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A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells Kidney Int. (IF 14.8) Pub Date : 2024-06-18 Joseph C. Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Thitinee Vanichapol, Evan Streeter, Zainab Almuallim, Akira Oda, Takuto Chiba, Anne Silva-Barbosa, Jonathan Franks, Joshua Hislop, Alex Hill, Haojia Wu, Katherine Pfister, Sara E. Howden, Simon C. Watkins, Melissa H. Little, Benjamin D. Humphreys, Samira Kiani, Alan Watson, Donna B. Stolz, Alan J. Davidson, Tom
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A meta-analysis of randomized controlled clinical trials for implications of acute treatment effects on glomerular filtration rate for long-term kidney protection Kidney Int. (IF 14.8) Pub Date : 2024-06-18 Hiddo J.L. Heerspink, Devin Eddington, Juhi Chaudhari, Raymond Estacio, Enyu Imai, Marian Goicoechea, Thierry Hannedouche, Richard Haynes, Tazeen H. Jafar, David W. Johnson, Rob C.M. van Kruijsdijk, Julia B. Lewis, Philip K.T. Li, Brendon L. Neuen, Ronald D. Perrone, Piero Ruggenenti, Christoph Wanner, Mark Woodward, Di Xie, Tom Greene, Lesley A. Inker
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Effects of microplastics on the kidneys: a narrative review Kidney Int. (IF 14.8) Pub Date : 2024-06-18 Rodrigo Bueno de Oliveira, Lauter E. Pelepenko, Daniela A. Masaro, Glauco M.M.M. Lustosa, Mariana Cassani, Noemí A.V. Roza, Marina A. Marciano, Luciene M. dos Reis, Saïd Kamel, Loïc Louvet, Talita Mazon
Microplastics (MPs) and nanoplastics are small synthetic organic polymer particles (<5 mm and <1 μm, respectively) that originate directly from plastic compounds or result from the degradation of plastic. These particles are a global concern because they are widely distributed in water, air, food, and soil, and recent scientific evidence has linked MPs to negative biological effects. Although these
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The role of complement in kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Kidney Int. (IF 14.8) Pub Date : 2024-06-04 Marina Vivarelli, Jonathan Barratt, Laurence H. Beck Jr., Fadi Fakhouri, Daniel P. Gale, Elena Goicoechea de Jorge, Marta Mosca, Marina Noris, Matthew C. Pickering, Katalin Susztak, Joshua M. Thurman, Michael Cheung, Jennifer M. King, Michel Jadoul, Wolfgang C. Winkelmayer, Richard J.H. Smith, for Conference Participants, Federico Alberici, Luca Antonucci, Tadej Avcin, Arvind Bagga, Ingeborg M. Bajema
Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. Although complement activation plays a causal role in atypical hemolytic uremic syndrome and C3 glomerulopathy, over the past decade, a rapidly accumulating body of evidence has shown a role for complement activation in multiple other kidney diseases, including diabetic nephropathy and several
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Platelets, inflammation, and purinergic receptors in chronic kidney disease Kidney Int. (IF 14.8) Pub Date : 2024-05-29 Adam L. Corken, Vincz Ong, Rajshekhar Kore, Sai N. Ghanta, Oleg Karaduta, Rupak Pathak, Shannon Rose, Craig Porter, Nishank Jain
Platelets are anucleated cells that circulate in the bloodstream. Historically, platelets were thought to perform a singular function—stop bleeding via clotting. Although platelets do play a key role in hemostasis and thrombosis, recent studies indicate that platelets also modulate inflammation, and this platelet-induced inflammation contributes to the pathophysiology of various diseases such as atherosclerosis
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Signaling through cAMP-Epac1 induces metabolic reprogramming to protect podocytes in glomerulonephritis Kidney Int. (IF 14.8) Pub Date : 2024-05-29 Lilia Abbad, Maximin Détrait, Panagiotis Kavvadas, Dorian Bergonnier, Lisa Melis, Marion Laudette, Tiffany Migeon, Marie-Christine Verpont, Alexandre Lucas, Christos Chatziantoniou, Frank Lezoualc’h
