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Association of Anaesthetists guidelines: the use of blood components and their alternatives 2024 Anaesthesia (IF 7.5) Pub Date : 2025-01-09
Akshay Shah, Andrew A. Klein, Seema Agarwal, Andrew Lindley, Aamer Ahmed, Kerry Dowling, Emma Jackson, Sumit Das, Divya Raviraj, Rachel Collis, Anna Sharrock, Simon J. Stanworth, Paul MoorThe administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri-operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and improved haemovigilance, have become apparent over the past decade. The
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Elective peri-operative management of adults taking glucagon-like peptide-1 receptor agonists, glucose-dependent insulinotropic peptide agonists and sodium-glucose cotransporter-2 inhibitors: a multidisciplinary consensus statement Anaesthesia (IF 7.5) Pub Date : 2025-01-09
Kariem El-Boghdadly, Jugdeep Dhesi, Philippa Fabb, Nicholas Levy, Dileep N. Lobo, Andrew McKechnie, Omar Mustafa, Philip Newland-Jones, Anil Patel, Dimitri J. Pournaras, Ken Clare, Ketan DhatariyaGlucagon-like peptide-1 receptor agonists, dual glucose-dependent insulinotropic peptide receptor agonists and sodium-glucose cotransporter-2 inhibitors are used increasingly in patients receiving peri-operative care. These drugs may be associated with risks of peri-operative pulmonary aspiration or euglycaemic ketoacidosis. We produced a consensus statement for the peri-operative management of adults
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Peri-operative identification and management of patients with unhealthy alcohol intake Anaesthesia (IF 7.5) Pub Date : 2025-01-09
Matthew J. A. Jenkins, Stephen M. Kinsella, Matthew D. Wiles, Brijesh Srivastava, Catherine Griffiths, Jacquelyn Lewin, Stephen Usher, Gautam Mehta, Abi Berger, Dereck Gondongwe, Isra HassanThis consensus statement gives practical advice for the safe management of patients with harmful alcohol intake undergoing elective and emergency surgery. The wide spectrum of alcohol-related organ dysfunction observed in this cohort of patients may have a profound impact on care, and the additional effects of alcohol withdrawal may further exacerbate postoperative morbidity and mortality.
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Mortality prediction after major surgery in a mixed population through machine learning: a multi-objective symbolic regression approach Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Pietro Arina, Davide Ferrari, Nicholas Tetlow, Amy Dewar, Robert Stephens, Daniel Martin, Ramani Moonesinghe, Vasa Curcin, Mervyn Singer, John Whittle, Evangelos B. MazomenosUnderstanding 1-year mortality following major surgery offers valuable insights into patient outcomes and the quality of peri-operative care. Few models exist that predict 1-year mortality accurately. This study aimed to develop a predictive model for 1-year mortality in patients undergoing complex non-cardiac surgery using a novel machine-learning technique called multi-objective symbolic regression
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Emergency and postoperative access to critical and enhanced care: a multicentre prospective observational study* Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Andy Georgiou, David Cain, Martin Schuster Bruce, Denise Axelsen, Tom Woodward, Tom Baumer, Katie Preston, James Ward, Jack Ingham, Alun RobertsThe ability to admit patients to enhanced or critical care may be limited by bed availability. In a network with low provision of critical and enhanced care beds, we aimed to assess the proportion of patients having surgery with moderate (1%–< 5%) or high (≥ 5%) predicted risk of 30-day postoperative mortality and their postoperative care location. We also aimed to study referral and admission outcomes
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The increasing global burden of cancer: implications for anaesthesia and peri‐operative medicine Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Carlos E. Guerra‐Londono, Santiago Uribe‐Marquez, Rupen Shah, Vijaya GottumukkalaSummaryIntroductionMost patients with cancer will require surgery at some point in their lifetime. As the global burden of cancer continues to increase, changes and challenges in cancer epidemiology and care are also borne peri‐operatively.MethodsDue to its broad scope, a formal systematic electronic literature search was not performed. This narrative review examines how an increasing global burden
