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Streamlined collaboration can boost CRISPR gene therapies for rare diseases Nature (IF 50.5) Pub Date : 2024-07-02
Letter to the Editor
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Killer immune cells pile on the pressure to slay their foes Nature (IF 50.5) Pub Date : 2024-07-02
Immune-system assassins called killer T cells compress target cells, forming a destructive crater.
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Unchanged power dynamics still block progress for under-represented groups in academia Nature (IF 50.5) Pub Date : 2024-07-02
Letter to the Editor
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To regain lost public trust, incorporate research ethics into graduate training Nature (IF 50.5) Pub Date : 2024-07-02
Letter to the Editor
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I use ethnobotany to bring India’s medicinal plants into urban landscapes Nature (IF 50.5) Pub Date : 2024-07-02
N. M. Ganesh Babu collects, studies and propagates his country’s Indigenous flora for their herbal and aesthetic qualities.
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Did the diarist who chronicled the Great Fire of London make up a scientific instrument? Nature (IF 50.5) Pub Date : 2024-07-02
Snippets from Nature’s past
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Climate change is worsening the housing crisis — we must tackle the two together Nature (IF 50.5) Pub Date : 2024-07-02
Thousands of people are being displaced across the Arctic. Governments must listen to Indigenous and local communities and act on their advice.
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UK election: three research priorities for the next government Nature (IF 50.5) Pub Date : 2024-07-02
Ministers must take a global view of science, address a growing crisis in university finances and put a stop to interference in research autonomy.
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Neuroscientists must not be afraid to study religion Nature (IF 50.5) Pub Date : 2024-07-02 Patrick McNamara, William Newsome, Brie Linkenhoker, Jordan Grafman
Scientists interested in the brain have tended to avoid studying religion or spirituality for fear of being seen as unscientific. That needs to change.
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What drives mosquitoes’ bloodlust? Their hormones Nature (IF 50.5) Pub Date : 2024-07-01
One hormone seems to boosts the insects’ thirst for a blood meal, while another shuts it off.
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Bionic leg moves like a natural limb — without conscious thought Nature (IF 50.5) Pub Date : 2024-07-01
Computer interface links signals from the brain to an artificial limb, giving the wearer better balance, flexibility and speed.
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Daily briefing: See a smiling face made of living human skin cells Nature (IF 50.5) Pub Date : 2024-07-01
A robotic face is made from living human skin cells anchored to a ‘skeleton’ with ligament-like structures. Plus, massive old stars reveal the true nature of the Milky Way and how AI could help identify researchers with untapped innovation potential.
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Daily briefing: How obesity drugs like Ozempic create a full feeling Nature (IF 50.5) Pub Date : 2024-06-28
The brain areas involved in the feeling of fullness experienced by people taking GLP-1 drugs. Plus, an ‘epigenome editor’ silences a gene linked to deadly brain disorders and a ‘jumping gene’ enzyme edits genomes without breaking DNA.
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Combined COVID-flu vaccines are coming: Moderna jab clears major test Nature (IF 50.5) Pub Date : 2024-06-28
First large trial suggests mRNA drug gives better protection from SARS-CoV-2 and influenza viruses than single-target shots.
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Choose your own adventure: navigating retirement after an academic career Nature (IF 50.5) Pub Date : 2024-06-28
How do you have a full and meaningful retirement? Late-career researchers and retired colleagues discuss the many options available.
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The Milky Way is ‘less weird’ than we thought Nature (IF 50.5) Pub Date : 2024-06-28
The Galaxy’s core isn't as densely packed with stars as models suggested, a study finds, aligning it more closely with similar spiral galaxies.
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Audio long read: How NASA astronauts are training to walk on the Moon in 2026 Nature (IF 50.5) Pub Date : 2024-06-28
Listen to an audio version of a recent Nature Feature.
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Deep-sea creatures survive crushing pressures with just the right fats Nature (IF 50.5) Pub Date : 2024-06-27
Tiny predators called comb jellies have cell-membrane lipids that form curving structures under pressure.
