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A portable and efficient dementia screening tool using eye tracking machine learning and virtual reality npj Digit. Med. (IF 12.4) Pub Date : 2024-08-22 Ying Xu, Chi Zhang, Baobao Pan, Qing Yuan, Xu Zhang
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Digital biomarkers for precision diagnosis and monitoring in Parkinson’s disease npj Digit. Med. (IF 12.4) Pub Date : 2024-08-21 Yue-meng Sun, Zhi-yun Wang, Yuan-yuan Liang, Chen-wei Hao, Chang-he Shi
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FDA launches health care at home initiative to drive equity in digital medical care npj Digit. Med. (IF 12.4) Pub Date : 2024-08-21 Stefanie Brückner, Celia Brightwell, Stephen Gilbert
A highly ambitious FDA initiative will explore, through a hub and ideas lab, how equitable healthcare at home can be delivered, recognizing that this is unlikely to come about without intervention. Market forces, as shaped by current regulations, are leading to digital health tools developed and operating in islands rather than enabling integrated digital care. Can the initiative, which adopts system-level
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Closing the gap: addressing telehealth disparities across specialties in the sustained pandemic era npj Digit. Med. (IF 12.4) Pub Date : 2024-08-21 Saki Amagai, Edward Vonesh, James Adams, Yuan Luo
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Harnessing the power of longitudinal medical imaging for eye disease prognosis using Transformer-based sequence modeling npj Digit. Med. (IF 12.4) Pub Date : 2024-08-16 Gregory Holste, Mingquan Lin, Ruiwen Zhou, Fei Wang, Lei Liu, Qi Yan, Sarah H. Van Tassel, Kyle Kovacs, Emily Y. Chew, Zhiyong Lu, Zhangyang Wang, Yifan Peng
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EU-US data transfers: an enduring challenge for health research collaborations npj Digit. Med. (IF 12.4) Pub Date : 2024-08-16 Teodora Lalova-Spinks, Peggy Valcke, John P. A. Ioannidis, Isabelle Huys
EU-US data transfers for health research remain a particularly thorny issue in view of the stringent rules of the EU General Data Protection Regulation (GDPR) and the challenges related to US mass surveillance programs, particularly the manner in which US law enforcement and national security agencies can access personal data originating from the EU. Since the entry into force of the GDPR, evidence
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Dose–response relationship between computerized cognitive training and cognitive improvement npj Digit. Med. (IF 12.4) Pub Date : 2024-08-15 Liyang Liu, Haibo Wang, Yi Xing, Ziheng Zhang, Qingge Zhang, Ming Dong, Zhujiang Ma, Longjun Cai, Xiaoyi Wang, Yi Tang
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Robust automated calcification meshing for personalized cardiovascular biomechanics npj Digit. Med. (IF 12.4) Pub Date : 2024-08-15 Daniel H. Pak, Minliang Liu, Theodore Kim, Caglar Ozturk, Raymond McKay, Ellen T. Roche, Rudolph Gleason, James S. Duncan
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Lessons learned from an unsuccessful decentralized clinical trial in Oncology npj Digit. Med. (IF 12.4) Pub Date : 2024-08-13 Antonis Valachis, Henrik Lindman
Decentralized clinical trials have gained in popularity over the last years due to their advantages related to broadening recruitment strategies and resource saving possibilities. As more clinical trials adopt decentralized strategies, it is essential to share the knowledge about both successful and unsuccessful efforts in the research community. In the present commentary, we explore potential reasons
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Core elements of national policy for digital health technology evidence and access npj Digit. Med. (IF 12.4) Pub Date : 2024-08-13 Megan Coder, Lacey McBride, Samantha McClenahan
