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Effect of a spatial repellent on malaria incidence in an area of western Kenya characterised by high malaria transmission, insecticide resistance, and universal coverage of insecticide treated nets (part of the AEGIS Consortium): a cluster-randomised, controlled trial Lancet (IF 98.4) Pub Date : 2024-12-19 Eric O Ochomo, John E Gimnig, Quentin Awori, Bernard Abong'o, Prisca Oria, Nickline K Ashitiba, Brian Polo, Vincent Moshi, Hilda Otanga, Ferdinard Adung'o, Eunice A Ouma, Susan Outa, Edith Ramaita, Rebecca Levine, Wycliffe Odongo, Steven A Harvey, April Monroe, Ashley Hudson, Bradley Sandberg, Jared Hendrickson, John P Grieco
BackgroundSpatial repellent products are used for prevention of insect bites, and a body of evidence exists on spatial repellent entomological efficacy. A new option for vector control, spatial repellent products are designed to release active ingredient into the air for disruption of human–vector contact thereby reducing human exposure to mosquito-borne pathogens. Clinical trials have shown spatial
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Pandemic financing should learn from revolving funds Lancet (IF 98.4) Pub Date : 2024-12-19 Hampus Holmer, Simon Reid-Henry, Irene A Agyepong, Francisco F Songane, David L Heymann
No Abstract
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Beyond repellents: spatial emanators for the control of malaria in Africa Lancet (IF 98.4) Pub Date : 2024-12-19 Johnson Kyeba Swai, Sarah Jane Moore
No Abstract
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Declaration of martial law in South Korea: a threat to democracy Lancet (IF 98.4) Pub Date : 2024-12-19 Seong-Uk Baek
No Abstract
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Winner of the 2024 Wakley Prize Essay: a deeper kind of caring Lancet (IF 98.4) Pub Date : 2024-12-19 Joanna Palmer, Jessamy Bagenal, Beth Francis, Gabriella Merry, Sara Phillips, Paula Preyzner, Maneet Virdi, Chloe Wilson, Chris Wortley
No Abstract
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Highlights 2024: diverse insights and perspectives on health stories Lancet (IF 98.4) Pub Date : 2024-12-19 Joanna Palmer
No Abstract
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Another claw hand in a Renaissance portrait Lancet (IF 98.4) Pub Date : 2024-12-19 Alexis Demas
No Abstract
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Top ten menopause research priorities Lancet (IF 98.4) Pub Date : 2024-12-19 Zachary Nash, Monica Christmas, Toto Gronlund, Martha Hickey
No Abstract
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End non-consensual surgeries on intersex children in Serbia Lancet (IF 98.4) Pub Date : 2024-12-19 Valentina Opancina, Y Tony Yang
No Abstract
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From bad to worse: the unbreathable air of Lahore Lancet (IF 98.4) Pub Date : 2024-12-19 Sikandar Khan
No Abstract
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HIV and alcohol misuse among miners in Zimbabwe Lancet (IF 98.4) Pub Date : 2024-12-19 Moira Majaha, Chido Dziva Chikwari, Samuel Kizito, Dingani Moyo, Fred Ssewamala
No Abstract
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Combined liver–kidney transplantation: 40 years of saving lives Lancet (IF 98.4) Pub Date : 2024-12-19 Xuyong Sun, Xiaocong Kuang, Ning Wen, Zhiying Lei, Liugen Lan, Jihua Wu, Ke Mo, Xing Niu
No Abstract
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Xenotransplantation: the future is closer than we think Lancet (IF 98.4) Pub Date : 2024-12-19 Pedro Antonio Cascales Campos, Pablo Ramirez
No Abstract
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Physician associates, competence expansion, and general practitioner burnout Lancet (IF 98.4) Pub Date : 2024-12-19 Richard Armitage
No Abstract
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Concerns about the role of physician associates in UK clinical practice Lancet (IF 98.4) Pub Date : 2024-12-19 Ian Kunkler
No Abstract
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Physician associates and patient safety Lancet (IF 98.4) Pub Date : 2024-12-19 Matt Kneale, Helen Fernandes
No Abstract
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The role of physican associates under Labour reforms Lancet (IF 98.4) Pub Date : 2024-12-19 Hamsa Aden, Yahya Ali
No Abstract
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Department of Error Lancet (IF 98.4) Pub Date : 2024-12-19
Morris MJ, Castellano D, Herrmann K, et al. 177Lu-PSMA-617 versus a change of androgen receptor pathway inhibitor therapy for taxane-naive patients with progressive metastatic castration-resistant prostate cancer (PSMAfore): a phase 3, randomised, controlled trial. Lancet 2024; 404: 1227–39—Appendix 1 of this Article has been corrected as of December 19, 2024.