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Return to intended oncological therapy following advanced ovarian cancer surgery: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Ka Yu Tse, Mandy Man Yee Chu, Jessie Wan Kam Chiu, Shuk Tak Kwok, Michael G. Irwin, Aaron Hey Yin Chan, Polly Ho, Calvin Pak Wing Cheng, Siew Fei Ngu, Karen Kar Loen ChanSummaryIntroductionPatients with advanced ovarian cancer often require radical cytoreductive surgery and chemotherapy, with or without targeted therapy. Return to intended oncological therapy after surgery is a crucial metric, as delay can worsen survival. The concept of return to intended oncological therapy is important because it highlights the need for not just successful surgical outcomes, but
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Anaesthetic management of oncological disease in pregnancy: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Ben Sharif, Melanie Nana, Rachel Kearns, Queenie Lo, Yavor MetodievSummaryIntroductionCancer complicates approximately 1 in 2000 pregnancies, with increasing incidence due to factors such as increased maternal age, obesity and advancements in antenatal testing. Anaesthetists play a crucial role in managing pregnant patients with cancer, both during delivery and in providing anaesthesia for oncological treatments. This review explores the challenges in anaesthetic
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Recurrence‐free survival after hepatectomy using propofol‐based total intravenous anaesthesia and sevoflurane‐based inhalational anaesthesia: a randomised controlled study Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Ji‐Hye Kwon, Jeayoun Kim, Hyean Yeo, Keoungah Kim, Jinsoo Rhu, Gyu‐Seong Choi, Jongman Kim, Jae‐Won Joh, Kyunga Kim, Min‐Ji Kim, Ji Seon Jeong, Jong‐Hwan Lee, Sangbin Han, Justin S. Ko, Mi Sook Gwak, Gaab Soo KimSummaryBackgroundWhile evidence from preclinical and observational cohort studies have suggested potential disparities in tumour behaviour associated with the choice of intra‐operative anaesthetics, clinical evidence of tumour recurrence and metastasis remains inconclusive. We aimed to compare the impact of intra‐operative anaesthesia on oncologic outcomes following hepatectomy for hepatocellular carcinoma
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Systemic anti‐cancer therapy and anaesthesia: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Jamie M. J. Weaver, Susannah J. PateySummaryIntroductionCancer research has revolutionised the treatment, quality of life and life expectancy of people living with cancer. Systemic anti‐cancer treatments have expanded to involve not only cytotoxic drugs, but targeted drugs and immunotherapy. Although highly effective in many patients, these drugs can cause serious and sometimes life‐threatening adverse reactions. As part of their treatment
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Cardiotoxicity and peri‐operative considerations in immune checkpoint inhibitor and chimeric antigen receptor T‐cell therapy: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Aishwarya Malode, Bhargav Makwana, Vahin Patel, Sumanth Khadke, Aneri Parikh, Arindam Bagga, Sourbha Dani, Sarju GanatraSummaryIntroductionImmunotherapy has transformed cancer treatment, particularly with immune checkpoint inhibitors and chimeric antigen receptor T‐cell therapy. Despite their efficacy, these therapies can induce cardiotoxicity, presenting significant clinical challenges. Immune checkpoint inhibitors can cause myocarditis; pericarditis; arrhythmias; and myocardial infarction through immune‐mediated inflammation
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The inequalities and challenges of prehabilitation before cancer surgery: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Hilary Stewart, Sophie Stanley, Xiubin Zhang, Lisa Ashmore, Christopher Gaffney, Jo Rycroft‐Malone, Andrew F. Smith, Laura Wareing, Cliff SheltonSummaryIntroductionPrehabilitation seeks to enhance functional capacity and preparedness before surgery with the aim of improving outcomes; it is generally based on exercise, diet and psychological interventions. While there is obvious appeal to this approach in terms of patient experience and resource use, the interventions are complex and the evidence base for prehabilitation before cancer surgery
