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Application of high-dimensional propensity score methods to the National Health and Aging Trends Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-18 Ali G Hamedani, Thanh Phuong Pham Nguyen, Allison W Willis, John R Tazare
Background High-dimensional propensity scoring (HDPS) is a method for empirically identifying potential confounders within large healthcare databases such as administrative claims data. However, this method has not yet been applied to large national health surveys such as the National Health and Aging Trends Study (NHATS), an ongoing nationally representative survey of older adults in the U.S and important
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A Preliminary Analysis of Stress Burden and Cognitive Function and Clinically-Adjudicated Cognitive Outcomes in Black American Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-16 Wendy M Troxel, Tamara Dubowitz, Ann Haas, Bonnie Ghosh-Dastidar, Meryl A Butters, Tiffany L Gary-Webb, Andrea Weinstein, Ada Ibeanu, La’Vette Wagner, Ariel Gildengers, Andrea L Rosso
Background The combination of exposure to multiple stressors and psychological distress may contribute to the disproportionate burden of dementia risk among Black Americans. This study estimates the effect of an index of stress and psychological distress (i.e., “stress burden”) on cognitive function and clinically-adjudicated cognitive outcomes among older Black American adults, and examines sleep
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Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-15 Michelle C Odden, Yongmei Li, Vasantha Jotwani, Sylvie Dobrota, Annabel Tan, Steven R Cummings, Michael G Shlipak, Rebecca Scherzer, Joachim H Ix, Marion Buckwalter, Gregory J Tranah
Background Mitochondrial dysfunction manifests in neurodegenerative diseases and other age-associated disorders. In this study, we examined variation in inherited mitochondrial DNA (mtDNA) sequences in Black and White participants from two large aging studies to identify variants related to cognitive function. Methods Participants included self-reported Black and White adults aged ≥ 70 years in the
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Enhancing Care for Older Adults and Dementia Patients with Large Language Models: Proceedings of the National Institute on Aging –Artificial Intelligence & Technology Collaboratory for Aging Research Symposium J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Peter M Abadir, Alexis Battle, Jeremy D Walston, Rama Chellappa
Large Language Models (LLMs) stand on the brink of reshaping the field of aging and dementia care, challenging the one-size-fits-all paradigm with their capacity for precision medicine and individualized treatment strategies. The "Large Pre-Trained Models with a Focus on AD/ADRD and Healthy Aging" symposium, organized by the National Institute on Aging and the Johns Hopkins AI & Technology Collaboratory
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Causal Relationship between Gut Microbiota, Metabolites, and Sarcopenia: A Mendelian Randomization Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Xiangyu Zhang, Guang Yang, Shide Jiang, Bingzhou Ji, Wenqing Xie, Hengzhen Li, Jianfeng Sun, Yusheng Li
Background Gut microbiota imbalance and sarcopenia are frequently observed in the elderly population. Gut Microbiota and their metabolites are considered risk factors contributing to the heightened risk of sarcopenia, but whether these associations are causal remains unclear. Methods We conducted linkage disequilibrium score regression and two-sample Mendelian randomization methods with SNPs sourced
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Longitudinal changes in a claims-based frailty proxy measure compared to concurrent changes in the Fried frailty phenotype J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Emilie D Duchesneau, Dae Hyun Kim, Til Stürmer, Katherine Reeder-Hayes, Jessie K Edwards, Keturah R Faurot, Jennifer L Lund
Background Frailty is a dynamic aging-related syndrome, but measuring frailty transitions is challenging. The Faurot frailty index is a validated Medicare claims-based frailty proxy based on demographic and billing information. We evaluated whether three-year changes in the Faurot frailty index were consistent with concurrent changes in the frailty phenotype in a cohort of older adults. Methods We
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Deciphering the Biological Ageing Impact on Alveolar Bone Loss: Insights from α-Klotho and Renal Function Dynamics J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-12 Zifei Wang, Hao Xue, Yuqiang Sun, Qing Wang, Wansu Sun, Hengguo Zhang
Alveolar bone loss is generally considered as a chronological age-related disease. As biological ageing process is not absolutely determined by increasing age, whether alveolar bone loss associated with increasing chronological age or biological ageing remains unclear. Accurately distinguishing whether alveolar bone loss is chronological age-related or biological ageing-related is critical for selecting
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Growth differentiation factor 15 (GDF-15) as a biomarker of cardiovascular risk in chronic musculoskeletal pain J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-06 Rocío León-González, Rosario Ortolá, Adrián Carballo-Casla, Mercedes Sotos-Prieto, Antonio Buño-Soto, Isabel Rodríguez-Sánchez, Roberto Pastor-Barriuso, Fernando Rodríguez-Artalejo, Esther García-Esquinas