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Department of Error Lancet (IF 98.4) Pub Date : 2024-12-19
Jairath V, Acosta Felquer ML, Jaihyun Cho R. IL-23 inhibition for chronic inflammatory disease. Lancet 2024; 404: 1679–92—In this Therapeutics paper, the name IL-23A in the abstract should have been IL-23. Also, the model of TYK2 activation shown in the figure is incorrect. TYK2 activates via IL-12Rβ1, not IL-23R. These corrections were made to the online version as of December 19, 2024.
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Department of Error Lancet (IF 98.4) Pub Date : 2024-12-19
Andersen BK, Sejr-Hansen M, Maillard L, et al. Quantitative flow ratio versus fractional flow reserve for coronary revascularisation guidance (FAVOR III Europe): a multicentre, randomised, non-inferiority trial. Lancet 2024; 404: 1835–46—In this Article, author Eric Van Belle's name should have been written as E Van Belle in the affiliations section. This correction has been made to the online version
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Abscopal response in a patient with fibrolamellar hepatocellular carcinoma following radiotherapy Lancet (IF 98.4) Pub Date : 2024-12-19 Jonathan D Schoenfeld, Daphne A Haas-Kogan, Allison F O'Neill
Section snippets ContributorsDAH-K and AFO’N provided clinical care for this patient. JDS and AFO’N acquired the images. All authors wrote, reviewed, and revised the manuscript. Written consent for publication was obtained from the patient. Declaration of interestsJDS declares support paid to his institution from Merck, BMS, Regeneron, Debiopharm, Seimens, and EMD Serono; consulting or participation
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Physical findings Lancet (IF 98.4) Pub Date : 2024-12-19 Jennifer Furin
Section snippets Declaration of interestsI declare no competing interests.
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The first 100 days of the mpox response in Africa Lancet (IF 98.4) Pub Date : 2024-12-18 Nicaise Ndembi, Yap Boum, Moréniké O Foláyan
No Abstract
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The perils of RFK Junior's anti-vaccine leadership for public health Lancet (IF 98.4) Pub Date : 2024-12-18 Y Tony Yang
No Abstract
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Guselkumab in the IL-23 inhibition landscape for ulcerative colitis Lancet (IF 98.4) Pub Date : 2024-12-17 Beatriz Gros, Laura E Targownik
No Abstract
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Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies Lancet (IF 98.4) Pub Date : 2024-12-17 David T Rubin, Jessica R Allegretti, Julián Panés, Nicole Shipitofsky, Shadi S Yarandi, Kuan-Hsiang Gary Huang, Matthew Germinaro, Rebbecca Wilson, Hongyan Zhang, Jewel Johanns, Brian G Feagan, Tadakazu Hisamatsu, Gary R Lichtenstein, Brian Bressler, Laurent Peyrin-Biroulet, Bruce E Sands, Axel Dignass
BackgroundInterleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis. MethodsThe primary populations of these two phase
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Assisted dying, complex systems, and global equity in palliative care Lancet (IF 98.4) Pub Date : 2024-12-16 Libby Sallnow, Beatriz E Dorsey-Rivera, Christian Ntizimira, Nezamuddin Ahmad, Suresh Kumar
No Abstract
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Making CAR T-cell therapies more affordable Lancet (IF 98.4) Pub Date : 2024-12-13 Kathryn Senior
No Abstract
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Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis Lancet (IF 98.4) Pub Date : 2024-12-12 Huseyin Naci, Peter Murphy, Beth Woods, James Lomas, Jinru Wei, Irene Papanicolas
BackgroundHealth systems experience difficult trade-offs when paying for new drugs. In England, funding recommendations by the National Institute for Health and Care Excellence (NICE) for new drugs might generate health gains, but inevitably result in forgone health as the funds cannot be used for alternative treatments and services. We aimed to evaluate the population-health impact of NICE recommendations
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What price is society willing to pay for new drugs? Lancet (IF 98.4) Pub Date : 2024-12-12 Victoria Charlton
