Cancer presents a significant global public health challenge. Within the tumor microenvironment (TME), macrophages are the most abundant immune cell population. Tumor-associated macrophages (TAMs) undergo metabolic reprogramming through influence of the TME; thus, by manipulating key metabolic pathways such as glucose, lipid, or amino acid metabolism, it may be possible to shift TAMs towards an antitumor state, enhancing the immune response against tumors. Here, we highlight the metabolic reprogramming of macrophages as a potential approach for cancer immunotherapy. We explore the major pathways involved in the metabolic reprogramming of TAMs and offer new and valuable insights on the current technologies utilized for TAM reprogramming, including genome editing, antibodies, small molecules, nanoparticles and other in situ editing strategies.

中文翻译：

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癌症治疗中巨噬细胞的代谢重编程。


癌症是一项重大的全球公共卫生挑战。在肿瘤微环境（TME）中，巨噬细胞是最丰富的免疫细胞群。肿瘤相关巨噬细胞 (TAM) 通过 TME 的影响进行代谢重编程；因此，通过操纵关键的代谢途径，如葡萄糖、脂质或氨基酸代谢，有可能将TAM转变为抗肿瘤状态，从而增强针对肿瘤的免疫反应。在这里，我们强调巨噬细胞的代谢重编程作为癌症免疫治疗的潜在方法。我们探索 TAM 代谢重编程涉及的主要途径，并对 TAM 重编程当前使用的技术提供新的、有价值的见解，包括基因组编辑、抗体、小分子、纳米粒子和其他原位编辑策略。