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Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function J. Med. Chem. (IF 6.8) Pub Date : 2024-12-20 Gwenaëlle Jézéquel, Zoé Grimanelli, Carole Guimard, Joëlle Bigay, Juliano Haddad, Jérôme Bignon, Cécile Apel, Vincent Steinmetz, Laurie Askenatzis, Hélène Levaïque, Clara Pradelli, Van Cuong Pham, Doan T. M. Huong, Marc Litaudon, Romain Gautier, Chaker El Kalamouni, Bruno Antonny, Sandy Desrat, Bruno Mesmin, Fanny Roussi
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MoA Studies of the TEAD P-Site Binding Ligand MSC-4106 and Its Optimization to TEAD1-Selective Amide M3686 J. Med. Chem. (IF 6.8) Pub Date : 2024-12-20 Timo Heinrich, Daniel Schwarz, Carl Petersson, Jakub Gunera, Sakshi Garg, Richard Schneider, Marina Keil, Lisa Grimmeisen, Andrea Unzue Lopez, Lisa Albers, Sarah Schlesiger, Alessia Gambardella, Joerg Bomke, Emma Carswell, Heike Schilke, Patrizia Diehl, Benjamin Doerfel, Djordje Musil, Elisabeth Trivier, Rebecca Broome, Sam Marshall, Alexander Balsiger, Erik Friedrich, Ana R. Lemos, Sandra P. Santos
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Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery J. Med. Chem. (IF 6.8) Pub Date : 2024-12-20 Fangyuan Chen, Qingmei Liu, Lei Ma, Cuishi Yan, Haiman Zhang, Zhi Zhou, Wei Yi
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Identification of Novel Human 15-Lipoxygenase-2 (h15-LOX-2) Inhibitors Using a Virtual Screening Approach J. Med. Chem. (IF 6.8) Pub Date : 2024-12-19 Lucas G. Viviani, Thais S. Iijima, Erika Piccirillo, Leandro Rezende, Thiago G. P. Alegria, Luis Eduardo S. Netto, Antonia T.-do Amaral, Sayuri Miyamoto
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Corrigendum to “Improvement of TNBC immune checkpoint blockade with a microwave-controlled ozone release nanosystem” [Journal of Controlled Release, 351 (2022), 954–969] J. Control. Release (IF 10.5) Pub Date : 2024-12-19 Linlin Song, Dan Zheng, Jinshun Xu, Tianyue Xu, Zhihui Liu, Huan Zhang, Yi Li, Yulan Peng, Hubing Shi
The authors regret the misplacement of the TUNEL image for the Blank group in Fig. 7. Below is the corrected Fig. 7, in which the images for the Blank group in the abscopal tumor have been replaced. This correction does not affect any other results or the scientific conclusions. Download: Download high-res image (2MB) Download: Download full-size image
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Ultrasound-triggered drug release in vivo from antibubble-loaded macrophages J. Control. Release (IF 10.5) Pub Date : 2024-12-19 Omkar Desai, Mario Köster, Doreen Kloos, Nico Lachmann, Hansjörg Hauser, Albert Poortinga, Dagmar Wirth
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Inflammation-reducing thermosensitive hydrogel with photothermal conversion for skin cancer therapy J. Control. Release (IF 10.5) Pub Date : 2024-12-19 Mengqi Jia, Ruilin Lu, Pengfei Li, Xiaoming Liao, Yanfei Tan, Shiyong Zhang
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White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin J. Control. Release (IF 10.5) Pub Date : 2024-12-20 Maria Dul, Mohammed Alali, Mahmoud Ameri, Matthew Douglas Burke, Benjamin Paul Creelman, Lisa Dick, Ryan F. Donnelly, Michael N. Eakins, Collrane Frivold, Angus Harry Forster, Philippe-Alexandre Gilbert, Stefan Henke, Sebastien Henry, Desmond Hunt, Hayley Lewis, Jessica Joyce Mistilis, Jung-Hwan Park, Mark R. Prausnitz, David Kenneth Robinson, Carmen Amelia Rodriguez Hernandez, Sion A. Coulman
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Engineered virus-mimicking nanovaccine with lymph node–tumor dual-targeting and STING-activating capacity for robust cancer immunotherapy J. Control. Release (IF 10.5) Pub Date : 2024-12-20 Zhongjie Wang, Shujun Liu, Ruiqi Ming, Weiwei Wang, Chenguang Wang, Chuyu Li, Jiahua Yang, Fan Zhang, Guihong Lu, Lin Mei, Li-Li Huang
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Hyaluronic acid coating of poly(β-amino ester)/mRNA polyplexes enables ultra-high transfection efficiency J. Control. Release (IF 10.5) Pub Date : 2024-12-20 Rui Guo, Zhili Li, Jiahao Shi, Haiyang Yong, Chenfei Wang, Jianzhong Li, Chaoting Zhang, Dezhong Zhou
