hamsters demonstrate intrinsic tolerance to transplantation-like stimuli, cross-species comparative metabolomic analyses were conducted with hamster, rat, and donor liver samples to seek hepatic cold and IR-adaptive mechanisms. Lower hepatic phosphocholine contents
-
Why partial heart transplantation could be regulated as organ transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-13 Alexandra K. Glazier, Gianna Dafflisio, Taufiek Konrad Rajab, David Kalfa, James Jaggers, Sitaram Emani, Melissa A. Greenwald
Partial heart transplant (PHT) is a recent clinical innovation involving the transplantation of a segment of the heart (valves) directly from the deceased donor into the recipient patient. This procedure holds out the possibility of significant benefit, especially for pediatric patients because these grafts show growth potential after transplant, reducing or eliminating the current need for repeat
-
Prevention of delayed graft function: Another brick in the wall Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-12 Christophe Legendre
-
The suggestion of mitigating disparity in the liver transplantation field among ABO blood type Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-10 Miho Akabane, Yuki Imaoka, Carlos O. Esquivel, W. Ray Kim, Kazunari Sasaki
Medical literature highlights differences in liver transplantation (LT) waitlist experiences among ABO blood types. Type AB candidates reportedly have higher LT rates and reduced mortality. Despite liver offering guidelines, ABO disparities persist. This study examines LT access discrepancies among blood types, focusing on type AB, and seeks equitable strategies. Using the United Network for Organ
-
The prevalence of postacute sequelae of coronavirus disease 2019 in solid organ transplant recipients: Evaluation of risk in the National COVID Cohort Collaborative Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-08 Amanda J. Vinson, Makayla Schissel, Alfred J. Anzalone, Ran Dai, Evan T. French, Amy L. Olex, Stephen B. Lee, Michael Ison, Roslyn B. Mannon, National COVID Cohort Collaborative, Adam B. Wilcox, Adam M. Lee, Alexis Graves, Alfred Jerrod Anzalone, Amin Manna, Amit Saha, Amy Olex, Andrea Zhou, Andrew E. Williams, Andrew Southerland, Andrew T. Girvin, Anita Walden, Anjali A. Sharathkumar, Benjamin Amor
Postacute sequelae after the coronavirus disease (COVID) of 2019 (PASC) is increasingly recognized, although data on solid organ transplant (SOT) recipients (SOTRs) are limited. Using the National COVID Cohort Collaborative, we performed 1:1 propensity score matching (PSM) of all adult SOTR and nonimmunosuppressed/immunocompromised (ISC) patients with acute COVID infection (August 1, 2021 to January
-
Virus-specific T cell therapy to treat refractory viral infections in solid organ transplant recipients Am. J. Transplant. (IF 8.9) Pub Date : 2024-06-08 Lorne Schweitzer, Pawel Muranski
Solid organ transplant recipients require ongoing immunosuppression to prevent acute rejection, which puts them at risk of opportunistic infections. Viral infections are particularly challenging to prevent and treat as many establish latency and thus cannot be eliminated, whereas targets for small molecule antiviral medications are limited. Resistance to antivirals and unacceptable toxicity also complicate
-
Sowing “seeds of trust”: How trust in normothermic regional perfusion is built in a continuum of care Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-31 Mary Ott, Nicholas Murphy, Lorelei Lingard, Marat Slessarev, Laurie Blackstock, John Basmaji, Mayur Brahmania, Andrew Healey, Sam Shemie, Anton Skaro, Charles Weijer
Normothermic regional perfusion (NRP) is a promising technology to improve organ transplantation outcomes by reversing ischemic injury caused by controlled donation after circulatory determination of death. However, it has not yet been implemented in Canada due to ethical questions. These issues must be resolved to preserve public trust in organ donation and transplantation. This qualitative, constructivist
-
