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Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-20 Orsolya I. Gaal, Megan Leask, Valentin Nica, Georgiana Cabău, Medeea Badii, Ioana Hotea, Dennis M de Graaf, Zhenhua Zhang, Yang Li, Cristina Pamfil, Simona Rednic, Tony R. Merriman, Tania O. Crișan, Leo A.B. Joosten
Gout is caused by the response of the innate immune system to monosodium urate (MSU) crystals. A recent gout GWAS identified a signal of genetic association at a locus encompassing IL1RN-IL1F10. Colocalisation analysis using Genotype Tissue Expression Database (GTEx) eQTL data showed that the signal overlaps with genetic control of IL1RN/IL1F10 gene expression. We assess the functional implications
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Semaphorin 5A promotes Th17 differentiation via PI3K-Akt-mTOR in systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-19 Xin Chen, Lingjiang Zhu, Jieying Xu, Qi Cheng, Yuanji Dong, Yifan Xie, Li Hua, Yan Du
Previously, we reported that serum Semaphorin 5 A (Sema5A) levels were increased in systemic lupus erythematosus (SLE) patients compared with healthy controls (HC), and elevated Sema5A correlated with disease activity and lupus nephritis in SLE patients. In this study, we aimed to further understand the role of Sema5A in promoting Th17 cells differentiation in SLE. Sema5A, interferon gamma (IFN-γ)
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Automatic knee osteoarthritis severity grading based on X-ray images using a hierarchical classification method Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-18 Jian Pan, Yuangang Wu, Zhenchao Tang, Kaibo Sun, Mingyang Li, Jiayu Sun, Jiangang Liu, Jie Tian, Bin Shen
This study aims to develop a hierarchical classification method to automatically assess the severity of knee osteoarthritis (KOA). This retrospective study recruited 4074 patients. Clinical diagnostic indicators and clinical diagnostic processes were applied to develop a hierarchical classification method that involved four sub-task classifications. These four sub-task classifications were the classification
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Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-18 Yan-lin Wu, Shao-gui Wan, Yi Long, Hua Ye, Jia-ming Yang, Yun Luo, Yan-biao Zhong, Li Xiao, Hai-yan Chen, Mao-yuan Wang
Knee osteoarthritis (KOA) is characterized by mitochondrial damage and increased inflammation. Circulating cell-free mitochondrial DNA (ccf-mtDNA), which originates from damaged mitochondria, is an endogenous damage-associated molecular pattern (DAMPs) molecule that may trigger inflammation and is recognized as a potential biomarker for various diseases. In this study, we investigated the potential
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Therapeutic effects of extracellular vesicles derived from mesenchymal stem cells primed with disease-conditioned-immune cells in systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-18 Eun Wha Choi, Il Seob Shin, I-Rang Lim, Jihye Lee, Bongkum Choi, Sungjoo Kim
Systemic lupus erythematosus (SLE) is an incurable chronic autoimmune disease of unknown etiology. Therefore, the development of new treatments is urgently needed. This study aimed to investigate the therapeutic effects of extracellular vesicles (EV) derived from immortalized mesenchymal stem cells (iMSCs) primed with conditioned media obtained from disease-conditioned immune cells (CM-EV) and iMSC-derived
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Investigation of GPM6B as a novel therapeutic target in Osteoarthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-12 Chongyang Feng, Lin Liu, Jinxue Zhang, Linxiao Wang, Ke Lv, Hongbo Li, Yong Ding
Osteoarthritis (OA) is the most common motor system disease in older people, characterized by a high incidence and significant social and economic burden. Women have a higher risk of OA, more severe clinical symptoms, and a higher rate of disabilities than men. However, the pathogenesis of OA remains unclear. Therefore, we screened for differentially expressed genes (DEGs) in OA patients of different
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Small heterodimer partner-interacting leucine zipper protein suppresses pain and cartilage destruction in an osteoarthritis model by modulating the AMPK/STAT3 signaling pathway Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-12 Jeonghyeon Moon, Keun-Hyung Cho, JooYeon Jhun, JeongWon Choi, Hyun-Sik Na, Jeong Su Lee, Seung Yoon Lee, Jun-Ki Min, Anan Shetty, Sung-Hwan Park, Seok Jung Kim, Mi-La Cho
Osteoarthritis (OA) is a degenerative joint disease caused by the breakdown of joint cartilage and adjacent bone. Joint injury, being overweight, differences in leg length, high levels of joint stress, abnormal joint or limb development, and inherited factors have been implicated in the etiology of OA. In addition to physical damage to the joint, a role for inflammatory processes has been identified
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Clinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA) Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-12 Takahisa Onishi, Ken-ei Sada, Keigo Hayashi, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato, Michio Fujiwara, Nobuyuki Yajima, Takashi Kida, Yusuke Matsuo, Keisuke Nishimura, Takashi Yamane
Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in patients undergoing immunosuppressive therapy, such as glucocorticoid (GC) medication, for systemic autoimmune diseases like systemic lupus erythematosus (SLE). Despite the confirmed effectiveness of PCP prophylaxis, its clinical administration, especially in conjunction with GC dosage, remains unclear. We aimed to describe the
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Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis refractory to biologic therapy: 2-year clinical and radiographic results from the open-label extension of the SELECT-AXIS 2 study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-12 Xenofon Baraliakos, Désirée van der Heijde, Joachim Sieper, Robert Davies Inman, Hideto Kameda, Walter Peter Maksymowych, Ivan Lagunes-Galindo, Xianwei Bu, Peter Wung, Koji Kato, Anna Shmagel, Atul Deodhar
The efficacy and safety of upadacitinib in patients with ankylosing spondylitis (AS) and inadequate response/intolerance to biologic disease-modifying antirheumatic drugs (bDMARD-IR) were evaluated through 1 year in the SELECT-AXIS 2 study. Here, we assess 2-year efficacy, safety, and imaging outcomes in SELECT-AXIS 2. Patients who received continuous upadacitinib, and those who switched from placebo
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Neutrophil and mononuclear leukocyte pathways and upstream regulators revealed by serum proteomics of adult and juvenile dermatomyositis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-11 A. Clare Sparling, James M. Ward, Kakali Sarkar, Adam Schiffenbauer, Payam Noroozi Farhadi, Michael A. Smith, Saifur Rahman, Kamelia Zerrouki, Frederick W. Miller, Jian-Liang Li, Kerry A. Casey, Lisa G. Rider
Serum protein abundance was assessed in adult and juvenile dermatomyositis (DM and JDM) patients to determine differentially regulated proteins, altered pathways, and candidate disease activity biomarkers. Serum protein expression from 17 active adult DM and JDM patients each was compared to matched, healthy control subjects by a multiplex immunoassay. Pathway analysis and protein clustering of the
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Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-11 Yu Katayama, Yoshia Miyawaki, Kenta Shidahara, Shoichi Nawachi, Yosuke Asano, Eri Katsuyama, Takayuki Katsuyama, Mariko Takano-Narazaki, Yoshinori Matsumoto, Nao Oguro, Nobuyuki Yajima, Yuichi Ishikawa, Natsuki Sakurai, Chiharu Hidekawa, Ryusuke Yoshimi, Shigeru Ohno, Takanori Ichikawa, Dai Kishida, Yasuhiro Shimojima, Ken-ei Sada, Jun Wada, David H. Thom, Noriaki Kurita
Patient trust plays a central role in the patient-physician relationship. This study aimed to determine whether the number of outpatient visits with a covering rheumatologist is associated with patient trust in their usual rheumatologist. Japanese adults with systemic lupus erythematosus (SLE) who met the 1997 revised classification criteria of the American College of Rheumatology and had outpatient
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Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-08 Xinyu Tong, Huilin He, Shihan Xu, Rui Shen, Zihan Ning, Xiaofeng Zeng, Qian Wang, Dong Xu, Zuo-Xiang He, Xihai Zhao
Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patients. This study aimed to investigate the resting state (RS) functional alternations of SSc patients and the potential influenced factors. Forty-four SSc patients (mean age, 46.3 ± 11.4 years; 40 females) and 19 age and sex comparable healthy volunteers (mean age, 42.6 ± 11.3 years;
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Prevalence of and trends in hyperuricemia by race and ethnicity among US adolescents, 1999–2018 Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-08 Kaifeng Guo, Yali Han, Shuang Liu, Hang Sun, Xiaojing Lin, Shaoling Yang, Yining Gao, Haibing Chen
Our objective was to ascertain the most recent prevalence and trends of hyperuricemia among adolescents, stratified by sex and race/ethnicity subgroups, as well as to investigate potential risk factors associated with hyperuricemia in US adolescents. Data were obtained from adolescents aged 12–17 years in the 1999–2018 NHANES cycles. Hyperuricemia for adolescents was defined as ≥ 5.5 mg/dL. The prevalence
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Timely escalation to second-line therapies after failure of methotrexate in patients with early rheumatoid arthritis does not reduce the risk of becoming difficult-to-treat Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-08 Bernardo D’Onofrio, Ludovico De Stefano, Emanuele Bozzalla Cassione, Valentina Morandi, Francesca Cuzzocrea, Garifallia Sakellariou, Antonio Manzo, Carlomaurizio Montecucco, Serena Bugatti
To investigate the frequency of difficult-to-treat (D2T) rheumatoid arthritis (RA) in patients early escalated to biologic/targeted synthetic disease modifying anti-rheumatic drugs (b/tsDMARDs) after failure of treat-to-target with methotrexate (MTX). From a prospective cohort of early RA, all patients with their first access in the years 2005–2018, and eventually starting a b/tsDMARD before the end