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DNA-binding protein-A promotes kidney ischemia/reperfusion injury and participates in mitochondrial function Kidney Int. (IF 14.8) Pub Date : 2024-05-29 Charlotte Reichardt, Sabine Brandt, Anja Bernhardt, Anna Krause, Jonathan A. Lindquist, Sönke Weinert, Robert Geffers, Tobias Franz, Sascha Kahlfuss, Anne Dudeck, Akash Mathew, Rajiv Rana, Berend Isermann, Peter R. Mertens
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Evaluation of glomerular hemodynamic changes by sodium-glucose-transporter 2 inhibition in type 2 diabetic rats using in vivo imaging Kidney Int. (IF 14.8) Pub Date : 2024-05-25 Yoshihisa Wada, Kengo Kidokoro, Megumi Kondo, Atsuyuki Tokuyama, Hiroyuki Kadoya, Hajime Nagasu, Eiichiro Kanda, Tamaki Sasaki, David Z.I. Cherney, Naoki Kashihara
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Environmental pollution to kidney disease: an updated review of current knowledge and future directions Kidney Int. (IF 14.8) Pub Date : 2024-05-24 Xiang Qian Lao, Yacong Bo, Dezhong Chen, Kai Zhang, Cheuk-Chun Szeto
Environmental pollution significantly impacts global disease burden. However, the contribution of environmental pollution to kidney disease is often overlooked in nephrology. This review examines the growing body of research demonstrating the significant impacts of environmental pollutants, with a focus on air pollution as a primary factor, and acknowledges the roles of other pollutants, such as heavy
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Dietary potassium loads call on intercalated cell PIEZO1 to go with the flow Kidney Int. (IF 14.8) Pub Date : 2024-05-24 Seth L. Alper, Fouad T. Chebib
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ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging Kidney Int. (IF 14.8) Pub Date : 2024-05-24 Quan Jiang, Guiyu Song, Liying He, Xue Li, Bo Jiang, Qianxun Wang, Shaoxun Wang, Catherine Kim, Mahsa Nouri Barkestani, Roberto Lopez, Matthew Fan, Kujani Wanniarachchi, Maya Quaranta, Xuefei Tian, Arya Mani, Anjelica Gonzalez, Julie E. Goodwin, William C. Sessa, Shuta Ishibe, Dan Jane-wit
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A stepped wedge cluster randomized trial of graphical surveillance of kidney function data to reduce late presentation for kidney replacement therapy Kidney Int. (IF 14.8) Pub Date : 2024-05-24 Hugh Gallagher, Shona Methven, Anna Casula, Hugh Rayner, Erik Lenguerrand, Nicola Thomas, Anne Dawnay, David Kennedy, Lesley Woolnough, Michael Nation, Fergus J. Caskey
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Genome-wide association study of hospitalized patients and acute kidney injury Kidney Int. (IF 14.8) Pub Date : 2024-05-24 E.D. Siew, J.N. Hellwege, A.M. Hung, B.C. Birkelo, A.J. Vincz, S.K. Parr, J. Denton, R.A. Greevy, C. Robinson-Cohen, H. Liu, K. Susztak, M.E. Matheny, D.R. Velez Edwards
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Kidney macrophages keep the stones rolling Kidney Int. (IF 14.8) Pub Date : 2024-05-23 Maria B. Rodrigo, Christian Kurts
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Salvaging donated kidneys from prolonged warm ischemia during ex vivo hypothermic oxygenated perfusion Kidney Int. (IF 14.8) Pub Date : 2024-05-22 Peng Zhang, Chao Sun, Shuyong Mo, Chaoyu Hu, Yuxiang Ning, Han Liang, Zhongzhong Liu, Xiaoli Fan, Yanfeng Wang
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The glycolytic enzyme PFKFB3 drives kidney fibrosis through promoting histone lactylation-mediated NF-κB family activation Kidney Int. (IF 14.8) Pub Date : 2024-05-22 Yating Wang, Hongyu Li, Simin Jiang, Dongying Fu, Xiaohui Lu, Miaoqing Lu, Yi Li, Dan Luo, Kefei Wu, Yiping Xu, Guanglan Li, Yi Zhou, Yiming Zhou, Wei Chen, Qinghua Liu, Haiping Mao
