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Epilepsy prevalence studies and the lingering treatment gap in Africa Lancet Global Health (IF 19.9) Pub Date : 2024-07-05 Dilraj Singh Sokhi, Pauline Samia
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Prevalence of all epilepsies in urban informal settlements in Nairobi, Kenya: a two-stage population-based study Lancet Global Health (IF 19.9) Pub Date : 2024-07-05 Daniel M Mwanga MSc, Damazo T Kadengye PhD, Peter O Otieno PhD, Frederick M Wekesah PhD, Prof Isaac C Kipchirchir PhD, Prof George O Muhua PhD, Joan W Kinuthia BSc, Thomas Kwasa MMed FECSACOP, Abigael Machuka MBChB, Quincy Mongare MD, Samuel Iddi PhD, Gabriel Davis Jones MD, Prof Josemir W Sander FMedSci, Symon M Kariuki DPhil, Prof Arjune Sen FRCP, Prof Charles R Newton MD, Gershim Asiki PhD, EPInA
WHO estimates that more than 50 million people worldwide have epilepsy and 80% of cases are in low-income and middle-income countries. Most studies in Africa have focused on active convulsive epilepsy in rural areas, but there are few data in urban settings. We aimed to estimate the prevalence and spatial distribution of all epilepsies in two urban informal settlements in Nairobi, Kenya. We did a two-stage
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Does every move really count towards better health? Lancet Global Health (IF 19.9) Pub Date : 2024-06-25 Andrea Ramirez Varela, Pedro C Hallal
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National, regional, and global trends in insufficient physical activity among adults from 2000 to 2022: a pooled analysis of 507 population-based surveys with 5·7 million participants Lancet Global Health (IF 19.9) Pub Date : 2024-06-25 Tessa Strain PhD, Seth Flaxman PhD, Regina Guthold PhD, Elizaveta Semenova PhD, Melanie Cowan MPH, Leanne M Riley MSc, Prof Fiona C Bull PhD, Gretchen A Stevens DSc, Country Data Author Group
Insufficient physical activity increases the risk of non-communicable diseases, poor physical and cognitive function, weight gain, and mental ill-health. Global prevalence of adult insufficient physical activity was last published for 2016, with limited trend data. We aimed to estimate the prevalence of insufficient physical activity for 197 countries and territories, from 2000 to 2022. We collated
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Hypoxaemia and risk of death among children: rethinking oxygen saturation, risk-stratification, and the role of pulse oximetry in primary care Lancet Global Health (IF 19.9) Pub Date : 2024-06-21 Hamish R Graham PhD, Carina King PhD, Prof Trevor Duke MD, Salahuddin Ahmed PhD, Prof Abdullah H Baqui DrPH, Prof Tim Colbourn PhD, Prof Adegoke G Falade MD, Helena Hildenwall PhD, Shubhada Hooli MD, Yewande Kamuntu MPharm, Rami Subhi MPH, Eric D McCollum MD
Pulse oximeters are essential for assessing blood oxygen levels in emergency departments, operating theatres, and hospital wards. However, although the role of pulse oximeters in detecting hypoxaemia and guiding oxygen therapy is widely recognised, their role in primary care settings is less clear. In this Viewpoint, we argue that pulse oximeters have a crucial role in risk-stratification in both hospital
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News media as a commercial determinant of health Lancet Global Health (IF 19.9) Pub Date : 2024-06-19 Dan Even PhD, Salma M Abdalla PhD, Nason Maani PhD, Sandro Galea MD DrPH
Commercial determinants of health frameworks aim to identify the features and actions of corporate entities that can influence health. This Viewpoint conceptualises the work of the news media as a set of commercial forces and provides a framework that can help researchers better understand how features and actions of the news media shape health and health equity. We discuss four key features of news
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Balancing global access to opioids Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 The Lancet Global Health
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Analysis of opioid analgesic consumption in Africa Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Eve Namisango, Katherine Pettus
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Aligning meta-regression analyses of cost-effectiveness evidence to policy makers' needs Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Cassandra Nemzoff