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Association between peri‐operative red blood cell transfusion and cancer recurrence in patients undergoing major cancer surgery: an umbrella review* Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Joshua Etheridge, Panth Shah, Simon J. Stanworth, Ewen Harrison, Michael Gillies, Timothy S. Walsh, Akshay ShahSummaryIntroductionPeri‐operative allogeneic red blood cell transfusion is hypothesised to increase the risk of cancer recurrence following cancer surgery. However, previous data supporting this association are limited by residual confounding. We conducted an umbrella review (i.e. a systematic review of systematic reviews) to synthesise and evaluate the evidence between red blood cell transfusion and
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The evolution and key components of onco‐anaesthesia: a narrative review* Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Raghav Gupta, Sushma BhatnagarSummaryIntroductionOnco‐anaesthesia is a specialised branch of anaesthesia dedicated to enhancing outcomes, prioritising patient safety and improving the overall care of patients with cancer during surgery. We outline the global epidemiology of cancer, emphasising the necessity for this subspecialty, and discuss the criteria supporting its establishment.MethodsWe performed searches of electronic databases
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Immunotherapy on ICU: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Sef Carter, Timothy WigmoreSummaryBackgroundPatients with cancer account for 15% of all admissions to critical care and so an understanding of the pathophysiology and anticipated complications of specialist treatment is essential for the intensive care clinician. The development of chimeric antigen receptor T‐cell therapy for haematological malignancies and immune checkpoint inhibitors for solid organ tumours has led to significant
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Peri‐operative mental health interventions for surgical oncology patients: a narrative synthesis and meta‐analysis Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Joanna Abraham, Katherine J. Holzer, Lavanya Pedamallu, Benjamin D. Kozower, Michael S. Avidan, Eric J. LenzeSummaryIntroductionOncologic surgeries are common and rates of depression and anxiety are high in the peri‐operative period, potentially interfering with successful recovery.MethodsWe conducted a narrative review and meta‐analysis focusing on randomised controlled trials evaluating the effect of peri‐operative mental health interventions on anxiety and/or depression in adult patients having oncological
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The effect of the type of anaesthesia on long‐term outcomes after cancer resection surgery: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Lucillia Bezu, Lua S. Rahmani, Donal J. BuggySummaryBackgroundThe peri‐operative period may create a biological environment conducive to cancer cell survival and dissemination. Microscopic residual tumours (micrometastases) can be dislodged even with excellent surgical technique. At the same time, the stress response from surgery can temporarily impair immune function and activate inflammatory processes, increasing the risk of tumour proliferation
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Anaesthesia for paediatric radiotherapy: A narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Lauren Oswald, Sam Al‐Kadhimi, Nicola ThorpSummaryIntroductionRadiotherapy is currently used in approximately one‐third of children with cancer. Treatments are typically received as weekday outpatient appointments over 3–6 weeks. The treatment is painless but requires a still, co‐operative patient who can lie alone in set positions, facilitated by the use of immobilisation devices, for up to 1 h.MethodsWe conducted a literature search to identify
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Optimisation of the patient having oncological surgical through prehabilitation: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
John Moore, Alec Beaney, Liam Humphreys, Zoe Merchant, Krishna Kholia Parmar, Denny LevettSummaryIntroductionPrehabilitation aims to improve physiological reserve and psychological resilience, enabling patients to better tolerate the physiological stress of major surgery, thereby reducing the risk of complications and improving surgical outcomes. In this review, we provide an update of the development of prehabilitation in patients having cancer surgery.MethodsWe searched databases of peer‐reviewed
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Patient‐centred outcome measures for oncological surgery: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Rachel Blackman‐Mack, George Chater, Geeta AggarwalSummaryIntroductionPeri‐operative medicine is becoming increasingly relevant in the context of managing frail patients with cancer. This paper outlines how demographic shifts in populations are affecting cancer incidence and frailty rates, the relevance this holds to the management of cancer care, and the outcome measures that should be used to gauge best clinical practice to ensure patient‐centred