Digital health technologies (DHT) offer the ability to deliver personalized care, lower barriers to access, and positively impact health outcomes. However, DHT utilization is impacted by insufficient market access pathways. A policy “full-stack”—including regulatory authorization, product value assessment, pricing and reimbursement, and patient access infrastructure—offers a framework for DHT integration
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Navigating the European Union Artificial Intelligence Act for Healthcare npj Digit. Med. (IF 12.4) Pub Date : 2024-08-12 Felix Busch, Jakob Nikolas Kather, Christian Johner, Marina Moser, Daniel Truhn, Lisa C. Adams, Keno K. Bressem
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Biometrics of complete human pregnancy recorded by wearable devices npj Digit. Med. (IF 12.4) Pub Date : 2024-08-12 Lauryn Keeler Bruce, Dalila González, Subhasis Dasgupta, Benjamin L. Smarr
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Disparities in clinical studies of AI enabled applications from a global perspective npj Digit. Med. (IF 12.4) Pub Date : 2024-08-10 Rui Yang, Sabarinath Vinod Nair, Yuhe Ke, Danny D’Agostino, Mingxuan Liu, Yilin Ning, Nan Liu
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Responsible development of clinical speech AI: Bridging the gap between clinical research and technology npj Digit. Med. (IF 12.4) Pub Date : 2024-08-09 Visar Berisha, Julie M. Liss
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Evaluating multimodal AI in medical diagnostics npj Digit. Med. (IF 12.4) Pub Date : 2024-08-07 Robert Kaczmarczyk, Theresa Isabelle Wilhelm, Ron Martin, Jonas Roos
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A deep learning system for myopia onset prediction and intervention effectiveness evaluation in children npj Digit. Med. (IF 12.4) Pub Date : 2024-08-07 Ziyi Qi, Tingyao Li, Jun Chen, Jason C. Yam, Yang Wen, Gengyou Huang, Hua Zhong, Mingguang He, Dan Zhu, Rongping Dai, Bo Qian, Jingjing Wang, Chaoxu Qian, Wei Wang, Yanfei Zheng, Jian Zhang, Xianglong Yi, Zheyuan Wang, Bo Zhang, Chunyu Liu, Tianyu Cheng, Xiaokang Yang, Jun Li, Yan-Ting Pan, Xiaohu Ding, Ruilin Xiong, Yan Wang, Yan Zhou, Dagan Feng, Sichen Liu, Linlin Du, Jinliuxing Yang, Zhuoting Zhu
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The METRIC-framework for assessing data quality for trustworthy AI in medicine: a systematic review npj Digit. Med. (IF 12.4) Pub Date : 2024-08-03 Daniel Schwabe, Katinka Becker, Martin Seyferth, Andreas Klaß, Tobias Schaeffter
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Eye tracking insights into physician behaviour with safe and unsafe explainable AI recommendations npj Digit. Med. (IF 12.4) Pub Date : 2024-08-02 Myura Nagendran, Paul Festor, Matthieu Komorowski, Anthony C. Gordon, Aldo A. Faisal
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AI-enhanced reconstruction of the 12-lead electrocardiogram via 3-leads with accurate clinical assessment npj Digit. Med. (IF 12.4) Pub Date : 2024-08-01 Federico Mason, Amitabh C. Pandey, Matteo Gadaleta, Eric J. Topol, Evan D. Muse, Giorgio Quer
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Joint AI-driven event prediction and longitudinal modeling in newly diagnosed and relapsed multiple myeloma npj Digit. Med. (IF 12.4) Pub Date : 2024-07-29 Zeshan Hussain, Edward De Brouwer, Rebecca Boiarsky, Sama Setty, Neeraj Gupta, Guohui Liu, Cong Li, Jaydeep Srimani, Jacob Zhang, Rich Labotka, David Sontag
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Expert gaze as a usability indicator of medical AI decision support systems: a preliminary study npj Digit. Med. (IF 12.4) Pub Date : 2024-07-27 Nora Castner, Lubaina Arsiwala-Scheppach, Sarah Mertens, Joachim Krois, Enkeleda Thaqi, Enkelejda Kasneci, Siegfried Wahl, Falk Schwendicke