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Skilled birth attendance: safeguarding mothers and newborns Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Edward Kwabena Ameyaw
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Cost-effectiveness of interventions for HIV/AIDS, malaria, syphilis, and tuberculosis in 128 countries: a meta-regression analysis Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Fiona Silke MA, Lauren Earl MILS, Johnathan Hsu BA, Mark M Janko PhD, Jonah Joffe MS, Aishe Memetova MPH, Danielle Michael MS, Peng Zheng PhD, Aleksandr Aravkin PhD, Christopher J L Murray DPhil, Prof Marcia R Weaver PhD
Cost-effectiveness analyses have been conducted for many interventions for HIV/AIDS, malaria, syphilis, and tuberculosis, but they have not been conducted for all interventions that are currently recommended in all countries. To support national decision makers in the effective allocation of resources, we conducted a meta-regression analysis of published incremental cost-effectiveness ratios (ICERs)
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Why are the Sustainable Development Goals failing? Overcoming the paradox of unimplementability Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Eivind Engebretsen, Trisha Greenhalgh
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Trade-offs between clinical performance and test accessibility in tuberculosis diagnosis: a multi-country modelling approach for target product profile development Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Alexandra de Nooy BSc, Tom Ockhuisen MSc, Alexei Korobitsyn MD, Shaukat A Khan PhD, Morten Ruhwald MD PhD, Prof Nazir Ismail MD, Mikashmi Kohli PhD, Brooke E Nichols PhD
Tuberculosis continues to be a leading cause of infectious disease mortality, and effective screening and diagnosis remains crucial. Despite progress made, diagnostic gaps remain due to poor access to diagnostic tools and testing, particularly in rural and remote areas. As such, the development of target product profiles is essential in guiding the development of new diagnostic tools, however target
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Neurodevelopment in preschool children exposed and unexposed to Zika virus in utero in Nicaragua: a prospective cohort study Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Ryan Max MSPH, Christian Toval-Ruiz MSc, Sylvia Becker-Dreps MD, Anna M Gajewski MPH, Evelin Martinez MSc, Kaitlyn Cross MSc, Bryan Blette PhD, Oscar Ortega MD, Damaris Collado BSc, Omar Zepeda MSc, Itziar Familiar PhD, Prof Michael J Boivin PhD, Meylin Chavarria BSc, María José Meléndez BSc, Juan Carlos Mercado BSc, Prof Aravinda de Silva PhD, Matthew H Collins MD, Prof Daniel Westreich PhD, Sandra
Data on long-term neurodevelopmental outcomes of normocephalic children (born with normal head circumference) exposed to Zika virus in utero are scarce. We aimed to compare neurodevelopmental outcomes in normocephalic children up to age 48 months with and without Zika virus exposure in utero. In this prospective cohort study, we included infants from two cohorts of normocephalic children born in León
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Diagnostic yield as an important metric for the evaluation of novel tuberculosis tests: rationale and guidance for future research Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Tobias Broger MSc, Florian M Marx MD, Prof Grant Theron PhD, Prof Ben J Marais MD, Prof Mark P Nicol MD, Andrew D Kerkhoff MD, Ruvandhi Nathavitharana MBBS, Helena Huerga PhD, Ankur Gupta-Wright MD, Mikashmi Kohli PhD, Brooke E Nichols PhD, Monde Muyoyeta PhD, Prof Graeme Meintjes PhD, Morten Ruhwald PhD, Prof Rosanna W Peeling PhD, Nitika Pant Pai MD, Nira R Pollock MD, Prof Madhukar Pai MD, Adithya
Better access to tuberculosis testing is a key priority for fighting tuberculosis, the leading cause of infectious disease deaths in people. Despite the roll-out of molecular WHO-recommended rapid diagnostics to replace sputum smear microscopy over the past decade, a large diagnostic gap remains. Of the estimated 10·6 million people who developed tuberculosis globally in 2022, more than 3·1 million