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Daily briefing: How this lab became one of the most successful in the world Nature (IF 50.5) Pub Date : 2024-06-27
Study reveals secrets of Cambridge’s Laboratory of Molecular Biology. Plus, the first 3D-model brains with cells from several people and five new ways to catch gravitational waves.
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‘Epigenome editor’ silences gene that causes deadly brain disorders Nature (IF 50.5) Pub Date : 2024-06-27
Prion diseases are caused by misfolded proteins, but a new tool can stop them forming in mice.
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How blockbuster obesity drugs create a full feeling — even before one bite of food Nature (IF 50.5) Pub Date : 2024-06-27
Scientists identify brain area that holds two groups of neurons: one for pre-meal sensations of fullness and one for post-meal satiety.
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No CRISPR: oddball ‘jumping gene’ enzyme edits genomes without breaking DNA Nature (IF 50.5) Pub Date : 2024-06-27
A programmable RNA that bridges a genetic donor and a target could herald a safer and more flexible approach to large-scale chromosome changes.
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Ketamine for depression: slow-release pills could make treatment more accessible Nature (IF 50.5) Pub Date : 2024-06-27
A ketamine-containing tablet could be a convenient alternative to intravenous treatments, with fewer unpleasant side effects.
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An intermediate Rb–E2F activity state safeguards proliferation commitment Nature (IF 50.5) Pub Date : 2024-06-26 Yumi Konagaya, David Rosenthal, Nalin Ratnayeke, Yilin Fan, Tobias Meyer
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Daily briefing: ‘Polar rain aurora’ seen from Earth for the first time Nature (IF 50.5) Pub Date : 2024-06-25
Scientists got the first-ever unimpeded view from Earth of a rare aurora spanning more than 3,000 kilometres across the North Pole. Plus, ‘fantastic’ particle could be the most energetic neutrino ever detected and why extreme wildfires are now more common.
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Smile! Living skin helps robot make a happy face Nature (IF 50.5) Pub Date : 2024-06-27
Anchors inspired by skin ligaments connect cell-based composite to robotic visage.
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Five new ways to catch gravitational waves — and the secrets they’ll reveal Nature (IF 50.5) Pub Date : 2024-06-27
Observatories, experiments and techniques are being developed to spot ripples in space-time at frequencies that currently can’t be detected.
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Mechanism for the initiation of spliceosome disassembly Nature (IF 50.5) Pub Date : 2024-06-26 Matthias K. Vorländer, Patricia Rothe, Justus Kleifeld, Eric Cormack, Lalitha Veleti, Daria Riabov-Bassat, Laura Fin, Alex W. Phillips, Luisa Cochella, Clemens Plaschka
Pre-mRNA splicing requires the assembly, remodeling, and disassembly of the multi-megadalton ribonucleoprotein complex called the spliceosome1. Recent studies have shed light on spliceosome assembly and remodeling for catalysis2–6, but the mechanism of disassembly remains unclear. Here, we report 2.6 to 3.2 Å resolution cryo-electron microscopy structures of nematode and human terminal intron-lariat
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Buried interface molecular hybrid for inverted perovskite solar cells Nature (IF 50.5) Pub Date : 2024-06-26 Sanwan Liu, Jingbai Li, Wenshan Xiao, Rui Chen, Zhenxing Sun, Yong Zhang, Xia Lei, Shuaifeng Hu, Manuel Kober-Czerny, Jianan Wang, Fumeng Ren, Qisen Zhou, Hasan Raza, You Gao, Yitong Ji, Sibo Li, Huan Li, Longbin Qiu, Wenchao Huang, Yan Zhao, Baomin Xu, Zonghao Liu, Henry J. Snaith, Nam-Gyu Park, Wei Chen
Perovskite solar cells (PSCs) with an “inverted” architecture are a key pathway for commercializing this emerging photovoltaic technology due to the better power conversion efficiency (PCE) and operational stability as compared to the “normal” device structure. Specifically, PCEs of the inverted PSCs have exceeded 25% owing to the development of improved self-assembled molecules (SAMs)1-5 and passivation
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Aged mice regain youthful muscles thanks to a compound that acts on the genes Nature (IF 50.5) Pub Date : 2024-06-26
A molecule increases levels of a protein that maintains telomeres, the caps on the ends of chromosomes.
