Santomauro DF, Vos T, Whiteford HA, Chisholm D, Saxena S, Ferrari AJ. Service coverage for major depressive disorder: estimated rates of minimally adequate treatment for 204 countries and territories in 2021. Lancet Psychiatry 2024; 11: 1012–21—In figures 1 and 3 of this Article, the colours for some locations have been updated and statements added to the legends regarding WHO standards for geographical

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BackgroundPsychological interventions are increasingly discussed as a method to prevent major depressive disorder (MDD) in adults who already experience subthreshold depressive symptoms. In this individual participant data meta-analysis, we quantify the effect of preventive interventions against control on MDD onset in this population, and explore effect modifiers. MethodsIn this systematic review

BackgroundThe association between lithium use and chronic kidney disease, and the effect of comorbidities on this association are poorly understood. Our aim was to examine the risk of developing stage 3 or higher chronic kidney disease among people receiving lithium therapy. MethodsThis was a retrospective, population-based cohort study of all adults (aged ≥18 years) in Iceland treated with lithium

BackgroundAccess to effective treatment for major depressive disorder remains limited and difficult to track across place and time. We analysed the available data on minimally adequate treatment (MAT) for major depressive disorder globally with the aim of providing a useful metric against which to monitor national responses to the growing public health burden imposed by major depressive disorder. MethodsMAT

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The understanding and treatment of psychiatric disorders present unique challenges due to these conditions' multifaceted nature, comprising dynamic interactions between biological, psychological, social, and environmental factors. Traditional reductionistic approaches often simplify these conditions into linear cause-and-effect relationships, overlooking the complexity and interconnectedness inherent

BackgroundAntipsychotic polypharmacy remains a clinical reality, despite an increased risk of adverse events and little evidence of additional efficacy compared with antipsychotic monotherapy. In this systematic review and meta-analysis, we aimed to provide a comprehensive assessment of antipsychotic polypharmacy prevalence, trends, and correlates across mental disorders. MethodsWe searched MEDLINE

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BackgroundPsychological distress is common among mothers in low-income and middle-income countries, limiting their capacity to care for themselves and their children. This study aimed to test the feasibility and acceptability of an adapted psychosocial intervention for distressed mothers in low-resource settings. MethodsIn this open-label trial, we enrolled women living in Lusaka, Zambia, with high

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Pinchuk I, Leventhal B L, Ladyk-Bryzghalova A, et al. The Lancet Psychiatry Commission on mental health in Ukraine. Lancet Psychiatry 2024; 11: 910–33—In this Commission, the affiliation for author Marisa Casanova Dias MD MSc is incorrect. The correct affiliation is National Centre for Mental Health, Cardiff University, Cardiff, UK. This correction has been made to the online version as of Nov 4.

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Herrera-Ferrá K, Muñoz JM, Becerril A, et al. The regulation of neurotechnology: the neurorights bill in Mexico. Lancet Psychiatry 2024; published online Oct 8, 2024. https://doi.org/10.1016/S2215-0366(24)00286-4—In this Comment, the spelling of author Jesús Alejandro Alonso Olamendi's name was incorrect. This correction has been made to the online version as of Oct 17, 2024, and will be made to the

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Pinchuk I, Leventhal B L, Ladyk-Bryzghalova A, et al. The Lancet Psychiatry Commission on mental health in Ukraine. Lancet Psychiatry 2024; 11: 910–33—In this Commission, the value of the total health-care expenditure of US$ 13·5 per capita given in sentence five in paragraph two of Part 5: Resourcing the future of mental health section is incorrect. The number should be $6·75 per capita. The name

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Research, mainly conducted in Europe and North America, has shown an inequitable burden of internalising mental health problems among adolescents from poorer households. We investigated whether these mental health inequalities differ across a diverse range of countries and multiple measures of economic circumstances.

Cognitive deficits are a key source of disability in individuals with major depressive disorder (MDD) and worsen with disease progression. Despite their clinical relevance, the underlying mechanisms of cognitive deficits remain poorly elucidated, hampering effective treatment strategies. Emerging evidence suggests that alterations in white matter microstructure might contribute to cognitive dysfunction

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Adolescence is a period of change and increased mental health difficulties, which are important for lifetime outcomes. Adolescent mental health is therefore an active research area, with large samples often drawing on self-report general measures (ie, not disorder-specific or focused on a narrow outcome). We argue that these measures have a key role in our understanding of issues such as prevalence

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Section snippets Executive summaryThe Russian invasion and annexation of eastern Ukraine and Crimea in 2014, along with the ongoing war since February, 2022, have inflicted incalculable damage to Ukraine with many deaths and injuries, massive population displacement, and extensive physical and emotional trauma. These events put an immense strain on the general health-care and mental health-care systems

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Conversion practices are associated with psychological morbidity, yet few studies have evaluated differences between efforts to change gender identity, sexual orientation, or both. We aimed to examine the individual and joint association of conversion practice recall targeted at gender identity or sexual orientation, or both, with current mental health symptoms among sexual and gender minority people

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Creswell C, Taylor L, Giles S, et al. Digitally augmented, parent-led CBT versus treatment as usual for child anxiety problems in child mental health services in England and Northern Ireland: a pragmatic, non-inferiority, clinical effectiveness and cost-effectiveness randomised controlled trial. Lancet Psychiatry 2024; 11: 193–209—The appendix of this Article has been corrected as of Sept 17, 2024

BackgroundAntibodies against the N-methyl-D-aspartate receptor (NMDAR) have been described in the serum of people with schizophrenia spectrum disorders (schizophrenia). However, the prevalence and clinical relevance of these antibodies in schizophrenia is unclear. This knowledge gap includes the possibility of such antibodies being associated with a distinct clinical profile, which in turn might warrant