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Impact of care–recipient relationship type on quality of life in caregivers of older adults with dementia over time Age Ageing (IF 6.0) Pub Date : 2024-07-19 Aiping Lai Kin, Lauren E Griffith, Ayse Kuspinar, Jenna Smith-Turchyn, Julie Richardson
Background Dementia caregiving is a dynamic and multidimensional process. To gain a comprehensive understanding of informal caregiving for people living with dementia (PLWD), it is pivotal to assess the quality of life (QoL) of informal caregivers. Objective To evaluate whether the care–recipient relationship type predicts changes in the QoL of informal caregivers of PLWD over a two-year period. Methods
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Epigenetic age acceleration and the risk of frailty, and persistent activities of daily living (ADL) disability Age Ageing (IF 6.0) Pub Date : 2024-07-19 Aung Zaw Zaw Phyo, Sara E Espinoza, Anne M Murray, Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Joanne Ryan
Background Epigenetic ageing is among the most promising ageing biomarkers and may be a useful marker of physical function decline, beyond chronological age. This study investigated whether epigenetic age acceleration (AA) is associated with the change in frailty scores over 7 years and the 7-year risk of incident frailty and persistent Activities of Daily Living (ADL) disability among 560 Australians
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Postdischarge functional outcomes in older patients with acute heart failure in Japan: the Longevity Improvement & Fair Evidence study Age Ageing (IF 6.0) Pub Date : 2024-07-18 Nobuhiro Narii, Tetsuhisa Kitamura, Atsushi Hirayama, Yoshimitsu Shimomura, Ling Zha, Masayo Komatsu, Sho Komukai, Yohei Sotomi, Katsuki Okada, Yasushi Sakata, Fumiko Murata, Megumi Maeda, Kosuke Kiyohara, Tomotaka Sobue, Haruhisa Fukuda
Background The association between care needs level (CNL) at hospitalisation and postdischarge outcomes in older patients with acute heart failure (aHF) has been insufficiently investigated. Methods This population-based cohort study was conducted using health insurance claims and CNL data of the Longevity Improvement & Fair Evidence study. Patients aged ≥65 years, discharged after hospitalisation
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Design and development of a new pictorial tool to facilitate communication around advance care planning Age Ageing (IF 6.0) Pub Date : 2024-07-18 Mireia Baylina Melé, Christian Villavicencio-Chávez, Cristina Garzón Rodríguez, Montserrat Edo-Gual, Iris Crespo
Background Advance care planning (ACP) aims to ensure that people with chronic or advanced disease receive medical care that is consistent with their values and preferences. However, professionals may find it challenging to engage these patients in conversations about the end of life. We sought to develop a pictorial tool to facilitate communication around ACP. Methods This was a three-phase study
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Hospital falls clinical practice guidelines: a global analysis and systematic review Age Ageing (IF 6.0) Pub Date : 2024-07-18 Jonathan P McKercher, Casey L Peiris, Anne-Marie Hill, Stephen Peterson, Claire Thwaites, Sally Fowler-Davis, Meg E Morris
Background Hospital falls continue to be a persistent global issue with serious harmful consequences for patients and health services. Many clinical practice guidelines now exist for hospital falls, and there is a need to appraise recommendations. Method A systematic review and critical appraisal of the global literature was conducted, compliant with the Preferred Reporting Items for Systematic Reviews
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Cardiovascular risk associated with changes in anticholinergic load on four different scales: a registry-based cohort study of geriatric outpatients Age Ageing (IF 6.0) Pub Date : 2024-07-16 Johannes Riis, Kristian Kragholm, Marc Meller Søndergaard, Silas Clemmensen, Lene Torp Hansen, Christian Torp-Pedersen, Dorte Melgaard
Background Recent studies have shown that anticholinergic medications are associated with cardiovascular disease. Little is known about how discontinuation of anticholinergic medication affects this association. We investigated how baseline anticholinergic load and change in anticholinergic load associates with major adverse cardiovascular events (MACE) on four different scales. Methods We included
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The electronic frailty index and outcomes in patients with myocardial infarction Age Ageing (IF 6.0) Pub Date : 2024-07-16 Matthew T H Lowry, Dorien M Kimenai, Dimitrios Doudesis, Konstantin Georgiev, Michael McDermott, Anda Bularga, Caelan Taggart, Ryan Wereski, Amy V Ferry, Stacey D Stewart, Christopher Tuck, David E Newby, Nicholas L Mills, Atul Anand
Background Frailty is increasingly present in patients with acute myocardial infarction. The electronic Frailty Index (eFI) is a validated method of identifying vulnerable older patients in the community from routine primary care data. Our aim was to assess the relationship between the eFI and outcomes in older patients hospitalised with acute myocardial infarction. Study design and setting Retrospective
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Out-of-hospital paramedic interactions with people living with dementia: a scoping review Age Ageing (IF 6.0) Pub Date : 2024-07-12 Ming Xuan Han, Linda Ross, Liam Hemingway, David Anderson, Cameron Gosling