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Chemical reservoir computation in a self-organizing reaction network Nature (IF 50.5) Pub Date : 2024-06-26 Mathieu G. Baltussen, Thijs J. de Jong, Quentin Duez, William E. Robinson, Wilhelm T. S. Huck
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Molecular basis for transposase activation by a dedicated AAA+ ATPase Nature (IF 50.5) Pub Date : 2024-06-26 Álvaro de la Gándara, Mercedes Spínola-Amilibia, Lidia Araújo-Bazán, Rafael Núñez-Ramírez, James M. Berger, Ernesto Arias-Palomo
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Zinc mediates control of nitrogen fixation via transcription factor filamentation Nature (IF 50.5) Pub Date : 2024-06-26 Jieshun Lin, Peter K. Bjørk, Marie V. Kolte, Emil Poulsen, Emil Dedic, Taner Drace, Stig U. Andersen, Marcin Nadzieja, Huijun Liu, Hiram Castillo-Michel, Viviana Escudero, Manuel González-Guerrero, Thomas Boesen, Jan Skov Pedersen, Jens Stougaard, Kasper R. Andersen, Dugald Reid
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TnpB homologues exapted from transposons are RNA-guided transcription factors Nature (IF 50.5) Pub Date : 2024-06-26 Tanner Wiegand, Florian T. Hoffmann, Matt W. G. Walker, Stephen Tang, Egill Richard, Hoang C. Le, Chance Meers, Samuel H. Sternberg
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Explainable El Niño predictability from climate mode interactions Nature (IF 50.5) Pub Date : 2024-06-26 Sen Zhao, Fei-Fei Jin, Malte F. Stuecker, Philip R. Thompson, Jong-Seong Kug, Michael J. McPhaden, Mark A. Cane, Andrew T. Wittenberg, Wenju Cai
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Cenozoic history of the tropical marine biodiversity hotspot Nature (IF 50.5) Pub Date : 2024-06-26 Skye Yunshu Tian, Moriaki Yasuhara, Fabien L. Condamine, Huai-Hsuan M. Huang, Allan Gil S. Fernando, Yolanda M. Aguilar, Hita Pandita, Toshiaki Irizuki, Hokuto Iwatani, Caren P. Shin, Willem Renema, Tomoki Kase
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Titanium:sapphire-on-insulator integrated lasers and amplifiers Nature (IF 50.5) Pub Date : 2024-06-26 Joshua Yang, Kasper Van Gasse, Daniil M. Lukin, Melissa A. Guidry, Geun Ho Ahn, Alexander D. White, Jelena Vučković
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Synaptic architecture of leg and wing premotor control networks in Drosophila Nature (IF 50.5) Pub Date : 2024-06-26 Ellen Lesser, Anthony W. Azevedo, Jasper S. Phelps, Leila Elabbady, Andrew Cook, Durafshan Sakeena Syed, Brandon Mark, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman
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Megastudy shows that reminders boost vaccination but adding free rides does not Nature (IF 50.5) Pub Date : 2024-06-26 Katherine L. Milkman, Sean F. Ellis, Dena M. Gromet, Youngwoo Jung, Alex S. Luscher, Rayyan S. Mobarak, Madeline K. Paxson, Ramon A. Silvera Zumaran, Robert Kuan, Ron Berman, Neil A. Lewis, John A. List, Mitesh S. Patel, Christophe Van den Bulte, Kevin G. Volpp, Maryann V. Beauvais, Jonathon K. Bellows, Cheryl A. Marandola, Angela L. Duckworth
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Connectomic reconstruction of a female Drosophila ventral nerve cord Nature (IF 50.5) Pub Date : 2024-06-26 Anthony Azevedo, Ellen Lesser, Jasper S. Phelps, Brandon Mark, Leila Elabbady, Sumiya Kuroda, Anne Sustar, Anthony Moussa, Avinash Khandelwal, Chris J. Dallmann, Sweta Agrawal, Su-Yee J. Lee, Brandon Pratt, Andrew Cook, Kyobi Skutt-Kakaria, Stephan Gerhard, Ran Lu, Nico Kemnitz, Kisuk Lee, Akhilesh Halageri, Manuel Castro, Dodam Ih, Jay Gager, Marwan Tammam, Sven Dorkenwald, Forrest Collman, Casey