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Analysis of opioid analgesics consumption in Africa: a longitudinal study from a 20-year continental perspective Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Yacine Hadjiat MD, Prof Jallal Toufiq MD, Christian Ntizimira MD, Prof Lars Arendt-Nielsen MD, Benoit Burucoa MD, Erwan Treillet MD, Prof Nicolas Authier MD, Prof Serge Perrot MD
Opioid analgesics are essential for managing acute and chronic pain in diseases such as cancer. Inadequate opioid access remains a major public health concern in low-income regions including Africa. This study aimed to provide updated and comprehensive data on changes in opioid consumption, specifically in Africa. This longitudinal study has updated and expanded upon the International Narcotics Control
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Factors associated with skilled birth attendance in 37 low-income and middle-income countries: a secondary analysis of nationally representative, individual-level data Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Jan Priebe PhD, Prof John Amuasi PhD, Teguh Dartanto PhD, Prof Ghyslain Mombo-Ngoma MD, Maximilian Guigas MSc
Progress on skilled birth attendance (SBA) has been very uneven across low-income and middle-income countries (LMICs). There is scant empirical evidence on the role of fundamental development processes in explaining differences in SBA outcomes across world regions over time in these settings. We therefore aimed to estimate how these processes have contributed to observed changes in SBA across Latin
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The drug drought in maternal health: an ongoing predicament Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Anne Ammerdorffer PhD, Annie R A McDougall PhD, Andrew Tuttle MPH, Sara Rushwan PhD, Lester Chinery, Prof Joshua P Vogel PhD, Maya Goldstein MA, Prof A Metin Gülmezoglu PhD
We developed a comprehensive database of medicines that are used or are being investigated for pre-eclampsia or eclampsia, preterm birth or labour, postpartum haemorrhage, intrauterine growth restriction, and fetal distress and that were in active development between 2000 and 2021. A total of 444 candidates were identified: approximately half of candidates were in active development, two-thirds had
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Global health for rare diseases through primary care Lancet Global Health (IF 19.9) Pub Date : 2024-06-12 Gareth Baynam MD, Adam L Hartman MD, Mary Catherine V Letinturier MD, Matt Bolz-Johnson MA, Prescilla Carrion MSc, Alice Chen Grady MD, Xinran Dong PhD, Marc Dooms PharmD, Lauren Dreyer CN, Holm Graessner PhD, Alicia Granados MD, Tudor Groza PhD, Elisa Houwink MD, Saumya Shekhar Jamuar MD, Tania Vasquez-Loarte MD, Biruté Tumiene MD, Samuel Agyei Wiafe MPhil, Heidi Bjornson-Pennell, Stephen Groft PharmD
Rare diseases affect over 300 million people worldwide and are gaining recognition as a global health priority. Their inclusion in the UN Sustainable Development Goals, the UN Resolution on Addressing the Challenges of Persons Living with a Rare Disease, and the anticipated WHO Global Network for Rare Diseases and WHO Resolution on Rare Diseases, which is yet to be announced, emphasise their significance
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Erasing stigma around rare diseases Lancet Global Health (IF 19.9) Pub Date : 2024-05-29 David A Pearce, Gareth Baynam
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For and with people: announcing the Lancet Global Health Commission on people-centred care for universal health coverage and a call for commissioner nominations Lancet Global Health (IF 19.9) Pub Date : 2024-05-29 David B Duong, Bethany Holt, Chris Munoz, Todd M Pollack
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Digital solutions for rare diseases in global health Lancet Global Health (IF 19.9) Pub Date : 2024-05-24 Ayla Gerk, Shreenik Kundu, John G Meara, Jorgelina Stegmann
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When sex is demanded as payment for health-care services Lancet Global Health (IF 19.9) Pub Date : 2024-05-24 Michele L Coleman MPH, Manuela Colombini PhD, Sarah Bandali DrPH, Tom Wright MA, Maryam Chilumpha MSSC, Prof Dina Balabanova PhD