Background Dementia encompasses neurodegenerative disorders that account for a global estimated healthcare expenditure of 1.3 trillion US dollars. In Australia, one in 12 people aged ≥65 has a diagnosis of dementia and it is the second leading cause of death. Paramedics play a crucial role in person-centred dementia care, particularly in the community. While consensus has been established on paramedicine’s
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Pattern of heterogeneity in normal brain ageing: screening for mild cognitive impairment and its risk of progression with a radiomics model Age Ageing (IF 6.0) Pub Date : 2024-07-10 Yuting Yan, Xiaodong He, Yuyun Xu, Fanfan Zhao, Jiaxuan Peng, Yuan Shao
Purpose This study aimed to develop a normal brain ageing model based on magnetic resonance imaging and radiomics, therefore identifying radscore, an imaging indicator representing white matter heterogeneity and exploring the significance of radscore in detecting people’s cognitive changes. Methods Three hundred sixty cognitively normal (CN) subjects from the Alzheimer’s Disease Neuroimaging Initiative
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Leisure-time physical activity and the incidence of atrial fibrillation in senior adults: a prospective cohort study Age Ageing (IF 6.0) Pub Date : 2024-07-10 Yunting Mei, Li Huang, Cong Gong, Wenjing Zhao, Ming Gui, Quan Qiu, Zhiwei Wang, Yufeng Chen, Yuanling Xie, Xueqing Cai, Yue-Shuang Yuan, Zhen-Feng Zheng, Yumei Xue, Hai Deng, Xudong Liu
Objective Whether physical activity could reduce the risk of atrial fibrillation (AF) remains unclear. This study was to investigate the relationship of leisure-time physical activity (LTPA) with AF incidence among Chinese older adults. Methods A total of 3253 participants aged ≥60 years from the Guangzhou Heart Study were successfully followed between March 2018 and September 2019. LTPA was assessed
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Effects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial Age Ageing (IF 6.0) Pub Date : 2024-07-06 Jonathan M K Bogaerts, Jacobijn Gussekloo, Bianca E M de Jong-Schmit, Saskia Le Cessie, Simon P Mooijaart, Roos C van der Mast, Wilco P Achterberg, Rosalinde K E Poortvliet
Background Based on observational studies and randomised controlled trials (RCTs), the benefit–harm balance of antihypertensive treatment in older adults with dementia is unclear. Objective To assess whether discontinuing antihypertensive treatment reduces neuropsychiatric symptoms (NPSs) and maintains quality of life (QoL) in nursing home residents with dementia. Design Open-label, blinded-outcome
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The use of natural language processing for the identification of ageing syndromes including sarcopenia, frailty and falls in electronic healthcare records: a systematic review Age Ageing (IF 6.0) Pub Date : 2024-07-06 Mo Osman, Rachel Cooper, Avan A Sayer, Miles D Witham
Background Recording and coding of ageing syndromes in hospital records is known to be suboptimal. Natural Language Processing algorithms may be useful to identify diagnoses in electronic healthcare records to improve the recording and coding of these ageing syndromes, but the feasibility and diagnostic accuracy of such algorithms are unclear. Methods We conducted a systematic review according to a
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Strategies to improve end-of-life decision-making and palliative care following hip fracture in frail older adults: a scoping review Age Ageing (IF 6.0) Pub Date : 2024-07-06 Alexandra Tremblay, Stéphane Pelet, Étienne Belzile, Justine Boulet, Chantal Morency, Norbert Dion, Marc-Aurèle Gagnon, Lynn Gauthier, Amal Khalfi, Mélanie Bérubé
Background Although surgery is the gold standard following a hip fracture, the potential for rehabilitation and survival rates are low in frail older patients. Some patients may derive more benefit from palliative care. The objectives of this review were to identify the available strategies to improve end-of-life decision-making and palliative care for frail patients with hip fractures and to synthetise
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Determinants influencing the implementation of multifactorial falls risk assessment and multidomain interventions in community- dwelling older people: a systematic review Age Ageing (IF 6.0) Pub Date : 2024-07-02 Sara Vandervelde, Natalie Van den Bosch, Ellen Vlaeyen, Bernadette Dierckx de Casterlé, Johan Flamaing, Goedele Belaen, Krizia Tuand, Thomas Vandendriessche, Koen Milisen
Background Multifactorial falls risk assessment and multidomain interventions are recommended by the World guidelines for falls prevention and management. To successfully implement these interventions, it is important to understand determinants influencing the implementation. Methods A literature search was conducted for this systematic review on the 3 December 2021 and updated on the 3 April 2023
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Detection of anxiety symptoms and disorders in older adults: a diagnostic accuracy systematic review Age Ageing (IF 6.0) Pub Date : 2024-07-02 Kayla Atchison, Pauline Wu, Leyla Samii, Michael Walsh, Zahinoor Ismail, Andrea Iaboni, Zahra Goodarzi
Background Anxiety symptoms and disorders are common in older adults and often go undetected. A systematic review was completed to identify tools that can be used to detect anxiety symptoms and disorders in community-dwelling older adults. Methods MEDLINE, Embase and PsycINFO were searched using the search concepts anxiety, older adults and diagnostic accuracy in March 2023. Included articles assessed