Invasive aspergillosis in liver transplant recipientsin the current era Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-25 Muneyoshi Kimura, Matteo Rinaldi, Sagar Kothari, Maddalena Giannella, Shweta Anjan, Yoichiro Natori, Pakpoom Phoompoung, Emily Gault, Jonathan Hand, Matilde D’Asaro, Dionysios Neofytos, Nicolas J. Mueller, Andreas E. Kremer, Tereza Rojko, Marija Ribnikar, Fernanda P. Silveira, Joshua Kohl, Angela Cano, Julian Torre-Cisneros, Rafael San-Juan, Jose Maria Aguado, Armaghan-e-Rehman Mansoor, Ige Abraham
Invasive aspergillosis (IA) is a rare but fatal disease among liver transplant recipients (LiTRs). We performed a multicenter 1:2 case-control study comparing LiTRs diagnosed with proven/probable IA and controls with no invasive fungal infection. We included 62 IA cases and 124 matched controls. Disseminated infection occurred only in 8 cases (13%). Twelve-week all-cause mortality of IA was 37%. In
-
Xenotransplantation under the Food and Drug Administration’s Expanded Access pathway Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-22 Christopher Bobier, Daniel J. Hurst, Daniel Rodger
-
Donor and recipient genetics: Implications for the development of posttransplant diabetes mellitus Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-21 Oren Shaked, Bao-Li Loza, Kim M. Olthoff, Kuchikula Rajender Reddy, Brendan J. Keating, Giuliano Testa, Sumeet K. Asrani, Abraham Shaked
Posttransplant diabetes mellitus (PTDM) is a prevalent complication of liver transplantation and is associated with cardiometabolic complications. We studied the consequences of genetic effects of liver donors and recipients on PTDM outcomes, focusing on the diverse genetic pathways related to insulin that play a role in the development of PTDM. One thousand one hundred fifteen liver transplant recipients
-
Enhanced role of multipair donor swaps in response to size incompatibility: The first two 5-way and the first 6-way liver paired exchanges Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-18 Sezai Yilmaz, Tayfun Sönmez, M. Utku Ünver, Volkan Ince, Sami Akbulut, Kemal Baris Sarici, Burak Isik
A significant portion of liver transplantations in many countries is conducted via living-donor liver transplantation (LDLT). However, numerous potential donors are unable to donate to their intended recipients due to factors such as blood type incompatibility or size incompatibility. Despite this, an incompatible donor for one recipient may still be a viable donor for another patient. In recent decades
-
Financial toxicity in living donor liver transplantation: A call to action for financial neutrality Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-18 Alyson Kaplan, Elizabeth S. Aby, Sonia Scott, Christopher Sonnenday, Alyson Fox, Amit Mathur, Kim Olthoff, Julie Heimbach, Keren Ladin, Juliet Emamaullee, the NALLDIG Consortium, G. Testa, A. Gupta, S. Lee, Z. Fricker, K. Hashimoto, D. Kwon, J. Emond, A. Fox, B. Samstein, R. Brown, R. Rosenblatt, A. Kubal, R. Gilroy, E. King, J. Heimbach, T. Taner, K. Watt, K. Chacko, D. von Ahrens, B. Fortune, S.
After 2 decades of limited growth, living donor liver transplant (LDLT) has been increasingly accepted as a promising solution to the growing organ shortage in the US. With experience, LDLT offers superior graft and patient survival with low rates of rejection. However, not all waitlisted patients have equal access to LDLT, with financial toxicity representing a substantial barrier. Potential living
-
uLIPSTIC: A universal tool for in vivo tracking of cellular interaction networks Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-16 Im-Hong Sun, James M. Gardner
-
Corrigendum to ‘Expected effect of the lung Composite Allocation Score system on US lung transplantation’ [American Journal of Transplantation. Volume 22, Issue 12 (December 2022) Pages 2971-2980] Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-11 Maryam Valapour, Carli J. Lehr, Andrew Wey, Melissa A. Skeans, Jonathan Miller, Erika D. Lease
-
Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-10 Zhongyang Zhang, Zeguo Sun, Peter Heeger, Madhav C. Menon
-
Successful BK virus–specific T cell therapy in a kidney transplant recipient with progressive multifocal leukoencephalopathy Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-09 Abiu Sempere, Nerea Castillo, Francesc Rudilla, Sergi Querol, Emma Enrich, Cristina Prat-Vidal, Margarita Codinach, Frederic Cofan, Vicens Torregrossa, Fritz Dieckmann, Marta Bodro
