Section snippets Author’s contributionsDA, Initial draft, revision, and editing, KA, Data acquisition and editing, GNR, Final approval Financial support and sponsorshipNone Declaration of Competing InterestNothing to report

Section snippets Authors' contributions:All authors were responsible for the study concept, data acquisition and analysis, the integrity of the data and the accuracy of the data analysis, the drafting, and the critical revision of the manuscript for important intellectual content, and approved the final version of the article. Terry Yip is the submission’s guarantor of the article. Financial support:None

Section snippets Limitations in ctDNA DetectionThe study reports a concordance sensitivity of 84.8% for ctDNA when compared with tissue-based genomic profiling. While promising, this sensitivity indicates that certain actionable mutations present in tissue samples may not be detected by ctDNA alone, raising concerns about its efficacy as a standalone diagnostic approach. Evidence from other studies

Section snippets Author’s contributionsPeng Luo : Study design & Manuscript Writing.Anqi Lin and Kai Miao : Study design & Manuscript Revision. Declaration of Competing InterestWe declare there is no any conflict of interest. Acknowledgements & FundingNone

Liver transplantation is associated with a high risk of postoperative complications due to the complexity of the surgical procedure, recipient disease severity and wide range of graft quality which remains somewhat unpredictable. However, survival rates after transplantation continue to improve and the focus has thus turned to other clinically relevant endpoints including posttransplant complications

Section snippets Authors ContributionsAM drafted the letter. All authors (AM, MRP and ET) contributed equally to the study concept, reviewed and approved the final version of letter. Financial SupportNilGEMA-Na: a crucial step in solving to the MELD-Creatinine dilemmaWe read with great interest the study by Dr Rosenstengle and colleagues examining MELD subtypes and the effect on intention-to-treat

Section snippets AcknowledgementsA.M. is supported by a personal ZONMW-VENI grant 2023 (09150162310148)

No Abstract

No Abstract

No Abstract

No Abstract

No Abstract

No Abstract

Section snippets Low-to-moderate alcohol consumption is associated with increased fibrosis in MASLDMarti-Aguado, Calleja and coworkers attempted to evaluate the prevalence and impact of different levels of alcohol consumption on the severity of metabolic dysfunction-associated steatotic liver disease (MASLD). The authors found that obesity, diabetes and alcohol consumption were independently associated

No Abstract

No Abstract

Section snippets DescriptionA 74-year-old male was admitted to our hospital with subtle jaundice and weight loss. His medical history included ulcerative colitis, well-controlled with mesalazine, and HCV infection successfully treated with direct-acting antivirals 2 years prior. Last liver stiffness measurement was 4.4 kPa. Laboratory tests showed a normal hemogram, moderate elevation of aminotransferases

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy).

Section snippets Authors’ contributionsCAP designed the study and wrote the manuscript, AHT and AL acquired, compiled, and analysed the data, JM and RV finalized the manuscript and made critical revisions, all authors accepted the final version of manuscript for submission. Financial supportThe authors received no financial support to produce this manuscript. Declaration of Competing InterestThe authors

Section snippets Authors contributionsQin Guo: Conceptualization, Writing – original draft; Hui Li: Conceptualization, Funding acquisition, Writing – review & editing; Chengshan Guo: Funding acquisition, Writing – review & editing. Financial support statementThis work was supported by the Medical and Health Research Project of Baoan District (No. 2023JD250), and the Key Specialties in Clinical Medicine

Section snippets Author contributionsConceptualization, data curation, formal analysis and writing of the manuscript were performed by EV and WL. Financial supportNone. Declaration of Competing InterestWL serves as a consultant for Cook Medical, MRM Health, and CSL Behring, and has received speaker’s fees from Boston Scientific. No other conflicts of interest were withheld. AcknowledgementsWe wish

Section snippets Conflict of interest statementThe authors declare no conflict of interest. Uncited reference[17]; [18]; [19]; [17]; [18]; [19]. Authors' contributionsJGH and NV developed the ideas presented and wrote the manuscript. Financial supportNo particulars to report

Section snippets Financial supportFunded by the National Cancer Institute Intramural Research Program. Declaration of Competing InterestThe authors declare no conflicts of interest that pertain to this work.Please refer to the accompanying ICMJE disclosure forms for further details.Adipose triglyceride lipase (ATGL), encoded by the PNPLA2 gene in humans, hydrolyzes triacylglycerols to diacylglycerols