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Temporal dynamics of depressive symptoms and cognitive decline in the oldest old: dynamic time warp analysis of the Leiden 85-plus study Age Ageing (IF 6.0) Pub Date : 2024-07-02 Abe J C van der Slot, Anne Suzanne Bertens, Stella Trompet, Simon P Mooijaart, Jacobijn Gussekloo, Frederiek van den Bos, Erik J Giltay
Background The prevalence of depressive symptoms and cognitive decline increases with age. We investigated their temporal dynamics in individuals aged 85 and older across a 5-year follow-up period. Methods Participants were selected from the Leiden 85-plus study and were eligible if at least three follow-up measurements were available (325 of 599 participants). Depressive symptoms were assessed at
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Effectiveness of non-pharmacological interventions delivered at home for urinary and faecal incontinence with homebound older people: systematic review of randomised controlled trials Age Ageing (IF 6.0) Pub Date : 2024-06-28 Jackie Buck, Julia Fromings Hill, Rachael Collins, Joanne Booth, Jane Fleming
Introduction Incontinence is a common, distressing condition, most prevalent in older people. There is an unmet need for effective interventions to support continence. This review focuses on non-pharmacological interventions to reduce incontinence among homebound older people. Aim: to identify interventions with potential to be delivered by care workers, nurses or family members in a person’s home
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Small World derived index to distinguish Alzheimer’s type dementia and healthy subjects Age Ageing (IF 6.0) Pub Date : 2024-06-27 Fabrizio Vecchio, Francesca Miraglia, Chiara Pappalettera, Lorenzo Nucci, Alessia Cacciotti, Paolo Maria Rossini
Background This article introduces a novel index aimed at uncovering specific brain connectivity patterns associated with Alzheimer's disease (AD), defined according to neuropsychological patterns. Methods Electroencephalographic (EEG) recordings of 370 people, including 170 healthy subjects and 200 mild-AD patients, were acquired in different clinical centres using different acquisition equipment
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Development and validation of a frailty index for use in the osteoarthritis initiative Age Ageing (IF 6.0) Pub Date : 2024-06-27 Myles W O’Brien, Selena P Maxwell, Rebecca Moyer, Kenneth Rockwood, Olga Theou
Background The Osteoarthritis Initiative (OAI) evaluates the development and progression of osteoarthritis. Frailty captures the heterogeneity in aging. Use of this resource-intensive dataset to answer aging-related research questions could be enhanced by a frailty measure. Objective To: (i) develop a deficit accumulation frailty index (FI) for the OAI; (ii) examine its relationship with age and compare
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Should patients with exceptional longevity be treated for osteoporosis after a hip fracture? Age Ageing (IF 6.0) Pub Date : 2024-06-20 Montserrat Barceló, Jordi Casademont, Jordi Mascaró, Ignasi Gich, Olga Herminia Torres
Background There are no studies focusing on treatment for osteoporosis in patients with exceptional longevity after suffering a hip fracture. Objective To assess the advisability of initiating treatment for osteoporosis after a hip fracture according to the incidence of new fragility fractures after discharge, risk factors for mortality and long-term survival. Design Retrospective review. Setting A
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Investigating the link between antipsychotic use and post-stroke infections in older people: multi-centre propensity score analysis Age Ageing (IF 6.0) Pub Date : 2024-06-16 Hae-Yeon Park, Moa Jung, Geun-Young Park, Jong In Lee, Youngkook Kim, Yeo Hyung Kim, Seong Hoon Lim, Yeun Jie Yoo, Sun Im
Background The risk of stroke increases with age, and although previous reports have suggested that infection risk may increase with antipsychotic use, relevant studies after stroke are scarce. We aimed to investigate whether antipsychotics increase post-stroke infection risk in the acute stroke period. Methods This propensity score matching study included adults diagnosed with first-ever stroke between
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Stakeholder perceptions of and attitudes towards problematic polypharmacy and prescribing cascades: a qualitative study Age Ageing (IF 6.0) Pub Date : 2024-06-08 Aisling A Jennings, Ann Sinéad Doherty, Barbara Clyne, Fiona Boland, Frank Moriarty, Tom Fahey, Larry Hally, Seán P Kennelly, Emma Wallace
Introduction Problematic polypharmacy is the prescribing of five or more medications potentially inappropriately. Unintentional prescribing cascades represent an under-researched aspect of problematic polypharmacy and occur when an adverse drug reaction (ADR) is misinterpreted as a new symptom resulting in the initiation of a new medication. The aim of this study was to elicit key stakeholders’ perceptions
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A systematic review of the psychometric properties of physical performance tests for sarcopenia in community-dwelling older adults Age Ageing (IF 6.0) Pub Date : 2024-06-08 Sabien H Exter, Niek Koenders, Philip Wees, Manon G A Berg