Sexual corruption or sextortion has gained recent attention in the anti-corruption space. It occurs when a sexual favour is used as the currency for a bribe. Sexual corruption is a manifestation of gender-based violence, is inherently a human rights violation, and is a grave public health concern because of its effects on the physical, emotional, and mental wellbeing of the person who has experienced
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Hernia repair as a tracer for elective surgical care Lancet Global Health (IF 19.9) Pub Date : 2024-05-23 Rovine Naluyimbazi, Tamara N Fitzgerald
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Geospatial disparities in breast cancer care in sub-Saharan Africa: time to act Lancet Global Health (IF 19.9) Pub Date : 2024-05-21 Adewale O Adisa
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Geospatial disparities in survival of patients with breast cancer in sub-Saharan Africa from the African Breast Cancer-Disparities in Outcomes cohort (ABC-DO): a prospective cohort study Lancet Global Health (IF 19.9) Pub Date : 2024-05-21 Joanne Kim PhD, Peter M Macharia PhD, Valerie McCormack PhD, Milena Foerster PhD, Moses Galukande MD, Maureen Joffe PhD, Herbert Cubasch MD, Annelle Zietsman MD, Angelica Anele MD, Shadrach Offiah MD, Groesbeck Parham MD, Leeya F Pinder MD, Benjamin O Anderson MD, Joachim Schüz PhD, Isabel dos Santos-Silva PhD, Kayo Togawa PhD
There is an urgent need to improve breast cancer survival in sub-Saharan Africa. Geospatial barriers delay diagnosis and treatment, but their effect on survival in these settings is not well understood. We examined geospatial disparities in 4-year survival in the African Breast Cancer-Disparities in Outcomes cohort. In this prospective cohort study, women (aged ≥18 years) newly diagnosed with breast
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Preventing maternal and child mortality: upcoming WHO Resolution must galvanise action to tackle the unacceptable weight of preventable deaths Lancet Global Health (IF 19.9) Pub Date : 2024-05-20 Ali Hajji Adam, Mekdes Daba
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Nodding syndrome and doxycycline: promising findings with open questions Lancet Global Health (IF 19.9) Pub Date : 2024-05-13 Emmanuel Olal, Ritah Nantale, David Lagoro Kitara
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Doxycycline for the treatment of nodding syndrome: a randomised, placebo-controlled, phase 2 trial Lancet Global Health (IF 19.9) Pub Date : 2024-05-13 Richard Idro PhD, Rodney Ogwang PhD, Ronald Anguzu PhD, Pamela Akun MA, Albert Ningwa BSc, Catherine Abbo PhD, Maria P Giannoccaro PhD, Joseph Kubofcik PhD, Prof Amos D Mwaka PhD, Phellister Nakamya MSc, Bernard Opar MBChB, Prof Mark Taylor PhD, Thomas B Nutman PhD, Prof Alison Elliott PhD, Prof Angela Vincent FRCPath, Prof Charles R Newton MD, Prof Kevin Marsh MBBS
Nodding syndrome is a poorly understood neurological disorder that predominantly occurs in Africa. We hypothesised that nodding syndrome is a neuroinflammatory disorder, induced by antibodies to or its symbiont, cross-reacting with host neuronal proteins (HNPs), and that doxycycline can be used as treatment. In this randomised, double-blind, placebo-controlled, phase 2 trial, we recruited participants
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The surge of mpox in Africa: a call for action Lancet Global Health (IF 19.9) Pub Date : 2024-05-09 Jean B Nachega, Nadia A Sam-Agudu, Dimie Ogoina, Placide Mbala-Kingebeni, Francine Ntoumi, Emmanuel Nakouné, Richard Njouom, Rosamund F Lewis, Monica Gandhi, Philip J Rosenthal, Angeli Rawat, Lindsay A Wilson, Jason Kindrachuk, Laurens Liesenborghs, Edward J Mills, Wolfgang Preiser, Anne W Rimoin, Nancy J Sullivan, Martine Peeters, Eric Delaporte, Cheryl Baxter, Lee Harrison, Michel P Hermans, Emma
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Decolonising global health: why the new Pandemic Agreement should have included the principle of subsidiarity Lancet Global Health (IF 19.9) Pub Date : 2024-05-09 Thana C de Campos-Rudinsky DPhil, Sarah L Bosha LLM, Daniel Wainstock JD, Prof Sharifah Sekalala PhD, Sridhar Venkatapuram PhD, Caesar Alimsinya Atuire PhD
