This Medial News article discusses recent research showing that current COVID-19 vaccines fail to elicit enough of a mucosal immune response to prevent infection.

This Medical News article is an interview with Michael Pencina, PhD, Duke Health’s chief data scientist, about the need for health systems to collaborate to keep up with the AI revolution.

BackgroundSpatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human–vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial

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Morris MJ, Castellano D, Herrmann K, et al. 177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate cancer (PSMAfore): a phase 3, randomised, controlled trial. Lancet 2024; 404: 1227–39—Appendix 1 of this Article has been corrected as of December 19, 2024.

Jairath V, Acosta Felquer ML, Jaihyun Cho R. IL-23 inhibition for chronic inflammatory disease. Lancet 2024; 404: 1679–92—In this Therapeutics paper, the name IL-23A in the abstract should have been IL-23. Also, the model of TYK2 activation shown in the figure is incorrect. TYK2 activates via IL-12Rβ1, not IL-23R. These corrections were made to the online version as of December 19, 2024.

Andersen BK, Sejr-Hansen M, Maillard L, et al. Quantitative flow ratio versus fractional flow reserve for coronary revascularisation guidance (FAVOR III Europe): a multicentre, randomised, non-inferiority trial. Lancet 2024; 404: 1835–46—In this Article, author Eric Van Belle's name should have been written as E Van Belle in the affiliations section. This correction has been made to the online version

Section snippets ContributorsDAH-K and AFO’N provided clinical care for this patient. JDS and AFO’N acquired the images. All authors wrote, reviewed, and revised the manuscript. Written consent for publication was obtained from the patient. Declaration of interestsJDS declares support paid to his institution from Merck, BMS, Regeneron, Debiopharm, Seimens, and EMD Serono; consulting or participation

Section snippets Declaration of interestsI declare no competing interests.

Inés Azofeifa Rojas monitors troop behaviour to maintain canopy connectivity.

Listen to our reporters’ podcast highlights of 2024.

Models and experiments demonstrate what happens when a knitted fabric is deformed.

More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.

By providing measures of novelty, DeSci Publish hopes to shift the bargaining power between journals and authors.

Faculty members say academic freedom is under fire, and many are seeking work outside the region.

We investigate how ancient humans ran and hear from climate scientists who are rising to the challenges of an impending Trump presidency.

Recently, the bilayer nickelate La3Ni2O7 has been discovered as a new superconductor with transition temperature Tc near 80 K under high pressure1–3. Despite extensive theoretical and experimental work to understand the nature of its superconductivity4–29, the requirement of extreme pressure restricts the use of many experimental probes and limits its application potential. Here, we present signatures

Objective To evaluate the cognitive abilities of the leading large language models and identify their susceptibility to cognitive impairment, using the Montreal Cognitive Assessment (MoCA) and additional tests. Design Cross sectional analysis. Setting Online interaction with large language models via text based prompts. Participants Publicly available large language models, or “chatbots”: ChatGPT versions

The evolution of the lunar dynamo is essential for deciphering the deep interior structure, thermal history, and surface environment of the Moon1-4. Previous palaeomagnetic investigations on samples returned from the nearside of the Moon have established the general variation of the lunar magnetic field5-7. However, limited spatial and temporal palaeomagnetic constraints leave the evolution of the

Objectives To compare the manual dexterity and composure under pressure of people in different hospital staff roles using a buzz wire game. Design Prospective, observational, comparative study (Tremor study). Setting Leeds Teaching Hospitals NHS Trust, Leeds, UK, during a three week period in 2024. Participants 254 hospital staff members comprising of 60 physicians, 64 surgeons, 69 nurses, and 61 non-clinical

The effects of low sea ice on ocean circulation and storms.

What price experience? I have been working across several safety critical industries for years and in terms of the approaches that these industries take to workforce issues there are some stark differences between safety critical industries and healthcare. One of the most striking differences is the failure to value a risk facing, proficient workforce where safety and productivity are two sides of

Peter was born in Bradford, where his father was a carpenter, and he had one sister, Anne. He attended school in Bradford, proceeding to medical school in Edinburgh, where he was a keen athlete. This remained an interest throughout his working life: he enjoyed orienteering and completed several marathons, including the London Marathon twice. He had many days on the Scottish hills with friends and climbed

Mathew is correct that patients need to understand what is causing musculoskeletal symptoms; she is wrong that the diagnosis lies in expensive magnetic resonance imaging (MRI).1 The advanced nurse practitioners, extended scope physiotherapists, and musculoskeletal physicians in specialty clinics usually do have the understanding of musculoskeletal symptoms and management. What they might need to …

Fairy tales offer opportunities to engage with children about healthy and disordered sleep, say Megan Thomas and colleagues Healthy sleep is a public health priority, with at least a third of children and adults reporting insufficient sleep.12 It is essential for children’s growth and development and optimal physical and mental wellbeing. Consistent bedtime routines, with a calming activity before

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Proteins could serve as biomarkers for senescent cells, which have stopped dividing but have not yet died.

3D models of Australopithecus afarensis suggest the muscular adaptations that made modern humans better runners.

People have profoundly altered the planet’s soundscape. It’s time to quieten down so that other species can thrive.

Antibody production in the skin might lead to new vaccination strategies.

For centuries we’ve linked what we consume to how we feel about ourselves.

A commanding examination of the factors that play into women’s mental ill health should prompt soul searching by readers of all stripes.

Three researchers talk about life in companies and the key to unlocking opportunities.

Human treponemal infections are caused by a family of closely related Treponema pallidum that give rise to the diseases yaws, bejel, pinta and, most famously, syphilis1. Debates on both a common origin for these pathogens and the history of syphilis itself has weighed evidence for the “Columbian hypothesis”2, which argues for an American origin, against that for the “pre-Columbian hypothesis”3, which

A battery-like technology uses a metal called tantalum to create an equivalent of digital 0s and 1s.

In a fiendish quiz our contestants battle to remember the details of the science stories that made 2024 special.

Listen to the Nature Podcast's annual festive spectacular!