Section snippets Financial suppportThe research of the authors is supported in part by grants from the German Federal Ministry of Health (BMG), the Ministry of Culture and Science of the State North Rhine Westphalia (MKW NRW) to DDZ, and the German Federal Ministry of Education and Research (BMBF) and the MKW NRW to German Center for Diabetes Research (DZD e. V.). The research of M.R. is supported

Section snippets Author contributionsconcept and design: DS, AZ, FS; drafted the letter: DS, AZ, FS. All authors approved the final version of this letter. Financial supportNo financial support was received for this study. Declaration of Competing InterestFS has received lecture fees and research grant from W.L. Gore, Cook Medical and Echosens.

Section snippets Grant supportThis work was supported by National IT Industry Promotion Agency grant funded by the Korea Ministry of Science and ICT (S0252-21-1001), Liver Research Foundation of Korea as part of Bio Future Strategies Research Project, and Seoul National University Hospital Research Fund (04-2019-3090). Authors’ contributionsMH and JL both drafted and reviewed the letter equally Declaration

Section snippets Author’s contributionsZhigang Wei: Study design & Manuscript Writing.Dan Shan and Chaojie Liang: Study design & Manuscript Revision. Declaration of Competing InterestWe declare there is no any conflict of interest. Acknowledgements & FundingThis work was supported by Shanxi Medical University Doctoral Start-up Fund (XD1802) and Shanxi Scholarship Council of China (20221852).

Section snippets Financial disclosure fundingNo financial support was received for this letter. Funding fundingNone Conflict-of-interest statement COIThe authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Author contributions author-disclosureHCM: manuscript drafting; YHH: critical expert

Section snippets Author’s contributionBBL prepared the first draft. SA critically reviewed and approved the final manuscript. Financial disclosureNone Declaration of Competing InterestBikrant Bihari Lal and Seema Alam declare no financial or non-financial conflict of interest.

Section snippets Data availability statementGWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (https://gwas.mrcieu.ac.uk/). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (https://r11.finngen.fi/). Authors’ contributionsQZ, H-WC, and SZ drafted the manuscript and performed the main MR analyses. X-BW and

It has come to our attention that the following text should have been included in the ‘Financial support’ section of this article: “Dr. Mehal has an appointment at the West Haven VA Medical Center and this work was supported by a US Department of Veterans Office of Research & Development with grant BX003259-05A1”. We apologise for any inconvenience caused.

Section snippets Financial disclosures fundingNone Conflicts of interest COIThe authors declare no conflicts of interest Authors contributions author-disclosureSB and SS wrote the initial draft. S revised the paper. All authors approved the final manuscript.

Professor Francesco Salerno was a brilliant man who dedicated his life to helping patients with advanced chronic liver diseases and who was internationally renowned for his studies on the pathophysiology of cirrhosis and its complications, as well as the management of patients with ascites, renal dysfunction and bacterial infections. He contributed to the foundation of key international groups such

Section snippets Financial supportThe author received no financial support to produce this manuscript. Authors’ contributionsXiang-Yu Han: manuscript writing; Hui-ru Qi: critical revision Declaration of Competing InterestThe author declare no conflicts of interest.

Section snippets Authors’ contributionsJunhao Chen: conceptualization and manuscript draft. Haifeng Wang: supporting role in revision for important intellectual content. Shi Fu: critical revision for important intellectual content, final approval. Financial supportNone Declaration of Competing InterestThe authors of this study declare that they do not have any conflict of interest.

Section snippets Declaration of Competing Interestnone Financial disclosurenone Author contributionsall authors contributed equally to the manuscript in terms of concept, writing, editing.