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Causes and management of acute oncological pain: a narrative review Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Helen Laycock, Candice Ramdin, Justin Grayer, Matthew R. D. BrownSummaryIntroductionAcute pain in cancer is an important but often overlooked feature of many patients' oncological journey. Cancer‐related pain is associated commonly with more persistent pain states caused by both the disease and its treatment, but there are numerous causes of acute pain which can develop in patients with cancer. This pain is frequently severe, can be challenging to manage and its
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Prevalence and outcomes of patients taking oral corticosteroids for over 1 month undergoing major surgery in England 2010–2020 Anaesthesia (IF 7.5) Pub Date : 2025-01-08
Jessica Harris, Georgina Russell, Barnaby Reeves, Ben GibbisonSummaryIntroductionApproximately 1% of the UK population is prescribed oral corticosteroids at any one time. It is not known how many of these patients present for major surgery. We aimed to establish the prevalence, characteristics and outcomes of patients taking oral corticosteroids.MethodsWe identified patients aged > 18 y undergoing major surgery between 1 April 2010 and 31 March 2020 from Hospital
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Accurate prediction of postoperative complications in older patients: a long way to go Anaesthesia (IF 7.5) Pub Date : 2025-01-07
Zhendong Ding, Qin Liao, Yongzhong TangWe read with interest the Science Letter by Dubowitz et al. [1]. The application of biological instead of chronological age for the prediction of postoperative complications in patients is a promising advance, and we concur with the authors' perspective on the potential association between biological ageing and postoperative complications after cancer surgery. This study helps prompt surgeons and anaesthetists
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Diagnostic accuracy of qualitative gastric ultrasound assessment for detecting high gastric fluid volume in children: a prospective randomised study Anaesthesia (IF 7.5) Pub Date : 2025-01-07
Eloïse Cercueil, Anaïs Henriet, Corwyn Barbe, Guinter Santos Machado, Lionel BouvetSummaryIntroductionThe diagnostic accuracy of gastric ultrasound in children has not been assessed thoroughly. We aimed to determine the sensitivity and specificity in children of a qualitative ultrasound examination of the gastric antrum in the supine 45° semi‐recumbent position and a clinical algorithm for detecting a gastric fluid volume > 1.25 ml.kg‐1, reported to represent an ‘at‐risk stomach’
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Instructional design features in ultrasound‐guided regional anaesthesia simulation‐based training: a systematic review Anaesthesia (IF 7.5) Pub Date : 2025-01-07
Pooyan Sekhavati, Tristan Wild, Ingrid D. P. C. Martinez, Pierre‐Marc Dion, Michael Woo, Reva Ramlogan, Sylvain Boet, Risa Shorr, Yuqi GuSummaryIntroductionUltrasound‐guided regional anaesthesia enhances pain control, patient outcomes and lowers healthcare costs. However, teaching this skill effectively presents challenges with current training methods. Simulation‐based medical education offers advantages over traditional methods. However, the use of instructional design features in ultrasound‐guided regional anaesthesia simulation
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Prevalence of smoking and postoperative outcomes in people undergoing coronary artery bypass grafting: a UK registry analysis Anaesthesia (IF 7.5) Pub Date : 2025-01-07
Emma Sewart, Alexander Isted, Kitty H. F. Wong, Gudrun Kunst, Ronelle MoutonTobacco smoking is the leading behavioural risk factor for cardiovascular disease and may double the risk of long-term mortality after coronary artery bypass grafting (CABG) [1, 2]. Smoking cessation interventions, which combine pharmacological treatment and behavioural support, are effective at supporting abstinence at the time of surgery and at 12 months postoperatively [3]. However, smoking remains
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Enhancing outcomes in acute type A aortic dissection through early diagnosis and access to specialist surgical care Anaesthesia (IF 7.5) Pub Date : 2025-01-06
Carlos Corredor, Aung OoClick on the article title to read more.
