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Geo-Net: Geometry-Guided Pretraining for Tooth Point Cloud Segmentation J. Dent. Res. (IF 5.7) Pub Date : 2024-11-16 Y. Liu, X. Liu, C. Yang, Y. Yang, H. Chen, Y. Yuan
Accurately delineating individual teeth in 3-dimensional tooth point clouds is an important orthodontic application. Learning-based segmentation methods rely on labeled datasets, which are typically limited in scale due to the labor-intensive process of annotating each tooth. In this article, we propose a self-supervised pretraining framework, named Geo-Net, to boost segmentation performance by leveraging
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Global, Regional, and Country-Level Economic Impacts of Oral Conditions in 2019 J. Dent. Res. (IF 5.7) Pub Date : 2024-11-13 M. Jevdjevic, S. Listl
The recent World Health Organization (WHO) Oral Health Resolution and the subsequent WHO Global Oral Health Action Plan highlight the key relevance of providing information on the economic impacts of oral conditions. The purpose of this study was to provide updated estimates for the global, regional, and country-level economic impacts of oral conditions in 2019. Extending previously established methods
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Oral Health Research in the WHO African Region between 2011 and 2022: A Scoping Review J. Dent. Res. (IF 5.7) Pub Date : 2024-10-29 T.F. Labarca, D. Ortuño, L. Neira, G. Andrade, F.J. Bravo, C.R. Cantarutti, M. Dallaserra, A. Gatarayiha, J. Karajgikar, R.J. Kulchar, X. Liu, C.C. Martins-Pfeifer, N. Olivares, L. Pilcher, S. Pahlke, C. Pirela, J.M. Sanchez, A. Song, O. Urquhart, J.P. Vargas, C. Véliz, F. Verdugo-Paiva, P. Vergara, V. Zaffiri, J. Zuñiga, Y. Makino, M. Glick, A. Carrasco-Labra
The status of oral health research in the World Health Organization (WHO) African region is unclear, yet the need for such information is central to moving an oral health agenda forward. Such an agenda is essential for effectively translating research into actionable practices and supporting regional strategies. The aim of this scoping review was to provide data on the scope and output of oral health
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Advanced Imaging in Dental Research: From Gene Mapping to AI Global Data J. Dent. Res. (IF 5.7) Pub Date : 2024-10-28 D.T. Graves, S.E. Uribe
Advances in imaging technologies combined with artificial intelligence (AI) are transforming dental, oral, and craniofacial research. This editorial highlights breakthroughs ranging from gene expression mapping to visualizing the availability of global AI data, providing new insights into biological complexity and clinical applications.
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Small Nucleolar RNAs in Head and Neck Squamous Cell Carcinomas J. Dent. Res. (IF 5.7) Pub Date : 2024-10-25 C. Duan, Y. Abola, J. Zhao, Y. Wang
Small nucleolar RNAs (snoRNAs), a distinct class of noncoding RNAs, encompass highly diverse structures and have a range of 60 to 300 nucleotides in length. About 90% of human snoRNAs are intronic and embedded within introns of their host gene transcripts. Most snoRNAs enriched in specific tissue correlate in abundance with their parental host genes. Advancements in high-throughput sequencing have
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Publicly Available Dental Image Datasets for Artificial Intelligence J. Dent. Res. (IF 5.7) Pub Date : 2024-10-18 S.E. Uribe, J. Issa, F. Sohrabniya, A. Denny, N.N. Kim, A.F. Dayo, A. Chaurasia, A. Sofi-Mahmudi, M. Büttner, F. Schwendicke
The development of artificial intelligence (AI) in dentistry requires large and well-annotated datasets. However, the availability of public dental imaging datasets remains unclear. This study aimed to provide a comprehensive overview of all publicly available dental imaging datasets to address this gap and support AI development. This observational study searched all publicly available dataset resources
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Oral Health Care Out-of-Pocket Costs and Financial Hardship: A Scoping Review J. Dent. Res. (IF 5.7) Pub Date : 2024-10-17 D. Proaño, H. Huang, S. Allin, B.M. Essue, S. Singhal, C. Quiñonez
The objective of this study is to characterize how financial hardship related to oral health care (OHC) out-of-pocket (OOP) spending has been conceptualized, defined, and measured in the literature and to identify evidence gaps in this area. This scoping review follows Arksey and O’Malley’s framework and synthesizes financial hardship from OHC concepts, methodologies, and evidence gaps. We searched