Background It is unknown whether growth differentiation factor 15 (GDF-15) is associated with chronic musculoskeletal pain (CMP) and whether or not its association with incident cardiovascular disease (CVD) changes according to CMP status. Methods 1,957 randomly-selected adults aged ≥65 years without prior CVD were followed up between 2015-2023. CMP was classified according to its intensity, frequency
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Extracellular Vesicle MicroRNAs as Predictive Biomarkers in Postoperative Delirium after Spine Surgery; Preliminary Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-06 Young-Eun Cho, Jeongmin Kim, Rany Vorn, Hyunmi Cho, Wonhee Baek, Hyunki Park, Sijung Yun, Hyung-Suk Kim, Ann K Cashion, Jessica Gill, Bon-Nyeo Koo, Hyangkyu Lee
Postoperative Delirium (POD) can cause poor patient outcomes in older adults who undergo surgery. In this study, we tested plasma extracellular vesicle (EV) miRNAs obtained before the delirium event to find predictive POD biomarkers after spine surgery. We recruited patients who are over 70 years old and have undergone spine surgery. Finally, POD patients (n=31) were included, with no-POD patients
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Frailty was associated with atmospheric NO2 levels: a geospatial approach J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-02 Emmanuel Gonzalez-Bautista, Susana Román-Pérez, Betty Soledad Manrique-Espinoza, Aaron Salinas-Rodríguez, René Santos-Luna
Background Recent evidence has linked air pollution with frailty, yet little is known about the role of NO2 in this association. Our aim was to assess the association between frailty and NO2 air concentrations in Mexican older adults. Methods We used georeferenced data from the population-based Nutrition and Health Survey in Mexico (NHNS) 2021, representative of national and subnational regions, to
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Association between subclinical thyroid dysfunction and cognitive decline: findings from the ELSA-Brasil study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-07-01 Natalia Gomes Gonçalves, Claudia Szlejf, Paulo Andrade Lotufo, Isabela M Bensenor, Claudia Kimie Suemoto
Background Thyroid dysfunction has been associated with cognitive decline and dementia. However, the role of subtle thyroid hormone alterations in cognitive function is still debatable. Methods Participants without overt thyroid dysfunction aged 35-74 years at baseline were evaluated in three study waves (2008-10, 2012-14, and 2017-19). We assessed baseline thyroid stimulating hormone (TSH), free thyroxine
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Trends in memory function and memory impairment among older adults in the USA and Europe, 1996-2018 J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-30 Mikko Myrskylä, Jo Mhairi Hale, Daniel C Schneider, Neil K Mehta
Background Single-country studies document varying time trends in memory function and impairment. Comparative analyses are limited. Methods We used self-respondent data on adults aged 50+ years in 13 countries from three surveys (USA: HRS, 1998-2018; England: ELSA, 2002-2018; 11 European countries: SHARE, 2004-2019). Memory is measured with tests of immediate and delayed word recall. Unweighted age-
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DNA Methylation Mediates the Association between Cardiometabolic Risk Factors and Cognition: Findings from the Health and Retirement Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-29 Zengyi Wan, Lori B Chibnik, Linda Valeri, Timothy M Hughes, Deborah Blacker, Yuan Ma
The association between cardiometabolic risk factors and cognitive function has been well documented, but the underlying mechanisms are not fully understood. This longitudinal study aimed to investigate the potential mediating role of DNA methylation in this association. We conducted the analyses in 3708 participants (mean [SD] age: 67.3 [9.49], women: 57.9%) from the Health and Retirement Study who
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Life-course pathways to exceptional longevity: Evidence from the Lothian Birth Cohort of 1921 J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-27 Janie Corley, Alison Pattie, G David Batty, Simon R Cox, Ian J Deary
Background Longevity, a hallmark of successful ageing, is a multifactorial trait with influences from birth onwards. However, limited evidence exists on the pathways linking diverse life-course exposures to longevity, especially within a single cohort. Methods We investigated associations between life-course factors and longevity among community-dwelling adults aged 79 (N=547) from the Lothian Birth
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Balance, Strength, and Risk of Dementia: Findings from the Health and Retirement Study and the English Longitudinal Study on Ageing J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-26 Yannick Stephan, Angelina R Sutin, Martina Luchetti, Damaris Aschwanden, Selin Karakose, Antonio Terracciano
Background Slow gait speed has been consistently associated with an increased risk of dementia. This study examined whether measures of balance and lower limb strength are similarly related to the risk of developing dementia. Methods Participants from the Health and Retirement Study (HRS, N= 5658, Mean Age= 73.23, SD= 6.22) and the English Longitudinal Study of Ageing (ELSA, N= 3667, Mean age= 69.90