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Trends in comorbidities and complications among patients undergoing elective total hip and knee arthroplasty in the USA Anaesthesia (IF 7.5) Pub Date : 2025-01-06
Lisa Reisinger, Crispiana Cozowicz, Jashvant Poeran, Haoyan Zhong, Alex Illescas, Periklis Giannakis, Jiabin Liu, Stavros G. MemtsoudisSummaryBackgroundDemand for total hip and knee arthroplasty procedures continues to rise. Ongoing changes in surgical care and patient populations require continued monitoring of outcome trends. Using nationwide data from the USA, we aimed to describe updated trends in patient and peri‐operative care characteristics as well as complications among total hip and knee arthroplasty recipients.MethodsWe
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Implementation of the TALK© clinical self-debriefing tool in operating theatres. Comment on Br J Anaesth 2024; 133: 853-61. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-03
Stephen Waite,Charlotte Jane Dewdney -
Altered thrombin generation with prothrombin complex concentrate is not detected by viscoelastic testing: an in vitro study. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-03
Nikolaus Hofmann,Herbert Schöchl,Johannes Zipperle,Johannes Gratz,Felix C F Schmitt,Daniel OberladstätterBACKGROUND Bleeding guidelines currently recommend use of viscoelastic testing (VET) to direct haemostatic resuscitation in severe haemorrhage. However, VET-derived parameters of clot initiation, such as clotting time (CT) and activated clotting time (ACT), might not adequately reflect a clinically relevant interaction of procoagulant and anticoagulant activity, as revealed by thrombin generation assays
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The diverse effects of ketamine, a jack-of-all-trades: a narrative review. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Nicholas D Richards,Simon J Howell,Mark C Bellamy,James BeckKetamine, an N-methyl-D-aspartic acid receptor antagonist that was first discovered in 1962, has become established in anaesthesia providing dose-dependent anaesthetic, sedative, and analgesic effects. Ketamine, however, also acts on a wide range of other cellular targets, resulting in interesting and diverse effects on both physiological and pathological processes. Potential beneficial properties
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Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Giacomo Monti,Luca Cabrini,Yuki Kotani,Claudia Brusasco,Assiya Kadralinova,Giuseppe Giardina,Athanasios Chalkias,Cristina Nakhnoukh,Ioannis Pantazopoulos,Federico Mattia Oliva,Federico Dazzi,Agostino Roasio,Martina Baiardo Redaelli,Vincenzo Francesco Tripodi,Giada Cucciolini,Alessandro Belletti,Rosanna Vaschetto,Giulia Maj,Giovanni Borghi,Francesco Savelli,Silvia Boni,Filippo D'Amico,Sarah CavalleroBACKGROUND The impact of noninvasive ventilation (NIV) managed outside the intensive care unit in patients with early acute respiratory failure remains unclear. We aimed to determine whether adding early NIV prevents the progression to severe respiratory failure. METHODS In this multinational, randomised, open-label controlled trial, adults with mild acute respiratory failure (arterial oxygen partial
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microRNAs involved in neuropathic pain can be measured in saliva. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Kesava Kovanur-Sampath,Jayanthi B Papannarao,Etelini Roberts,Daryl Schwenke,Rajesh Katare -
Preoperative estimated glomerular filtration rate to predict cardiac events in major noncardiac surgery: a secondary analysis of two large international studies. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Pavel S Roshanov,Michael W Walsh,Amit X Garg,Meaghan Cuerden,Ngan N Lam,Ainslie M Hildebrand,Vincent W Lee,Marko Mrkobrada,Kate Leslie,Matthew T V Chan,Flavia K Borges,Chew Yin Wang,Denis Xavier,Daniel I Sessler,Wojciech Szczeklik,Christian S Meyhoff,Sadeesh K Srinathan,Alben Sigamani,Juan Carlos Villar,Clara K Chow,Carísi A Polanczyk,Ameen Patel,Tyrone G Harrison,Vikram Fielding-Singh,Juan P CataBACKGROUND Optimised use of kidney function information might improve cardiac risk prediction in noncardiac surgery. METHODS In 35,815 patients from the VISION cohort study and 9219 patients from the POISE-2 trial who were ≥45 yr old and underwent nonurgent inpatient noncardiac surgery, we examined (by age and sex) the association between continuous nonlinear preoperative estimated glomerular filtration