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β-catenin Orchestrates Gli1+ Cell Fate in Condylar Development and TMJOA J. Dent. Res. (IF 5.7) Pub Date : 2024-10-14 J. Wang, X. Dong, J. Lei, Y. Zhang, S. Chen, Y. He
The fibrocartilage stem cells (FCSCs) on the surface of the condyle play an essential role in cartilage homeostasis and regeneration. However, few well-defined stem cell markers have been identified for the analysis of FCSCs’ cell fate and regulation mechanism. In this study, we first mapped the transcriptional landscape of the condylar cartilage and identified a Gli1+ subset. Label-retaining cells
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Colin Dawes In Memoriam: JDR Editor Emeritus and Pioneer in Salivary Research J. Dent. Res. (IF 5.7) Pub Date : 2024-10-14 J.M. Richman, W.L. Siqueira
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Economic Considerations in Oral Health: Bridging Gaps, Broadening Horizons J. Dent. Res. (IF 5.7) Pub Date : 2024-10-12 H. Benzian, F. Schwendicke
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Oral Microbiota Development in the First 60 Months: A Longitudinal Study J. Dent. Res. (IF 5.7) Pub Date : 2024-10-12 K. Yama, S. Morishima, K. Tsutsumi, R. Jo, Y. Aita, T. Inokuchi, T. Okuda, D. Watai, K. Ohara, M. Maruyama, T. Chikazawa, T. Iwamoto, Y. Kakizawa, T. Oniki
Childhood is considered crucial in the establishment of future oral microbiota. However, the precise period of oral microbiota development remains unclear. This study aimed to identify the progression of oral microbiota formation in children. We longitudinally investigated the salivary microbiota of 54 children across 13 time points from 1 wk to 60 mo (5 y) old and their parents at 2 time points as
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Immune Dysregulation in the Oral Cavity during Early SARS-CoV-2 Infection J. Dent. Res. (IF 5.7) Pub Date : 2024-10-12 C. Graves, E. Babikow, N. Ghaltakhchyan, T.Q. Ngo, C. Li, S. Wang, A. Shoji, C. Bocklage, S.T. Phillips, M. Markovetz, S.A. Frazier-Bowers, K. Divaris, M. Freire, S. Wallet, D. Wu, L.A. Jacox
Tissue-specific immune responses are critical determinants of health-maintaining homeostasis and disease-related dysbiosis. In the context of COVID-19, oral immune responses reflect local host-pathogen dynamics near the site of infection and serve as important “windows to the body,” reflecting systemic responses to the invading SARS-CoV-2 virus. This study leveraged multiplex technology to characterize
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Fumarate Restrains Alveolar Bone Restoration via Regulating H3K9 Methylation J. Dent. Res. (IF 5.7) Pub Date : 2024-10-12 Y.Y. Zhang, J. Xiang, Y.Y. He, X. Liu, H.Y. Ye, L. Xu, H.L. Bai, H. Zhang, H.M. Zhang, W.Z. Liu, Q.M. Zhai, P. Ji, R.D. Cannon
Nonresolving inflammation causes irreversible damage to periodontal ligament stem cells (PDLSCs) and impedes alveolar bone restoration. The impaired tissue regeneration ability of stem cells is associated with abnormal mitochondrial metabolism. However, the impact of specific metabolic alterations on the differentiation process of PDLSCs remains to be understood. In this study, we found that inflammation
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Ferroptosis Induction Enhances Photodynamic Therapy Efficacy for OLK J. Dent. Res. (IF 5.7) Pub Date : 2024-10-12 D. Yang, D. Yang, Y. Song, J. Liu, Y. Wang, X. Feng, X. Zeng, Q. Chen, J. Li, H. Dan
Oral leukoplakia (OLK) is the most representative oral potentially malignant disorder, with a high risk of malignant transformation and unclear mechanisms of occurrence. Recently, photodynamic therapy (PDT) has exhibited great potential in the treatment of OLK. However, the efficacy of PDT is difficult to predict and varies from person to person. Ferroptosis-related pathways are upregulated in many
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Recent Advances in Intraoral Scanners J. Dent. Res. (IF 5.7) Pub Date : 2024-10-10 F. Eggmann, M.B. Blatz
Intraoral scanners (IOSs) have emerged as a cornerstone technology in digital dentistry. This article examines the recent advancements and multifaceted applications of IOSs, highlighting their benefits in patient care and addressing their current limitations. The IOS market has seen a competitive surge. Modern IOSs, featuring continuous image capture and advanced software for seamless image stitching
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Spatial Transcriptomics Unravel the Tissue Complexity of Oral Pathogenesis J. Dent. Res. (IF 5.7) Pub Date : 2024-10-10 J. Haller, N. Abedi, A. Hafedi, O. Shehab, M.S. Wietecha
