During the process of implantation, the embryo first attaches to the uterine epithelium and then invades the underlying stroma, resulting in the transformation of the stroma into a secretory tissue that surrounds the embryo. An intricate dialogue allows the developing embryo and the maternal tissue to be in constant communication with each other. In many mammals, including humans, embryo implantation and early pregnancy events take place in a low-oxygen environment regulated by hypoxia-inducible transcription factors. The mechanisms by which maternal and embryonic tissue compartments adapt to hypoxia are essential for the success of pregnancy outcomes. In this review we highlight recent work describing signaling pathways that operate in the hypoxic uterus to facilitate embryo implantation and promote the successful establishment of pregnancy.

中文翻译：

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妊娠早期适应缺氧的母胎机制。


在着床过程中，胚胎首先附着在子宫上皮上，然后侵入下面的间质，导致间质转化为胚胎周围的分泌组织。复杂的对话使得发育中的胚胎和母体组织能够不断地相互沟通。在包括人类在内的许多哺乳动物中，胚胎植入和早期妊娠事件发生在由缺氧诱导转录因子调节的低氧环境中。母体和胚胎组织适应缺氧的机制对于妊娠结局的成功至关重要。在这篇综述中，我们重点介绍了最近的工作，描述了在缺氧子宫中起作用的信号通路，以促进胚胎植入并促进妊娠的成功建立。