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D-arginine-loaded pH-responsive mesoporous silica nanoparticles enhances the efficacy of water jet therapy in decontaminating biofilm-coated titanium surface J. Control. Release (IF 10.5) Pub Date : 2024-12-20 Yirou Wang, Yi Liu, Ji Chen, Zeyang Ge, Jing Wang, Dehua Li
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Fluorinated Coumarin Derivatives as Selective PET Tracer for MAO-B Imaging J. Med. Chem. (IF 6.8) Pub Date : 2024-12-19 Nan Wu, Xiaojun Zhang, Yuying Li, Jinming Zhang, Mengchao Cui
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Design, Synthesis, and Biological Evaluation of 2-Arylaminopyrimidine Derivatives as Dual Cathepsin L and JAK Inhibitors for the Treatment of Acute Lung Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-19 Chunwei Shen, Zhengtong Mao, Tianpeng Chen, Yingying Wei, Tao Zhou, Ningyuan Zhong, Gaoyang Zhu, Qiwen Shi, Zheyu Xie, Huajun Zhao, Xingxian Zhang
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Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Nidhi Rani, Raju S. Rajmani, Avadhesha Surolia
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Eradication of Therapy-Resistant Cancer Stem Cells by Novel Telmisartan Derivatives J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Anna M. Schoepf, Maximilian Gebhart, Martin Federspiel, Isabel Heidegger, Martin Puhr, Madlen Hotze, Marcel Kwiatkowski, Andreas Pircher, Dominik Wolf, Sieghart Sopper, Ronald Gust, Stefan Salcher
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Activated neutrophil membrane-coated tRF-Gly-CCC nanoparticles for the treatment of aortic dissection/aneurysm J. Control. Release (IF 10.5) Pub Date : 2024-12-19 Tian-xiang Li, Yan-yan Yang, Jin-bao Zong, Min Li, Xiu-xiu Fu, Xiao-xin Jiang, Wen-tao Wang, Xiao-qian Li, Hong-zhao Qi, Tao Yu
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Reactive oxygen species switcher via MnO2-coated Prussian blue loaded hyaluronic acid methacrylate hydrogel microspheres for local anti-tumor treatment J. Control. Release (IF 10.5) Pub Date : 2024-12-19 Huijie Han, Shiqi Wang, Mohammad-Ali Shahbazi, Inge S. Zuhorn, Zhengwei Cai, Jie Chen, Jiachen Li, Yu Chen, Yawei Du, Raquel Bártolo, Liang Chen, Hélder A. Santos, Wenguo Cui
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Local glycolysis-modulating hydrogel microspheres for a combined anti-tumor and anti-metastasis strategy through metabolic trapping strategy J. Control. Release (IF 10.5) Pub Date : 2024-12-18 Huijie Han, Shiqi Wang, Mohammad-Ali Shahbazi, Yawei Du, Inge S. Zuhorn, Jiachen Li, Jie Chen, Yu Chen, Raquel Bártolo, Wenguo Cui, Hélder A. Santos
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Application of pharmacometrics in drug development Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-12-19 Yuan Xiong, Mahesh N. Samtani, Daniele Ouellet
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3D printing of pharmaceutical dosage forms: Recent advances and applications Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-12-19 Auel Tobias, Mentrup Aaron Felix Christofer, Oldfield Lee Roy, Seidlitz Anne
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3D extrusion bioprinting of microbial inks for biomedical applications Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-12-19 Nicolas Burns, Arjun Rajesh, Avinash Manjula-Basavanna, Anna Duraj-Thatte
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Hypoxia Activated Nitric Oxide Donor Compounds for the Prevention and Treatment of Myocardial Hypoxia-Induced Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Wanxiang Yang, Wen Zhou, Shaohua Gou
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Impact of Linker Composition on VHL PROTAC Cell Permeability J. Med. Chem. (IF 6.8) Pub Date : 2024-12-18 Yordanos Esubalew Abeje, Lianne H. E. Wieske, Vasanthanathan Poongavanam, Stefanie Maassen, Yoseph Atilaw, Philipp Cromm, Lutz Lehmann, Mate Erdelyi, Daniel Meibom, Jan Kihlberg