Spatial transcriptomics (ST) is a cutting-edge methodology that enables the simultaneous profiling of global gene expression and spatial information within histological tissue sections. Traditional transcriptomic methods lack the spatial resolution required to sufficiently examine the complex interrelationships between cellular regions in diseased and healthy tissue states. We review the general workflows
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Periodontitis and Diabetes Differentially Affect Inflammation in Obesity J. Dent. Res. (IF 5.7) Pub Date : 2024-10-10 S. SantaCruz-Calvo, S. Saraswat, H. Hasturk, D.R. Dawson, X.D. Zhang, B.S. Nikolajczyk
Periodontitis (PD) potentiates systemic inflammatory diseases and fuels a feed-forward loop of pathogenic inflammation in obesity and type 2 diabetes (T2D). Published work in this area often conflates obesity with obesity-associated T2D; thus, it remains unclear whether PD similarly affects the inflammatory profiles of these 2 distinct systemic diseases. We collected peripheral blood mononuclear cells
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A Deep Learning System to Predict Epithelial Dysplasia in Oral Leukoplakia J. Dent. Res. (IF 5.7) Pub Date : 2024-10-10 J. Adeoye, A. Chaurasia, A. Akinshipo, I.K. Suleiman, L.-W. Zheng, A.W.I. Lo, J.J. Pu, S. Bello, F.O. Oginni, E.T. Agho, R.O. Braimah, Y.X. Su
Oral leukoplakia (OL) has an inherent disposition to develop oral cancer. OL with epithelial dysplasia (OED) is significantly likely to undergo malignant transformation; however, routine OED assessment is invasive and challenging. This study investigated whether a deep learning (DL) model can predict dysplasia probability among patients with leukoplakia using oral photographs. In addition, we assessed
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Nuclear TOP1MT Confers Cisplatin Resistance via Pseudogene in HNSCC J. Dent. Res. (IF 5.7) Pub Date : 2024-10-10 T. Tong, P. S. Zhai, X. Qin, Z. Zhang, C. W. Li, H. Y. Guo, H. L. Ma
Cisplatin resistance is one of the major causes of treatment failure in head and neck squamous cell carcinoma (HNSCC). There is an urgent need to uncover the underlying mechanism for developing effective treatment strategies. A quantitative proteomics assay was used to identify differential proteins in cisplatin-resistant cells. Mitochondrial topoisomerase I (TOP1MT) localization was determined using
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Genetically Supported Drug Targets and Dental Traits: A Mendelian Randomization Study J. Dent. Res. (IF 5.7) Pub Date : 2024-10-08 L. Liu, T. Wang, C. Duan, S. Mao, B. Wu, Y. Chen, D. Huang, Y. Cao
Current interventions for oral/dental diseases heavily rely on operative/surgical procedures, while the discovery of novel drug targets may enable access to noninvasive pharmacotherapy. Therefore, this study aims to leverage large-scale data and Mendelian randomization (MR) techniques, utilizing genetic variants as instruments, to identify potential therapeutic targets for oral and dental diseases
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The Therapeutic Use of Dental Mesenchymal Stem Cells in Human Clinical Trials J. Dent. Res. (IF 5.7) Pub Date : 2024-10-08 S. Ivanovski, P. Han, O.A. Peters, M. Sanz, P.M. Bartold
Mesenchymal stem cells (MSCs), characterized by their undifferentiated and multipotent nature, can be derived from various sources, including bone marrow, adipose, and dental tissues. Among these, dental MSCs (DSCs) exhibit universal MSC characteristics and are attracting considerable attention for regenerating oral and craniofacial tissues. This review provides a contemporary overview of recently
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Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells J. Dent. Res. (IF 5.7) Pub Date : 2024-10-08 Y. Netanely, O. Barel, R. Naamneh, Y. Jaber, S. Yacoub, Y. Saba, K. Zubeidat, O. Saar, L. Eli-Berchoer, S. Yona, A. Brand, T. Capucha, A. Wilensky, K. Loser, B.E. Clausen, A.-H. Hovav
Due to its capacity to drive osteoclast differentiation, the receptor activator of nuclear factor kappa-β ligand (RANKL) is believed to exert a pathological influence in periodontitis. However, RANKL was initially identified as an activator of dendritic cells (DCs), expressed by T cells, and exhibits diverse effects on the immune system. Hence, it is probable that RANKL, acting as a bridge between
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A Review of Immunotherapy for Head and Neck Cancer J. Dent. Res. (IF 5.7) Pub Date : 2024-10-08 J.W. Goetz, G. Rabinowits, N. Kalman, A. Villa