The negotiations for the WHO Pandemic Agreement have brought attention to issues of racism and colonialism in global health. Although the agreement aims to promote global solidarity, it fails to address these deeply embedded problems. This Viewpoint argues that not including the principle of subsidiarity into Article 4 of the agreement as a pragmatic strategy was a missed opportunity to decolonise
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Short-term aid or long-term gains? Harnessing Sudan's humanitarian response for the resilience of its health system Lancet Global Health (IF 19.9) Pub Date : 2024-04-30 Maisoon Elbukhari Ibrahim MBBS, Dell D Saulnier PhD, Prof Karl Blanchet PhD
The Sudan 2023 Humanitarian Response Plan was revised in May, 2023, due to the escalating violence in the country. This revision increased the scale of assistance and protection activities and suspended the funding allocated for access to livelihood, access to basic services, and for the implementation of resilience solutions. We call to rethink Sudan's current humanitarian response through a pro-resilience
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Facilitating the development of urgently required combination vaccines Lancet Global Health (IF 19.9) Pub Date : 2024-04-15 William P Hausdorff PhD, Prof Shabir A Madhi PhD, Gagandeep Kang PhD, Lassané Kaboré PhD, Marta Tufet Bayona PhD, Birgitte K Giersing PhD
The essence of a vaccine lies in its ability to elicit a set of immune responses specifically directed at a particular pathogen. Accordingly, vaccines were historically designed, developed, registered, recommended, procured, and administered as monopathogen formulations. Nonetheless, the control and elimination of an astonishing number of diseases was realised only after several once-separate vaccines
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Advancing equity in medical device performance Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 The Lancet Global Health
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Disability and mortality in LMICs: why we need to know more Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Nora Ellen Groce
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Increasing women's access to household environments free from air pollution during pregnancy Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Lorretta Favour Chizomam Ntoimo
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Introduction and rollout of malaria vaccines in Cameroon and Burkina Faso: early lessons learned Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Adidja Amani, Franck Mboussou, Benido Impouma, Joseph Cabore, Matshidiso R Moeti
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Adapting existing tools to control and eliminate protracted epidemics and pandemics Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Godfrey Bwire, Fahima Chowdhury, Ashraful Islam Khan, Joseph Francis Wamala, Christopher Garimoi Orach, Firdausi Qadri
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Can navigation applications facilitate equity in geographical access to emergency obstetric care? Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Michael C Ezeanochie, Ruth Jahonga
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Assisted partner services for people with HIV who inject drugs Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Tapiwa A Tembo, Saeed Ahmed, Nora E Rosenberg
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HIV vulnerability among older Chinese men: new perspectives Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Chengmeng Zhang
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Safety and immunogenicity of the Euvichol-S oral cholera vaccine for prevention of Vibrio cholerae O1 infection in Nepal: an observer-blind, active-controlled, randomised, non-inferiority, phase 3 trial Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Katerina Rok Song MD, Ram Hari Chapagain MD, Dipesh Tamrakar MD, Rajeev Shrestha PhD, Piush Kanodia MD, Shipra Chaudhary MD, T Anh Wartel MD, Jae Seung Yang PhD, Deok Ryun Kim PhD, Jinae Lee PhD, Eun Lyeong Park MSc, Haeun Cho MSc, Jiyoung Lee MSc, Patchara Thaisrivichai MSc, Sridhar Vemula MPharm, Bo Mi Kim BSc, Birendra Gupta PhD, Tarun Saluja MD, Ruchir Kumar Pansuriya PhD, Ravi Ganapathy PhD, Yeong