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Authorship misconduct: professional misconduct in editorial handling of authorship. Comment on Br J Anaesth 2024; 133: 1134-6. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Christine T Vo,Mary C Greenough,Brad Luo,Amir L Butt -
Dual antiplatelet therapy and tracheostomy practice in the intensive care unit: a survey of selected urban ICUs in the UK. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Nick Barnett,Nithin Thoppuram,William Seligman,Anja Drebes -
Motor-sparing regional anaesthesia for total knee arthroplasty: a narrative and systematic literature review. Br. J. Anaesth. (IF 9.1) Pub Date : 2025-01-02
Leigh White,Michael Kerr,Christopher Thang,Amit PawaTotal knee arthroplasty is a life-changing surgical procedure that is associated with a high incidence of severe postoperative pain. Key to enhancing recovery after surgery is effective analgesia and early mobilisation. Innovations in motor-sparing regional anaesthesia techniques that have improved recovery include targeted surgical local infiltration analgesia, adductor canal blockade, genicular nerve
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Hemodynamic Management guided by the Hypotension Prediction Index in Abdominal Surgery: A Multicenter Randomized Clinical Trial. Anesthesiology (IF 9.1) Pub Date : 2025-01-02
Javier Ripollés-Melchor,José L Tomé-Roca,Andrés Zorrilla-Vaca,César Aldecoa,María J Colomina,Eva Bassas-Parga,Juan V Lorente,Alicia Ruiz-Escobar,Laura Carrasco-Sánchez,Marc Sadurni-Sarda,Eva Rivas,Jaume Puig,Elizabeth Agudelo-Montoya,Sabela Del Rio-Fernández,Daniel García-López,Ana B Adell-Pérez,Antonio Guillen,Rocío Venturoli-Ojeda,Bartolomé Fernández-Torres,Ane Abad-Motos,Irene Mojarro,José L Garrido-CalmaestraBACKGROUND Postoperative acute kidney injury (AKI) after major abdominal surgery leads to poor outcomes. The Hypotension Prediction Index (HPI) may aid in managing intraoperative hemodynamic instability. This study assessed if HPI-guided therapy reduces moderate-to-severe AKI incidence in moderate-to-high-risk elective abdominal surgery patients. METHODS This multicenter randomized trial was conducted
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Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis Anaesthesia (IF 7.5) Pub Date : 2025-01-02
Angela R. Tognolini, Xin Liu, Saurabh Pandey, Jason A. Roberts, Steven C. Wallis, Dwane Jackson, Victoria A. EleySummaryIntroductionEvidence to support intra‐operative lidocaine infusion regimens in patients with obesity is lacking, risking underdosing or toxicity. We aimed to measure the plasma concentrations of lidocaine and its active metabolites to develop a pharmacokinetic model and optimised dosing regimen in patients with obesity.MethodsA standardised weight‐based intravenous lidocaine regimen was administered
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Postpartum Epidural Morphine for Post-Vaginal Delivery-an Underutilized Resource? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-02
Richard Smiley -
Intraoperative Neuromonitoring: Are Two Really Better Than One? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-02
Sanchit Ahuja,Nikolaos J Skubas,Andra E Duncan -
Neostigmine: Incompletely Understood and Perhaps Incorrectly Utilized. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-02
Stephan R Thilen,Ken B Johnson -
Sexual Harassment in Academic Anesthesiology: A Survey of Prevalence, Sources, Impact, and Recommendations. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-02
Maya J Hastie,Aaron Mittel,Vidya Raman,Joseph Szokol,Robert Whittington,Maria Bustillo,Shahla Siddiqui,Tracey Straker,Tetsuro Sakai,Valerie Armstead,Jeanine Wiener-Kronish,Chelcie Jewitt,George A MashourBACKGROUND A report by the American Association of Medical Colleges (AAMC) showed that academic anesthesiology has the highest prevalence of sexual harassment among specialties for both men and women. We aimed to explore the prevalence, sources, and impact of sexual harassment on anesthesiologists in academic centers in the United States and Canada. We also sought recommendations for its mitigation