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Synthetic nanoparticles functionalized with cell membrane-mimicking, bone-targeting, and ROS-controlled release agents for osteoporosis treatment J. Control. Release (IF 10.5) Pub Date : 2024-12-18 Weijun Zhang, Ye Zhang, Zhengan Hao, Pengjie Yao, Jinwu Bai, Hongyu Chen, Xiaoyong Wu, Yuliang Zhong, Deting Xue
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Delivery of FBXO6 with highly branched poly(β-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis J. Control. Release (IF 10.5) Pub Date : 2024-12-17 Yongxiang Shi, Shuying Shen, Dongdong Huang, Kamuran Yilamu, Zhengju Chen, Kefan Wang, Pengyu Chen, Nan Pan, Zhanping Jin, Lei Guo, Wenbin Xu, Xing Zhao
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FDA approves first HER2 × HER3 bispecific antibody Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-18
Discover the world’s best science and medicine | Nature.com
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Pairing up with GLP-1 to combat obesity Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-18
Discover the world’s best science and medicine | Nature.com
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Open Targets: 10 years of partnership in target discovery Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-17 David G. Hulcoop, Gosia Trynka, Ellen M. McDonagh
The Open Targets consortium was founded in 2014 to translate insights from genetics and functional genomics into identifying and prioritizing therapeutic targets. We highlight key achievements and insights stemming from this partnership of academic and industry scientists.
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Discovery of N-Trifluoromethylated Noscapines as Novel and Potent Agents for the Treatment of Glioblastoma J. Med. Chem. (IF 6.8) Pub Date : 2024-12-17 Guangwei Cui, Yuhang Fan, Yue Yang, Yiwen Ma, Haiyang Deng, Pan Wang, Yuxin Zhu, Jian Li, Jinlian Wei, Yongqiang Zhang
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Modulating the Potency of BRD4 PROTACs at the Systems Level with Amine-Acid Coupling Reactions J. Med. Chem. (IF 6.8) Pub Date : 2024-12-17 Andrew McGrath, Haiyan Huang, Jean-Francois Brazeau, Zirong Zhang, Christopher O. Audu, Nadeem A. Vellore, Lu Zhu, Zhicai Shi, Jennifer D. Venable, Christine F. Gelin, Tim Cernak
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Pivotal Role of the Intracellular Microenvironment in the High Photodynamic Activity of Cationic Phthalocyanines J. Med. Chem. (IF 6.8) Pub Date : 2024-12-17 Dmitry A. Bunin, Roman A. Akasov, Alexander G. Martynov, Maria P. Stepanova, Svetlana V. Monich, Aslan Yu. Tsivadze, Yulia G. Gorbunova
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Guardians at the Gate: Optimization of Small Molecule Entry Inhibitors of Ebola and Marburg Viruses J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Malaika D. Argade, Jazmin Galván Achi, Ryan Bott, Kimberly M. Morsheimer, Callum D. Owen, Christian A. Zielinski, Arsen M. Gaisin, Mario Alvarez, Terry W. Moore, Fan Bu, Fang Li, Michael Cameron, Manu Anantpadma, Robert A. Davey, Norton P. Peet, Lijun Rong, Irina N. Gaisina
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Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Guang Huang, Rhiannon Stevens, Devon G. Hucek, Trupta Purohit, Shuangjiang Li, Hongzhi Miao, Elise Trost, Geoff Hewett, Bradley Clegg, Se Ra Park, Krishani Rajanayake, Bo Wen, Duxin Sun, Tomasz Cierpicki, Jolanta Grembecka
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Recent Advances of Metal Complexes in the Treatment of Hepatocellular Carcinoma J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Zhongren Xu, Yu Liu, Jiaqi Yang, Fuwei Li, Wukun Liu
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Combinatorial Synthesis toward the Discovery of Highly Cytotoxic Fe(III) Complexes J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Felix Niemeier, Lisa-Marie Servos, Zisis Papadopoulos, Nicolás Montesdeoca, Kaixin Ni, Sascha Heinrich, Johannes Karges