The introduction of immune checkpoint inhibitors (ICIs) to oncological care has transformed the management of various malignancies, including head and neck squamous cell carcinoma (HNSCC), offering improved outcomes. The first-line treatment of recurrent and malignant HNSCC for many years was combined platinum, 5-fluorouracil, and cetuximab. Recently, the ICI pembrolizumab was approved as a first-line
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Surrogate Endpoints: CONSORT and SPIRIT Extensions J. Dent. Res. (IF 5.7) Pub Date : 2024-10-07 F. Schwendicke, N.S. Jakubovics
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Coloring Multilayer Zirconia May Affect Its Optical and Mechanical Properties J. Dent. Res. (IF 5.7) Pub Date : 2024-10-04 S.M. Čokić, M. Li, S. Huang, J. Vleugels, B. Van Meerbeek, F. Zhang
The coloring process of monolithic dental zirconia caused considerable debate on the possible effects of different coloring methods. The main objective of this study was to investigate the influence of pigments in 3 multilayer 5-mol% yttria partially stabilized zirconia (5Y-PSZ) disks (Lava Esthetic A2 [Zr-AGG_A2] and Bleach [Zr-AGG_BL], both 3M Oral Care, and Katana STML A2 [Zr-NoAGG], Kuraray Noritake)
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Big Data in Epidemiology: Brave New World? J. Dent. Res. (IF 5.7) Pub Date : 2024-10-03 R.A. Jordan, R.K. Celeste, E. Bernabe, F. Schwendicke
Epidemiology is experiencing a significant shift toward the utilization of big data for health monitoring and decision-making. This article discusses the recent example of the World Health Organization (WHO) global oral health status report and regional summaries, which faced criticisms due to its reliance on big data from the Global Burden of Disease (GBD) study. We address the arguments for and against
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Response to the Letter to the Editor, “Sjögren’s Disease Is Not a Clinical Risk Factor for Periodontitis” J. Dent. Res. (IF 5.7) Pub Date : 2024-10-01 S.L. Reckelkamm, Z. Alayash, B. Holtfreter, M. Nolde, S.-E. Baumeister
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Heterogeneity in Dental Tissue–Derived MSCs Revealed by Single-Cell RNA-seq J. Dent. Res. (IF 5.7) Pub Date : 2024-09-27 C. Behm, O. Miłek, K. Schwarz, A. Kovar, S. Derdak, X. Rausch-Fan, A. Moritz, O. Andrukhov
Mesenchymal stromal cells (MSCs) are multipotent, progenitor cells that reside in tissues across the human body, including the periodontal ligament (PDL) and gingiva. They are a promising therapeutic tool for various degenerative and inflammatory diseases. However, different heterogeneity levels caused by tissue-to-tissue and donor-to-donor variability, and even intercellular differences within a given
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Trustworthy Artificial Intelligence in Dentistry: Learnings from the EU AI Act J. Dent. Res. (IF 5.7) Pub Date : 2024-09-23 M. Ducret, E. Wahal, D. Gruson, S. Amrani, R. Richert, M. Mouncif-Moungache, F. Schwendicke
Artificial intelligence systems (AISs) gain relevance in dentistry, encompassing diagnostics, treatment planning, patient management, and therapy. However, questions about the generalizability, fairness, and transparency of these systems remain. Regulatory and governance bodies worldwide are aiming to address these questions using various frameworks. On March 13, 2024, members of the European Parliament
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ALKBH5 Regulates Osteogenic Differentiation via the lncRNA/mRNA Complex J. Dent. Res. (IF 5.7) Pub Date : 2024-09-23 Y. Song, H. Gao, Y. Pan, Y. Gu, W. Sun, Y. Wang, J. Liu
Human adipose-derived stem cells (hASCs) are commonly used in bone tissue regeneration. The N6-methyladenosine (m6A) modification has emerged as a novel regulatory mechanism for gene expression, playing a critical role in osteogenic differentiation of stem cells. However, the precise role and mechanism of alkylation repair homolog 5 (ALKBH5) in hASC osteogenesis remain incompletely elucidated and warrant
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Acceleration of HDL-Mediated Cholesterol Efflux Alleviates Periodontitis J. Dent. Res. (IF 5.7) Pub Date : 2024-09-23 T.-T. Tran, G. Lee, Y.H. Huh, K.-H. Chung, S.Y. Lee, K.H. Park, J.-H. Kim, M.-S. Kook, J. Ryu, O.-S. Kim, H.-P. Lim, J.-T. Koh, J.-H. Ryu
Periodontitis (PD) is a common inflammatory disease known to be closely associated with metabolic disorders, particularly hyperlipidemia. In the current study, we demonstrated that hypercholesterolemia is a predisposing factor in the development of PD. Logistic regression analysis revealed a strong positive correlation between PD and dyslipidemia. Data from in vivo (PD mouse model subjected to a high