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Force-fluctuations during role-differentiated bimanual movements reflect cognitive impairments in older adults. A cohort sequential study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-22 Julian Rudisch, Stephanie Fröhlich, Dieter F Kutz, Claudia Voelcker-Rehage
During role-differentiated bimanual movements (RDBM), an object is typically stabilized with one hand and manipulated with the other. RDBM require coupling both hands for coordinated action (achieved through interhemispheric connections), but also inhibition of crosstalk to avoid involuntary movements in the stabilizing hand. We investigated how healthy cognitive aging and mild cognitive impairments
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Are We Adding Pain-Free Years to Life? A Test of Compression Versus Expansion of Morbidity J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-15 Zachary Zimmer, Feinuo Sun, Amber Duynisveld
Background There has been debate regarding whether increases in longevity result in longer and healthier lives or more disease and suffering. To address the issue, this paper uses health expectancy methods and tests an expansion versus compression of morbidity with respect to pain. Methods Data are from 1993 to 2018 Health and Retirement Study. Pain is categorized as no pain, non-limiting and limiting
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The bispectral electroencephalography (BSEEG) method quantifies post-operative delirium-like states in young and aged male mice after head mount implantation surgery J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-15 Tsuyoshi Nishiguchi, Kazuki Shibata, Kyosuke Yamanishi, Mia Nicole Dittrich, Noah Yuki Islam, Shivani Patel, Nathan James Phuong, Pedro S Marra, Johnny R Malicoat, Tomoteru Seki, Yoshitaka Nishizawa, Takehiko Yamanashi, Masaaki Iwata, Gen Shinozaki
Delirium, a syndrome characterized by an acute change in attention, awareness, and cognition, is commonly observed in older adults, although there are few quantitative monitoring methods in the clinical setting. We developed a bispectral electroencephalography (BSEEG) method capable of detecting delirium and can quantify the severity of delirium using a novel algorithm. Pre-clinical application of
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Somatic factors predict on-road driving skills in older drivers and drivers with mild cognitive impairment J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-13 Maximilian Flieger, Wolf Schäbitz, Daniel A Schlueter, Kim L Austerschmidt, Jessica Koenig, Thomas Beblo, Martin Driessen, Max Toepper
Background On-road driving skills can be impaired in older drivers and in drivers with mild cognitive impairment (MCI) due to different driving-relevant deficits. Among these deficits, somatic factors have received little attention so far. Methods In a prospective observational on-road driving study, we examined whether somatic factors can predict on-road driving skills in a mixed sample of healthy
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GWAS identifies DPP6 as risk gene of cognitive decline in Parkinson’s disease J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-13 Chunyu Li, Yanbing Hou, Ruwei Ou, Qianqian Wei, Lingyu Zhang, Kuncheng Liu, Junyu Lin, Xueping Chen, Wei Song, Bi Zhao, Ying Wu, Huifang Shang
Background Cognitive decline is among the most common non-motor symptoms in Parkinson’s disease (PD), while its physiological mechanisms remain poorly understood. Genetic factors constituted a fundamental determinant in the heterogeneity of cognitive decline among PD patients. However, the underlying genetic background was still less studied. Methods To explore the genetic determinants contributing
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Is the risk of Alzheimer's disease and related dementias among U.S. veterans influenced by the intersectionality of housing status, HIV/AIDS, hepatitis C, and psychiatric disorders? J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-12 Hind A Beydoun, Dorota Szymkowiak, Rebecca Kinney, May A Beydoun, Alan B Zonderman, Jack Tsai
Background Homelessness and housing instability disproportionately affect U.S. veterans with psychiatric disorders, HIV/AIDS, hepatitis C, and Alzheimer’s Disease and Related Disorders (ADRD). We examined housing status and/or HIV/AIDS in relation to ADRD risk and evaluated hepatitis C, substance use, and mental health disorders as mediators and/or moderators of hypothesized relationships, among U
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High-impact pain is associated with epigenetic aging among middle-aged and older adults: Findings from the Health and Retirement Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-10 Javier A Tamargo, Larissa J Strath, Yenisel Cruz-Almeida
Background Chronic pain has been associated with accelerated biological aging, which may be related to epigenetic alterations. We evaluated the association of high-impact pain (i.e., pain that limits activities and function) with epigenetic aging, a measure of biological aging, in a nationally representative sample of middle-aged and older adults in the United States. Methods Cross-sectional analysis
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METTL3 promotes nucleus pulposus cell senescence in intervertebral disc degeneration by regulating TLR2 m6A methylation and gut microbiota J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-10 Shuangfei Ni, Xiusheng Huang, Xuesen Li, Chenhao Shi, Mingzhe Fan, Lantian Zhao, Zijie Rong, Huafeng Zhang