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Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-07 Lian Gui, Xiaoyu Zuo, Junmei Feng, Mingbang Wang, Zena Chen, Yuhan Sun, Jun Qi, Zhuanggui Chen, Janak L. Pathak, Yanli Zhang, Chunping Cui, Pingping Zhang, Xinghua Guo, Qing Lv, Xi Zhang, Yan Zhang, Jieruo Gu, Zhiming Lin
Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to investigate SLE-pathogenic gut microbes and their potential mechanisms. There were 134 healthy controls (HCs) and 114 SLE cases for 16 S ribosomal RNA (rRNA) sequencing and 97 HCs and 124 SLE cases for shotgun metagenomics. Faecal microbial changes and associations with clinical
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Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-06 Molly Klimak, Amanda Cimino, Kristin L. Lenz, Luke E. Springer, Kelsey H. Collins, Natalia S. Harasymowicz, Nathan Xu, Christine T.N. Pham, Farshid Guilak
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by increased levels of inflammation that primarily manifests in the joints. Macrophages act as key drivers for the progression of RA, contributing to the perpetuation of chronic inflammation and dysregulation of pro-inflammatory cytokines such as interleukin 1 (IL-1). The goal of this study was to develop a macrophage-based cell
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Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-05 Stephanie L. Smith, Lorna Paul, Martijn P. M. Steultjens, Rebecca L. Jones
Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. This review aimed to identify associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis. A systematic literature review
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Integrated multi-omics revealed that dysregulated lipid metabolism played an important role in RA patients with metabolic diseases Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-11-01 Xiaoting Zhu, Wubin Long, Jing Zhang, Congcong Jian, Jianghua Chen, Jiaxin Huang, Shilin Li, Jie Zhang, Liang Wang, Yan Chen, Jianhong Wu, Tingting Wang, Qinghua Zou, Jing Zhu, Fanxin Zeng
Patients with rheumatoid arthritis (RA) commonly experience a high prevalence of multiple metabolic diseases (MD), leading to higher morbidity and premature mortality. Here, we aimed to investigate the pathogenesis of MD in RA patients (RA_MD) through an integrated multi-omics approach. Fecal and blood samples were collected from a total of 181 subjects in this study for multi-omics analyses, including
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Infiltrations of plasma cells in synovium predict inadequate response to Adalimumab in Rheumatoid Arthritis patients Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-31 Jian Bin Li, Peng Cheng Liu, Liming Chen, Rui Wu
Rheumatoid arthritis (RA) is a clinically heterogeneous and complex autoimmune disease, making the prediction of therapeutic responses a significant challenge. This study aims to assess the role of clinical and synovial biomarkers in predicting poor response to adalimumab treatment in RA patients. This single-center prospective study included 56 RA patients who had an inadequate response to methotrexate
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Does regression of skin thickening predict improvement of internal organ involvement and survival in patients with diffuse cutaneous systemic sclerosis? A EUSTAR analysis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-31 Anja Wyss, Suzana Jordan, Nicole Graf, Patricia E. Carreira, Jörg Distler, Marco Matucci Cerinic, Elise Siegert, Jörg Henes, Elisabetta Zanatta, Valeria Riccieri, Marie-Elise Truchetet, Fahrettin Oksel, Mengtao Li, Eugene J. Kucharz, Kilian Eyerich, Francesco Del Galdo, Madelon C. Vonk, Anna-Maria Hoffman Vold, Armando Gabrielli, Oliver Distler
Patients with diffuse cutaneous systemic sclerosis (dcSSc) frequently show spontaneous improvement of skin fibrosis. Our aim was to examine whether an improvement in skin fibrosis predicts lower likelihood of visceral organ progression and better survival. Patients from the European Scleroderma Trials and Research (EUSTAR) cohort with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, and valid
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Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-29 Hui-Chun Yu, Hsien-Yu Huang Tseng, Hsien-Bin Huang, Ming-Chi Lu
To investigate the roles of Ca2+ influx-regulated circular RNAs (circRNAs) in T cells from patients with systemic lupus erythematosus (SLE). The expression profile of circRNAs in Jurkat cells, co-cultured with and without ionomycin, was analyzed by next-generation sequencing and validated using real-time polymerase chain reaction. The identified Ca2+ influx-regulated circRNAs were further examined
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Increased serum level of IL-6 predicts poor prognosis in anti-MDA5-positive dermatomyositis with rapidly progressive interstitial lung disease Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-28 Yuanyuan Niu, Suling Liu, Qian Qiu, Di Fu, Youjun Xiao, Liuqin Liang, Yang Cui, Shanhui Ye, Hanshi Xu
Anti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5-positvie DM) is a subtype of dermatomyositis with a poor prognosis, characterized by rapidly progressive interstitial lung disease (RP-ILD). The study aims to investigate the significance of serum cytokines profiles and peripheral lymphocytes in predicting prognoses of anti-MDA5-positvie DM with RP-ILD.