In October, 2017, WHO launched a strategy to eliminate cholera by 2030. A primary challenge in meeting this goal is the limited global supply capacity of oral cholera vaccine and the worsening of cholera outbreaks since 2021. To help address the current shortage of oral cholera vaccine, a WHO prequalified oral cholera vaccine, Euvichol-Plus was reformulated by reducing the number of components and
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Neonatal mortality during the war in Tigray: a cross-sectional community-based study Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Mache Tsadik PhD, Awol Yemane Legesse MD, Hale Teka MD, Hiluf Ebuy Abraha MSc, Girmatsion Fisseha PhD, Mohamedawel Mohamedniguss Ebrahim MD, Bereket Berhe MD, Martha Yemane Hadush MD, Gebrehaweria Gebrekurstos MSc, Brhane Ayele MPH, Haile Tsegay MPH, Tesfit Gebremeskel MSc, Tsega Gebremariam MD, Tigist Hagos MPH, Abraha Gebreegziabher MD, Kibrom Muoze BSc, Afewerk Mulugeta PhD, Mulugeta Gebregziabher
Neonatal mortality is among the key national and international indicators of health services. The global Sustainable Development Goal target for neonatal mortality is fewer than 12 deaths per 1000 livebirths, by 2030. Neonatal mortality estimates in the 2019 Ethiopian Demographic Health Survey found 25·7 deaths per 1000 livebirths. Subnational surveys specific to Tigray, Ethiopia, reported a neonatal
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Masculinities and sexual and reproductive health and rights: a global research priority setting exercise Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Aoibheann Brennan-Wilson PhD, Magaly Marques, Anna Coates PhD, Avni Amin PhD, Prof John Garry PhD, Prof Mark Tomlinson PhD, Anam Nyembezi PhD, Prof Asha George PhD, Prof Maria Lohan PhD
Engaging men and boys in sexual and reproductive health and rights (SRHR) and doing so in a way that challenges harmful masculinities, is both neglected and vital for improving the SRHR of both women and men. To address this gap, WHO commissioned a global research priority setting exercise on masculinities and SRHR. The exercise adapted the quantitative child health and nutrition research initiative
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Efficacy of assisted partner services for people who inject drugs in Kenya to identify partners living with HIV and hepatitis C virus infection: a prospective cohort study Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Aliza Monroe-Wise MD, Loice Mbogo BS, Betsy Sambai MSc, Natasha Ludwig-Barron PhD, Brandon L Guthrie PhD, David Bukusi MBChB, Bhavna H Chohan PhD, Sarah Masyuko PhD, Prof John Scott MD, Emily Juma, Paul Macharia PhD, Hanley Kingston MS, William Sinkele DMin, Esther Gitau BA, Rose Bosire PhD, Helgar Musyoki MPH, Joshua Herbeck PhD, Prof Carey Farquhar MD
People who inject drugs are at increased risk of both HIV and hepatitis C virus (HCV) infections but face barriers to testing and engagement in care. Assisted partner services are effective in locating people with HIV but are understudied among people who inject drugs. We assessed whether assisted partner services could be used to find, test for HIV and HCV infections, and link to care the partners
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Cooperation for malaria control and elimination in the Guiana Shield Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Alice Sanna MD, Prof Martha Suárez-Mutis PhD, Yann Lambert PhD, Luisiane Carvalho MPH, Hedley Cairo MD, Horace Cox MD, Clara de Bort MSc, Margarete Gomes do Socorro Mendonça PhD, David A Forero-Peña MD, Juan Carlos Gabaldón-Figueira MD, Prof Maria Eugenia Grillet PhD, François Klein MSc, Clément Lazarus MD, Yassamine Lazrek MD, Prof Jaime Louzada PhD, Dorinaldo Malafaia MSc, Paola Marchesini PhD, Lise
The Guiana Shield, a small region of South America, is currently one of the main hotspots of malaria transmission on the continent. This Amazonian area is characterised by remarkable socioeconomic, cultural, health, and political heterogeneity and a high degree of regional and cross-border population mobility, which has contributed to the increase of malaria in the region in the past few years. In