The strategy for progressive multifocal leukoencephalopathy (PML) in solid organ transplant recipients primarily focuses on reducing immunosuppressive therapy. However, this approach offers limited efficacy and carries a high risk of graft loss. Here, we present the case of a 64-year-old male kidney transplant recipient with a high degree of immunosuppression who developed PML in October 2022. Despite
-
Machine perfusion and liver transplant center behavior: Answers or more questions? Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-09 Amit K. Mathur, Shimul A. Shah
-
Considerations in gender-affirming hormone therapy in transgender and gender diverse patients undergoing liver transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-08 Newsha Nikzad, Andrew R. Fisher, Anjana Pillai, Laura E. Targownik, Helen S. Te, Andrew Aronsohn, Sonali Paul
Liver transplantation is lifesaving for patients with end-stage liver disease. Similar to the role of transplantation for patients with end-stage liver disease, gender-affirming hormone therapy (GAHT) can be lifesaving for transgender and gender diverse (TGGD) patients who experience gender dysphoria. However, management of such hormone therapy during the perioperative period is unknown and without
-
Robotic living donor hepatectomy is associated with superior outcomes for both the donor and the recipient compared with laparoscopic or open - A single-center prospective registry study of 3448 cases Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-07 Dimitri A. Raptis, Yasser Elsheikh, Yasir Alnemary, Kris Ann H. Marquez, Khalid Bzeizi, Saad Alghamdi, Saleh Alabbad, Saleh A. Alqahtani, Roberto I. Troisi, Markus U. Boehnert, Massimo Malago, Yao-Ming Wu, Dieter C. Broering, The OTCE KFSHRC Collaborative (Appendix), Agniesza Lepiesza, Bedour A. AlMudaiheem, Bilal Elmikkaoui, Hazem Zakaria, Yogesh Vashist, Leen Alshibi, Sami A. Kareem
Minimally invasive donor hepatectomy is an emerging surgical technique in living donor liver transplantation (LDLT). We examined outcomes across open, laparoscopic, and robotic LDLT using a prospective registry. We analyzed 3448 cases (1724 donor-recipient pairs) from January 2011 to March 2023 (NCT06062706). Among donors, 520 (30%) were female. Adult-to-adult LDLT comprised 1061 (62%) cases. A total
-
The role of neutrophil extracellular trap formation in kidney transplantation: Implications from donors to the recipient Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-06 Maryna van Zyl, Elodie Cramer, Jan-Stephan F. Sanders, Henri G.D. Leuvenink, Ton Lisman, Mia-Jeanne van Rooy, Jan-Luuk Hillebrands
Kidney transplantation remains the gold standard for patients with end-stage renal disease, but severe donor organ shortage has led to long waiting lists. The utilization of expanded criteria donor kidneys within the category of deceased donors has enlarged the pool of available kidneys for transplantation; however, these grafts often have an increased risk for delayed graft function or reduced graft
-
Successful living donor liver transplant from donor with false-positive human immunodeficiency virus test in recipient without human immunodeficiency virus Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-04 Monica Fung, Ricardo M. La Hoz, Christine M. Durand, Dong Heun Lee, David Sears, Caitlin Hohe, Peter Chin-Hong, John P. Roberts
-
Chimeric autoantibody-receptor T cells mediate depletion of autoantibody-producing B cells Am. J. Transplant. (IF 8.9) Pub Date : 2024-05-01 Han S. Yin, Eva M. Gillis-Buck, James M. Gardner
-
TEMPORARY REMOVAL: A novel scoring system to predict short-term mortality after living donor liver transplantation for acute liver failure Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-29 Keita Shimata, Young-In Yoon, Taizo Hibi, Jun Morinaga, Anila Kutty Narayanan, Takeo Toshima, Takashi Ito, Nobuhisa Akamatsu, Yoshihito Kotera, Suk Kyun Hong, Yasushi Hasegawa, Yuzo Umeda, Mettu Srinivas Reddy, Aldwin De Leon Ong, Saraswathy Sivaprasadan, Joy Varghese, Yasuhiko Sugawara, Chao-Long Chen, Kyung-Suk Suh, Toru Ikegami, Kwang-Woong Lee, Sung-Gyu Lee, Vanguard Multicenter Study of International
The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated.