Background This review provides an overview of the psychometric properties of the short physical performance battery (SPPB), timed up and go test (TUG), 4 m gait speed test (4 m GST) and the 400 m walk test (400 m WT) in community-dwelling older adults. Methods A systematic search was conducted in MEDLINE, CINAHL and EMBASE, resulting in the inclusion of 50 studies with data from in total 19,266 participants
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Impact of a prospective feedback loop aimed at reducing non-beneficial treatments in older people admitted to hospital and potentially nearing the end of life. A cluster stepped-wedge randomised controlled trial Age Ageing (IF 6.0) Pub Date : 2024-06-08 Nicole M White, Adrian G Barnett, Xing J Lee, Alison Farrington, Hannah Carter, Steven M McPhail, Magnolia Cardona, Kenneth Hillman, Leonie Callaway, Lindy Willmott, Ben P White, Gillian Harvey, Nicholas Graves, Christine Brown
Objectives To investigate if a prospective feedback loop that flags older patients at risk of death can reduce non-beneficial treatment at end of life. Design Prospective stepped-wedge cluster randomised trial with usual care and intervention phases. Setting Three large tertiary public hospitals in south-east Queensland, Australia. Participants 14 clinical teams were recruited across the three hospitals
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Educational interventions to reduce depression and anxiety in older adults with cancer in the community: a systematic review, meta-analysis and meta-regression of randomised controlled trials Age Ageing (IF 6.0) Pub Date : 2024-06-01 Chen Ee Low, Renish M Pillay, Finn Jing Jie Teo, Caitlin Yuen Ling Loh, Chun En Yau, Ainsley Ryan Yan Bin Lee, Cyrus Su Hui Ho, Matthew Zhixuan Chen
Background Older adults make up half of those with cancer and are prone to mood disorders, such as depression and severe anxiety, resulting in negative repercussions on their health-related quality-of-life (HRQOL). Educational interventions have been shown to reduce adverse psychological outcomes. We examined the effect of educational interventions on the severity of psychological outcomes in older
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A process evaluation of the NIDUS-Professional dementia training intervention for UK homecare workers Age Ageing (IF 6.0) Pub Date : 2024-05-26 Daniel Kelleher, Karen Windle, Rebecca Randell, Kathryn Lord, Larisa Duffy, Amirah Akhtar, Jessica Budgett, Sedigheh Zabihi, Sara Banks, Penny Rapaport, Teresa Lee, Julie Barber, Vasiliki Orgeta, Jill Manthorpe, Kate Walters, Kenneth Rockwood, Briony Dow, Juanita Hoe, Sube Banerjee, Claudia Cooper
Introduction This process evaluation was conducted in parallel to the randomised controlled feasibility trial of NIDUS-Professional, a manualised remote dementia training intervention for homecare workers (HCWs), delivered alongside an individualised intervention for clients living with dementia and their family carers (NIDUS-Family). The process evaluation reports on: (i) intervention reach, dose
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Effectiveness of dance interventions for falls prevention in older adults: systematic review and meta-analysis Age Ageing (IF 6.0) Pub Date : 2024-05-22 Kimberly Lazo Green, Yang Yang, Ukachukwu Abaraogu, Claire H Eastaugh, Fiona R Beyer, Gill Norman, Chris Todd
Introduction Fall prevention is a global health priority. Strength and balance exercise programmes are effective at reducing falls. Emerging literature suggests dance is an enjoyable and sociable form of exercise. However, there is little evidence that dance reduces fall incidence. Methods Systematic review and meta-analysis examining effectiveness and cost-effectiveness of dance for falls prevention
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Age-associated changes in multimodal pain perception Age Ageing (IF 6.0) Pub Date : 2024-05-22 Yongkang Zhi, Yu Zhang, Yu Zhang, Ming Zhang, Yazhuo Kong
Background Pain sensitivity varies across multimodal somatosensory stimuli that can rely on different conductive fibres, which, when damaged, will lead to neuropathies. However, there is limited research examining the characteristics of perceived pain, particularly as affected by the ageing process, as induced by various somatosensory stimuli that may rely on small or large fibres. Methods Using heat
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Introducing a machine learning algorithm for delirium prediction—the Supporting SURgery with GEriatric Co-Management and AI project (SURGE-Ahead) Age Ageing (IF 6.0) Pub Date : 2024-05-22 Samuel Benovic, Anna H Ajlani, Christoph Leinert, Marina Fotteler, Dennis Wolf, Florian Steger, Hans Kestler, Dhayana Dallmeier, Michael Denkinger, Gerhard W Eschweiler, Christine Thomas, Thomas D Kocar
Introduction Post-operative delirium (POD) is a common complication in older patients, with an incidence of 14–56%. To implement preventative procedures, it is necessary to identify patients at risk for POD. In the present study, we aimed to develop a machine learning (ML) model for POD prediction in older patients, in close cooperation with the PAWEL (patient safety, cost-effectiveness and quality
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The effect of oral probiotics on response to vaccination in older adults: a systematic review of randomised controlled trials Age Ageing (IF 6.0) Pub Date : 2024-05-15 Hediye Arioz Tunc, Caroline E Childs, Jonathan R Swann, Philip C Calder