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WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-23 Liping Tan, Yu Fan, Xinyi Xu, Tianshu Zhang, Xiangyu Cao, Chenghao Zhang, Jun Liang, Yayi Hou, Huan Dou
Neuropsychiatric systemic lupus erythematosus (NPSLE) often manifests as cognitive deterioration, with activated microglia and blood-brain barrier (BBB) disruption implicated in these neurological complications. Wnt-inhibitory factor-1 (WIF-1), a secreted protein, has been detected in the cerebrospinal fluid (CSF) of NPSLE patients. However, the contribution of WIF-1 in contributing to lupus cognitive
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Long-term outcome of autologous haematopoietic stem cell transplantation in patients with systemic sclerosis: a comparison with patients treated with rituximab and with traditional immunosuppressive agents Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-23 Nicoletta Del Papa, Silvia Cavalli, Andrea Rindone, Francesco Onida, Giorgia Saporiti, Antonina Minniti, Maria Rosa Pellico, Claudia Iannone, Giorgia Trignani, Nicoletta D’Angelo, Manuel Sette, Raffaella Greco, Claudio Vitali, Roberto Caporali
Autologous haematopoietic stem cell transplantation (AHSCT) is more effective than conventional immunosuppressive therapies (CIT) in improving the outcome of patients with rapidly progressive diffuse cutaneous systemic sclerosis (dcSSc). So far, there is still a paucity of data comparing AHSCT with rituximab (RTX). Aim of the study is to retrospectively compare, in patients with dcSSc, the effectiveness
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Oxysterols contribute to immune cell recruitment in SLE skin lesions Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-22 Xiaoyun Chen, Lianlian Ouyang, Sujie Jia, Ming Zhao
Abnormal oxysterol metabolism has been observed in the peripheral blood of SLE patients, but its role in systemic lupus erythematosus (SLE) skin lesions remains unclear. Targeted oxidized lipid metabolomics analysis using liquid chromatography-mass spectrometry (LC-MS) was performed to quantify oxysterols in SLE skin lesions. Immunohistochemical staining and single-cell sequencing data analysis confirmed
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Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-22 Ruiling Feng, Xian Xiao, Bo Huang, Kai Zhang, Xia Zhang, Zhanguo Li, Yuan Jia, Jing He
Low-dose IL-2 (Ld-IL2) has shown favorable therapeutic effects in systemic lupus erythematosus (SLE) therapy. However, previous clinical trials reported an SLE Responder Index-4 (SRI-4) response rate of 65.52%-68%, with approximately half failing to achieve the primary endpoint by week 24. Our study aims to determine the real-world use of Ld-IL2 and to identify determinants of its effectiveness in
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Cardiovascular health metrics and all-cause mortality in osteoarthritis, inflammatory arthritis, and unclassified arthritis patients: a national prospective cohort study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-16 Yu Zhu, Yang-Zhen Wang, Yi-tian Chen, Jie Guo, Zhen-Zhong Wang
Arthritis notably elevates mortality risk. It remains unclear whether the cardiovascular health (CVH) metrics improves the risk of all-cause mortality in patients with all types of arthritis. This study data from the National Health and Nutrition Examination Survey to probe the link between CVH and all-cause mortality among arthritis sufferers in the United States. CVH evaluation employed the Life's
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Methotrexate promotes the release of granulocyte–macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine interleukin-1 signaling Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-11 Beatrice Bergström, Tilia Selldén, Miriam Bollmann, Mattias N. D. Svensson, Anna-Karin Hultgård Ekwall
Activated fibroblast-like synoviocytes (FLS) are drivers of synovitis and structural joint damage in rheumatoid arthritis (RA). Despite the use of disease-modifying drugs, only about 50% of RA patients reach remission in real-world settings. We used an unbiased approach to investigate the effects of standard-of-care methotrexate (MTX) and a Janus kinase inhibitor, tofacitinib (TOFA), on gene expression
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Correction: Depressive symptoms are associated with fatigue, poorer functional status and less engagement in sports in axSpA and PsA: an analysis from the RABBIT-SpA cohort Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-11 Andreas Reich, Anja Weiß, Lisa Lindner, Xenofon Baraliakos, Denis Poddubnyy, Silke Zinke, Carsten Stille, Anja Strangfeld, Anne C. Regierer
Correction: Arthritis Res Ther 25, 136 (2023) https://doi.org/10.1186/s13075-023-03127-2. Following publication of the original article [1], the authors reported an error under the Abstract, Result sub-section. The sentence currently reads: In both diagnoses, the proportion of patients with moderate depressive symptoms was 8% and 21% with severe symptoms. The sentence should read: In both diagnoses
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Changes and associations between synovial fluid and magnetic resonance imaging markers of osteoarthritis after high tibial osteotomy Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-10 Jenna M. Schulz, Trevor B. Birmingham, Holly T. Philpott, C. Thomas Appleton, Hayden F. Atkinson, J. Robert Giffin, Frank Beier
Mechanobiological mechanisms of osteoarthritis (OA) are unclear. Our objectives were to explore: 1) changes in knee joint physiology using a large panel of synovial fluid biomarkers from before to one year after high tibial osteotomy (HTO) surgery, and 2) the association of changes in the synovial fluid biomarkers with the changes in MRI measures of knee effusion-synovitis and articular cartilage composition