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Precise Carrier-Free Pt(IV)-Nanobombs for Apoptosis/Ferroptosis Synergistic Tumor Therapy: A New Effective Method to Obtain Good Chemotherapy and Low Toxicity J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Xu Guo, Xue-Jiao Liang, Jia-Le Liu, Zhi-Hui Li, Zhihao You, Dandan Zhao, Yali Song, Longfei Li, Xue-Qing Song
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Discovery of N-Phenyl-5-propyl-1H-pyrazole-3-carboxamide, with Selective Inhibition and Degradation of HDAC6 for the Treatment of Acute Liver Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Hao Cui, Guodong Zhang, Liyuan Zhang, Shilong Sun, Kang Yang, Aixin Gen, Penfeng Wang, Hui Wang, Qing-Qing Zhou, Hongmei Li, Yadong Chen, Yuqin Yao, Tao Lu, Lei Zhang, Yong Zhu
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Evaluation of Dynamic Light Scattering as an Effective Quality Control Method for Aggregates in Radiolabeled Antibodies J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Huu Bao Nguyen, Hyun Park, Jeong Eun Lim, Thuy Tien Nguyen, Hwan Hui Kim, Kyeongwon Kim, Jung Young Kim, Kyo Chul Lee, Jeongsoo Yoo
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Antibody-Vincristine Conjugates as Potent Anticancer Therapeutic Agents J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Agathe Boos, Julien Most, Héloïse Cahuzac, Louis Moreira da Silva, François Daubeuf, Stéphane Erb, Sarah Cianférani, Oscar Hernandez-Alba, Constantin Semenchenko, Igor Dovgan, Sergii Kolodych, Alexandre Detappe, Françoise Dantzer, Alain Wagner, Maria Zeniou, Guilhem Chaubet
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Design, Synthesis, and Biochemical Evaluation of Novel MLK3 Inhibitors: A Target Hopping Example J. Med. Chem. (IF 6.8) Pub Date : 2024-12-16 Pascal Sander, Martin P. Schwalm, Andreas Krämer, Lewis Elson, Alexander Rasch, Benedikt Masberg, Roland Selig, Adrian Sievers-Engler, Michael Lämmerhofer, Susanne Müller, Stefan Knapp, Wolfgang Albrecht, Stefan A. Laufer
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Photothrombolytics: A light-driven technology for the targeted lysis of thrombi J. Control. Release (IF 10.5) Pub Date : 2024-12-17 Basanta Acharya, Caylie A. McGlade, Haifeng Yin, Tomohiro Kawano, Lauren Haar, Nigel Mackman, Rani S. Sellers, Xianming Tan, Aadra P. Bhatt, David S. Lawrence, Brianna M. Vickerman
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Harnessing extracellular vesicle-mediated crosstalk between T cells and cancer cells for therapeutic applications J. Control. Release (IF 10.5) Pub Date : 2024-12-16 Omar M. Budayr, Brian C. Miller, Juliane Nguyen
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Chemical engineering of CRISPR–Cas systems for therapeutic application Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-17 Halle M. Barber, Adrian A. Pater, Keith T. Gagnon, Masad J. Damha, Daniel O’Reilly
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Low-inflammatory lipid nanoparticle-based mRNA vaccine elicits protective immunity against H5N1 high-pathogenicity avian influenza virus with reduced adverse reactions. Mol. Ther. (IF 12.1) Pub Date : 2024-12-17 Atsushi Kawai,Taro Shimizu,Hiroki Tanaka,Shintaro Shichinohe,Jessica Anindita,Mika Hirose,Eigo Kawahara,Kota Senpuku,Makoto Shimooka,Le Thi Quynh Mai,Ryo Suzuki,Takuto Nogimori,Takuya Yamamoto,Toshiro Hirai,Takayuki Kato,Tokiko Watanabe,Hidetaka Akita,Yasuo Yoshioka
Messenger RNA vaccines based on lipid nanoparticles (mRNA-LNPs) are promising vaccine modalities. However, mRNA-LNP vaccines frequently cause adverse reactions such as swelling and fever in humans, partly due to the inflammatory nature of LNP. Modification of the ionizable lipids used in LNP is one approach to avoid these adverse reactions. Herein, we report the development of mRNA-LNP vaccines with
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Enhancing protective immunity against SARS-CoV-2 with a self-amplifying RNA lipid nanoparticle vaccine J. Control. Release (IF 10.5) Pub Date : 2024-12-16 Guibin Lin, Yan-Lai Tang, Zhengqiang Fu, Runjun Chen, Yan Liu, Zhanyan Liu, Xueli Kuang, Jing Sun, Jincun Zhao, Yuan Zhang