This systematic review evaluated the impact of oral probiotics on the immune response to vaccination in older people. A literature search was performed in three electronic databases up to January 2023. Randomised controlled trials (RCTs) conducted in older people (age ≥ 60 years) investigating oral probiotics and vaccine response outcomes were included. Characteristics and outcome data of the included
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Dietary characteristics of community-dwelling older adults with poor appetite: a cross-sectional analysis Age Ageing (IF 6.0) Pub Date : 2024-05-15 Pia Scheufele, Anja Rappl, Marjolein Visser, Eva Kiesswetter, Dorothee Volkert
Rationale Poor appetite is considered a key factor in the development of malnutrition, a link that can be explained by alterations in dietary intake. Given the limited data on dietary characteristics in community-dwelling older adults with poor appetite, the present study aimed to examine whether poor appetite is associated with lower nutrient intake and more unfavourable food choices. Methods In 569
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Nutrition for dementia prevention: a state of the art update for clinicians Age Ageing (IF 6.0) Pub Date : 2024-05-15 Rebecca Townsend, Andrea Fairley, Sarah Gregory, Craig Ritchie, Emma Stevenson, Oliver M Shannon
Background and objectives Dementia prevalence continues to rise. It is therefore essential to provide feasible and effective recommendations to encourage healthy brain ageing and reduce dementia risk across the population. Appropriate nutrition represents a potential strategy to mitigate dementia risk and could be recommended by clinicians as part of mid-life health checks and other health initiatives
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The association between adherence to the EAT-Lancet diet and cognitive ageing Age Ageing (IF 6.0) Pub Date : 2024-05-15 Annick P M van Soest, Ondine van de Rest, Renger F Witkamp, Lisette C P G M de Groot
Background The EAT-Lancet commission has proposed a dietary pattern that is both sustainable and healthy. However, the impact of this diet on cognition in older adults remains unexplored. Therefore, we examined the association between adherence to the EAT-Lancet diet and cognitive ageing. Methods We used data from a previous intervention study involving cognitively healthy community-dwelling adults
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Association of dietary and nutritional factors with cognitive decline, dementia, and depressive symptomatology in older individuals according to a neurogenesis-centred biological susceptibility to brain ageing Age Ageing (IF 6.0) Pub Date : 2024-05-15 Andrea Du Preez, Sophie Lefèvre-Arbogast, Raúl González-Domínguez, Vikki Houghton, Chiara de Lucia, Hyunah Lee, Dorrain Y Low, Catherine Helmer, Catherine Féart, Cécile Delcourt, Cécile Proust-Lima, Mercè Pallàs, Alex Sánchez-Pla, Mireia Urpi-Sardà, Silvie R Ruigrok, Barbara Altendorfer, Ludwig Aigner, Paul J Lucassen, Aniko Korosi, Claudine Manach, Cristina Andres-Lacueva, Cécilia Samieri, Sandrine
Hippocampal neurogenesis (HN) occurs throughout the life course and is important for memory and mood. Declining with age, HN plays a pivotal role in cognitive decline (CD), dementia, and late-life depression, such that altered HN could represent a neurobiological susceptibility to these conditions. Pertinently, dietary patterns (e.g., Mediterranean diet) and/or individual nutrients (e.g., vitamin D
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The effect of increased fruit and vegetable consumption on blood pressure and lipids: a pooled analysis of six randomised controlled fruit and vegetable intervention trials Age Ageing (IF 6.0) Pub Date : 2024-05-15 Nour A Elsahoryi, Charlotte E Neville, Chris C Patterson, Michelle C McKinley, Francina R Baldrick, Ciara Mulligan, Damian O McCall, Rebecca L Noad, Ciara Rooney, Ian Wallace, Claire T McEvoy, Steven Hunter, David R McCance, David J Edgar, Stuart J Elborn, Pascal P McKeown, Ian S Young, Rachel E Moore, Anne P Nugent, Jayne V Woodside
Background Increasing fruit and vegetable (FV) consumption is associated with reduced cardiovascular disease risk in observational studies but with little evidence from randomised controlled trials (RCTs). The impact of concurrent pharmacological therapy is unknown. Objective To pool data from six RCTs to examine the effect of increasing FV intake on blood pressure (BP) and lipid profile, also exploring
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Identifying the relation between food groups and biological ageing: a data-driven approach Age Ageing (IF 6.0) Pub Date : 2024-05-15 Ynte Biemans, Daimy Bach, Pariya Behrouzi, Steve Horvath, Charlotte S Kramer, Simin Liu, JoAnn E Manson, Aladdin H Shadyab, James Stewart, Eric A Whitsel, Bo Yang, Lisette de Groot, Pol Grootswagers
Background Heterogeneity in ageing rates drives the need for research into lifestyle secrets of successful agers. Biological age, predicted by epigenetic clocks, has been shown to be a more reliable measure of ageing than chronological age. Dietary habits are known to affect the ageing process. However, much remains to be learnt about specific dietary habits that may directly affect the biological
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Biomarker signatures associated with ageing free of major chronic diseases: results from a population-based sample of the EPIC-Potsdam cohort Age Ageing (IF 6.0) Pub Date : 2024-05-15 Robin Reichmann, Matthias B Schulze, Tobias Pischon, Cornelia Weikert, Krasimira Aleksandrova