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Structural mechanism of bridge RNA-guided recombination Nature (IF 50.5) Pub Date : 2024-06-26 Masahiro Hiraizumi, Nicholas T. Perry, Matthew G. Durrant, Teppei Soma, Naoto Nagahata, Sae Okazaki, Januka S. Athukoralage, Yukari Isayama, James J. Pai, April Pawluk, Silvana Konermann, Keitaro Yamashita, Patrick D. Hsu, Hiroshi Nishimasu
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Experimental observation of repulsively bound magnons Nature (IF 50.5) Pub Date : 2024-06-26 Zhe Wang, Catalin-Mihai Halati, Jean-Sébastien Bernier, Alexey Ponomaryov, Denis I. Gorbunov, Sandra Niesen, Oliver Breunig, J. Michael Klopf, Sergei Zvyagin, Thomas Lorenz, Alois Loidl, Corinna Kollath
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Hotspot shelters stimulate frog resistance to chytridiomycosis Nature (IF 50.5) Pub Date : 2024-06-26 Anthony W. Waddle, Simon Clulow, Amy Aquilina, Erin L. Sauer, Shannon W. Kaiser, Claire Miller, Jennifer A. Flegg, Patricia T. Campbell, Harrison Gallagher, Ivana Dimovski, Yorick Lambreghts, Lee Berger, Lee F. Skerratt, Richard Shine
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Measuring gravitational attraction with a lattice atom interferometer Nature (IF 50.5) Pub Date : 2024-06-26 Cristian D. Panda, Matthew J. Tao, Miguel Ceja, Justin Khoury, Guglielmo M. Tino, Holger Müller
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Unconventional superconductivity in chiral molecule–TaS2 hybrid superlattices Nature (IF 50.5) Pub Date : 2024-06-26 Zhong Wan, Gang Qiu, Huaying Ren, Qi Qian, Yaochen Li, Dong Xu, Jingyuan Zhou, Jingxuan Zhou, Boxuan Zhou, Laiyuan Wang, Ting-Hsun Yang, Zdeněk Sofer, Yu Huang, Kang L. Wang, Xiangfeng Duan
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Brain Chimeroids reveal individual susceptibility to neurotoxic triggers Nature (IF 50.5) Pub Date : 2024-06-26 Noelia Antón-Bolaños, Irene Faravelli, Tyler Faits, Sophia Andreadis, Rahel Kastli, Sebastiano Trattaro, Xian Adiconis, Anqi Wei, Abhishek Sampath Kumar, Daniela J. Di Bella, Matthew Tegtmeyer, Ralda Nehme, Joshua Z. Levin, Aviv Regev, Paola Arlotta
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Transposase-assisted target-site integration for efficient plant genome engineering Nature (IF 50.5) Pub Date : 2024-06-26 Peng Liu, Kaushik Panda, Seth A. Edwards, Ryan Swanson, Hochul Yi, Pratheek Pandesha, Yu-Hung Hung, Gerald Klaas, Xudong Ye, Megan V. Collins, Kaili N. Renken, Larry A. Gilbertson, Veena Veena, C. Nathan Hancock, R. Keith Slotkin
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Bridge RNAs direct programmable recombination of target and donor DNA Nature (IF 50.5) Pub Date : 2024-06-26 Matthew G. Durrant, Nicholas T. Perry, James J. Pai, Aditya R. Jangid, Januka S. Athukoralage, Masahiro Hiraizumi, John P. McSpedon, April Pawluk, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu
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Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair Nature (IF 50.5) Pub Date : 2024-06-26 Parul Mehrotra, Sophia Maschalidi, Laura Boeckaerts, Christian Maueröder, Rochelle Tixeira, Jonathan Pinney, Javier Burgoa Cardás, Vladimir Sukhov, Yunus Incik, Christopher. J. Anderson, Bing Hu, Burcu N. Keçeli, Amanda Goncalves, Lieselotte Vande Walle, Nina Van Opdenbosch, Alexey Sergushichev, Esther Hoste, Umang Jain, Mohamed Lamkanfi, Kodi S. Ravichandran