Background Nucleus pulposus cell (NPC) senescence in intervertebral disc (IVD) tissue is the major pathological cause during intervertebral disc degeneration (IDD). N6-methyladenosine (m6A) methylation and gut microbiota play important roles in the progression of IDD. This study investigated whether methyltransferase-like 3 (METTL3) regulates TLR2 m6A modification and gut microbiota to influence NPC
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The physiologic complexity of prefrontal oxygenation dynamics is associated with age and executive function: an exploratory study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-06-10 Yinglu Hong, Junhong Zhou, Wanting Yu, Ikechukwu Iloputaife, Dapeng Bao, Yuncong Zhou, Brad Manor, Lewis A Lipsitz, Azizah J Jor'dan
Background The hemodynamics of prefrontal cortex (PFC) oxygenation are regulated by numerous processes operating over multiple temporal scales, producing complex patterns in its output fluctuations. Age may alter this multiscale regulation of PFC oxygenation, leading to diminished physiologic complexity of this important regulatory process. We aimed to characterize the effects of age on such complexity
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Does Social Support Moderate the Relationship between Frailty and Functional Ability Trajectory Among Community-Dwelling Older Adults? J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-29 Jiaqi Yu, Huaxin Si, Qinqin Liu, Yanyan Li, Wendie Zhou, Cuili Wang
Background Functional ability is the important prerequisite to live independently and achieve aging in place, which depends on the complex interaction of intrinsic and extrinsic factors. Identifying the trends and influencing factors of functional ability would contribute to the accurate assessment and intervention of geriatric health. This study aimed to disentangle the moderating effect of three
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Projecting Long-term Care Costs among Older Adults with ADL Disability and Cognitive Impairment in China J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-27 Haiyu Jin, Chenkai Wu
Background Mounting evidence suggests that cognitive impairment is strongly associated with difficulties in performing activities of daily living (ADL disability). This study aims to estimate and project the trend in the number of older adults in China with ADL disability and cognitive impairment and the associated long-term care (LTC) costs in the next 20 years. Methods We used data from 37,942 adults
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Association of cardiovascular fibrosis, remodeling, and dysfunction with frailty, pre-frailty, and functional performance: the Multi-Ethnic Study of Atherosclerosis (MESA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-25 Jaclyn Sesso, Jeremy Walston, Karen Bandeen-Roche, Colin Wu, Alain G Bertoni, Sanjiv Shah, Joao A C Lima, Bharath Ambale-Venkatesh
Background Cardiovascular disease is associated with higher incidence of frailty. However, the nature of the mechanisms underlying this association remain unclear. The purpose of this study is to identify cardiovascular phenotypes most associated with physical frailty and functional performance in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods As part of the MESA study, 3045 participants
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Association of exposure to ambient air pollutants with cognitive performance and dementia risk and the mediating role of pulmonary function: Evidence from the UK Biobank J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-23 Fabin Lin, Lili Wang, Yisen Shi, Xuanjie Chen, Yixiang Lin, Jiayi Zheng, Ke Chen, Qinyong Ye, Guoen Cai
BACKGROUND The pathways by which air pollution affects cognition remain to be explored. This study aimed to explore how single air pollutants [including nitrogen oxide (NOX), nitrogen dioxide (NO2), particulate matter with a diameter of 2.5 micrometers (PM2.5), PM10, and PM2.5-10], and air pollution mixture could affect cognitive function and the incidence of dementia, and determine whether pulmonary
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Neighborhood Walkability is Associated with Global Positioning System (GPS)-derived Community Mobility of Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-23 Kyle D Moored, Breanna M Crane, Michelle C Carlson, Pamela M Dunlap, Jennifer S Brach, Andrea L Rosso
Background Neighborhood walkability may encourage greater out-of-home travel (i.e., community mobility) to support independent functioning in later life. We examined associations between a novel walkability audit index and Global Positioning System (GPS)-derived community mobility in community-dwelling older adults. We compared associations with the validated Environmental Protection Agency (EPA) National
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Sex differences in the trajectories of cognitive decline and affected cognitive domains among older adults with controlled and uncontrolled glycemia J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-22 Natália Cochar-Soares, Dayane C de Oliveira, Mariane M Luiz, Márlon J R Aliberti, Claudia K Suemoto, Andrew Steptoe, Cesar de Oliveira, Tiago S Alexandre
Background We aimed to analyze the trajectories of cognitive decline as a function of the presence of type 2 diabetes and glycemic control in analyzes stratified by sex in an eight-year follow-up period. Methods A total of 1,752 men and 2,232 women aged ≥50 years who participated in the English Longitudinal Study of Ageing (ELSA), conducted from 2004 to 2012, were analyzed. The outcomes of interest