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Contribution of inflammation markers and quantitative sensory testing (QST) indices of central sensitisation to rheumatoid arthritis pain Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-08 Vasileios Georgopoulos, Stephanie Smith, Daniel F. McWilliams, Eamonn Ferguson, Richard Wakefield, Dorothy Platts, Susanne Ledbury, Deborah Wilson, David A. Walsh
Pain, the primary complaint in rheumatoid arthritis (RA), is multifaceted, and may be driven by inflammatory disease activity and central sensitisation. We aimed to ascertain what proportion of RA pain severity is explained by markers of inflammation and quantitative sensory testing (QST) indices of central sensitisation. This was a cross-sectional analysis of data from individuals with clinically
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Incidence rate of recurrent cardiovascular events in patients with radiographic axial spondyloarthritis and the effect of tumor necrosis factor inhibitors Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-10-04 Oh Chan Kwon, Hye Sun Lee, So Young Jeon, Min-Chan Park
Patients with radiographic axial spondyloarthritis (r-axSpA) are at increased risk of incident cardiovascular events. Tumor necrosis factor inhibitors (TNFi) have shown a protective effect against incident cardiovacular events. However, the incidence of recurrent cardiovascular events in patients with r-axSpA with a history of cardiovascular events, and the effect of TNFi on recurrent cardiovascular
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Low dose methotrexate impaired T cell transmigration through down-regulating CXCR4 expression in rheumatoid arthritis (RA) Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-30 Lei Ding, Daniel H. Park, Bo Gao, Lingyuan Wu, Meizhang Li, Haitham Abedelhakim, Ming Zhang
CXC chemokine CXCL12 is involved in the pathological development of rheumatoid arthritis (RA) through abnormal migration of peripheral immune cells in the joint. Although low dose methotrexate (MTX) is clinically used to treat RA patients, CXCL12 signaling responses to MTX-mediated treatments is still not well understood. In this study, we examined the expression of CXCR4 (cognatic receptor for CXCL12)
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Four-year effectiveness, safety and drug retention rate of secukinumab in psoriatic arthritis: a real-life Italian multicenter cohort Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-28 Roberta Ramonda, Mariagrazia Lorenzin, Maria Sole Chimenti, Fabiola Atzeni, Angelo Semeraro, Salvatore D’Angelo, Carlo Selmi, Augusta Ortolan, Antonio Marchesoni, Maria Manara, Michele Maria Luchetti Gentiloni, Leonardo Santo, Carlo Salvarani, Alberto Cauli, Maurizio Rossini, Giorgio Amato, Giacomo Cozzi, Laura Scagnellato, Mario Ferraioli, Antonio Carriero, Elena Fracassi, Francesco Giorgio, Andrea
to evaluate over a 48-month follow-up period the: 1) long-term effectiveness and safety; 2) drug retention rate (DRR); 3) impact of comorbidities and bDMARDs line on MDA and DAPSA remission/low disease activity (LDA) of secukinumab in a multicenter Italian cohort of PsA patients. Consecutive PsA patients receiving secukinumab were followed prospectively in Italian centers between 2016 and 2023. Disease
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Diminished expression of the ubiquitin-proteasome system in early treatment-naïve patients with rheumatoid arthritis and concomitant type 2 diabetes may be linked to IL-1 pathway hyper-activity; results from PEAC cohort Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-28 Piero Ruscitti, Damiano Currado, Felice Rivellese, Marta Vomero, Luca Navarini, Paola Cipriani, Costantino Pitzalis, Roberto Giacomelli
Based on the recent evidence of IL-1 inhibition in patients with rheumatoid arthritis (RA) and concomitant type 2 diabetes (T2D), we evaluated the synovial tissue expression of IL-1 related genes in relationship to the ubiquitin–proteasome system and the effects of insulin on ubiquitinated proteins in fibroblast-like synoviocytes (FLSs). The synovial expression of IL-1 pathway genes was compared in
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Novel endothelial progenitor cells populations as biomarkers of damage and remission in systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-28 Carlos Rafael-Vidal, Sara Martínez-Ramos, Beatriz Malvar-Fernández, Irene Altabás-González, Coral Mouriño, Pablo Pazos-López, Arturo Fraga-Bau, José María Pego Reigosa, Samuel García
Endothelial progenitor cells (EPCs) are essential for maintenance of vascular homeostasis and stability, key processes in the pathogenesis of systemic lupus erythematosus (SLE). However, the role and phenotypic characterization of EPCs populations in SLE have not been completely elucidated. To identify EPCs specific subpopulations in patients with SLE using a novel flow cytometry tool. Peripheral blood
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Patients’ recollection about the onset of Sjögren’s disease – a mixed methods study on the patients’ perspective Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-28 Angelika Lackner, Barbara Dreo, Josef Hermann, Sabine Zenz, Johannes Fessler, Jens Thiel, Martin Helmut Stradner
Little is known about the symptoms at the onset of Sjögren’s Disease (SjD) and it is unclear whether SjD starts with characteristic symptoms that could be differentiated from dryness of other origin (sicca syndrome). The aim of this study was to investigate patients’ recollection of initial events and first symptoms of SjD. The second aim was to verify and quantify these aspects in a representative
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Effects of chronic ankle instability after grade I ankle sprain on the post-traumatic osteoarthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-28 Yan Du, Shuo Wang, Fanlei Yang, Hao Xu, Yu Cheng, Jia Yu