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Multi-Institutional Study of Multimodal Analgesia Practice, Pain Trajectories, and Recovery Trends After Spine Fusion for Idiopathic Scoliosis. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-02
Lisa M Einhorn,Constance L Monitto,Arjunan Ganesh,Qing Duan,Jiwon Lee,Radhamangalam J Ramamurthi,Kristi Barnett,Lili Ding,Vidya ChidambaranBACKGROUND Posterior spinal fusion (PSF) surgery for correction of idiopathic scoliosis is associated with chronic postsurgical pain (CPSP). In this multicenter study, we describe perioperative multimodal analgesic (MMA) management and characterize postoperative pain, disability, and quality of life over 12 months after PSF in adolescents and young adults. METHODS Subjects (8-25 years) undergoing PSF
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Peripheral Nerve Blockade for Tibia Fractures: To Block or Not to Block? Is It Still a Question? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-02
Ron E Samet,Jason C Brookman,Thomas E Grissom -
Kappa opioid receptor internalisation-induced p38 nuclear translocation suppresses glioma progression. Br. J. Anaesth. (IF 9.1) Pub Date : 2024-12-30
Yong Li,Wenying Wang,Han She,Zhibo Cui,Zhengchao Liu,Hai Yang,Jun Zhang,Xiaoqiong Zhou,Daiqin Bao,Yu Yao,Shaliu Luo,Ruili Cai,Yu Shi,Yi-Fang Ping,Qingxiang MaoBACKGROUND Recent studies have implicated a role for perioperative medications in determining patient outcomes after surgery for malignant tumours, including relapse and metastasis. METHODS A combined approach spanned molecular, cellular, and organismal levels, including bioinformatics, immunohistochemical staining of clinical and animal samples, RNA sequencing of glioblastoma multiforme (GBM) cells
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Do some operations still need more diamorphine? Anaesthesia (IF 7.5) Pub Date : 2024-12-30
D. Leslie, N. StranixThe systematic review and meta-analysis by Grape et al. [1] suggests that there is no evidence of benefit to doses of intrathecal diamorphine exceeding 0.2 mg. Their systematic review identified 12 trials (712 patients), 11 of which included only patients undergoing orthopaedic or obstetric procedures. There was a single trial including 30 patients having inguinal hernia repair, lower limb arterial
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Genome‐wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank Anaesthesia (IF 7.5) Pub Date : 2024-12-30
Song Li, Masja K. Toneman, Judith P. M. Mangnus, Stefano Strocchi, Regina L. M. van Boekel, Kris C. P. Vissers, Richard P. G. ten Broek, Marieke J. H. CoenenSummaryIntroductionChronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear. This study aimed to identify single‐nucleotide polymorphisms associated with developing chronic postsurgical pain after abdominal
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Parental presence in the operating room during emergency laparotomy Anaesthesia (IF 7.5) Pub Date : 2024-12-30
Loes Bruijstens, Marieke Stulp, Solange Pans, Jan BollenWe read with interest the results of the 7th National Audit Project (NAP7), dealing with peri-operative cardiac arrest in children [1, 2] and wish to discuss our experience of parental presence during resuscitation in the operating theatre. An adolescent patient with suspected gastrointestinal bleeding needed urgent tracheal intubation for endoscopy and surgery. He arrived at the operating theatre
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Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery: A Double-blind Randomized Controlled Trial. Anesthesiology (IF 9.1) Pub Date : 2024-12-27
Qirui Zhang,Xuyang Ye,Shuqing Shi,Songhua Zhou,Daqing Ma,Wen Ouyang,Jianbin Tong,Yuan LeBACKGROUND Postoperative nausea and vomiting (PONV) are common complications after gynecological laparoscopic surgery. Pyridoxine has been recommended as a first-line drug to prevent and treat nausea and vomiting during pregnancy; however, its efficacy in preventing PONV remains unclear. METHODS Patients of 18 to 65 years old, who received elective gynecological laparoscopic surgery under general anesthesia