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DNA methyltransferase 1 (DNMT1) promotes cyst growth and epigenetic age acceleration in autosomal dominant polycystic kidney disease Kidney Int. (IF 14.8) Pub Date : 2024-05-21 Julie Xia Zhou, Linda Xiaoyan Li, Hongbing Zhang, Ewud Agborbesong, Peter C. Harris, James P. Calvet, Xiaogang Li
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Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation Kidney Int. (IF 14.8) Pub Date : 2024-05-21 Shuwen Yu, Xiangchen Gu, Qimin Zheng, Yunzi Liu, Teija Suhas, Wen Du, Lin Xie, Zhengying Fang, Yafei Zhao, Mingxin Yang, Jing Xu, Yimei Wang, Meei-Hua Lin, Xiaoxia Pan, Jeffrey H. Miner, Yuanmeng Jin, Jingyuan Xie
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The innate immune cells at the heart of kidney allograft rejection Kidney Int. (IF 14.8) Pub Date : 2024-05-14 Griffith B. Perkins, James D. Zuiani, P. Toby Coates
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Variant upon variant: kidney-disease risk associated with APOL1 G2 genetic variants is abrogated by the APOL1 p.N264K variant Kidney Int. (IF 14.8) Pub Date : 2024-05-14 Sethu M. Madhavan, Johannes S. Schlöndorff
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Corrigendum to “Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Management of ANCA–Associated Vasculitis.” Kidney International 2024;105(3):447–449 Kidney Int. (IF 14.8) Pub Date : 2024-05-13 Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Ethan M. Balk, Craig E. Gordon, Gaelen Adam, Marcello A. Tonelli, Michael Cheung, Amy Earley, Brad H. Rovin
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Corrigendum to “KDIGO 2024 Clinical Practice Guideline for the Management of Antineutrophil Cytoplasmic Antibody (ANCA)–Associated Vasculitis.” Kidney International 2024;105(3S):S71–S116 Kidney Int. (IF 14.8) Pub Date : 2024-05-13 Kidney Disease: Improving Global Outcomes (KDIGO) ANCA Vasculitis Work Group, Jürgen Floege, David R.W. Jayne, Jan-Stephan F. Sanders, Vladimír Tesar, Brad H. Rovin
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Monoclonal immunoglobulin crystalline nephropathies Kidney Int. (IF 14.8) Pub Date : 2024-05-07 Samih H. Nasr, Christophe Sirac, Nelson Leung, Frank Bridoux
Monoclonal Ig crystalline nephropathies are rare lesions resulting from precipitation of monoclonal Igs in the kidney as crystalline inclusions. They can be categorized into lesions with predominant intracellular crystals (light chain [LC] proximal tubulopathy, LC crystal-storing histiocytosis, and LC crystalline podocytopathy) and lesions with predominant extracellular crystals (crystalglobulin-induced
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Frailty in patients on dialysis Kidney Int. (IF 14.8) Pub Date : 2024-05-03 Gordon Chun-Kau Chan, Kamyar Kalantar-Zadeh, Jack Kit-Chung Ng, Na Tian, Aine Burns, Kai-Ming Chow, Cheuk-Chun Szeto, Philip Kam-Tao Li
Frailty is a condition that is frequently observed among patients undergoing dialysis. Frailty is characterized by a decline in both physiological state and cognitive state, leading to a combination of symptoms, such as weight loss, exhaustion, low physical activity level, weakness, and slow walking speed. Frail patients not only experience a poor quality of life, but also are at higher risk of hospitalization
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Long-term impact of immediate versus deferred antiretroviral therapy on kidney health in people with HIV Kidney Int. (IF 14.8) Pub Date : 2024-05-01 Annegret Pelchen-Matthews, Amanda Mocroft, Lene Ryom, Michael J. Ross, Shweta Sharma, Steven Coca, Amit Achhra, Elaine Cornell, Russell Tracy, Andrew Phillips, Marta Montero Alonso, Giota Toulomi, Brian K. Agan, Nicholas Medland, Christina M. Wyatt, INSIGHT START Study Group