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Toward Better Reporting in Oral Health Research J. Dent. Res. (IF 5.7) Pub Date : 2024-09-21 N.S. Jakubovics, F. Schwendicke
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m6Am Methyltransferase PCIF1 Regulates Periodontal Inflammation J. Dent. Res. (IF 5.7) Pub Date : 2024-09-18 W. Song, L. Liu, H. Liang, H. Cheng, W. He, Q. Yin, Z. Zhang, W. Lin, H. Li, Q. Li, W. Liu, D. Zhang, D. Chen, Q. Yuan
N6,2′-O-dimethyladenosine (m6Am), a common mRNA modification in eukaryotic capped mRNAs, plays a pivotal role in cellular functions and disease progression. However, its involvement in host inflammation remains elusive. Here, we demonstrate that loss of m6Am methyltransferase phosphorylated CTD interacting factor 1 (PCIF1) attenuates periodontal inflammation in whole-body and myeloid lineage–specific
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Multiscale Imaging to Monitor Functional SHED-Supported Engineered Vessels J. Dent. Res. (IF 5.7) Pub Date : 2024-09-18 E. Chatzopoulou, N. Bousaidi, T. Guilbert, G. Rucher, J. Rose, S. Germain, F. Rouzet, C. Chaussain, L. Muller, C. Gorin
Regeneration of orofacial tissues is hampered by the lack of adequate vascular supply. Implantation of in vitro engineered, prevascularized constructs has emerged as a strategy to allow the rapid vascularization of the entire graft. Given the angiogenic properties of dental pulp stem cells, we hereby established a preclinical model of prevascularized constructs loaded with stem cells from human exfoliating
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Recurrence in Oral Leukoplakia: A Systematic Review and Meta-analysis J. Dent. Res. (IF 5.7) Pub Date : 2024-09-18 B.P. Bhattarai, A.K. Singh, R.P. Singh, R. Chaulagain, T.M. Søland, B. Hasséus, D. Sapkota
The management of oral leukoplakia (OL) is challenging because of a high risk for recurrence and malignant transformation (MT), and recurrent OL is associated with a higher risk of MT than nonrecurrent OL. The present meta-analysis aimed to examine the association between OL recurrence and surgical techniques used for their management as well as their clinicopathological factors. Electronic searches
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A Mentoring Network for Diversity in Dental, Oral, and Craniofacial Research J. Dent. Res. (IF 5.7) Pub Date : 2024-09-17 S.S. Herren, E. Ioannidou, D. Drake, E. Bernstein, N. Mickel, C.H. Fox
The American Association for Dental, Oral, and Craniofacial Research (AADOCR) has developed a national and sustainable mentoring and mentor training network titled AADOCR Mentoring an Inclusive Network for a Diverse Workforce of the Future (AADOCR MIND the Future). This program is instrumental in fostering a diverse group of early-career investigators in dental, oral, and craniofacial (DOC) research
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Mechanics- and Behavior-Related Temporomandibular Joint Differences J. Dent. Res. (IF 5.7) Pub Date : 2024-09-14 J.C. Nickel, Y.M. Gonzalez, Y. Liu, H. Liu, L.M. Gallo, L.R. Iwasaki
Fatigue of temporomandibular joint (TMJ) tissues reflects the effects of magnitude (energy density; ED) and frequency of loading (jaw muscle duty factor; DF). This observational study measured these variables and tested for differences in mechanobehavior scores (MBS = ED2 × DF) and component variables in subjects with and without TMJ disc displacement (±D). In accordance with Institutional Review Board
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Computational Methods for Image Analysis in Craniofacial Development and Disease J. Dent. Res. (IF 5.7) Pub Date : 2024-09-14 E. James, A.J. Caetano, P.T. Sharpe
Observation is at the center of all biological sciences. Advances in imaging technologies are therefore essential to derive novel biological insights to better understand the complex workings of living systems. Recent high-throughput sequencing and imaging techniques are allowing researchers to simultaneously address complex molecular variations spatially and temporarily in tissues and organs. The
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Apoptotic Vesicles: Therapeutic Mechanisms and Critical Issues J. Dent. Res. (IF 5.7) Pub Date : 2024-09-14 Q. Ou, W. Huang, B. Wang, L. Niu, Z. Li, X. Mao, S. Shi
Apoptosis is the most prominent mode of programmed cell death and is necessary for the maintenance of tissue homeostasis. During cell apoptosis, a distinctive population of extracellular vesicles is generated, termed apoptotic vesicles (apoVs). ApoVs inherit a variety of biological molecules such as proteins, RNAs, nuclear components, lipids, and gasotransmitters from their parent cells. ApoVs have