-
Exploring kidney allograft rejection: A proof-of-concept study using spatial transcriptomics Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-29 Cristina Martin-Martin, Beatriz Suarez-Alvarez, Monika González, Irina B. Torres, Oriol Bestard, José E. Martín, Gwendolyn Barceló-Coblijn, Francesc Moreso, Ana M. Aransay, Carlos Lopez-Larrea, Ramon M. Rodriguez
In this proof-of-concept study, spatial transcriptomics combined with public single-cell ribonucleic acid-sequencing data were used to explore the potential of this technology to study kidney allograft rejection. We aimed to map gene expression patterns within diverse pathologic states by examining biopsies classified across nonrejection, T cell–mediated acute rejection, interstitial fibrosis, and
-
Calcineurin inhibitor toxicity in de novo thrombotic microangiopathy—Is the culprit what we think it is? Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-25 Vojtech Petr, Ivan Zahradka, Ondrej Viklicky
-
Interim effectiveness of the updated 2023-2024 COVID-19 vaccines in adults with immunocompromizing conditions Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-25 Marcus R. Pereira
-
Undocumented immigrants: A glaring inequity in transplant Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-23 Lara C. Pullen PhD
-
Cyclic guanosine monophosphate-adenosine monophosphate synthetase/stimulator of interferon genes signaling aggravated corneal allograft rejection through neutrophil extracellular traps Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-20 Chao Wei, Qing Huang, Fanxing Zeng, Li Ma, Xiaofei Bai, Xuejing Zhu, Hua Gao, Xiaolin Qi
The activation of innate immunity following transplantation has been identified as a crucial factor in allograft inflammation and rejection. However, the role of cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signaling-mediated innate immunity in the pathogenesis of allograft rejection remains unclear. Utilizing a well-established murine
-
Third-party virus-specific T cells for the treatment of double-stranded DNA viral reactivation and posttransplant lymphoproliferative disease after solid organ transplant Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-19 Ruby Khoury, Michael S. Grimley, Adam S. Nelson, Tom Leemhuis, Jose A. Cancelas, Eleanor Cook, YunZu Wang, Daria Heyenbruch, Catherine M. Bollard, Michael D. Keller, Patrick J. Hanley, Carolyn Lutzko, Giang Pham, Stella M. Davies, Jeremy D. Rubinstein
Reactivation or primary infection with double-stranded DNA viruses is common in recipients of solid organ transplants (SOTs) and is associated with significant morbidity and mortality. Treatment with conventional antiviral medications is limited by toxicities, resistance, and a lack of effective options for adenovirus (ADV) and BK polyomavirus (BKPyV). Virus-specific T cells (VSTs) have been shown
-
The emerging era of organ transplantation and anti-CD154mAb Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-19 Jean Kwun, Allan D. Kirk, Stuart J. Knechtle
-
Comparing the prognostic performance of iBOX and biopsy-proven acute rejection for long-term kidney graft survival Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-19 Amanda Klein, Luke Kosinski, Alexandre Loupy, Eric Frey, Mark Stegall, Ilkka Helanterä, Kenneth Newell, Herwig-Ulf Meier-Kriesche, Roslyn B. Mannon, William E. Fitzsimmons, Transplant Therapeutics Consortium
Biopsy-proven acute rejection (BPAR) occurs in approximately 10% of kidney transplant recipients in the first year, making superiority trials unfeasible. iBOX, a quantitative composite of estimated glomerular filtration rate, proteinuria, antihuman leukocyte antigen donor-specific antibody, and + full/− abbreviated kidney histopathology, is a new proposed surrogate endpoint. BPAR’s prognostic ability
-
Pretransplant use of immune checkpoint inhibitors for hepatocellular carcinoma: A multicenter, retrospective cohort study Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-18 Zhiyong Guo, Yao Liu, Qi Ling, Leibo Xu, Tielong Wang, Jiaxing Zhu, Yimou Lin, Xinjun Lu, Wei Qu, Fan Zhang, Zhijun Zhu, Jian Zhang, Zehua Jia, Ping Zeng, Wenjing Wang, Qiang Sun, Qijie Luo, Zemin Hu, Zhouying Zheng, Yingbin Jia, Jian Li, Yujian Zheng, Mengchao Wang, Shaoping Wang, Zemin Han, Sheng Yu, Chuanjiang Li, Shuhua Zhang, Jun Xiong, Feiwen Deng, Ying Liu, Huanwei Chen, Yanfeng Wang, Ling Li
Immune checkpoint inhibitors (ICIs) as a downstaging or bridging therapy for liver transplantation (LT) in hepatocellular carcinoma patients are rapidly increasing. However, the evidence about the feasibility and safety of pre-LT ICI therapy is limited and controversial. To this end, a multicenter, retrospective cohort study was conducted in 11 Chinese centers. The results showed that 83 recipients