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Drosophila immune cells transport oxygen through PPO2 protein phase transition Nature (IF 50.5) Pub Date : 2024-06-26 Mingyu Shin, Eunji Chang, Daewon Lee, Nayun Kim, Bumsik Cho, Nuri Cha, Ferdinand Koranteng, Ji-Joon Song, Jiwon Shim
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Terahertz phonon engineering with van der Waals heterostructures Nature (IF 50.5) Pub Date : 2024-06-26 Yoseob Yoon, Zheyu Lu, Can Uzundal, Ruishi Qi, Wenyu Zhao, Sudi Chen, Qixin Feng, Woochang Kim, Mit H. Naik, Kenji Watanabe, Takashi Taniguchi, Steven G. Louie, Michael F. Crommie, Feng Wang
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Observations of diapycnal upwelling within a sloping submarine canyon Nature (IF 50.5) Pub Date : 2024-06-26 Bethan L. Wynne-Cattanach, Nicole Couto, Henri F. Drake, Raffaele Ferrari, Arnaud Le Boyer, Herlé Mercier, Marie-José Messias, Xiaozhou Ruan, Carl P. Spingys, Hans van Haren, Gunnar Voet, Kurt Polzin, Alberto C. Naveira Garabato, Matthew H. Alford
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Powerful laser miniaturized from tabletop to microchip Nature (IF 50.5) Pub Date : 2024-06-26 Ajanta Barh
An electronics-enabled platform for titanium–sapphire photonic devices.
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Controlled stacking of boron nitride layers for ferroelectric memory applications Nature (IF 50.5) Pub Date : 2024-06-26
A method for controlled stacking of boron nitride layers could be a boon for ferroelectric memory devices.
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Flies use blood cells to take a deep breath Nature (IF 50.5) Pub Date : 2024-06-26 Stefan Luschnig
Blood cells can transport oxygen to the tissues of fruit flies.
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Daily briefing: Blockbuster weight-loss drugs linked to unexpected pregnancies Nature (IF 50.5) Pub Date : 2024-06-26
Women on the pill or diagnosed as infertile have reported getting pregnant with ‘Ozempic babies’. Plus, the first ever rocks from the Moon’s far side land on Earth and the science of protests.
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Deep-sea dye confirms turbulent-mixing theory — with implications for climate Nature (IF 50.5) Pub Date : 2024-06-26 Ryan M. Holmes
Observations of upwelling in a deep-ocean canyon.
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Programmable RNA-guided enzymes for next-generation genome editing Nature (IF 50.5) Pub Date : 2024-06-26 Connor J. Tou, Benjamin P. Kleinstiver
Recombinase enzymes that recognize DNA sequences using a ‘bridge’ RNA.
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These 3D model brains with cells from several people are first of their kind Nature (IF 50.5) Pub Date : 2024-06-26
Chimeric brain ‘organoids’ promise to help reveal individual variation in brain development and in drug responses.
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Estonians gave their DNA to science — now they’re learning their genetic secrets Nature (IF 50.5) Pub Date : 2024-06-26
Project covering one-fifth of the country’s population is one of the largest-ever efforts to share results on genetic health risks with research participants.