Previously characterized as inert fat depots, adipocytes are now recognized as dynamic mediators of inflammatory tone, metabolic health, and nutrient homeostasis. As endocrine organs, specialized depots of adipose tissue engage in crosstalk between the gut, liver, pancreas, and brain to coordinate appetite, thermogenesis, and ultimately body weight. These functions are tightly linked to the inflammatory status of adipose tissue, which is in turn influenced by the health of the gut microbiome. Here, we review recent findings linking specific gut microbes and their secreted factors, including recently identified elements such as bacterial extracellular vesicles, to the functional status of adipocytes. We conclude that further study may generate novel approaches for treating obesity and metabolic disease.

中文翻译：

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炎症和产热中的脂肪组织-肠道微生物组串扰。


脂肪细胞以前被描述为惰性脂肪库，现在被认为是炎症张力、代谢健康和营养稳态的动态介质。作为内分泌器官，脂肪组织的特殊仓库参与肠道、肝脏、胰腺和大脑之间的串扰，以协调食欲、产热，并最终协调体重。这些功能与脂肪组织的炎症状态密切相关，而脂肪组织的炎症状态又受到肠道微生物组健康状况的影响。在这里，我们回顾了将特定肠道微生物及其分泌因子（包括最近发现的元素，如细菌细胞外囊泡）与脂肪细胞的功能状态联系起来的最新发现。我们得出的结论是，进一步的研究可能会产生治疗肥胖和代谢疾病的新方法。