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Harnessing the biology of regulatory T cells to treat disease Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-16 Christine M. Wardell, Dominic A. Boardman, Megan K. Levings
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IRDiRC perspectives on the application of digital biomarkers in therapeutic development for rare diseases Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2024-12-16 Rajesh Krishna, Anneliene H. Jonker, Thomas Morel, Ken Sakushima, Anna M. G. Pasmooij, Daniel O’Connor
New approaches are needed to streamline clinical trials of drugs for patients with rare diseases. Digital biomarkers offer one such approach, but several challenges must be addressed to realize their potential.
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In situ blockade of TNF-TNFR2 axis via oncolytic adenovirus improves antitumor efficacy in solid tumors. Mol. Ther. (IF 12.1) Pub Date : 2024-12-16 Xiaozhen Kang,Yifeng Han,Mengdi Wu,Yuxin Li,Peng Qian,Chuning Xu,Zhengyun Zou,Jie Dong,Jiwu Wei
Tumor necrosis factor (TNF) has been recognized as an immune activation factor in tumor immunotherapy. Our study demonstrated that TNF blockade markedly enhanced the antitumor efficacy of oncolytic adenovirus (AdV) therapy. To minimize systemic side effects, we engineered a recombinant oncolytic AdV encoding a TNF inhibitor (AdV-TNFi) to confine TNF blockade within the tumor microenvironment (TME)
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Connecting the dots: Contextualizing your work for drug delivery. J. Control. Release (IF 10.5) Pub Date : 2024-12-16 Honggang Cui
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Metabolic glycan labelling with bio-orthogonal targeting and its potential in drug delivery. J. Control. Release (IF 10.5) Pub Date : 2024-12-16 Yuen Yi Lam,Angel Tan,Kristian Kempe,Ben J Boyd
New modes of targeted drug delivery are emerging with promise of enhancing therapeutic efficacy while reducing side effects. This review examines the landscape of metabolic glycan labelling-a technique gaining traction for its potential in specific drug targeting. By exploiting the natural glycan synthetic pathway of monosaccharides, unnatural sugar analogues are incorporated into glycoproteins, allowing
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Visualizing kinetics of diffusional penetration in tissues using OCT-based strain imaging Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-12-10 Y.M. Alexandrovskaya, A.A. Sovetsky, E.M. Kasianenko, A.L. Matveyev, L.A. Matveev, O.I. Baum, V.Y. Zaitsev
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Droplet-based 3D bioprinting for drug delivery and screening Adv. Drug Deliver. Rev. (IF 15.2) Pub Date : 2024-12-10 Heqi Xu, Shaokun Zhang, Kaidong Song, Huayong Yang, Jun Yin, Yong Huang
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Trans-nasal brain delivery of anti-TB drugs by methyl-β-cyclodextrin microparticles show efficient mycobacterial clearance from central nervous system. J. Control. Release (IF 10.5) Pub Date : 2024-12-15 Krishna Jadhav,Agrim Jhilta,Raghuraj Singh,Shweta Sharma,Swarnima Negi,Kailash Ahirwar,Rahul Shukla,Amit Kumar Singh,Rahul Kumar Verma
Central nervous system tuberculosis (CNS-TB) is the most severe extra-pulmonary manifestation of tuberculosis (TB), facing significant challenges due to the limited penetration of anti-TB drugs (ATDs) across the blood-brain barrier (BBB) and their insufficient concentrations at the site of infection. This study aimed to enhance the efficacy of ATDs by encapsulating them in methyl-β-cyclodextrin (M-β-CD)
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Integrating targeting and drug retention: A promising approach for cancer treatment J. Control. Release (IF 10.5) Pub Date : 2024-12-14 Shenqiang Wang, Zhiyuan Zhong
Section snippets Declaration of competing interestNone.