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Unveiling the Neurodegenerative Alterations through Oral Stem Cells J. Dent. Res. (IF 5.7) Pub Date : 2024-09-14 M. Tatullo, T. Cocco, A. Ferretta, R. Caroppo, B. Marrelli, G. Spagnuolo, F. Paduano
Parkinson’s disease (PD) is a neurodegenerative condition characterized by the progressive and selective loss of dopaminergic (DAergic) neurons in the midbrain. The replacement of neuromelanin (NM)–containing DAergic neurons in the substantia nigra and the enhancement of NM concentration could offer a promising and safe approach to treating PD symptoms. The objective of this study was to investigate
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Metabolic and Aging Influence on Anticancer Immunity in Oral Cancer J. Dent. Res. (IF 5.7) Pub Date : 2024-08-26 T.P.M.d. Santos, W.L. Hicks, W.J. Magner, A. Al Afif, K.L. Kirkwood
The average age and obesity prevalence are increasing globally. Both aging and metabolic disease burden increase the risk of oral squamous cell carcinoma (OSCC) through profound effects on the immunological and metabolic characteristics within the OSCC tumor microenvironment. While the mechanisms that link aging and obesity to OSCC remain unclear, there is evidence that the antitumor responses are
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Engineered 3D Periodontal Ligament Model with Magnetic Tensile Loading J. Dent. Res. (IF 5.7) Pub Date : 2024-08-26 P. Mulimani, N.A. Mazzawi, A.J. Goldstein, A.M. Obenaus, S.M. Baggett, D. Truong, T.E. Popowics, N.J. Sniadecki
In vitro models are invaluable tools for deconstructing the biological complexity of the periodontal ligament (PDL). Model systems that closely reproduce the 3-dimensional (3D) configuration of cell–cell and cell–matrix interactions in native tissue can deliver physiologically relevant insights. However, 3D models of the PDL that incorporate mechanical loading are currently lacking. Hence, we developed
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Autophagy Regulates Age-Related Jawbone Loss via LepR+ Stromal Cells J. Dent. Res. (IF 5.7) Pub Date : 2024-08-26 B. Sun, Y. Xu, H. Wang, F. Wang, Q. Li, Y. Chen, Z. Wang
Bone aging and decreased autophagic activity are related but poorly explored in the jawbone. This study aimed to characterize the aging jawbones and jawbone-derived stromal cells (JBSCs) and determine the role of autophagy in jawbone mass decline. We observed that the jawbones of older individuals and mice exhibited similar age-related bone loss. Furthermore, leptin receptor (LepR)–lineage cells served
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Association between Periodontal Diseases and the Risk of Site-Specific Gastrointestinal Cancers: A Systematic Review and Meta-Analysis J. Dent. Res. (IF 5.7) Pub Date : 2024-08-26 Q. Wang, W.-J. Gu, F.-L. Ning, M. Sun, Z.-M.g Zhao, M.u Abe, Z.-N. Li, C.-D. Zhang
The association between periodontal diseases and the risk of gastrointestinal cancers, especially site-specific gastrointestinal cancers, remains unclear. Here, we comprehensively searched PubMed, EMBASE, Web of Science, and Google Scholar from inception to April 2024 to identify relevant studies. The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with a random-effects
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A Two-Sample Mendelian Randomization Study of Neuroticism and Sleep Bruxism J. Dent. Res. (IF 5.7) Pub Date : 2024-08-26 T. Strausz, S. Strausz, S.E. Jones, T. Palotie, F. Lobbezoo, J. Ahlberg, H.M. Ollila
Sleep bruxism (SB) affects a considerable part of the population and is associated with neuroticism, stress, and anxiety in various studies. However, the causal mechanisms between neuroticism and SB have not been examined. Understanding the reasons for SB is important as understanding bruxism may allow improved comprehensive management of the disorders and comorbidities related to it. Previous studies
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Periodontitis and Diabetes Complications: A Danish Population-Based Study J. Dent. Res. (IF 5.7) Pub Date : 2024-08-06 F.V. Bitencourt, A. Andersen, L. Bjerg, A. Sandbæk, H. Li, G.G. Nascimento, R. Spin-Neto, M.A. Peres, F.R.M. Leite
Conflicting evidence suggests a link between diabetes-related microvascular complications and periodontitis. Reliable estimates have been hindered by small sample sizes and residual confounding. Moreover, the combined effects of microvascular complications and dyslipidemia on periodontitis have not been explored. Therefore, this study aimed to investigate the association between individual and combined