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Podocyte-derived soluble RARRES1 drives kidney disease progression through direct podocyte and proximal tubular injury Kidney Int. (IF 14.8) Pub Date : 2024-04-30 Ye Feng, Zeguo Sun, Jia Fu, Fang Zhong, Weijia Zhang, Chengguo Wei, Anqun Chen, Bi-Cheng Liu, John C. He, Kyung Lee
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Assessment of biological organ age using molecular pathology in pre-transplant kidney biopsies Kidney Int. (IF 14.8) Pub Date : 2024-04-29 Roy Zhang, Patrick B. Trotter, James McCaffrey, Rory Fitzroy, Giorgio Trivioli, Benjamin J. Stewart, John R. Ferdinand, Kevin W. Loudon, Alexandra Riding, Jonathan West, Ashley Ferro, Menna R. Clatworthy
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High-dimensional mass cytometry identified circulating natural killer T-cell subsets associated with protection from cytomegalovirus infection in kidney transplant recipients Kidney Int. (IF 14.8) Pub Date : 2024-04-27 Laura Donadeu, Thomas Jouve, Sofia Bin, Susan Hartzell, Elena Crespo, Alba Torija, Marta Jarque, Delphine Kevella, José Zúñiga, Weijia Zhang, Zeguo Sun, Alberto Verlato, Mónica Martínez-Gallo, Cristina Font-Miñarro, Maria Meneghini, Nestor Toapanta, Irina B. Torres, Joana Sellarés, Manel Perelló, Hannah Kaminski, Lionel Couzi, Alexandre Loupy, Gaetano La Manna, Francesc Moreso, Paolo Cravedi, Oriol
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A cohort study of sodium-glucose cotransporter-2 inhibitors after acute kidney injury among Veterans with diabetic kidney disease Kidney Int. (IF 14.8) Pub Date : 2024-04-27 Daniel P. Murphy, Julian Wolfson, Scott Reule, Kirsten L. Johansen, Areef Ishani, Paul E. Drawz
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Seeing through the density of dense deposit disease Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Charles E. Alpers
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The Ottawa Statement implementation guidance document for cluster randomized trials in the hemodialysis setting Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Cory E. Goldstein, Monica Taljaard, Stuart G. Nicholls, Mary Beaucage, Jamie Brehaut, Charles L. Cook, Brenden B. Cote, Jonathan C. Craig, Stephanie N. Dixon, Jessica Du Toit, Catherine C.S. Du Val, Amit X. Garg, Jeremy M. Grimshaw, Shasikara Kalatharan, Scott Y.H. Kim, Austin Kinsella, Valerie Luyckx, Charles Weijer
Research teams are increasingly interested in using cluster randomized trial (CRT) designs to generate practice-guiding evidence for in-center maintenance hemodialysis. However, CRTs raise complex ethical issues. The , published in 2012, provides 15 recommendations to address ethical issues arising within 7 domains: justifying the CRT design, research ethics committee review, identifying research participants
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A pig kidney supporting human physiology Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Stuart J. Knechtle, Joseph M. Ladowski, Jean Kwun
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WIP1 inhibition as a new therapeutic strategy for collapsing glomerulopathy Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Shreeram Akilesh
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Targeting immune cell glutamyl-prolyl-transfer RNA synthetase 1 (EPRS1) to prevent fibrosis after tubulointerstitial nephritis Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Shishir Kumar Patel, Hamid Rabb
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Hereditary hypophosphatemic rickets with hypercalciuria (HHRH), a complex disorder in need of precision medicine Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Thorsten Schinke, Ralf Oheim