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Estimation of ventilatory thresholds during exercise using respiratory wearable sensors npj Digit. Med. (IF 12.4) Pub Date : 2024-07-26 Felipe Contreras-Briceño, Jorge Cancino, Maximiliano Espinosa-Ramírez, Gonzalo Fernández, Vader Johnson, Daniel E. Hurtado
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Clinical phenotypes and short-term outcomes based on prehospital point-of-care testing and on-scene vital signs npj Digit. Med. (IF 12.4) Pub Date : 2024-07-24 Raúl López-Izquierdo, Carlos del Pozo Vegas, Ancor Sanz-García, Agustín Mayo Íscar, Miguel A. Castro Villamor, Eduardo Silva Alvarado, Santos Gracia Villar, Luis Alonso Dzul López, Silvia Aparicio Obregón, Rubén Calderon Iglesias, Joan B. Soriano, Francisco Martín-Rodríguez
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Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine npj Digit. Med. (IF 12.4) Pub Date : 2024-07-23 Qiao Jin, Fangyuan Chen, Yiliang Zhou, Ziyang Xu, Justin M. Cheung, Robert Chen, Ronald M. Summers, Justin F. Rousseau, Peiyun Ni, Marc J. Landsman, Sally L. Baxter, Subhi J. Al’Aref, Yijia Li, Alexander Chen, Josef A. Brejt, Michael F. Chiang, Yifan Peng, Zhiyong Lu
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Autonomous artificial intelligence for diabetic eye disease increases access and health equity in underserved populations npj Digit. Med. (IF 12.4) Pub Date : 2024-07-22 Jane J. Huang, Roomasa Channa, Risa M. Wolf, Yiwen Dong, Mavis Liang, Jiangxia Wang, Michael D. Abramoff, T. Y. Alvin Liu
Diabetic eye disease (DED) is a leading cause of blindness in the world. Annual DED testing is recommended for adults with diabetes, but adherence to this guideline has historically been low. In 2020, Johns Hopkins Medicine (JHM) began deploying autonomous AI for DED testing. In this study, we aimed to determine whether autonomous AI implementation was associated with increased adherence to annual
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Orchestrating explainable artificial intelligence for multimodal and longitudinal data in medical imaging npj Digit. Med. (IF 12.4) Pub Date : 2024-07-22 Aurélie Pahud de Mortanges, Haozhe Luo, Shelley Zixin Shu, Amith Kamath, Yannick Suter, Mohamed Shelan, Alexander Pöllinger, Mauricio Reyes
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Estimating the household secondary attack rate and serial interval of COVID-19 using social media npj Digit. Med. (IF 12.4) Pub Date : 2024-07-20 Aarzoo Dhiman, Elad Yom-Tov, Lorenzo Pellis, Michael Edelstein, Richard Pebody, Andrew Hayward, Thomas House, Thomas Finnie, David Guzman, Vasileios Lampos, Ingemar J. Cox
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Large language models outperform mental and medical health care professionals in identifying obsessive-compulsive disorder npj Digit. Med. (IF 12.4) Pub Date : 2024-07-19 Jiyeong Kim, Kimberly G. Leonte, Michael L. Chen, John B. Torous, Eleni Linos, Anthony Pinto, Carolyn I. Rodriguez
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A systematic review of the impacts of remote patient monitoring (RPM) interventions on safety, adherence, quality-of-life and cost-related outcomes npj Digit. Med. (IF 12.4) Pub Date : 2024-07-18 Si Ying Tan, Jennifer Sumner, Yuchen Wang, Alexander Wenjun Yip
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A survey of skin tone assessment in prospective research npj Digit. Med. (IF 12.4) Pub Date : 2024-07-17 Vanessa R. Weir, Katelyn Dempsey, Judy Wawira Gichoya, Veronica Rotemberg, An-Kwok Ian Wong
Increasing evidence supports reduced accuracy of noninvasive assessment tools, such as pulse oximetry, temperature probes, and AI skin diagnosis benchmarks, in patients with darker skin tones. The FDA is exploring potential strategies for device regulation to improve performance across diverse skin tones by including skin tone criteria. However, there is no consensus about how prospective studies should