Background A number of biomarkers denoting various pathophysiological pathways have been implicated in the aetiology and risk of age-related diseases. Hence, the combined impact of multiple biomarkers in relation to ageing free of major chronic diseases, such as cancer, cardiovascular disease and type 2 diabetes, has not been sufficiently explored. Methods We measured concentrations of 13 biomarkers
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Quality of plant-based diets and frailty incidence: a prospective analysis of UK biobank participants Age Ageing (IF 6.0) Pub Date : 2024-05-10 Javier Maroto-Rodriguez, Rosario Ortolá, Esther García-Esquinas, Stefanos N Kales, Fernando Rodríguez-Artalejo, Mercedes Sotos-Prieto
Background Substantial evidence supports the inverse association between adherence to healthy dietary patterns and frailty risk. However, the role of plant-based diets, particularly their quality, is poorly known. Objective To examine the association of two plant-based diets with incidence of physical frailty in middle-aged and older adults. Design Prospective cohort. Setting United Kingdom Subjects
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Sarcopenia prevalence using handgrip strength or chair stand performance in adults living with type 2 diabetes mellitus Age Ageing (IF 6.0) Pub Date : 2024-05-06 Archie E Belfield, Thomas J Wilkinson, Joseph Henson, Jack A Sargeant, Leigh Breen, Andrew P Hall, Melanie J Davies, Thomas Yates
Background The updated European Working Group on Sarcopenia in Older People (EWGSOP2) recommends handgrip strength (HGS) and the chair stand test (CST) to assess muscle strength, with the CST being a convenient proxy for lower limb strength. However, adiposity may differentially influence these strength criteria and produce discrepant sarcopenia prevalence. Objective To determine the prevalence of
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How do primary care clinicians approach the management of frailty? A qualitative interview study Age Ageing (IF 6.0) Pub Date : 2024-05-06 Anna Seeley, Margaret Glogowska, Gail Hayward
Background Around 15% of adults aged over 65 live with moderate or severe frailty. Contractual requirements for management of frailty are minimal and neither incentivised nor reinforced. Previous research has shown frailty identification in primary care is ad hoc and opportunistic, but there has been little focus on the challenges of frailty management, particularly within the context of recent introduction
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Sporadic Creutzfeldt-Jakob disease in adults over 80 years: a 10-year review of United Kingdom surveillance Age Ageing (IF 6.0) Pub Date : 2024-05-06 Eugene Ace McDermott, Neil Watson, Johnny Tam, John Centola, Hatice Kurucu King, Jan Mackenzie, David Summers, Alison Green, Marcelo A Barria, Colin Smith, Suvankar Pal
Introduction Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive neurodegenerative disease with public health implications. Mean age of onset is 68 years. Age-specific incidence declines after 80 years. This may arise from under-ascertainment or other biological features of the disease. Accurate characterisation of late-onset sCJD is important for early diagnosis, avoiding unnecessary
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Efficacy of ferric carboxymaltose on haemoglobin response among older patients with gastrointestinal bleeding: a randomised clinical trial Age Ageing (IF 6.0) Pub Date : 2024-05-06 Nicolas Richard, Nadia Arab-Hocine, Margot Vannier, Rachida Leblanc-Boubchir, Agnès Pelaquier, Arnaud Boruchowicz, Marietta Musikas, Morgane Amil, Mathurin Fumery, Stéphane Nahon, Ramuntcho Arotcarena, Eve Gelsi, Arnaud Maurin, Xavier Hébuterne, Guillaume Savoye
Background Acute gastrointestinal bleeding (AGIB) is common in older patients but the use of iron in this context remains understudied. Aims This study aimed to evaluate prospectively the efficacy of ferric carboxymaltose to treat anaemia in older patients after AGIB. Methods This randomised double-blinded placebo-controlled clinical trial was conducted in 10 French centres. Eligible patients were
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‘I think we could probably do more’: an interview study to explore community pharmacists’ experiences and perspectives of frailty and optimising medicines use in frail older adults Age Ageing (IF 6.0) Pub Date : 2024-05-06 Lucy Faulkner, Carmel M Hughes, Heather E Barry
Background Community pharmacists potentially have an important role to play in identification of frailty and delivery of interventions to optimise medicines use for frail older adults. However, little is known about their knowledge or views about this role. Aim To explore community pharmacists’ knowledge of frailty and assessment, experiences and contact with frail older adults, and perceptions of
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New horizon in improving ageing with improvisational theatre Age Ageing (IF 6.0) Pub Date : 2024-05-06 Shoshi Keisari, Kristin R Krueger, Boaz M Ben-David, Mathieu Hainselin
Cognitive decline, mental health and mindset factors can all affect the autonomy and well-being of older adults. As the number of older adults across the globe increases, interventions to improve well-being are urgently needed. Improvisational theatre (improv) and improv-based interventions are well-suited to address this need. Studies have shown that participation in improv-based interventions has