-
An ethical analysis of conditional and partially directed live kidney donation among strangers—The Israeli experience Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-17 Penina Dienstag, Rana Halaseh, Keren Tzukert, Ashraf Imam, Abed Khalaileh, Aryeh Dienstag
Living donor kidney transplantation (LDKT) is one of the most effective treatment options for people with end-stage renal disease. Traditionally, LDKT can be either “directed” or “nondirected,” based on whether the recipient is specified by the donor. Recently, there has been an increase in conditional and semidirected live kidney donation among strangers, where the donor specifies the characteristics
-
Incomplete reporting of clinically significant acute rejection episodes in the national kidney transplant registry Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-16 Miko Yu, Kristen L. King, Lindsey M. Maclay, S. Ali Husain, Jesse D. Schold, Sumit Mohan
Administrative claims data could provide a unique opportunity to identify acute rejection (AR) events using specific antirejection medications and to validate rejected data reported to the Organ Procurement and Transplantation Network. This retrospective cohort study examined differences in registry-reported events and those identified using claims data among adult kidney transplant recipients from
-
Magnetic resonance imaging as a noninvasive adjunct to conventional assessment of functional differences between kidneys in vivo and during ex vivo normothermic machine perfusion Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-13 Tim L. Hamelink, Baran Ogurlu, Carolina C. Pamplona, Johannes Castelein, Sigrid S. Bennedsgaard, Haiyun Qi, Thomas Weiss, Veerle A. Lantinga, Merel B.F. Pool, Christoffer Laustsen, Bente Jespersen, Henri G.D. Leuvenink, Steffen Ringgaard, Ronald J.H. Borra, Anna K. Keller, Cyril Moers
Normothermic machine perfusion (NMP) is increasingly considered for pretransplant kidney quality assessment. However, fundamental questions about differences between in vivo and ex vivo renal function, as well as the impact of ischemic injury on ex vivo physiology, remain unanswered. This study utilized magnetic resonance imaging (MRI), alongside conventional parameters to explore differences between
-
Activation of farnesoid X receptor enhances the efficacy of normothermic machine perfusion in ameliorating liver ischemia-reperfusion injury Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-12 Qiang Zhao, Xiaobo Wang, Kunpeng Liu, Honghui Chen, Jia Dan, Zebin Zhu, Lili Guo, Huadi Chen, Weiqiang Ju, Dongping Wang, Yunhua Tang, Zhiyong Guo, Xiaoshun He
The shortage of transplant organs remains a severe global issue. Normothermic machine perfusion (NMP) has the potential to increase organ availability, yet its efficacy is hampered by the inflammatory response during machine perfusion. Mouse liver ischemia-reperfusion injury (IRI) models, discarded human liver models, and porcine marginal liver transplantation models were utilized to investigate whether
-
China issued rules on human organ donation and transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-04-12 Hao Chen, Di Lu, Shusen Zheng, Xiao Xu
-
Anti-intercellular adhesion molecule 1 monomaintenance therapy induced long-term liver allograft survival without chronic rejection Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-30 Dong Kyu Han, Suk Kyun Hong, Il Hee Yun, Ji-Jing Yan, Jisu Park, Sang Wha Kim, Seung Hyeok Seok, Haeryoung Kim, Gilyong Ji, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh, Jaeseok Yang, Nam-Joon Yi
Calcineurin inhibitors (CNIs) are essential in liver transplantation (LT); however, their long-term use leads to various adverse effects. The anti–intercellular adhesion molecule (ICAM)-1 monoclonal antibody MD3 is a potential alternative to CNI. Despite its promising results with short-term therapy, overcoming the challenge of chronic rejection remains important. Thus, we aimed to investigate the
-
Microbiome composition recovery after liver transplantation correlates with initial liver disease severity and antibiotics treatment Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-29 Sara Vega-Abellaneda, Cristina Dopazo, Francisca Yañez, Zaida Soler, Zixuan Xie, Aleix Canalda-Baltrons, Marc Pons-Tarín, Itxarone Bilbao, Chaysavanh Manichanh
Liver transplantation (LT) is crucial for end-stage liver disease, but it is linked to infection risks. Pathobionts, microorganisms potentially harmful under specific conditions, can cause complications posttransplant. Monitoring such pathogens in fecal samples can be challenging and therefore remains underexplored post-LT. This study aimed to analyze the gut microbiome before and after LT, tracking
-