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From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling npj Digit. Med. (IF 12.4) Pub Date : 2024-07-16 Hanwen Wang, Theinmozhi Arulraj, Alberto Ippolito, Aleksander S. Popel
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UCHealth’s virtual health center: How Colorado’s largest health system creates and integrates technology into patient care npj Digit. Med. (IF 12.4) Pub Date : 2024-07-11 Elizabeth Goldberg, Dave Kao, Bethany Kwan, Hemali Patel, Amy Hassell, Richard Zane
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Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art npj Digit. Med. (IF 12.4) Pub Date : 2024-07-11 Jules M. Janssen Daalen, Robin van den Bergh, Eva M. Prins, Mahshid Sadat Chenarani Moghadam, Rudie van den Heuvel, Jeroen Veen, Soania Mathur, Hannie Meijerink, Anat Mirelman, Sirwan K. L. Darweesh, Luc J. W. Evers, Bastiaan R. Bloem
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From silos to synergy: integrating academic health informatics with operational IT for healthcare transformation npj Digit. Med. (IF 12.4) Pub Date : 2024-07-09 Devin M. Mann, Elizabeth R. Stevens, Paul Testa, Nader Mherabi
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Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data npj Digit. Med. (IF 12.4) Pub Date : 2024-07-09 Chang Su, Yu Hou, Jielin Xu, Zhenxing Xu, Manqi Zhou, Alison Ke, Haoyang Li, Jie Xu, Matthew Brendel, Jacqueline R. M. A. Maasch, Zilong Bai, Haotan Zhang, Yingying Zhu, Molly C. Cincotta, Xinghua Shi, Claire Henchcliffe, James B. Leverenz, Jeffrey Cummings, Michael S. Okun, Jiang Bian, Feixiong Cheng, Fei Wang
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The ethics of ChatGPT in medicine and healthcare: a systematic review on Large Language Models (LLMs) npj Digit. Med. (IF 12.4) Pub Date : 2024-07-08 Joschka Haltaufderheide, Robert Ranisch
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Quantifying impairment and disease severity using AI models trained on healthy subjects npj Digit. Med. (IF 12.4) Pub Date : 2024-07-06 Boyang Yu, Aakash Kaku, Kangning Liu, Avinash Parnandi, Emily Fokas, Anita Venkatesan, Natasha Pandit, Rajesh Ranganath, Heidi Schambra, Carlos Fernandez-Granda
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Accuracy of dental implant placement using different dynamic navigation and robotic systems: an in vitro study npj Digit. Med. (IF 12.4) Pub Date : 2024-07-06 Zonghe Xu, Lin Zhou, Bin Han, Shuang Wu, Yanjun Xiao, Sihui Zhang, Jiang Chen, Jianbin Guo, Dong Wu
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Deep learning for multi-type infectious keratitis diagnosis: A nationwide, cross-sectional, multicenter study npj Digit. Med. (IF 12.4) Pub Date : 2024-07-06 Zhongwen Li, He Xie, Zhouqian Wang, Daoyuan Li, Kuan Chen, Xihang Zong, Wei Qiang, Feng Wen, Zhihong Deng, Limin Chen, Huiping Li, He Dong, Pengcheng Wu, Tao Sun, Yan Cheng, Yanning Yang, Jinsong Xue, Qinxiang Zheng, Jiewei Jiang, Wei Chen
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A systematic umbrella review and meta-meta-analysis of eHealth and mHealth interventions for improving lifestyle behaviours npj Digit. Med. (IF 12.4) Pub Date : 2024-07-05 Ben Singh, Mavra Ahmed, Amanda E. Staiano, Claire Gough, Jasmine Petersen, Corneel Vandelanotte, Chelsea Kracht, Christopher Huong, Zenong Yin, Maria F. Vasiloglou, Chen-Chia Pan, Camille E. Short, Matthew Mclaughlin, Lauren von Klinggraeff, Christopher D. Pfledderer, Lisa J. Moran, Alyssa M. Button, Carol A. Maher
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The long but necessary road to responsible use of large language models in healthcare research npj Digit. Med. (IF 12.4) Pub Date : 2024-07-04 Jethro C. C. Kwong, Serena C. Y. Wang, Grace C. Nickel, Giovanni E. Cacciamani, Joseph C. Kvedar
