Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for other microbial metabolites in shaping host health. In this review we summarize recent findings from dietary fiber intervention studies describing health impacts attributed to microbial metabolites other than SCFAs, particularly secondary bile acids (2°BAs), aromatic amino acid derivatives, neurotransmitters, and B vitamins. We also discuss shifts in microbial metabolism occurring through altered maternal dietary fiber intake and agricultural practices, which warrant further investigation. To optimize the health benefits of dietary fibers, it is essential to survey a range of metabolites and adapt recommendations on a personalized basis, according to the different functional aspects of the microbiome.

中文翻译：

---

与纤维发酵和宿主健康相关的非短链脂肪酸微生物代谢物。


膳食纤维被共生肠道微生物降解，产生对宿主有益的短链脂肪酸 (SCFA)，但对纤维补充剂的个性化反应凸显了其他微生物代谢物在塑造宿主健康方面的作用。在这篇综述中，我们总结了膳食纤维干预研究的最新发现，描述了 SCFA 以外的微生物代谢物对健康的影响，特别是次级胆汁酸 (2°BA)、芳香族氨基酸衍生物、神经递质和 B 族维生素。我们还讨论了通过改变母亲膳食纤维摄入量和农业实践而发生的微生物代谢变化，这值得进一步研究。为了优化膳食纤维的健康益处，有必要根据微生物组的不同功能方面调查一系列代谢物并个性化地调整建议。