OBJECTIVE To develop a consensus on histologic human ovarian follicle staging nomenclature, provide guidelines for follicle density calculation, and assess changes due to fixation to enhance communication among clinicians and ovarian biology researchers in order to gain a deeper understanding of human fertility. METHODS Beginning in March 2021, the Ovarian Nomenclature Workshop's Follicle Classification

Understanding the potential risks associated with fertility treatments (FTs) can guide clinical decision and patient counseling.

OBJECTIVE To compare efficacy and safety of hCG, GnRH agonist, dual, and double triggers in predicted normal responders undergoing ovarian stimulation and IVF DESIGN: A systematic review and network meta-analysis of randomized controlled trials (RCTs). DATA SOURCES RCTs indexed in PubMed, MEDLINE, EMBASE, clinical trial registries and Cochrane Database of Systematic Reviews up to December 2023. STUDY

OBJECTIVE To determine if translocation carriers have a reduced number of usable blastocysts compared to infertile controls. DESIGN Retrospective cohort study. SUBJECTS All cycles of balanced translocation carriers undergoing IVF with preimplantation genetic testing (PGT-SR) for structural rearrangements at a single infertility center compared to an age-matched control cycles of infertile patients

IMPORTANCE While childhood adversity has been extensively studied in relation to various health outcomes, investigation of its association with gynecological conditions remains limited. OBJECTIVE To systematically review studies examining the effect of childhood adversity on the prevalence of three gynecological conditions: endometriosis, fibroids, and polycystic ovary syndrome (PCOS) in the population

OBJECTIVE To evaluate the efficacy and safety of the estetrol (E4) 15 mg/drospirenone (DRSP) 3 mg combination in a cyclic regimen in Japanese women with primary and secondary dysmenorrhea. DESIGN A 16-week, multi-center, randomized, double-blind, placebo-controlled, parallel-group study, followed by a 36-week, open-label, extension study. SUBJECTS 162 Japanese women with primary and secondary dysmenorrhea

OBJECTIVES To assess if segmental aneuploid embryos display unique morphokinetic patterns DESIGN: Retrospective multicentre study including a total of 7,027 embryos cultured between 2016 and 2021 in 3 European IVF centres. Analysis was performed on aggregated multicentre data and separately for data from each centre. Embryos with no more than 4 chromosomal alterations were considered in the analysis

OBJECTIVE To study karyotypes of more than 8,200 oocyte donor candidates in nulliparous or multiparous women compared to a reference population. DESIGN A retrospective observational multicentric study. SUBJECTS The study included two cohorts of oocyte donor candidates recruited between January 2005 and October 2021: multiparous women with at least one child at the time of recruitment, and nulliparous

OBJECTIVE To examine the association between sociodemographic factors and utilization of infertility services by race and ethnicity in a state with a comprehensive infertility mandate. DESIGN Retrospective cohort. SETTING Academic-affiliated fertility center. SUBJECTS Women presenting for initial infertility evaluation from January 2010-December 2021. EXPOSURE Initial infertility evaluation and treatment

Aromatase inhibitors, particularly letrozole, are now established as first-line ovulation induction agents, offering an effective ovarian stimulation strategy to enhance outcomes of intrauterine insemination. In recent years, they have also emerged as potentially valuable adjuvants to gonadotropin ovarian stimulation for IVF, particularly in fertility preservation in women with estrogen-responsive