Untreated acute ankle sprains often result in chronic ankle instability (CAI) and can ultimately lead to the development of post-traumatic osteoarthritis (PTOA). At present, a typical animal model of ankle instability in mice is established by transecting the ligaments around the ankle joint. This study aimed to establish a grade I acute ankle sprain animal model by rapid stretching of peri-ankle joint
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Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-28 Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly
Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells has not been undertaken. The aim of this study was to isolate and characterise sEV from OA SF and to look at their ability to regulate OA chondrocyte effector responses relevant
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Serum syndecan1 has the potential to reflect activity at diagnosis and predict death during follow-up in patients with ANCA-associated vasculitis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-20 Taejun Yoon, Jang Woo Ha, Jung Yoon Pyo, Eunhee Ko, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
This study investigated whether serum syndecan1 at diagnosis reflects activity at diagnosis and predicts poor outcomes during follow-up in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). The study included 79 patients with AAV from the cohort of Korean patients diagnosed with AAV. AAV-specific indices, including the Birmingham vasculitis activity score (BVAS),
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Increased predictive value of optical spectral transmission in early rheumatoid arthritis through use of patient-adjusted cut-off scores Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-20 Konstantinos Triantafyllias, Khalid K. Altamimi, Florian Schederecker, Andreas Schwarting
The aims of this study were to suggest patient-adjusted optical spectral transmission (OST) cut-off values for the first time and to develop clinical models that predict the probability of an early rheumatoid arthritis (RA) diagnosis based on OST findings and the 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria as a reference standard. OST
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A versatile role for lung ultrasound in systemic autoimmune rheumatic diseases related pulmonary involvement: a narrative review Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-18 Yukai Wang, Shaoqi Chen, Shaoyu Zheng, Zexuan Zhou, Weijin Zhang, Guangzhou Du, Angelina Mikish, Barbara Ruaro, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Luna Gargani, Marco Matucci-Cerinic, Daniel E Furst
Systemic autoimmune rheumatic diseases (SARDs) related pulmonary disease is highly prevalent, with variable clinical presentation and behavior, and thus is associated with poor outcomes and negatively impacts quality of life. Chest high resolution computed tomography (HRCT) is still considered a fundamental imaging tool in the screening, diagnosis, and follow-up of pulmonary disease in patients with
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Use of belimumab in treating patients with systemic lupus erythematosus: a single-center, real-world retrospective study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-18 Zhaohui Su, Chunyi Zhang, Congcong Gao, Chaoying Li, Ruxv Li, Zhaohui Zheng
To investigate the efficacy and safety of belimumab in the treatment of systemic lupus erythematosus (SLE) in a real-world setting and provide a valuable reference for clinical treatment. In this retrospective study, 101 patients with SLE who came to our hospital from March 2020 to September 2022, 56 of whom with lupus nephritis (LN), were selected. All patients received belimumab in combination with
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Pain catastrophizing negatively impacts drug retention rate in patients with Psoriatic Arthritis and axial Spondyloarthritis: results from a 2-years perspective multicenter GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica) study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-18 Damiano Currado, Francesca Saracino, Piero Ruscitti, Annalisa Marino, Ilenia Pantano, Marta Vomero, Onorina Berardicurti, Viktoriya Pavlych, Claudio Di Vico, Francesco Caso, Luisa Costa, Marco Tasso, Federica Camarda, Francesca Misceo, Francesco De Vincenzo, Addolorata Corrado, Luisa Arcarese, Amelia Rigon, Marta Vadacca, Erika Corberi, Lyubomyra Kun, Francesca Trunfio, Andrea Pilato, Ludovica Lamberti
Chronic pain and inflammation are common features of rheumatic conditions such as Psoriatic Arthritis (PsA) and Axial Spondyloarthritis (axSpA), often needing prolonged medication treatment for effective management. Maintaining drug retention is essential for both achieving disease control and improving patients' quality of life. This study investigates the influence of pain catastrophizing, a psychological
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Truth unveiled by time and the marbled definition of D2T-RA: retrospective analysis on the persistence of the difficult-to-treat status among refractory RA patients Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-17 Gilberto Cincinelli, Gabriella Maioli, Cristina Posio, Ennio Giulio Favalli, Francesca Ingegnoli, Roberto Caporali
The current EULAR definition of difficult-to-treat rheumatoid arthritis (D2T-RA) identifies patients with active disease refractory to multiple treatments at a single time point, without considering the persistence of this condition over time. The study aimed to assess difficult-to-treat rheumatoid arthritis (D2T-RA) over 12 months, considering persistence over time rather than a single time point
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Prevalence of cardiovascular events in a population-based registry of patients with systemic lupus erythematosus Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-14 Daniel P. Joyce, Jeffrey S. Berger, Allison Guttmann, Ghadeer Hasan, Jill P. Buyon, H. Michael Belmont, Jane Salmon, Anca Askanase, Joan Bathon, Laura Geraldino-Pardilla, Yousaf Ali, Ellen M. Ginzler, Chaim Putterman, Caroline Gordon, Charles G. Helmick, Kamil E. Barbour, Heather T. Gold, Hilary Parton, Peter M. Izmirly