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Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model J. Dent. Res. (IF 5.7) Pub Date : 2024-08-06 K.L. Kirkwood, T.E. Van Dyke, C.L. Kirkwood, L. Zhang, J. Panezai, A.E. Duran-Pinedo, E.L. Figgins, L.K. Ryan, J.J. Frias-Lopez, G. Diamond
There is a strong association between vitamin D levels and periodontal disease based on numerous epidemiological studies. We have previously shown that experimental deficiency of serum vitamin D in mice leads to gingival inflammation and alveolar bone loss. Treatment of cultured oral epithelial cells with the active form of vitamin D, 1,25(OH)2 vitamin D3 (1,25(OH)2D3), inhibits the extracellular growth
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Changes in Use of Prenatal Dental Care After Brazil’s Incentive Policy J. Dent. Res. (IF 5.7) Pub Date : 2024-08-06 H.S. Schuch, M. Furtado, A.D.P. Chiavegatto Filho, H.W. Elani
In 2020, the Brazilian federal government launched the “Prevent Brazil” program to incentivize cities to improve their performance across 7 health care indicators, including prenatal dental care. Our study examines the impact of this policy on the use of oral health care among pregnant women in Brazil. We used a series of cross-sectional data from the Brazilian Public Health System from 2018 to 2023
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Periodontal Ligament Cell Apoptosis Activates Lepr+ Osteoprogenitors in Orthodontics J. Dent. Res. (IF 5.7) Pub Date : 2024-08-06 H. Liu, Y. Zhang, Y. Zhang, Y. Huang, Y. Yang, Y. Zhao, S. Chen, J. Deng, W. Li, B. Han
Alveolar bone (AB) remodeling, including formation and absorption, is the foundation of orthodontic tooth movement (OTM). However, the sources and mechanisms underlying new bone formation remain unclear. Therefore, we aimed to understand the potential mechanism of bone formation during OTM, focusing on the leptin receptor+ (Lepr+) osteogenitors and periodontal ligament cells (PDLCs). We demonstrated
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Macrophage Polarization during MRONJ Development in Mice J. Dent. Res. (IF 5.7) Pub Date : 2024-08-06 A. Soundia, N. Elzakra, D. Hadaya, I. Gkouveris, O. Bezouglaia, S. Dry, T. Aghaloo, S. Tetradis
Macrophages are important regulators of bone remodeling, and M1 polarization is observed in the setting of medication-related osteonecrosis of the jaws (MRONJ). Here, we characterize the phenotype of macrophages during early stages of MRONJ development in zoledronate (ZA)–treated mice with periodontal disease and explore the role of rosiglitazone, a drug that has been reported to lower the M1/M2 macrophage
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Salivary Microbiome Relates to Neoadjuvant Immunotherapy Response in OSCC J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 X.X. Wang, Y.T. Liu, J.G. Ren, H.M. Liu, Q. Fu, Y. Yang, Q.Y. Fu, G. Chen
Most patients diagnosed with oral squamous cell carcinoma (OSCC) present with locally advanced stages, which are typically associated with poor outcomes. Although immunotherapy offers potential improvements in patient survival, its efficacy is hampered by low response rates. The microbiome is widely involved in tumor immunity and may play a role in immunotherapy. This study aimed to investigate the
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Novel Antimitotic Agent SP-1-39 Inhibits Head and Neck Squamous Cell Carcinoma J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 K.L. Adeleye, A.R. Li, Y. Xie, S. Pochampally, D. Hamilton, F. Garcia-Godoy, D.D. Miller, W. Li
Effective management of head and neck cancer (HNC) poses a significant challenge in the field of oncology, due to its intricate pathophysiology and limited treatment options. The most common HNC malignancy is head and neck squamous cell carcinoma (HNSCC). HNSCC treatment includes a combination of surgery, radiation, and chemotherapy. While HNSCC is treatable if diagnosed early, this is often not the
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Complete Loss of Natural Teeth and Loneliness: A Fixed-Effect Analysis J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 Y. Matsuyama
Psychosocial properties of oral health have been reported. The present study aimed to investigate the causal effect of complete loss of natural teeth on loneliness by using fixed-effects analysis to control for confounding factors, including unmeasured time-invariant factors. Data from older adults participating in at least 2 consecutive waves of the English Longitudinal Study of Ageing in waves 3
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Melatonin and Metformin Mitigate Doxorubicin-Induced Alveolar Bone Toxicity J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 B. Srivichit, C. Thonusin, R. Aeimlapa, A. Arinno, T. Chunchai, N. Charoenphandhu, N. Chattipakorn, S.C. Chattipakorn