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Apolipoprotein ɛ4 is associated with increased risk of fall- and fracture-related hospitalisation: the Perth Longitudinal Study of Ageing Women J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-20 Jedd Pratt, Jack Dalla Via, Craig Sale, Abadi K Gebre, Blossom C M Stephan, Simon Laws, Kun Zhu, Wai H Lim, Richard L Prince, Joshua R Lewis, Marc Sim
Apolipoprotein ɛ4 (APOE ɛ4) may be a genetic risk factor for reduced bone mineral density (BMD) and muscle function, which could have implications for fall and fracture risk. We examined the association between APOE ɛ4 status and long-term fall- and fracture-related hospitalisation risk in older women. 1276 community-dwelling women from the Perth Longitudinal Study of Ageing Women (mean age ± SD =
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Linking Aging to Cancer: The Role of Chromatin Biology J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-18 Laura Corveleyn, Payel Sen, Peter Adams, Simone Sidoli
Epigenetic changes have been established to be a hallmark of aging, which implies that aging science requires collaborating with the field of chromatin biology. DNA methylation patterns, changes in relative abundance of histone post-translational modifications (PTMs), and chromatin remodeling are the central players in modifying chromatin structure. Aging is commonly associated with an overall increase
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The mediating role of kynurenine pathway metabolites on the relationship between inflammation and muscle mass in oldest-old men J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-18 Megan Hetherington-Rauth, Eileen Johnson, Eugenia Migliavacca, Lisa Langsetmo, Russell T Hepple, Terence E Ryan, Luigi Ferrucci, Denis Breuillé, John Corthesy, Nancy E Lane, Jérôme N Feige, Nicola Napoli, Flavia Tramontana, Eric S Orwoll, Peggy M Cawthon
Tryptophan (TRP) metabolites along the kynurenine (KYN) pathway (KP) have been found to influence muscle. Pro-inflammatory cytokines are known to stimulate the degradation of TRP down the KP. Given that both inflammation and KP metabolites have been connected with loss of muscle, we assessed the potential mediating role of KP metabolites on inflammation and muscle mass in older men. 505 men (85.0±4
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Association of Alzheimer’s Disease and Other Neuropathologies with Functional Disability in Persons With and Without Dementia J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-17 Jose M Farfel, Ana W Capuano, Aron S Buchman, Julie A Schneider, David A Bennett
Background Dementia results from multiple neuropathologies causing cognitive impairment sufficiently severe to impact functional status. However, these pathologies and functional impairment are common in persons without dementia. We examined the association of AD and multiple other neuropathologies with instrumental and basic activities of daily living in persons with and without dementia. Methods
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Historic Cognitive Function Trajectories as Predictors of Sedentary Behavior and Physical Activity in Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-15 Dori E Rosenberg, Yinxiang Wu, Abisola Idu, Mikael Anne Greenwood-Hickman, Susan M McCurry, Andrea Z LaCroix, Pamela A Shaw
Background We examined whether trajectories of cognitive function over 10 years predict later life physical activity (PA), sedentary time (ST), and sleep. Methods Participants were from the Adult Changes in Thought (ACT) cohort study. We included 611 ACT participants who wore accelerometers and had 3+ measures of cognition in the 10 years prior to accelerometer wear. The Cognitive Assessment Screening
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Differences in daily physical activity by Alzheimer’s risk markers among older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-14 Francesca R Marino, Jennifer A Deal, Ryan J Dougherty, Murat Bilgel, Qu Tian, Yang An, Eleanor M Simonsick, Susan M Resnick, Luigi Ferrucci, Adam P Spira, Amal A Wanigatunga, Jennifer A Schrack
BACKGROUND Daily physical activity patterns differ by Alzheimer’s disease (AD) status and might signal cognitive risk. It is critical to understand whether patterns are disrupted early in the AD pathological process. Yet, whether established AD risk markers (β-amyloid (Aβ) or APOE-ε4) are associated with differences in objectively measured activity patterns among cognitively unimpaired older adults
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Revised Recommendations on Methods for Assessing Multimorbidity Changes over Time: Aligning the Method to the Purpose J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-14 Corey L Nagel, Nicholas J Bishop, Anda Botoseneanu, Heather, G Allore, Jason T Newsom, David A Dorr, Ana R Quiñones
Background The rapidly growing field of multimorbidity research demonstrates that changes in multimorbidity in mid- and late-life have far reaching effects on important person-centered outcomes, such as health-related quality of life. However, there are few organizing frameworks and comparatively little work weighing the merits and limitations of various quantitative methods applied to the longitudinal
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Physical Activity Fragmentation and Falls in Older Adults: Findings from the National Health and Aging Trends Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-09 Braden K Popelsky, Kelley Pettee Gabriel, Erin E Dooley, Kelly R Ylitalo