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In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury J. Med. Chem. (IF 6.8) Pub Date : 2024-12-13 H. Rachel Lagiakos, Yefen Zou, Hideyuki Igawa, Eric Therrien, Morgan Lawrenz, Mitsunori Kato, Mats Svensson, Felicia Gray, Kristian Jensen, Markus K. Dahlgren, Robert D. Pelletier, Karen Dingley, Jeffrey A. Bell, Zhijian Liu, Yuansong Jiang, Hua Zhou, Robert J. Skene, Zhe Nie
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A Putative Frizzled 7-Targeting Compound Acts as a Firefly Luciferase Inhibitor J. Med. Chem. (IF 6.8) Pub Date : 2024-12-13 Julia Kinsolving, Lukas Grätz, Jan Hendrik Voss, Bente Löw, Emily Shorter, Baptiste Jude, Johanna T Lanner, Stefan Löber, Peter Gmeiner, Gunnar Schulte
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Journal of Medicinal Chemistry Collection: Drug Discovery in Italy J. Med. Chem. (IF 6.8) Pub Date : 2024-12-13 Antonella Ciancetta, Maria Laura Bolognesi
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Discovery of a Novel Mutant-Selective Epidermal Growth Factor Receptor Inhibitor Using an In Silico Enabled Drug Discovery Platform J. Med. Chem. (IF 6.8) Pub Date : 2024-12-12 Hideyuki Igawa, Zef A. Konst, Eric Therrien, Mee Shelley, Heidi Koldsø, Pieter H. Bos, Ana Negri, Andreas Verras, Jiaye Guo, Markus K. Dahlgren, Adam Levinson, Brendan T. Parr, Suresh E. Kurhade, Prashant Latthe, Rajesha Shetty, Sridhar Santhanakrishnan, Katherine Amberg-Johnson, Alan S. Futran, Christian Atsriku, Robert D. Pelletier, Zhijian Liu, Jeffrey A. Bell, Sathesh Bhat, Mats Svensson, Aleksey
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Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke J. Med. Chem. (IF 6.8) Pub Date : 2024-12-12 Barbara Mordyl, Nikola Fajkis-Zajączkowska, Katarzyna Szafrańska, Agata Siwek, Monika Głuch-Lutwin, Paweł Żmudzki, Jakub Jończyk, Tadeusz Karcz, Karolina Słoczyńska, Elżbieta Pękala, Bartosz Pomierny, Weronika Krzyżanowska, Jakub Jurczyk, Alicja Skórkowska, Aleksandra Sałach, Magdalena Jastrzębska-Więsek, Maria Walczak, Maciej Tadeusz Gawlik, Magdalena Smolik, Marcin Kolaczkowski, Monika Marcinkowska
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Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer J. Med. Chem. (IF 6.8) Pub Date : 2024-12-12 Kristoffer Peterson, Ulf J. Nilsson, Lise Gravelle, Ian Holyer, Karl Jansson, Barbro Kahl-Knutson, Hakon Leffler, Alison C. MacKinnon, James A. Roper, Robert J. Slack, Henrik von Wachenfeldt, Anders Pedersen, Fredrik R. Zetterberg
更新日期：2024-12-20
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