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Levamisole in childhood idiopathic nephrotic syndrome: new promises, and advocacy for global access Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Eugene Yu-hin Chan, Olivia Boyer
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Deciphering interleukin 37's therapeutic potential: insights into alleviating inflammation in autosomal dominant polycystic kidney disease Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Cheng Xue, Chenchen Zhou, Lijun Sun, Liming Zhang, Zhiguo Mao
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Endogenous adenine as a key player in diabetic kidney disease progression: an integrated multiomics approach Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Yu Ah Hong, Masaomi Nangaku
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B-cell lymphoma with intracellular crystals: a mimic of crystal-storing histiocytosis Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Michael G. Daniel, Craig R. Soderquist, Satoru Kudose
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Calprotectin, a misnomer for another player in vascular calcification Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Tilman B. Drueke, Ziad A. Massy
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The Case | Acute kidney injury in a patient with systemic necrotizing lesions Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Sébastien Kissling, Samuel Rotman, Fadi Fakhouri
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Bacillus Calmette-Guérin–induced kidney granulomas Kidney Int. (IF 14.8) Pub Date : 2024-04-18 Xueyan Zhang, Huixiu Lian, Xiaolei Song, Jun Li
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The key role of altered tubule cell lipid metabolism in kidney disease development Kidney Int. (IF 14.8) Pub Date : 2024-04-16 Lauren E. Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent
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NELL-1–associated membranous nephropathy linked to skin fairness cream use: insights from an Indian case series Kidney Int. (IF 14.8) Pub Date : 2024-04-12 Ranjit Narayanan, Sajeesh Sivadas, Anila Abraham Kurien
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Unexpected metabolic effects of sodium-glucose cotransporter 2 inhibitors Kidney Int. (IF 14.8) Pub Date : 2024-04-10 Tilman B. Drueke, Ziad A. Massy
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Deciphering missense coding variants with AlphaMissense Kidney Int. (IF 14.8) Pub Date : 2024-04-10 Zhicheng Pan, Chandra L. Theesfeld
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Implementation science: a tool to narrow know-do gap and widen equity in kidney diseases and transplantation Kidney Int. (IF 14.8) Pub Date : 2024-04-06 Ekamol Tantisattamo
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The authors reply Kidney Int. (IF 14.8) Pub Date : 2024-04-06 Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, writing team and the World Kidney Day Joint Steering Committee
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Bridging the knowledge–practice gap in kidney care: insights from a medical student in Thailand Kidney Int. (IF 14.8) Pub Date : 2024-04-06 Abhishet Varama
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The authors reply Kidney Int. (IF 14.8) Pub Date : 2024-04-06 Winston W.S. Fung, Valerie A. Luyckx, Katherine R. Tuttle, World Kidney Day Joint Steering Committee, Alessandro Balducci, Vassilios Liakopoulos, Li-Li Hsiao, Ricardo Correa-Rotter, Ifeoma Ulasi, Latha Kumaraswami, Siu Fai Lui, Dina Abdellatif, Ágnes Haris
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Time for action: recognizing chronic kidney disease as a major noncommunicable disease driver of premature mortality Kidney Int. (IF 14.8) Pub Date : 2024-04-04 Germaine Wong, Amélie Bernier-Jean, Brad Rovin, Pierre Ronco, Editors of Kidney International