The Manhattan Lupus Surveillance Program (MLSP), a population-based retrospective registry of patients with systemic lupus erythematosus (SLE), was used to investigate the prevalence of cardiovascular disease events (CVE) and compare rates among sex, age and race/ethnicity to population-based controls. Patients with prevalent SLE in 2007 aged ≥ 20 years in the MLSP were included. CVE required documentation
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Activation of circulating TFH17 cells associated with activated naive and double negative 2 B cell expansion, and disease activity in systemic lupus erythematosus patients Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-11 Tipanan Khunsri, Pongsakorn Thawornpan, Pachara Tianpothong, Thanitta Suangtamai, Pintip Ngamjanyaporn, Chaniya Leepiyasakulchai, Kittikorn Wangriatisak, Prapaporn Pisitkun, Patchanee Chootong
Systemic lupus erythematosus (SLE) is the quintessential autoimmune disease, as it is characterized by hyperactivity of CD4+ T cells and subsequently drives lupus pathology. Follicular helper T (TFH) cells play an important role in B cell maturation and antibody production. However, which specific subset of cTFH cells drives B cell function and contributes to the development of anti-dsDNA antibodies
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Association of anti-HMGCR antibodies of the IgM isotype with refractory immune-mediated necrotizing myopathy Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-11 Hongxia Yang, Chao Sun, Lifang Ye, Yuetong Xu, Sang Lin, Qinglin Peng, Guochun Wang, Xin Lu
Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies are one of the myositis-specific antibodies which is associated with immune-mediated necrotizing myopathy (IMNM). However, the relationship between anti-HMGCR isotypes and prognosis has not yet been fully investigated. This study was conducted to gain insight into the association between anti-HMGCR isotypes and clinical, and
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A phase 3, randomized, double-blind, active-controlled clinical trial to compare BAT1806/BIIB800, a tocilizumab biosimilar, with tocilizumab reference product in participants with moderate-to-severe rheumatoid arthritis with inadequate response to methotrexate: treatment period 2 analysis (week 24 to week 48) Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-07 Xiaomei Leng, Piotr Leszczyński, Slawomir Jeka, Shengyun Liu, Huaxiang Liu, Malgorzata Miakisz, Jieruo Gu, Lali Kilasonia, Mykola Stanislavchuk, Xiaolei Yang, Yinbo Zhou, Qingfeng Dong, Marian Mitroiu, Janet Addison, Mourad F. Rezk, Xiaofeng Zeng
Equivalent efficacy and comparable pharmacokinetic, immunogenicity, and safety profiles of the biosimilar BAT1806/BIIB800 and reference tocilizumab (TCZ) in participants with moderate-to-severe rheumatoid arthritis (RA) have been reported up to week 24 (treatment period [TP] 1) of the phase 3 study. Here we present results for TP2 (study weeks 24–48). In this phase 3, multicenter, multiregional, double-blind
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Factors related to elevated serum immunoglobulin G4 (IgG4) levels in a Japanese general population Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-06 Shunsuke Tsuge, Hiroshi Fujii, Mami Tamai, Hiromasa Tsujiguchi, Misaki Yoshida, Nobuhiro Suzuki, Yoshinori Takahashi, Akari Takeji, Shigeto Horita, Yuhei Fujisawa, Takahiro Matsunaga, Takeshi Zoshima, Ryo Nishioka, Hiromi Nuka, Satoshi Hara, Yukiko Tani, Yasunori Suzuki, Kiyoaki Ito, Kazunori Yamada, Satoshi Nakazaki, Akinori Hara, Atsushi Kawakami, Hiroyuki Nakamura, Ichiro Mizushima, Yasunori Iwata
Elevated serum immunoglobulin G4 (IgG4) concentrations are one of the characteristic findings in IgG4-related disease (IgG4-RD). This study investigated the frequency of elevated serum IgG4 levels and associated factors in a general Japanese population. Serum IgG4 concentrations were measured in 1,201 residents of Ishikawa prefecture who underwent general medical examinations. Factors associated with
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A Bayesian model to analyse the association of comorbidities with biosimilar treatment retention in a non-medical switch scenario in patients with inflammatory rheumatic musculoskeletal diseases Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-09-04 Imke Redeker, Stefan Moustakis, Styliani Tsiami, Xenofon Baraliakos, David Kiefer, Ioana Andreica, Björn Buehring, Jürgen Braun, Uta Kiltz
To analyse clinical outcomes of a non-medical switch from originator adalimumab (ADA) to its ABP501 biosimilar (ABP) over 6 months in patients with inflammatory rheumatic musculoskeletal diseases (RMD) in relation to comorbidity as a risk factor for therapy discontinuation. RMD patients switching from originator ADA to ABP were identified from a large routine database from October 2018 onwards. Documented
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Correction: S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-31 Hermine I Brunner, Grant S Schulert, Alyssa Sproles, Sherry Thornton, Gabriel Vega Cornejo, Jordi Antón, Ruben Cuttica, Michael Henrickson, Ivan Foeldvari, Daniel J Kingsbury, Margarita Askelson, Jinqi Liu, Sumanta Mukherjee, Robert L Wong, Daniel J Lovell, Alberto Martini, Nicolino Ruperto, Alexei A Grom
Correction: Arthritis Res Ther 26, 125 (2024) https://doi.org/10.1186/s13075-024-03347-0 Following publication of the original article [1], the authors reported an error to Supplementary Material 2. Supplementary Material 2 was removed as the file was only for the reviewers’ reference and not meant to be published. The original article [1] has been updated. Brunner HI, Schulert GS, Sproles A, et al