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Geographical accessibility to functional emergency obstetric care facilities in urban Nigeria using closer-to-reality travel time estimates: a population-based spatial analysis Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Aduragbemi Banke-Thomas PhD, Kerry L M Wong PhD, Tope Olubodun FMCPH, Peter M Macharia PhD, Narayanan Sundararajan PhD, Yash Shah BSc, Gautam Prasad PhD, Mansi Kansal MBA, Swapnil Vispute MSc, Tomer Shekel MBA, Olakunmi Ogunyemi MBBS, Uchenna Gwacham-Anisiobi MPH, Jia Wang PhD, Ibukun-Oluwa Omolade Abejirinde PhD, Prestige Tatenda Makanga PhD, Ngozi Azodoh MPH, Charles Nzelu PhD, Prof Bosede B Afolabi
Better accessibility for emergency obstetric care facilities can substantially reduce maternal and perinatal deaths. However, pregnant women and girls living in urban settings face additional complex challenges travelling to facilities. We aimed to assess the geographical accessibility of the three nearest functional public and private comprehensive emergency obstetric care facilities in the 15 largest
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The association between disability and all-cause mortality in low-income and middle-income countries: a systematic review and meta-analysis Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Tracey Smythe PhD, Prof Hannah Kuper ScD
There are 1·3 billion people with disabilities globally. On average, they have poorer health than their non-disabled peers, but the extent of increased risk of premature mortality is unknown. We aimed to systematically review the association between disability and mortality in low-income and middle-income countries (LMICs). We searched MEDLINE, Global Health, PsycINFO, and EMBASE from Jan 1, 1990 to
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Progress towards universal health coverage and inequalities in infant mortality: an analysis of 4·1 million births from 60 low-income and middle-income countries between 2000 and 2019 Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 Thomas Hone PhD, Judite Gonçalves PhD, Paraskevi Seferidi PhD, Rodrigo Moreno-Serra PhD, Rudi Rocha PhD, Indrani Gupta PhD, Vinayak Bhardwaj DrPH, Taufik Hidayat MSE, Chang Cai MA, Marc Suhrcke PhD, Christopher Millett PhD
Expanding universal health coverage (UHC) might not be inherently beneficial to poorer populations without the explicit targeting and prioritising of low-income populations. This study examines whether the expansion of UHC between 2000 and 2019 is associated with reduced socioeconomic inequalities in infant mortality in low-income and middle-income countries (LMICs). We did a retrospective analysis
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Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial Lancet Global Health (IF 19.9) Pub Date : 2024-04-11 William Checkley MD, Lisa M Thompson PhD, Shakir Hossen MBBS, Laura Nicolaou PhD, Kendra N Williams PhD, Stella M Hartinger PhD, Marilu Chiang MD, Kalpana Balakrishnan PhD, Sarada S Garg DNB, Gurusamy Thangavel MSc, Vigneswari Aravindalochanan PhD, Ghislaine Rosa PhD, Alexie Mukeshimana Adv Dip, Florien Ndagijimana MPH, John P McCracken ScD, Anaité Diaz-Artiga MPH, Sheela S Sinharoy PhD, Lance Waller
Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth. The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings
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Tuberculosis screening in adults with HIV: beyond symptoms Lancet Global Health (IF 19.9) Pub Date : 2024-04-04 Bianca Sossen, Gary Maartens
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Thinking beyond diagnostic accuracy to evaluate tuberculosis screening tests Lancet Global Health (IF 19.9) Pub Date : 2024-04-04 Emily L-H MacLean, H Manisha Yapa
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Point-of-care C-reactive protein and Xpert MTB/RIF Ultra for tuberculosis screening and diagnosis in unselected antiretroviral therapy initiators: a prospective, cross-sectional, diagnostic accuracy study Lancet Global Health (IF 19.9) Pub Date : 2024-04-04 Byron W P Reeve PhD, Gcobisa Ndlangalavu PhD, Hridesh Mishra PhD, Zaida Palmer MSc, Happy Tshivhula PhD, Loren Rockman BSc (Hons), Selisha Naidoo MSc, Desiree L Mbu MSc, Charissa C Naidoo PhD, Brigitta Derendinger PhD, Prof Gerhard Walzl MD PhD, Stephanus T Malherbe MD PhD, Prof Paul D van Helden PhD, Fred C Semitala MD, Christina Yoon MD, Rishi K Gupta MRCP PhD, Prof Mahdad Noursadeghi FRCP PhD, Prof