Large language models (LLMs) have shown promise in reducing time, costs, and errors associated with manual data extraction. A recent study demonstrated that LLMs outperformed natural language processing approaches in abstracting pathology report information. However, challenges include the risks of weakening critical thinking, propagating biases, and hallucinations, which may undermine the scientific
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Competing interests: digital health and indigenous data sovereignty npj Digit. Med. (IF 12.4) Pub Date : 2024-07-04 Ashley Cordes, Marieke Bak, Mataroria Lyndon, Maui Hudson, Amelia Fiske, Leo Anthony Celi, Stuart McLennan
Digital health is increasingly promoting open health data. Although this open approach promises a number of benefits, it also leads to tensions with Indigenous data sovereignty movements led by Indigenous peoples around the world who are asserting control over the use of health data as a part of self-determination. Digital health has a role in improving access to services and delivering improved health
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Pediatric sex estimation using AI-enabled ECG analysis: influence of pubertal development npj Digit. Med. (IF 12.4) Pub Date : 2024-07-02 Donnchadh O’Sullivan, Scott Anjewierden, Grace Greason, Itzhak Zachi Attia, Francisco Lopez-Jimenez, Paul A. Friedman, Peter Noseworthy, Jason Anderson, Anthony Kashou, Samuel J. Asirvatham, Benjamin W. Eidem, Jonathan N. Johnson, Talha Niaz, Malini Madhavan
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How can regulation and reimbursement better accommodate flexible suites of digital health technologies? npj Digit. Med. (IF 12.4) Pub Date : 2024-07-02 Rebecca Mathias, Peter McCulloch, Anastasia Chalkidou, Stephen Gilbert
Individual digital health devices are increasingly being bundled together as interacting, multicomponent suites, to deliver clinical services (e.g., teleconsultation and ‘hospital-at-home services’). In the first article of this two-article series we described the challenges in implementation and the current limitations in frameworks for the regulation, health technology assessment, and reimbursement
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Do engagement and behavioural mechanisms underpin the effectiveness of the Drink Less app? npj Digit. Med. (IF 12.4) Pub Date : 2024-06-29 Claire Garnett, Larisa-Maria Dinu, Melissa Oldham, Olga Perski, Gemma Loebenberg, Emma Beard, Colin Angus, Robyn Burton, Matt Field, Felix Greaves, Matthew Hickman, Eileen Kaner, Susan Michie, Marcus Munafò, Elena Pizzo, Jamie Brown
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Recommendations to advance digital health equity: a systematic review of qualitative studies npj Digit. Med. (IF 12.4) Pub Date : 2024-06-29 Sarah Wilson, Clare Tolley, Ríona Mc Ardle, Lauren Lawson, Emily Beswick, Nehal Hassan, Robert Slight, Sarah Slight
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Deep learning to quantify care manipulation activities in neonatal intensive care units npj Digit. Med. (IF 12.4) Pub Date : 2024-06-27 Abrar Majeedi, Ryan M. McAdams, Ravneet Kaur, Shubham Gupta, Harpreet Singh, Yin Li
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A multi-center study on the adaptability of a shared foundation model for electronic health records npj Digit. Med. (IF 12.4) Pub Date : 2024-06-27 Lin Lawrence Guo, Jason Fries, Ethan Steinberg, Scott Lanyon Fleming, Keith Morse, Catherine Aftandilian, Jose Posada, Nigam Shah, Lillian Sung
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Wearable sensor-based quantitative gait analysis in Parkinson’s disease patients with different motor subtypes npj Digit. Med. (IF 12.4) Pub Date : 2024-06-26 Weishan Zhang, Yun Ling, Zhonglue Chen, Kang Ren, Shengdi Chen, Pei Huang, Yuyan Tan
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A scoping review assessing the usability of digital health technologies targeting people with multiple sclerosis npj Digit. Med. (IF 12.4) Pub Date : 2024-06-25 Fiona Tea, Adam M. R. Groh, Colleen Lacey, Afolasade Fakolade