Maternal-fetal microchimerism as a durable but finite and replaceable alloantigen reservoir Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-29 Eva M. Gillis-Buck, James M. Gardner
-
Xenotransplantation moves toward clinical trials Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-29 Lara C. Pullen PhD
-
Total robotic liver transplant: the final frontier of minimally invasive surgery Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-29 Adeel S. Khan, Meranda Scherer, Roheena Panni, Darren Cullinan, Greg Martens, Ivan Kangarga, Christopher R. King, Richard Benzinger, Jason R. Wellen MD, William C. Chapman, Majella B. Doyle
The use of robotic surgery in transplantation is increasing; however, robotic liver transplantation (RLT) remains a challenging undertaking. To our knowledge, this is a report of the first RLT in North America and the first RLT using a whole graft from a deceased donor in the world. This paper describes the preparation leading to the RLT and the surgical technique of the operation. The operation was
-
Do you transplant hearts from donation after circulatory determination of death donors? Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-29 Lara C. Pullen PhD
-
Type 2 cytokines safeguard against cellular senescence and aging Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-27 Xian C. Li
-
Molecular diagnosis of antibody-mediated rejection: Evaluating biopsy-based transcript diagnostics in the presence of donor-specific antibodies but without microvascular inflammation, a single-center descriptive analysis Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-27 Dusan Harmacek, Lukas Weidmann, Kai Castrezana Lopez, Nicolas Schmid, Raphael Korach, Nicola Bortel, Seraina von Moos, Elena Rho, Birgit Helmchen, Ariana Gaspert, Thomas Schachtner
Biopsy-based transcript diagnostics may identify molecular antibody-mediated rejection (AMR) when microvascular inflammation (MVI) is absent. In this single-center cohort, biopsy-based transcript diagnostics were validated in 326 kidney allograft biopsies. A total of 71 histological AMR and 35 T cell–mediated rejection (TCMR) cases were identified as molecular AMR and TCMR in 55% and 63%, respectively
-
Differential induction of donor-reactive Foxp3+ regulatory T cell via blockade of CD154 vs CD40 Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-27 Danya Liu, Hongmin Yao, Ivana R. Ferrer, Mandy L. Ford
Recently published studies in both murine models and a meta-analysis of non-human primate renal transplant studies showed that anti-CD154 reagents conferred a significant survival advantage over CD40 blockers in both animal models and across multiple organs. Here we sought to compare the induction of donor-reactive forkhead box P3+-induced regulatory T cells (Foxp3 iTreg) in mice treated with anti-CD154
-
Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-26 Philip F. Halloran, Katelynn Madill-Thomsen, Arezu Z. Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Gökler, Shelley Hall, Aayla Jamil, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Vojtech Melenovsky, Jignesh Patel, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann
The first-generation Molecular Microscope (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose not only T cell–mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship
-
Bridging the critically ill patient with acute to chronic liver failure to liver transplantation Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-26 Javier Fernández, Annabel Blasi, Ernest Hidalgo, Constantine J. Karvellas
Liver transplantation (LT) has emerged as an effective therapy for severe forms of acute-on-chronic liver failure (ACLF), an entity characterized by the development of multiorgan failure and high short-term mortality. The aim of critical care management of ACLF patients is to rapidly treat precipitating events and aggressively support failing organs to ensure that patients may successfully undergo
-
Validation of a novel donor lung scoring system based on the updated lung Composite Allocation Score Am. J. Transplant. (IF 8.9) Pub Date : 2024-03-24 Zhizhou Yang, Yun Zhu Bai, Yan Yan, Ramsey R. Hachem, Chad A. Witt, Rodrigo Vazquez Guillamet, Derek E. Byers, Gary F. Marklin, Daniel Kreisel, Ruben G. Nava, Bryan F. Meyers, Benjamin D. Kozower, G. Alexander Patterson, Matthew G. Hartwig, Brendan T. Heiden, Varun Puri
Lung transplantation (LTx) continues to have lower rates of long-term graft survival compared with other organs. Additionally, lung utilization rates from brain-dead donors remain substantially lower compared with other solid organs, despite a growing need for LTx and the significant risk of waitlist mortality. This study aims to examine the effects of using a combination of the recently described