Background Physical activity (PA) may be an important fall prevention strategy. Current PA guidelines emphasize total PA dose, but daily patterning of PA is underappreciated. With aging, PA bouts become less frequent and shorter in duration (i.e.: more fragmented). PA fragmentation may be an indicator of fall risk, but the relationship is not well understood. This study examined daily PA accumulation
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Social environment, lifestyle, and genetic predisposition with dementia risk: A long-term longitudinal study among older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-09 Shu Chen, Shanquan Chen, Katja Hanewald, Yafei Si, Hazel Bateman, Bingqin Lin, Xiaolin Xu, Suraj Samtani, Chenkai Wu, Henry Brodaty
Background The role of social environment, i.e., the aggregate effect of social determinants of health (SDOHs), in determining dementia is unclear. Methods We developed a novel polysocial risk score for dementia based on 19 SDOH among 5,199 participants in the Health and Retirement Study, US, to measure the social environmental risk. We used a survival analysis approach to assess the association between
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Drug Burden Index is a Modifiable Predictor of 30-Day-Hospitalization in Community-Dwelling Older Adults with Complex Care Needs: Machine Learning Analysis of InterRAI Data J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-09 Robert T Olender, Sandipan Roy, Hamish A Jamieson, Sarah N Hilmer, Prasad S Nishtala
Background Older adults (≥ 65 years) account for a disproportionately high proportion of hospitalization and in-hospital mortality, some of which may be avoidable. Although machine learning (ML) models have already been built and validated for predicting hospitalization and mortality, there remains a significant need to optimise ML models further. Accurately predicting hospitalization may tremendously
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Associations and Mediating Pathways between Childhood Adversity and Risk of Dementia: A Cohort Study in the UK Biobank J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-09 Wei Hu, Weibo Zhang, Baopeng Liu, Cunxian Jia
Background While childhood adversity (CA) is known to be associated with multiple adverse outcomes, its link with dementia is an area with limited exploration and inconsistent agreement. The study aimed to examine the longitudinal associations of CA with incident all-cause dementia and to quantify the potential mediating pathways. Methods Data from the UK Biobank. CA, encompassing neglect and abuse
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The untapped potential of comparative biology in aging research; insights from the extraordinary-long-lived naked mole-rat J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-09 Rochelle Buffenstein, Vince G Amoroso
The search for solutions to the vagaries of aging have, historically, been akin to searching at night in the bright light under street lamps by utilizing the few preexisting and well-established animal model systems. Throughout my career as a comparative biologist, I have ventured into the darkness across four continents and studied over 150 different animal species, many of which have evolved remarkable
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Need to revise classification of physical activity intensity in older adults? The use of estimated METs, measured METs and V̇O2Reserve J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-05-04 Mathias Skjødt, Mark A Tully, Li-Tang Tsai, Kasper Degn Gejl, Niels Ørtenblad, Kurt Jensen, Annemarie Koster, Marjolein Visser, Marianne Skovsager Andersen, Paolo Caserotti
Background Multiples of resting metabolic rate (RMR) are often used to classify physical activity intensity, a concept known as the Metabolic Equivalent of Task (MET). However, the METs metrics may misclassify physical activity intensity in older adults because of age related changes in RMR and maximal aerobic capacity (V̇O2max). This study aimed to 1) compare classifications of activity intensity
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Selective orexin 2 receptor blockade alleviates cognitive impairments and the pathological progression of Alzheimer’s disease in 3xTg-AD mice J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-28 Xiao-Hong Hu, Kai-Yue Yu, Xin-Xin Li, Jin-Nan Zhang, Juan-Juan Jiao, Zhao-Jun Wang, Hong-Yan Cai, Lei Wang, Ye-Xin He, Mei-Na Wu
The orexin system is closely related to the pathogenesis of Alzheimer's disease (AD). Orexin-A aggravates cognitive dysfunction and increases amyloid β (Aβ) deposition in AD model mice, but studies of different dual orexin receptor (OXR) antagonists in AD have shown inconsistent results. Our previous study revealed that OX1R blockade aggravates cognitive deficits and pathological progression in 3xTg-AD
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Elevated blood homocysteine increases the risk of incident Motoric Cognitive Risk syndrome: A two cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-27 Kelly Cotton, Emmeline Ayers, Ying Jin, Olivier Beauchet, Carol A Derby, Richard B Lipton, Mindy Katz, Kevin Galery, Pierrette Gaudreau, Joe Verghese
Background Motoric Cognitive Risk (MCR) syndrome, a pre-dementia syndrome characterized by cognitive complaints and slow gait, may have an underlying vascular etiology. Elevated blood levels of homocysteine, a known vascular risk factor, have been linked to physical and cognitive decline in older adults, though the relationship with MCR is unknown. We aimed to identify the association between homocysteine