No Abstract
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Catching smoke: the rising and unequal burden of landscape fires on global health Lancet (IF 98.4) Pub Date : 2024-12-12 Miriam E Marlier, Tarik Benmarhnia
No Abstract
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New EU Health Commissioner appointed amid controversy Lancet (IF 98.4) Pub Date : 2024-12-12 Marianne Guenot
Section snippets A tumultuous appointment processVárhelyi's designation by von der Leyen was met by fierce opposition, mainly emerging from the Progressive Alliance of Socialists and Democrats and Renew Europe political groups. MEPs raised concerns about Hungary's approach to the COVID-19 vaccines—the only country to provide vaccines not approved by the European Medicines Agency (EMA) during the pandemic—as
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What will new assisted dying legislation mean for doctors? Lancet (IF 98.4) Pub Date : 2024-12-12 Jacqui Thornton
No Abstract
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Smog once again plagues India and Pakistan Lancet (IF 98.4) Pub Date : 2024-12-12 Talha Burki
No Abstract
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Emma Rawson-Te Patu: decolonising public health globally Lancet (IF 98.4) Pub Date : 2024-12-12 Aarathi Prasad
No Abstract
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A feminist psychiatry | Linda Gask, Out of Her Mind: How We Are Failing Women's Mental Health and What Must Change, Cambridge University Press (2024), p. 310, £20·00, ISBN: 9781009382465 Lancet (IF 98.4) Pub Date : 2024-12-12 Kate Womersley
No Abstract
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On paying attention Lancet (IF 98.4) Pub Date : 2024-12-12 Lydia S Dugdale, Daniel Marchalik
No Abstract
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Neurocysticercosis school outbreak in Belgium Lancet (IF 98.4) Pub Date : 2024-12-12 Koen Vanden Driessche, Veronique Dermauw, An-Sofie Schoonjans, Sarah Gabriël, Heidi Theeten
No Abstract
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Extended optical treatment for children with amblyopia in Europe: the EuPatch trial Lancet (IF 98.4) Pub Date : 2024-12-12 Catherine Stewart, Merrick Moseley, Alistair Fielder, Huibert Simonsz
No Abstract
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Extended optical treatment for children with amblyopia in Europe: the EuPatch trial Lancet (IF 98.4) Pub Date : 2024-12-12 Yue Li, Guangsen Liu
No Abstract
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Extended optical treatment for children with amblyopia in Europe: the EuPatch trial – Authors' reply Lancet (IF 98.4) Pub Date : 2024-12-12 Frank A Proudlock, Michael Hisaund, Eleni Papageorgiou, Ali Manouchehrinia, Irene Gottlob
No Abstract
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Sarcoidosis of the pituitary gland and stalk in a man presenting asthenia, impotence, loss of libido, polyuria, and polydipsia Lancet (IF 98.4) Pub Date : 2024-12-12 Jérémy Clément, Adeline Dubois de Mont-Marin
Section snippets ContributorsWe both cared for the patient. We both wrote, revised, and reviewed the manuscript. Written consent for publication was obtained from the patient. Declaration of interestsWe declare no competing interests. AcknowledgmentsWe would like to thank Prof Maria-Joao Santiago-Ribeiro at the University Hospital Centre of Tours for editing the 18F-fluorodeoxyglucose PET/CT scan reconstruction
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Regional action needed to halt antimalarial drug resistance in Africa Lancet (IF 98.4) Pub Date : 2024-12-12 Rosario Martinez-Vega, Deus S Ishengoma, Roly Gosling, Philip J Rosenthal, Arjen Dondorp, Karen I Barnes, Christian Nsanzabana, Abdoulaye A Djimde, Lynette I Ochola-Oyier, James Tibenderana, John Chimumbwa, Lemu Golassa, Ntuli A Kapologwe, Wilfred F Mbacham, Moses R Kamya, David A Fidock, Ryuichi Komatsu, Lorenz von Seidlein, Mehul Dhorda
No Abstract
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Endovascular therapy for ischaemic stroke due to vertebrobasilar artery occlusion Lancet (IF 98.4) Pub Date : 2024-12-12 Jan K Ho, Graeme J Hankey
