Axon regeneration requires the mobilization of intracellular resources, including proteins, lipids, and nucleotides. After injury, neurons need to adapt their metabolism to meet the biosynthetic demands needed to achieve axonal regeneration. However, the exact contribution of cellular metabolism to this process remains elusive. Insights into the metabolic characteristics of proliferative cells may illuminate similar mechanisms operating in axon regeneration; therefore, unraveling previously unappreciated roles of metabolic adaptation is critical to achieving neuron regrowth, which is connected to the therapeutic strategies for neurological conditions necessitating nerve repairs, such as spinal cord injury and stroke. Here, we outline the metabolic role in axon regeneration and discuss factors enhancing nerve regrowth, highlighting potential novel metabolic treatments for restoring nerve function.

中文翻译：

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释放轴突再生的代谢能力。


轴突再生需要动员细胞内资源，包括蛋白质、脂质和核苷酸。损伤后，神经元需要调整其代谢以满足实现轴突再生所需的生物合成需求。然而，细胞代谢对此过程的确切贡献仍然难以捉摸。对增殖细胞代谢特征的深入了解可能会阐明轴突再生中的类似机制。因此，阐明以前未被认识到的代谢适应的作用对于实现神经元再生至关重要，这与需要神经修复的神经系统疾病（例如脊髓损伤和中风）的治疗策略有关。在这里，我们概述了代谢在轴突再生中的作用，并讨论了促进神经再生的因素，强调了恢复神经功能的潜在新型代谢治疗方法。