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New horizons in undergraduate geriatric medicine education Age Ageing (IF 6.0) Pub Date : 2024-05-01 Andrew Teodorczuk, Petal S Abdool, Chloe X Yap, James M Fisher
Current projections show that between 2000 and 2050, increasing proportions of older individuals will be cared for by a smaller number of healthcare workers, which will exacerbate the existing challenges faced by those who support this patient demographic. This review of a collection of Age and Ageing papers on the topic in the past 10 years explores (1) what best practice geriatrics education is and
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Barriers and motivators to undertaking physical activity in adults over 70—a systematic review of the quantitative literature Age Ageing (IF 6.0) Pub Date : 2024-04-23 Alixe H M Kilgour, Matthew Rutherford, Joanna Higson, Samantha J Meredith, Jessica McNiff, Stephanie Mitchell, Anusan Wijayendran, Stephen E R Lim, Susan D Shenkin
Background Physical activity (PA) has multiple benefits for older adults (≥70 years old). Despite this many older adults do not undertake the World Health Organisation guideline recommended amount of PA. This systematic review examines barriers and motivators to PA in adults aged ≥70 years. Methods We analysed the quantitative literature, including observational studies and baseline data from randomised
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The impact of a hospital-based special care unit on behavioural and psychological symptoms in older people living with dementia Age Ageing (IF 6.0) Pub Date : 2024-04-22 Frederick A Graham, Lisa Kelly, Elizabeth A Burmeister, Amanda Henderson, Annette Broome, Ruth E Hubbard, Emily H Gordon
Background Hospital patients with behavioural and psychological symptoms of dementia (BPSD) are vulnerable to a range of adverse outcomes. Hospital-based Special Care Units (SCUs) are secure dementia-enabling environments providing specialised gerontological care. Due to a scarcity of research, their value remains unconfirmed. Objective To compare hospital based SCU management of BPSD with standard
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Sex differences in cognitive decline among middle-aged and older adults: a cohort study in Europe Age Ageing (IF 6.0) Pub Date : 2024-04-19 Katrin Wolfova, Barbora Frycova, Dominika Seblova, Sarah Tom, Vegard Fykse Skirbekk, Pavla Brennan Kearns
Objectives Previous studies on sex differences in cognitive decline provide inconsistent findings, with many European countries being underrepresented. We determined the association between sex and cognitive decline in a sample of Europeans and explored differences across birth cohorts and regions. Methods Participants 50+ years old enrolled in the Survey of Health, Ageing and Retirement in Europe
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Plasma metabolomic markers underlying skeletal muscle mitochondrial function relationships with cognition and motor function Age Ageing (IF 6.0) Pub Date : 2024-04-14 Qu Tian, Erin E Greig, Keenan A Walker, Kenneth W Fishbein, Richard G Spencer, Susan M Resnick, Luigi Ferrucci
Background Lower skeletal muscle mitochondrial function is associated with future cognitive impairment and mobility decline, but the biological underpinnings for these associations are unclear. We examined metabolomic markers underlying skeletal muscle mitochondrial function, cognition and motor function. Methods We analysed data from 560 participants from the Baltimore Longitudinal Study of Aging
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Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis Age Ageing (IF 6.0) Pub Date : 2024-04-13 Nicola White, Juan Carlos Bazo-Alvarez, Michel Koopmans, Emily West, Elizabeth L Sampson
Objective Delirium and pain are common in older adults admitted to hospital. The relationship between these is unclear, but clinically important. We aimed to systematically review the association between pain (at rest, movement, pain severity) and delirium in this population. Methods PubMed, EMBASE, CINAHL, PsycINFO, Cochrane and Web of Science were searched (January 1982–November 2022) for Medical
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Discrepancies in corrected calcium versus ionised calcium in a geriatric population: an observational study Age Ageing (IF 6.0) Pub Date : 2024-04-13 Alexandra P S P Suryapranata, Carolina J P W Keijsers, Steef Kurstjens, Astrid M Van Strien
Background Calcium can be measured as ionised (Ca-ionised) or albumin-adjusted total calcium (Ca-albumin). Current clinical guidelines predominantly utilise Ca-albumin, despite Ca-ionised being the gold standard. Discrepancies can occur between these measurement modalities and can lead to clinical dilemmas. It remains unclear how large these discrepancies are in older patients. This study investigated
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The association between cannabis use and neuroimaging measures in older adults: findings from the UK biobank Age Ageing (IF 6.0) Pub Date : 2024-04-08 Shiraz Vered, Sharon Sznitman, Galit Weinstein
Background Cannabis use has increased in recent years. However, the long-term implications of cannabis use on brain health remain unknown. We explored the associations of cannabis use with volumetric brain magnetic resonance imaging (MRI) measures in dementia-free older adults. Methods This cross-sectional and longitudinal study included dementia-free participants of the UK Biobank aged ≥60 years.