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Females present reduced minimum toe clearance during walking as compared to males in active older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-26 Aurélio Faria, Tiago Sousa, João R Vaz, Ronaldo Gabriel, Jorge Gama, Nick Stergiou
Background Physical decline due to aging has been associated with the risk of falls. Minimum toe clearance (MTC) is a gait parameter that might play a role in the mechanism of tripping and falling. However, it is unclear if there are any sex-related effects regarding MTC as people age. The present study investigated if there are sex-related differences in MTC in older active adults. Methods Twenty-three
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Trends in Number and Appropriateness of Prescription Medication Utilization among Community-Dwelling Older Adults in the US: 2011-2020 J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-22 Shaoxi Pan, Shanshan Li, Shaoxiang Jiang, Jung-Im Shin, Gordon G Liu, Hongyan Wu, Beini Lyu
Background Contemporary data on the quantity and quality of medication use among older adults are lacking. This study examined recent trends in number and appropriateness of prescription medication use among older adults in the US. Method Data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and March 2020 were used and 6336 adult participants aged 65 and older were included
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Dietary vitamin C intake and changes in frequency, severity, and location of pain in older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-22 Mario Delgado-Velandia, Rosario Ortolá, Esther García-Esquinas, Adrián Carballo-Casla, Mercedes Sotos-Prieto, Fernando Rodríguez-Artalejo
Background Oral vitamin C supplementation has been associated with lower risk of chronic postsurgical pain. However, the effect of dietary vitamin C on pain in a non-surgical setting is unknown. We aimed to investigate the association between dietary vitamin C intake and changes over time in chronic pain and its characteristics in community-dwelling adults aged 60+ years. Methods We pooled data from
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Inhaled pollutants of the Gero-Exposome and later life health J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-22 Caleb E Finch, Max A Thorwald
Inhaled air pollutants (AirP) comprise extraordinarily diverse particles, volatiles, and gases from traffic, wildfire, cigarette smoke, dust, and various other sources. These pollutants contain numerous toxic components which collectively differ in relative levels of components, but broadly share chemical classes. Exposure and health outcomes from AirP are complex, depending on pollutant source, duration
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Dementia Prevalence, Incidence and Mortality Trends Among US Adults Ages 72 and Older, 2011-2021 J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-20 Vicki A Freedman, Jennifer C Cornman
Background U.S.-focused studies have reported decreasing dementia prevalence in recent decades, but have not yet focused on the implications of the COVID-19 pandemic for trends. Methods We use the 2011-2021 National Health and Aging Trends Study (N=48,065) to examine dementia prevalence, incidence and mortality trends among adults ages 72 and older, and the contribution to prevalence trends of changes
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Kinship And Care: Racial Disparities In Potential Dementia Caregiving In The U.S. From 2000 To 2060 J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-20 Kai Feng, Xi Song, Hal Caswell
Background Although the family plays a pivotal role in older adults’ care, there is limited research on how evolving demographic trends affect older adults’ support networks and how the trends vary by race. To fill this gap, we examine the influence of shifting family demographics on future care needs for older adults with dementia, emphasizing the unequal health and potential caregiving burdens by
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Racial/Ethnic Differences in Self-Reported Upper Limb Limitations among U.S. Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-20 Rachel N Logue Cook, Matthew A Davis, Rebecca E Hasson, Dominique Kinnett-Hopkins, Susan H Brown
Background The development of disability related to activities of daily living (ADL) is of great concern in the aging population, particularly for Hispanic and Non-Hispanic (NH) Black older adults, where disability prevalence is greater compared to NH Whites. ADL-disability is typically measured across many functional tasks without differentiating upper- versus lower-limb limitations, hindering our
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The association of the 24-hour activity cycle profiles with cognition in older adults with mild cognitive impairment: A cross-sectional study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-20 Guilherme Moraes Balbim, Ryan S Falck, Nárlon Cássio Boa Sorte Silva, Arthur F Kramer, Michelle Voss, Teresa Liu-Ambrose
Background The relationship of cognition and the 24-hour activity cycles (24-HAC), encompassing physical activity, sedentary behaviour, and sleep, in older adults with mild cognitive impairment (MCI) remains uncertain. Distinct combinations of 24-HAC behaviours can characterize unique activity profiles and influence cognition. We aimed to characterize 24-HAC activity profiles in older adults with MCI