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Artificial intelligence-enhanced electrocardiography derived body mass index as a predictor of future cardiometabolic disease npj Digit. Med. (IF 12.4) Pub Date : 2024-06-25 Libor Pastika, Arunashis Sau, Konstantinos Patlatzoglou, Ewa Sieliwonczyk, Antônio H. Ribeiro, Kathryn A. McGurk, Sadia Khan, Danilo Mandic, William R. Scott, James S. Ware, Nicholas S. Peters, Antonio Luiz P. Ribeiro, Daniel B. Kramer, Jonathan W. Waks, Fu Siong Ng
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Can artificial intelligence improve medicine’s uncomfortable relationship with Maths? npj Digit. Med. (IF 12.4) Pub Date : 2024-06-22 Alexandra Valetopoulou, Simon Williams, Hani J. Marcus
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Validation and application of computer vision algorithms for video-based tremor analysis npj Digit. Med. (IF 12.4) Pub Date : 2024-06-21 Maximilian U. Friedrich, Anna-Julia Roenn, Chiara Palmisano, Jane Alty, Steffen Paschen, Guenther Deuschl, Chi Wang Ip, Jens Volkmann, Muthuraman Muthuraman, Robert Peach, Martin M. Reich
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Development and validation of a smartphone-based deep-learning-enabled system to detect middle-ear conditions in otoscopic images npj Digit. Med. (IF 12.4) Pub Date : 2024-06-20 Constance Dubois, David Eigen, François Simon, Vincent Couloigner, Michael Gormish, Martin Chalumeau, Laurent Schmoll, Jérémie F. Cohen
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PatchSorter: a high throughput deep learning digital pathology tool for object labeling npj Digit. Med. (IF 12.4) Pub Date : 2024-06-20 Cédric Walker, Tasneem Talawalla, Robert Toth, Akhil Ambekar, Kien Rea, Oswin Chamian, Fan Fan, Sabina Berezowska, Sven Rottenberg, Anant Madabhushi, Marie Maillard, Laura Barisoni, Hugo Mark Horlings, Andrew Janowczyk
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Development of an effective predictive screening tool for prostate cancer using the ClarityDX machine learning platform npj Digit. Med. (IF 12.4) Pub Date : 2024-06-20 M. Eric Hyndman, Robert J. Paproski, Adam Kinnaird, Adrian Fairey, Leonard Marks, Christian P. Pavlovich, Sean A. Fletcher, Roman Zachoval, Vanda Adamcova, Jiri Stejskal, Armen Aprikian, Christopher J. D. Wallis, Desmond Pink, Catalina Vasquez, Perrin H. Beatty, John D. Lewis
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Five million nights: temporal dynamics in human sleep phenotypes npj Digit. Med. (IF 12.4) Pub Date : 2024-06-20 Varun K. Viswanath, Wendy Hartogenesis, Stephan Dilchert, Leena Pandya, Frederick M. Hecht, Ashley E. Mason, Edward J. Wang, Benjamin L. Smarr
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From wearable sensor data to digital biomarker development: ten lessons learned and a framework proposal npj Digit. Med. (IF 12.4) Pub Date : 2024-06-18 Paola Daniore, Vasileios Nittas, Christina Haag, Jürgen Bernard, Roman Gonzenbach, Viktor von Wyl
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Digital health technologies need regulation and reimbursement that enable flexible interactions and groupings npj Digit. Med. (IF 12.4) Pub Date : 2024-06-18 Rebecca Mathias, Peter McCulloch, Anastasia Chalkidou, Stephen Gilbert
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Head movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning npj Digit. Med. (IF 12.4) Pub Date : 2024-06-18 Robert Peach, Maximilian Friedrich, Lara Fronemann, Muthuraman Muthuraman, Sebastian R. Schreglmann, Daniel Zeller, Christoph Schrader, Joachim K. Krauss, Alfons Schnitzler, Matthias Wittstock, Ann-Kristin Helmers, Steffen Paschen, Andrea Kühn, Inger Marie Skogseid, Wilhelm Eisner, Joerg Mueller, Cordula Matthies, Martin Reich, Jens Volkmann, Chi Wang Ip