Evidence concerning the osteotoxic effects of chemotherapy (doxorubicin) has been previously described. Periodontitis also progressively increases in patients receiving chemotherapy; however, the beneficial effects of melatonin and metformin on the alleviation of doxorubicin-induced osteotoxicity have never been investigated. Therefore, we investigated the negative impact of doxorubicin on alveolar
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Visualization of Pulpal Structures by SWIR in Endodontic Access Preparation J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 L. Benz, K. Heck, D. Hevisov, D. Kugelmann, P.-C. Tseng, Z. Sreij, F. Litzenburger, J. Waschke, F. Schwendicke, A. Kienle, R. Hickel, K.-H. Kunzelmann, E. Walter
Endodontic access preparation is one of the initial steps in root canal treatments and can be hindered by the obliteration of pulp canals and formation of tertiary dentin. Until now, methods for direct intraoperative visualization of the 3-dimensional anatomy of teeth have been missing. Here, we evaluate the use of shortwave infrared radiation (SWIR) for navigation during stepwise access preparation
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Six1 Regulates Mouse Incisor Development by Promoting Dlx1/2/5 Expression J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 S.Y. Luo, S. Wang, Z.X. Liu, Q. Bian, X.D. Wang
Tooth development is a complex process orchestrated by intricate gene regulatory networks, involving both odontogenic epithelium and ectomesenchyme. Six1, a pivotal transcription factor (TF), is involved in the development of the lower incisor. However, its precise role during incisor development and the molecular mechanisms underpinning its regulatory functions remain poorly understood. This study
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The PerioGene North Study Uncovers Serum Proteins Related to Periodontitis J. Dent. Res. (IF 5.7) Pub Date : 2024-08-05 M. Wänman, S. Betnér, A. Esberg, C.K. Holm, C. Isehed, A. Holmlund, P. Palmqvist, A. Lövgren, S. Lindquist, L. Hänström, U.H. Lerner, E. Kindstedt, P. Lundberg
The sequalae of periodontitis include irreversible degradation of tooth-supporting structures and circulatory spread of inflammatory mediators. However, the serum protein profile in periodontitis is not well described, which is partly attributable to the limited number of studies based on large and well-characterized periodontitis cohorts. This study aims to identify novel, circulating inflammation-related
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Type VI Collagen Deficiency Causes Enhanced Periodontal Tissue Destruction J. Dent. Res. (IF 5.7) Pub Date : 2024-06-24 T. Komori, V. Kram, S. Perry, H.T. Pham, P. Jani, T.M. Kilts, K. Watanabe, D.G. Kim, D. Martin, M.F. Young
The periodontal ligament (PDL) is a fibrillar connective tissue that lies between the alveolar bone and the tooth and is composed of highly specialized extracellular matrix (ECM) molecules and a heterogeneous population of cells that are responsible for collagen formation, immune response, bone formation, and chewing force sensation. Type VI collagen (COL6), a widely distributed ECM molecule, plays
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Detecting Mandible Fractures in CBCT Scans Using a 3-Stage Neural Network J. Dent. Res. (IF 5.7) Pub Date : 2024-06-24 N. van Nistelrooij, S. Schitter, P. van Lierop, K. El Ghoul, D. König, M. Hanisch, A. Tel, T. Xi, D.G.E. Thiem, R. Smeets, L. Dubois, T. Flügge, B. van Ginneken, S. Bergé, S. Vinayahalingam
After nasal bone fractures, fractures of the mandible are the most frequently encountered injuries of the facial skeleton. Accurate identification of fracture locations is critical for effectively managing these injuries. To address this need, JawFracNet, an innovative artificial intelligence method, has been developed to enable automated detection of mandibular fractures in cone-beam computed tomography
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PIEZO1 Promotes Odontoblast-Mediated Reactionary Dentinogenesis via SEMA3A J. Dent. Res. (IF 5.7) Pub Date : 2024-06-24 P. Huang, R.X. Jiang, F Wang, W.W. Qiao, Y.T. Ji, L.Y. Meng, Z. Bian
Located at the interface of the dentin–pulp complex, the odontoblasts are specialized cells responsible for dentin synthesis and nociceptive signal detection in response to external stimuli. Recent studies have shown that the mechanosensitive ion channel PIEZO1 is involved in bone formation and remodeling through the influx of calcium ions, and it is abundantly expressed in odontoblasts. However, the