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CAR T-cell therapy—paving the way for sensitized kidney transplant patients Kidney Int. (IF 14.8) Pub Date : 2024-04-02 Tambi Jarmi, Yan Luo, Rose Mary Attieh, Yaqing Qie, Martha E. Gadd, Tanya Hundal, Shennen Mao, Hemant S. Murthy, Burcin C. Taner, Mohamed A. Kharfan-Dabaja, Hong Qin
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Single-cell lineage tracing approaches to track kidney cell development and maintenance Kidney Int. (IF 14.8) Pub Date : 2024-03-28 Baul Yoon, Hayoung Kim, Su Woong Jung, Jihwan Park
The kidney is a complex organ consisting of various cell types. Previous studies have aimed to elucidate the cellular relationships among these cell types in developing and mature kidneys using Cre-loxP–based lineage tracing. However, this methodology falls short of fully capturing the heterogeneous nature of the kidney, making it less than ideal for comprehensively tracing cellular progression during
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Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy Kidney Int. (IF 14.8) Pub Date : 2024-03-28 Shubha S. Bellur, Stéphan Troyanov, Olga Vorobyeva, Rosanna Coppo, Ian S.D. Roberts, Validation in IgA Nephropathy study group, R. Coppo MD, J. Feehaly MD, S. Troyanov MD, D.C. Cattran MD, H.T. Cook MD, I. Roberts MD, John Radcliffe, M.L. Russo PhD, V. Tesar MD, D. Maixnerova MD, S. Lundberg MD, L. Gesualdo MD, F. Emma MD, L. Fuiano MD, G. Beltrame MD, C. Rollino MD, A. Amore MD, R. Camilla MD, L.
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A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy Kidney Int. (IF 14.8) Pub Date : 2024-03-27 Richard Lafayette, Sean Barbour, Rubeen Israni, Xuelian Wei, Necmi Eren, Jürgen Floege, Vivekanand Jha, Sung Gyun Kim, Bart Maes, Richard K.S. Phoon, Harmeet Singh, Vladimír Tesař, Celia J.F. Lin, Jonathan Barratt
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A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis Kidney Int. (IF 14.8) Pub Date : 2024-03-26 Wolfgang C. Winkelmayer, Anthonie W.A. Lensing, Ravi I. Thadhani, Kenneth W. Mahaffey, Michael Walsh, Ákos F. Pap, Stefan Willmann, Kirstin Thelen, Sophie Hodge, Alexander Solms, Sheila J.M. Ingham, John Eikelboom, RE-THINC investigators
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Transcription factor Nrf2 activation regulates NETosis, endothelial injury, and kidney disease in myeloperoxidase-positive antineutrophil cytoplasmic antibody-associated vasculitis Kidney Int. (IF 14.8) Pub Date : 2024-03-25 Yusho Ueda, Daigo Nakazawa, Saori Nishio, Satoka Shiratori-Aso, Takashi Kudo, Atsuko Miyoshi-Harashima, Kanako Watanabe-Kusunoki, Fumihiko Hattanda, Sari Iwasaki, Takahiro Tsuji, Utano Tomaru, Yasuaki Aratani, Mamiko Yamamoto, Akihiro Ishizu, Tatsuya Atsumi
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Hypermethylation leads to the loss of HOXA5, resulting in JAG1 expression and NOTCH signaling contributing to kidney fibrosis Kidney Int. (IF 14.8) Pub Date : 2024-03-21 Xiao Xiao, Wei Wang, Chunyuan Guo, Jiazhu Wu, Sheng Zhang, Huidong Shi, Sangho Kwon, Jiankang Chen, Zheng Dong
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Developing a genetic testing panel for evaluation of morbidities in kidney transplant recipients Kidney Int. (IF 14.8) Pub Date : 2024-03-21 Becky M. Ma, Naama Elefant, Martina Tedesco, Kelsie Bogyo, Natalie Vena, Sarath K. Murthy, Shiraz A. Bheda, Sandy Yang, Nikita Tomar, Jun Y. Zhang, Syed Ali Husain, Sumit Mohan, Krzysztof Kiryluk, Hila Milo Rasouly, Ali G. Gharavi
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Biomarker use in acute kidney injury: are we there yet? Kidney Int. (IF 14.8) Pub Date : 2024-03-20 T. Alp Ikizler