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Prevalence of swallowing disorder in different dementia subtypes among older adults: a meta-analysis Age Ageing (IF 6.0) Pub Date : 2024-03-27 Alfiani Rahmi Putri, Yu-Hao Chu, Ruey Chen, Kai-Jo Chiang, Kondwani Joseph Banda, Doresses Liu, Hui-Chen Lin, Shu-Fen Niu, Kuei-Ru Chou
Background Ageing process and abnormal protein accumulation in dementia damage neural pathways affecting the swallowing process and leading to swallowing disorder. Objective To estimate the prevalence of swallowing disorder among older adults with different dementia subtypes. Methods We conducted a systematic search across multiple databases, including PubMed, Embase, Scopus, Web of Science and OVID
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Navigating complexity of the medication management system within the home setting—a functional resonance analysis method (FRAM) analysis of people with dementia and their carers’ experiences Age Ageing (IF 6.0) Pub Date : 2024-03-25 Rosemary Lim, Mais Iflaifel, Zahra A L Qamariat, Clare Crowley, Taniya Sharmeen
Background There is a strong imperative to support people with dementia to live independently in their homes for as long as possible. A starting point is to understand how they manage medications on a daily basis. Aim To understand how people with dementia and their informal carers manage medications within the home setting to inform the identification of opportunities to improve medication management
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Pain trajectories and their associations with cognition among older adults: a 10-year cohort study from network perspective Age Ageing (IF 6.0) Pub Date : 2024-03-24 He-Li Sun, Wei Bai, Pan Chen, Ling Zhang, Robert D Smith, Zhaohui Su, Teris Cheung, Gabor S Ungvari, Chee H Ng, Qinge Zhang, Yu-Tao Xiang
Background Few studies have examined the associations between pain trajectories and cognitive function in older adults. This study explored the associations between pain trajectories and different cognitive domains in older adults from a network perspective. Methods Data on pain trajectories were derived from the Health and Retirement Study between 2010 and 2020 using latent class growth analyses.
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Measurement properties of the usual and fast gait speed tests in community-dwelling older adults: a COSMIN-based systematic review Age Ageing (IF 6.0) Pub Date : 2024-03-22 Ava Mehdipour, Selina Malouka, Marla Beauchamp, Julie Richardson, Ayse Kuspinar
Objective The gait speed test is one of the most widely used mobility assessments for older adults. We conducted a systematic review to evaluate and compare the measurement properties of the usual and fast gait speed tests in community-dwelling older adults. Methods Three databases were searched: MEDLINE, EMBASE and CINAHL. Peer-reviewed articles evaluating the gait speed test’s measurement properties
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Strategies used during the cognitive evaluation of older adults with dual sensory impairment: a scoping review Age Ageing (IF 6.0) Pub Date : 2024-03-20 Shirley Dumassais, Margaret Kathleen Pichora-Fuller, Dawn Guthrie, Natalie A Phillips, Marie Savundranayagam, Walter Wittich
Background Dual sensory impairment (DSI), the combination of visual and hearing impairments, is associated with increased risk for age-related cognitive decline and dementia. Administering cognitive tests to individuals with sensory impairment is challenging because most cognitive measures require sufficient hearing and vision. Considering sensory limitations during cognitive test administration is
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Short- and long-term safety of discontinuing chronic opioid therapy among older adults with Alzheimer’s disease and related dementia Age Ageing (IF 6.0) Pub Date : 2024-03-18 Yu-Jung Jenny Wei, Almut G Winterstein, Siegfried Schmidt, Roger B Fillingim, Stephan Schmidt, Michael J Daniels, Steven T DeKosky
Background Limited evidence exists on the short- and long-term safety of discontinuing versus continuing chronic opioid therapy (COT) among patients with Alzheimer’s disease and related dementias (ADRD). Methods This cohort study was conducted among 162,677 older residents with ADRD and receipt of COT using a 100% Medicare nursing home sample. Discontinuation of COT was defined as no opioid refills
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Multivariable machine learning models for clinical prediction of subsequent hip fractures in older people using the Chinese population database Age Ageing (IF 6.0) Pub Date : 2024-03-18 Wenbo Huang, Jie Wang, Jilai Xu, Guinan Guo, Zhenlei Chen, Haolei Xue
Purpose This study aimed to develop and validate clinical prediction models using machine learning (ML) algorithms for reliable prediction of subsequent hip fractures in older individuals, who had previously sustained a first hip fracture, and facilitate early prevention and diagnosis, therefore effectively managing rapidly rising healthcare costs in China. Methods Data were obtained from Grade A Tertiary
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Characteristics of older unpaid carers in England: a study of social patterning from the English Longitudinal Study of Ageing Age Ageing (IF 6.0) Pub Date : 2024-03-18 Laurie E Davies, Gemma F Spiers, David R Sinclair, Andrew Kingston, Barbara Hanratty
Background A growing number of older people provide unpaid care, but contemporary research evidence on this group is limited. Aim This study aims to describe the characteristics of older people who provide unpaid care and how these vary by socioeconomic position. Methods Using recent information from the English Longitudinal Study of Ageing (ELSA wave 9, 2019), we analysed cross-sectional data on 1