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Muscle mitochondrial bioenergetic capacities are associated with multimorbidity burden in older adults: the Study of Muscle, Mobility and Aging (SOMMA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-11 Theresa Mau, Terri L Blackwell, Peggy M Cawthon, Anthony J A Molina, Paul M Coen, Giovanna Distefano, Philip A Kramer, Sofhia V Ramos, Daniel E Forman, Bret H Goodpaster, Frederico G S Toledo, Kate A Duchowny, Lauren M Sparks, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings
Background The geroscience hypothesis posits that aging biological processes contribute to many age-related deficits, including the accumulation of multiple chronic diseases. Though only one facet of mitochondrial function, declines in muscle mitochondrial bioenergetic capacities may contribute to this increased susceptibility to multimorbidity. Methods The Study of Muscle, Mobility and Aging (SOMMA)
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Peripheral Blood Cells from Older Adults Exhibit Sex-Associated Differences in Mitochondrial Function J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-10 Gargi Mahapatra, Zhengrong Gao, James R Bateman, Samuel Neal Lockhart, Jaclyn Bergstrom, Jemima Elizabeth Piloso, Suzanne Craft, Anthony J A Molina
Blood based mitochondrial bioenergetic profiling is a feasible, economical, and minimally invasive approach that can be used to examine mitochondrial function and energy metabolism in human subjects. In this study, we use two complementary respirometric techniques to evaluate mitochondrial bioenergetics in both intact and permeabilized peripheral blood mononuclear cells (PBMCs) and platelets to examine
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Profiles of Lifestyle Health Behaviors and Postmortem Dementia-Related Neuropathology J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-10 Brittney S Lange-Maia, Maude Wagner, Christina A Rogers, Rupal I Mehta, David A Bennett, Christy Tangney, Michael E Schoeny, Shannon Halloway, Zoe Arvanitakis
High engagement in lifestyle health behaviors appears to be protective against cognitive decline in aging. We investigated the association between patterns of modifiable lifestyle health behaviors and common brain neuropathologies of dementia as a possible mechanism. We examined 555 decedents from the Rush Memory and Aging Project, free of dementia at their initial concurrent report of lifestyle health
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Abstracts BMAS Summer School 2023—2nd Bone Marrow Adiposity Society Summer School Meeting 2023 J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-06 Biagio Palmisano, Michaela Tencerova
Fat is the main component of an adult bone marrow and constitutes the so-called bone marrow adipose tissue (BMAT). Marrow adipocytes, which are the fat cells in the bone marrow, become more abundant with age, and may influence the whole-body metabolism. In osteoporotic patients, the amount of BMAT has an inverse correlation with the amount of bone mass. In people with anorexia nervosa that lose weight
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The Drug Burden Index is associated with Measures of Cognitive Function Among Older Adults in the Health, Aging, and Body Composition Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-03 Janie C DiNatale, Ian M McDonough, Amy C Ellis, Joy W Douglas, Kristine Yaffe, Kristi M Crowe-White
BACKGROUND Anticholinergic and sedative medications impact cognition among older adults. The Drug Burden Index (DBI) is a validated measure of exposure to these medications, with higher DBI scores indicating higher drug burden. This ancillary analysis investigated the association between DBI and cognition assessed by the Modified Mini-Mental State Examination (3MS) and the Digit Symbol Substitution
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An Increase in Vascular Stiffness is Positively Associated with Mitochondrial Bioenergetics Impairment of Peripheral Blood Mononuclear Cells in the Elderly Population J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-03 Tanawat Attachaipanich, Sirawit Sriwichaiin, Nattayaporn Apaijai, Sasiwan Kerdphoo, Nisakron Thongmung, Prin Vathesatogkit, Piyamitr Sritara, Nipon Chattipakorn, Chagriya Kitiyakara, Siriporn C Chattipakorn
The cardio-ankle vascular index (CAVI) is a non-invasive parameter reflecting vascular stiffness. CAVI correlates with the burden of atherosclerosis and future cardiovascular events. Mitochondria of peripheral blood mononuclear cells (PBMCs) have been identified as a non-invasive source for assessing systemic mitochondrial bioenergetics. This study aimed to investigate the relationship between CAVI
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Validation of a Rule-Based ICD-10-CM Algorithm to Detect Fall Injuries in Medicare Data J. Gerontol. A Biol. Sci. Med. Sci. (IF 4.3) Pub Date : 2024-04-03 David A Ganz, Denise Esserman, Nancy K Latham, Michael Kane, Lillian C Min, Thomas M Gill, David B Reuben, Peter Peduzzi, Erich J Greene
Background Diagnosis-code-based algorithms to identify fall injuries in Medicare data are useful for ascertaining outcomes in interventional and observational studies. However, these algorithms have not been validated against a fully external reference standard, in ICD-10-CM, or in Medicare Advantage (MA) data. Methods We linked self-reported fall injuries leading to medical attention (FIMA) from the