Triglyceride-rich lipoproteins (TRLs) play essential roles in human health and disease by transporting bulk lipids into the circulation. This review summarizes the fundamental mechanisms and diverse factors governing lipoprotein production, secretion, and regulation. Emphasizing the broader implications for human health, we outline the intricate landscape of lipoprotein research and highlight the potential coordination between the biogenesis and transport of TRLs in physiology, particularly the unexpected coupling of metabolic enzymes and transport machineries. Challenges and opportunities in lipoprotein biology with respect to inherited diseases and viral infections are also discussed. Further characterization of the biogenesis and transport of TRLs will advance both basic research in lipid biology and translational medicine for metabolic diseases.

中文翻译：

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富含甘油三酯的脂蛋白的生物合成和运输。


富含甘油三酯的脂蛋白（TRL）通过将大量脂质输送到循环系统中，在人类健康和疾病中发挥着重要作用。这篇综述总结了脂蛋白产生、分泌和调节的基本机制和多种因素。为了强调对人类健康的更广泛影响，我们概述了脂蛋白研究的复杂前景，并强调生理学中 TRL 的生物发生和运输之间的潜在协调，特别是代谢酶和运输机器的意外耦合。还讨论了脂蛋白生物学在遗传性疾病和病毒感染方面的挑战和机遇。 TRL 的生物发生和运输的进一步表征将推动脂质生物学的基础研究和代谢疾病的转化医学。