Obesity is a major global health issue with various metabolic complications. Both bariatric surgery and dieting achieve weight loss and improve whole-body metabolism, but vary in their ability to maintain these improvements over time. Adipose tissue and skeletal muscle metabolism are crucial in weight regulation, and obesity is linked to mitochondrial dysfunction in both tissues. The impact of bariatric surgery versus dieting on adipose tissue and skeletal muscle mitochondrial metabolism remains to be elucidated. Understanding the molecular pathways that modulate tissue metabolism following weight loss holds potential for identifying novel therapeutic targets in obesity management. This narrative review summarizes current knowledge on mitochondrial metabolism following bariatric surgery and diet-induced weight loss in adipose tissue and skeletal muscle, and sheds light on their respective effects.

中文翻译：

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减肥后的皮下脂肪组织和骨骼肌线粒体。


肥胖是一个重大的全球健康问题，伴有各种代谢并发症。减肥手术和节食都可以达到减肥和改善全身新陈代谢的目的，但随着时间的推移，它们维持这些改善的能力各不相同。脂肪组织和骨骼肌代谢对于体重调节至关重要，肥胖与这两种组织中的线粒体功能障碍有关。减肥手术与节食对脂肪组织和骨骼肌线粒体代谢的影响仍有待阐明。了解减肥后调节组织代谢的分子途径有可能确定肥胖管理中的新治疗靶点。这篇叙述性综述总结了减肥手术和饮食诱导的脂肪组织和骨骼肌减肥后线粒体代谢的最新知识，并阐明了它们各自的影响。