Tuberculosis, a major cause of death in people living with HIV, remains challenging to diagnose. Diagnostic accuracy data are scarce for promising triage and confirmatory tests such as C-reactive protein (CRP), sputum and urine Xpert MTB/RIF Ultra (Xpert Ultra), and urine Determine TB LAM Ag (a lateral flow lipoarabinomannan [LF-LAM] test), without symptom selection. We evaluated novel triage and confirmatory
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Blood RNA biomarkers for tuberculosis screening in people living with HIV before antiretroviral therapy initiation: a diagnostic accuracy study Lancet Global Health (IF 19.9) Pub Date : 2024-04-04 Tiffeney Mann MSc, Rishi K Gupta PhD, Byron W P Reeve PhD, Gcobisa Ndlangalavu PhD, Aneesh Chandran PhD, Amirtha P Krishna BSc, Claire J Calderwood MRCP, Happy Tshivhula PhD, Zaida Palmer MSc, Selisha Naidoo MSc, Desiree L Mbu MSc, Grant Theron PhD, Prof Mahdad Noursadeghi PhD
Undiagnosed tuberculosis remains a major threat for people living with HIV. Multiple blood transcriptomic biomarkers have shown promise for tuberculosis diagnosis. We sought to evaluate their diagnostic accuracy and clinical utility for systematic pre-antiretroviral therapy (ART) tuberculosis screening. We enrolled consecutive adults (age ≥18 years) referred to start ART at a community health centre
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The west Africa Ebola virus disease outbreak: 10 years on Lancet Global Health (IF 19.9) Pub Date : 2024-03-22 Henry Kyobe Bosa, Neema Kamara, Merawi Aragaw, Misaki Wayengera, Ambrose Talisuna, James Bangura, Henry G Mwebesa, Patrick D M C Katoto, Robert Kwame Agyarko, Chikwe Ihekweazu, Abdoulaye Bousso, Obasanya Joshua, Moussa Douno, Mosoka P Fallah, James Sylvester Squire, Tolbert Geewleh Nyenswah, Thelma V Nelson, Justin Maeda, Tajudeen Raji, Mamadou Souncalo Traoré, Olushayo Oluseun Olu, Yonas Tegegn Woldemariam
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A Global Tuberculosis Dictionary: unified terms and definitions for the field of tuberculosis Lancet Global Health (IF 19.9) Pub Date : 2024-03-22 Alberto L Garcia-Basteiro, Joanna Ehrlich, Maryline Bonnet, Marianne Calnan, Stephen M Graham, Sabine Hermans, Adriana Jarrett, Rhoda Lewa, Anna Mandalakas, Leonardo Martinez, Giovanni Battista Migliori, Catherine W M Ong, Larissa Otero, Molebogeng Xheedha Rangaka, Mario C B Raviglione, Barbara Seaworth, Willy Ssengooba, Grant Theron, Anete Trajman, Marcel A Behr
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Bubble continuous positive airway pressure for children with pneumonia and hypoxaemia in Ethiopia Lancet Global Health (IF 19.9) Pub Date : 2024-03-21 Eric D McCollum, Tisungane Mvalo
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Effectiveness of bubble continuous positive airway pressure for treatment of children aged 1–59 months with severe pneumonia and hypoxaemia in Ethiopia: a pragmatic cluster-randomised controlled trial Lancet Global Health (IF 19.9) Pub Date : 2024-03-21 Meseret Gebre MD, Kassa Haile MPH, Prof Trevor Duke FRACP, Md Tanveer Faruk MPH, Mehnaz Kamal MPH, Md Farhad Kabir MSc, Md Fakhar Uddin MSS, Muluye Shimelis BSc, Tigist Beyene MSc, Bethelhem Solomon MD, Meles Solomon MSc, Abebe Genetu Bayih PhD, Alemseged Abdissa PhD, Taye Tolera Balcha PhD, Rahel Argaw MD, Asrat Demtse MD, Abate Yeshidinber Weldetsadik MD, Abayneh Girma MD, Bitseat W Haile MD, Abu
The safety and efficacy of bubble continuous positive airway pressure (bCPAP) for treatment of childhood severe pneumonia outside tertiary care hospitals is uncertain. We did a cluster-randomised effectiveness trial of locally made bCPAP compared with WHO-recommended low-flow oxygen therapy in children with severe pneumonia and hypoxaemia in general hospitals in Ethiopia. This open, cluster-randomised
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The health and care workforce in the Pandemic Agreement: championing equity and protecting collective capacity for future pandemics Lancet Global Health (IF 19.9) Pub Date : 2024-03-14 Veena Sriram, Leah Shipton, Julia Smith, Katrina Plamondon
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Global brain health—the time to act is now Lancet Global Health (IF 19.9) Pub Date : 2024-03-14 Andrea S Winkler, Saksham Gupta, Vikram Patel, Arnold Bhebhe, Agnès Fleury, Camilla G Aukrust, Tarun Dua, Tamara M Welte, Sarbani Chakraborty, Kee B Park