No Abstract
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One term to transform: universal health coverage through professional community health workers Lancet (IF 98.4) Pub Date : 2024-12-12 Madeleine Ballard, Bernice Dahn, James O'Donovan, Ariwame Jiménez, Patrick Kawooya, Mallika Raghavan, Niloofar Ganjian, Ari D Johnson, Chisomo Boxer, Katelin Gray, Daniel Palazuelos, Christina Berry-Moorcroft, Zeus Aranda, M Matías Iberico, Laura Cordier, Dickson Mbewe, Erick Kiprotich Yegon, Josef Ernst, Lydia DiStefano, Tom Traill, Maryse Kok
No Abstract
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Endovascular therapy for acute vertebrobasilar occlusion (VERITAS): a systematic review and individual patient data meta-analysis Lancet (IF 98.4) Pub Date : 2024-12-12 Raul G Nogueira, Tudor G Jovin, Xinfeng Liu, Wei Hu, Lucianne C M Langezaal, Chuanhui Li, Qiliang Dai, Chunrong Tao, Francisco J A Mont'Alverne, Xunming Ji, Rui Liu, Rui Li, Diederik W J Dippel, Chuanjie Wu, Wusheng Zhu, Pengfei Xu, Wim H van Zwam, Longfei Wu, Chao Zhang, Patrik Michel, Wouter J Schonewille
BackgroundTrials of endovascular therapy for basilar artery occlusion, including vertebral occlusion extending into the basilar artery, have shown inconsistent results. We aimed to pool data to estimate safety and efficacy and to explore the benefit across pre-specified subgroups through individual patient data meta-analysis. MethodsVERITAS was a systematic review and meta-analysis that pooled patient-level
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Concurrent outbreaks of mpox in Africa—an update Lancet (IF 98.4) Pub Date : 2024-12-12 Camila G Beiras, Emile Malembi, Roser Escrig-Sarreta, Steve Ahuka, Placide Mbala, Hypolite M Mavoko, Lorenzo Subissi, Ana B Abecasis, Michael Marks, Oriol Mitjà
In this Review, we examine the concurrent outbreaks of mpox in Africa, focusing on clade 1a, the newly emerged clade 1b, and clade 2b lineage A, and how they differ from the 2022 global outbreak caused by clade 2b lineage B.1. Historically, clades 1a and 2a have caused sporadic, small outbreaks in central and west Africa, respectively, primarily through zoonotic transmission. Clade 2b first caused
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Re-envisioning the response to natural disasters by leveraging WHO emergency medical teams Lancet (IF 98.4) Pub Date : 2024-12-10 Attila J Hertelendy, Flavio Salio, Gregory R Ciottone
No Abstract
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Project ECHO: if we get it right, we can change the world Lancet (IF 98.4) Pub Date : 2024-12-10 Paul Adepoju
No Abstract
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The uncertainties of monitoring progress towards achieving global nutrition targets Lancet (IF 98.4) Pub Date : 2024-12-09 Anura V Kurpad, Harshpal Singh Sachdev
No Abstract
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Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021 Lancet (IF 98.4) Pub Date : 2024-12-09
BackgroundThe six global nutrition targets (GNTs) related to low birthweight, exclusive breastfeeding, child growth (ie, wasting, stunting, and overweight), and anaemia among females of reproductive age were chosen by the World Health Assembly in 2012 as key indicators of maternal and child health, but there has yet to be a comprehensive report on progress for the period 2012 to 2021. We aimed to evaluate
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Harnessing faith-based organisations for global health equity Lancet (IF 98.4) Pub Date : 2024-12-05 Aftab Ala, Morro M L Touray, Shuja Shafi, Bernadette Egan, Osman Dar, Farhan Essa, Nubia L C Flores, Ponsiano Ocama, Salim Parker, Markus Maeurer, Alimuddin Zumla
No Abstract
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How the US National Institutes of Health is confronting health threats in a changing world Lancet (IF 98.4) Pub Date : 2024-12-05 Jeanne Marrazzo, Kathleen Neuzil, Monica Bertagnolli
No Abstract
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PEPFAR's mission Lancet (IF 98.4) Pub Date : 2024-12-05 John Nkengasong, Rebecca Bunnell, Allyala Nandakumar, Ingrid Katz, Hamfrey Sanhokwe, Michael Reid
No Abstract