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Machine learning prediction and explanatory models of serious infections in patients with rheumatoid arthritis treated with tofacitinib Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-27 Merete Lund Hetland, Anja Strangfeld, Gianluca Bonfanti, Dimitrios Soudis, J. Jasper Deuring, Roger A. Edwards
Patients with rheumatoid arthritis (RA) have an increased risk of developing serious infections (SIs) vs. individuals without RA; efforts to predict SIs in this patient group are ongoing. We assessed the ability of different machine learning modeling approaches to predict SIs using baseline data from the tofacitinib RA clinical trials program. This analysis included data from 19 clinical trials (phase
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Association of anti-Ro-52 antibodies with occurrence of interstitial lung disease in patients with idiopathic inflammatory myopathy Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-22 Chia-Tse Weng, Tang-Hsiu Huang, Chun-Hsin Wu, Yuan-Ting Sun
Anti-Ro-52 antibodies have been associated with interstitial lung disease (ILD) in various autoimmune diseases. However, their role in ILD among patients with idiopathic inflammatory myopathies (IIMs) is relatively underexplored. This study aimed to investigate the association between anti-Ro-52 antibodies and the occurrence of ILD in individuals with IIMs. This retrospective observational study included
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Analysis of risk factors and development of a nomogram prediction model for renal tubular acidosis in primary Sjogren syndrome patients Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-22 Yanzhen Zeng, Runzhi Liu, Shuyi Li, Jingwen Wei, Fei Luo, Yongkang Chen, Dongmei Zhou
To investigate the risk factors of renal tubular acidosis (RTA) in patients with primary Sjögren’s syndrome (pSS) and create a personalized nomogram for predicting pSS-RTA patients. Data from 99 pSS patients who underwent inpatient treatment at our hospital from January 2012 to January 2024 were retrospectively collected and analyzed. Bootstrap resampling technique, single-factor, and multi-factor
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Inclusion of fibrinoid necrosis increases the accuracy of synovial tissue assessment in predicting response to methotrexate: analysis of the UCLouvain Brussels ERA Cohort Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-19 Francesco Natalucci, Clément Triaille, Cécile Van Mullem, Tatiana Sokolova, Emilie Sapart, Laurent Meric de Bellefon, Adrien Nzeusseu, Christine Galant, Bernard Lauwerys, Patrick Durez
Rheumatoid Arthritis (RA) often exhibits suboptimal treatment response despite early diagnosis and treatment. This study aimed to analyze Early Rheumatoid Arthritis (ERA) synovial biopsies through histology and immunohistochemistry (IHC) to identify predictive factors for treatment response to Methotrexate (MTX). 140 ERA patients from the UCLouvain Arthritis Cohort underwent synovial biopsy and were
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Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-07 Dongyao Yan, Di Chen, Simon M Cool, Andre J van Wijnen, Katalin Mikecz, Gillian Murphy, Hee-Jeong Im
Retraction Note: Arthritis Res Ther 13, R130 (2011) https://doi.org/10.1186/ar3441 The Editors-in-Chief have retracted this article because an investigation jointly conducted by Rush University and the Jesse Brown Veterans Affairs Medical Center (JBVAMC) has determined that Fig. 5B contains fabricated and/or falsified data. Gillian Murphy agrees with this retraction. Simon M. Cool, Andre J. van Wijnen
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The mode of action of IL-23 in experimental inflammatory arthritic pain and disease Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-06 Kevin M.-C. Lee, Tanya Lupancu, Leon Chang, Carl L. Manthey, Martha Zeeman, Anne M. Fourie, John A. Hamilton
We have previously reported using gene-deficient mice that the interleukin (IL)-23p19 subunit is required for the development of innate immune-driven arthritic pain and disease. We aimed to explore here, using a number of in vivo approaches, how the IL-23p19 subunit can mechanistically control arthritic pain and disease in a T- and B- lymphocyte-independent manner. We used the zymosan-induced arthritis
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Significant overlap of inflammatory and degenerative features on imaging among patients with degenerative disc disease, diffuse idiopathic skeletal hyperostosis and axial spondyloarthritis: a real-life cohort study Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-08-03 Nelly Ziade, Melanie Udod, Nikolaos Kougkas, Styliani Tsiami, Xenofon Baraliakos
Differentiating between degenerative disc disease (DDD), diffuse idiopathic skeletal hyperostosis (DISH), and axial spondyloarthritis (axSpA) represents a diagnostic challenge in patients with low back pain (LBP). We aimed to evaluate the distribution of inflammatory and degenerative imaging features in a real-life cohort of LBP patients referred to a tertiary university rheumatology center. In a retrospective
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IL-40 is up-regulated in the synovial fluid and cartilage of osteoarthritis patients and contributes to the alteration of chondrocytes phenotype in vitro Arthritis Res. Ther. (IF 4.4) Pub Date : 2024-07-30 L. Andrés Cerezo, A. Navrátilová, M. Kuklová, A. Prokopcová, J. Baloun, T. Kropáčková, D. Veigl, S. Popelka, P. Fulín, R. Ballay, K. Pavelka, J. Vencovský, L. Šenolt
IL-40 is a novel cytokine associated with autoimmune connective tissue disorders such as rheumatoid arthritis (RA) or Sjögren syndrome. We have previously shown an accumulation of IL-40 in the RA joint and its expression by immune cells and fibroblasts. Therefore, we aimed to assess the role of IL-40 in association with hyaline cartilage and chondrocyte activity. Immunohistochemistry was employed to