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Impact of a personalized intervention on preoperative anxiety and determination of the minimal clinically important difference in anxiety levels - a randomized clinical trial. Anesthesiology (IF 9.1) Pub Date : 2024-12-26
Stefan Salzmann,Laura Kikker,Ellen Tosberg,Noah Becker,Markus Spies,Frank Euteneuer,Dirk RüschBACKGROUND Preoperative anxiety is common and most patients experiencing preoperative anxiety would welcome support to cope with their anxiety. Studies examining the effectiveness of information to reduce anxiety have been inconsistent. In addition, it is unclear whether results reported to be statistically significant are also clinically relevant. This study's primary objective was to test the hypothesis
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Task-sharing with families for early detection of postoperative complications in resource-limited settings. Br. J. Anaesth. (IF 9.1) Pub Date : 2024-12-24
Sakina Bhaloo,James Glasbey,Aneel BhanguPostoperative mortality in Africa is twice that of wealthier countries. The SMARTER trial underscores this critical issue and aims to address the high mortality rates by harnessing a readily available resource requiring minimal funding. Conducted in Mbale, Uganda, this innovative trial trained family members to monitor basic vital signs following surgery. This task is usually performed by healthcare
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Associations Between Social Determinants of Health and Opioid-Use Disorder Among Chronic Pain Patients From a Multi-Institutional Dataset. Anesth. Analg. (IF 4.6) Pub Date : 2024-12-23
Veena M Do,Sierra Simpson,Kathleen M Fisch,Rodney A GabrielBACKGROUND This study examined the association between opioid-use disorder (OUD)-related diagnoses (eg, opioid dependence) and social determinants of health (SDoH) among patients with chronic pain. METHODS A cross-sectional study was performed using the All of Us dataset (including >70,000 patients) to measure associations between SDoH and OUD using population- and individual-level surveys. Mixed-effects
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Early endovascular reperfusion during extracorporeal support for massive pulmonary embolism. Br. J. Anaesth. (IF 9.1) Pub Date : 2024-12-20
Lorenzo Giosa,Francesca Momigliano,Emilia Tomarchio,Ken-Win To,Patrick Collins,Jonathan Dutton,Nishanth Sivarasan,Narayan Karunanithy,Benjamin Garfield,Luigi Camporota -
Preoperative activation of the renin-angiotensin system and myocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial. Br. J. Anaesth. (IF 9.1) Pub Date : 2024-12-20
Ana Gutierrez Del Arroyo,Tom E F Abbott,Akshaykumar Patel,Salma Begum,Priyanthi Dias,David Brealey,Rupert M Pearse,Vikas Kapil,Gareth L Ackland,BACKGROUND Hypertension therapy in older adults is often suboptimal, in part because of inadequate suppression of the renin-angiotensin-aldosterone system (RAAS). We hypothesised that distinct endotypes of RAAS activation before noncardiac surgery are associated with increased risk of myocardial injury. METHODS This was a prespecified exploratory analysis of a multicentre randomised controlled trial
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Effectiveness of Ventilation via an Endotracheal Tube in Pharynx Versus a Facemask in Patients With Potentially Difficult Airway: A Randomized, Crossover, and Blind Trial. Anesth. Analg. (IF 4.6) Pub Date : 2024-12-20
Travis Markham,Abraham S AlFarra,Mubeen Tejani,Daniel J Tate,Jose E Barrera,Sreelekha Paladugu,Sepideh Saroukhani,Yandong JiangBACKGROUND The difficult airway is frequently encountered across many scenarios. The extreme form is a "cannot intubate and cannot oxygenate" scenario, which lacks a reliable rescue technique. Previous case reports or studies with small sample sizes indicate the feasibility and efficiency of an endotracheal tube in the pharynx (TTIP) to ventilate patients. We hypothesize that ventilation via TTIP is
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Erythrocytes and Platelets Autotransfusion in High Hemorrhagic Risk Cardiac Surgery: A Single-Center Pilot Analysis of the Multicentric SEPIA Registry. Anesth. Analg. (IF 4.6) Pub Date : 2024-12-20
Abdellah Aouifi,David Faraoni,Geoffray Keller,Flora Ketels,Olivier Raspado,Joel Lapeze,Fadi Farhat