Section snippets Author ContributionsRWH Hui was involved in manuscript design and drafting of manuscript. LY Mak was involved in critical revision of manuscript. MF Yuen was involved in critical revision of manuscript and overall study supervision. The authors declare that they have participated in the preparation of the manuscript and have seen and approved the final version. Disclosures/ Conflict

Section snippets AUTHOR CONTRIBUTIONSRWH Hui was involved in manuscript design and drafting of manuscript. LY Mak was involved in critical revision of manuscript. MF Yuen was involved in critical revision of manuscript and overall study supervision. The authors declare that they have participated in the preparation of the manuscript and have seen and approved the final version. DISCLOSURES/ CONFLICT

In order to understand and curb the harms related to alcohol, it will be necessary to think beyond patterns of use that meet criteria for a diagnosis of alcohol use disorder, or addiction. Current research suggests that regular daily alcohol use does not confer a health benefit, and for many persons, even relatively low consumption is associated with a health risk. Determining a safe limit for alcohol

Liver transplantation (LT) is an established life-saving procedure. The field of LT has changed in the past 10 years from several perspectives, with the expansion of indications, transplantation of patients with acute-on-chronic liver failure, evolution of transplant oncology, the use of donations after cardiac death, new surgical techniques, and prioritisation of recipients on the waiting list. In

Section snippets Authors' contributions:P.R., K.N.: Writing - Original Draft, Data curation, Formal Analysis; D.D.P, D.P.: Data curation, Formal Analysis, Writing - Review & Editing; D.A.S.: Conceptualization, Methodology, Formal Analysis, Writing – Review and Editing, Supervision. Financial support:NoneThe recently published multicenter study of Porto-Sinusoidal Vascular Disorder (PSVD) patients by

Section snippets Authors' contributions:WG, WC and HX conceived and designed the study. WG and WC collected and analyzed the data. HX provided clinical expertise and interpreted the results. WG drafted the manuscript. All authors critically revised the manuscript and approved the final version. Data Availability StatementThis data can be accessed through the FDA's FAERS Public Dashboard athttps://fis

Section snippets Author contributionsall authors contributed equally to the reply letter Financial supportThe study was supported by Gilead Sciences and the German Center for Infection Research (TTU Hepatitis 05.822; 05.820). Declaration of Competing InterestLA declares no conflict of interest. JJW and BD are employees of Gilead Sciences and holders of Gilead stock. MD: Research collaboration with

Section snippets Authors' contributionsKarina Raikhelson wrote the original draft, Sergey Okovityi, Dzhamal Abdurakhmanov reviewed and edited this Correspondence; All the authors approved the final manuscript. Financial supportThe authors received no financial support to produce this manuscript. Declaration of Competing InterestThe authors declare no conflict of interest pertaining to this article

Section snippets AbbreviationsMetabolic dysfunction-associated steatotic liver disease (MASLD), non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), metabolic dysfunction-associated fatty liver disease (MAFLD), non-alcoholic steatohepatitis (NASH), metabolic dysfunction-associated steatohepatitis (MASH)”Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as

Section snippets Authors’ contributionMKN, JAK and FD wrote the manuscript and revised it Financial supportnone

It has come to our attention that the following text should have been included in the ‘Financial support’ section of this article: “Dr. Mehal has an appointment at the West Haven VA Medical Center and this work was supported by a US Department of Veterans Office of Research & Development with grant BX003259-05A1”. We apologise for any inconvenience caused.

Section snippets Clinical trial number:not applicable. Conflict of interest:Edo Dongelmans has no conflicts of interests; Milan Sonneveld receives speakers’ fees and research support from Roche, Bristol Myers Squibb, Gilead Sciences, and Fujirebio. Harry Janssen received grants from: Gilead Sciences, GlaxoSmithKline, Janssen, Roche, Vir Biotechnology Inc. and is consultant for: Aligos, Gilead Sciences

Section snippets Authors' contributionsZheng Li, Yue Hu, and Dan Cao contributed to the study conception and design. Zheng Li, Yali Shen, Zhiping Li, Dan Cao, and Yue Hu performed data acquisition, analysis, and interpretation. Zheng Li, Yali Shen, and Zhiping Li wrote the initial draft, Yue Hu and Dan Cao revised the manuscript. All authors reviewed and approved the final manuscript. Data availability

Section snippets Author contributions:VT and TR both drafted and reviewed the reply letter for intellectual content. Financial support:none. Declaration of Competing Interest:VT is funded by the Christian-Doppler Research Association and Boehringer Ingelheim RCV GmbH & Co KG (CD10271603); Romanian Ministry of Research, Innovation and Digitalization (PNRR/2022/C9/MCID/I8).TR received grant support from