Liver diseases represent a growing global health challenge, and the increasing prevalence of obesity and metabolic disorders is set to exacerbate this crisis. To meet evolving regulatory demands, patient-specific in vitro liver models are essential for understanding disease mechanisms and developing new therapeutic approaches. Organoid models, which faithfully recapitulate liver biology, can be established from both non-malignant and malignant liver tissues, offering insight into various liver conditions, from acute injuries to chronic diseases and cancer. Improved understanding of liver microenvironments, innovative biomaterials, and advanced imaging techniques now facilitate comprehensive and unbiased data analysis, paving the way for personalised medicine. In this review, we discuss state-of-the-art patient-derived liver organoid models, recent technological advancements, and strategies to enhance their clinical impact.

中文翻译：

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源自患者的类器官模型可解读肝脏病理生理学。


肝病是一个日益严峻的全球健康挑战，而肥胖和代谢紊乱的日益流行将加剧这一危机。为了满足不断变化的监管需求，患者特异性体外肝脏模型对于了解疾病机制和开发新的治疗方法至关重要。可以从非恶性和恶性肝组织中建立忠实地再现肝脏生物学的类器官模型，从而深入了解从急性损伤到慢性疾病和癌症的各种肝脏状况。对肝脏微环境、创新生物材料和先进成像技术的更好理解现在促进了全面和公正的数据分析，为个性化医疗铺平了道路。在这篇综述中，我们讨论了最先进的患者来源的肝脏类器官模型、最新的技术进步以及增强其临床影响的策略。