The gut microbiota plays a crucial role in maintaining homeostasis and promoting health. A growing number of studies have indicated that gut microbiota can affect cancer development, prognosis, and treatment through their metabolites. By remodeling the tumor microenvironment and regulating tumor immunity, gut microbial metabolites significantly influence the efficacy of anticancer therapies, including chemo-, radio-, and immunotherapy. Several novel therapies that target gut microbial metabolites have shown great promise in cancer models. In this review, we summarize the current research status of gut microbial metabolites in cancer, aiming to provide new directions for future tumor therapy.

中文翻译：

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癌症治疗中的肠道微生物代谢物。


肠道微生物群在维持体内平衡和促进健康方面发挥着至关重要的作用。越来越多的研究表明，肠道微生物群可以通过其代谢物影响癌症的发展、预后和治疗。通过重塑肿瘤微环境和调节肿瘤免疫，肠道微生物代谢物显着影响抗癌疗法的疗效，包括化疗、放疗和免疫疗法。几种针对肠道微生物代谢物的新疗法在癌症模型中显示出了巨大的前景。本文综述了肠道微生物代谢产物在癌症中的研究现状，旨在为未来肿瘤治疗提供新的方向。