Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery,Advanced Drug Delivery Reviews

当前位置： X-MOL 学术 › Adv. Drug Deliver. Rev. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mitochondrial endogenous substance transport-inspired nanomaterials for mitochondria-targeted gene delivery
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-06-05 , DOI: 10.1016/j.addr.2024.115355
Yi Wang ₁ , Jing-Song Yang ₁ , Min Zhao ₁ , Jia-Qi Chen ₁ , Hai-Xin Xie ₁ , Hao-Yuan Yu ₁ , Na-Hui Liu ₁ , Zi-Juan Yi ₁ , Hui-Lin Liang ₁ , Lei Xing ₁ , Hu-Lin Jiang ₂

Affiliation

Mitochondrial genome (mtDNA) independent of nuclear gene is a set of double-stranded circular DNA that encodes 13 proteins, 2 ribosomal RNAs and 22 mitochondrial transfer RNAs, all of which play vital roles in functions as well as behaviors of mitochondria. Mutations in mtDNA result in various mitochondrial disorders without available cures. However, the manipulation of mtDNA via the mitochondria-targeted gene delivery faces formidable barriers, particularly owing to the mitochondrial double membrane. Given the fact that there are various transport channels on the mitochondrial membrane used to transfer a variety of endogenous substances to maintain the normal functions of mitochondria, mitochondrial endogenous substance transport-inspired nanomaterials have been proposed for mitochondria-targeted gene delivery. In this review, we summarize mitochondria-targeted gene delivery systems based on different mitochondrial endogenous substance transport pathways. These are categorized into mitochondrial steroid hormones import pathways-inspired nanomaterials, protein import pathways-inspired nanomaterials and other mitochondria-targeted gene delivery nanomaterials. We also review the applications and challenges involved in current mitochondrial gene editing systems. This review delves into the approaches of mitochondria-targeted gene delivery, providing details on the design of mitochondria-targeted delivery systems and the limitations regarding the various technologies. Despite the progress in this field is currently slow, the ongoing exploration of mitochondrial endogenous substance transport and mitochondrial biological phenomena may act as a crucial breakthrough in the targeted delivery of gene into mitochondria and even the manipulation of mtDNA.

中文翻译：

线粒体内源物质运输启发的纳米材料用于线粒体靶向基因传递

线粒体基因组（mtDNA）是一组独立于核基因的双链环状DNA，编码13种蛋白质、2种核糖体RNA和22种线粒体转移RNA，所有这些都在线粒体的功能和行为中发挥着重要作用。线粒体 DNA 突变会导致各种线粒体疾病，且无法治愈。然而，通过线粒体靶向基因传递来操纵 mtDNA 面临着巨大的障碍，特别是由于线粒体双膜的原因。鉴于线粒体膜上存在多种转运通道，用于转运多种内源物质以维持线粒体的正常功能，因此线粒体内源物质转运纳米材料被提出用于线粒体靶向基因递送。在这篇综述中，我们总结了基于不同线粒体内源物质转运途径的线粒体靶向基因传递系统。这些材料分为线粒体类固醇激素输入途径启发的纳米材料、蛋白质输入途径启发的纳米材料和其他线粒体靶向基因传递纳米材料。我们还回顾了当前线粒体基因编辑系统所涉及的应用和挑战。这篇综述深入研究了线粒体靶向基因传递的方法，提供了线粒体靶向传递系统的设计细节以及各种技术的局限性。尽管目前该领域进展缓慢，但对线粒体内源物质转运和线粒体生物学现象的持续探索可能成为基因靶向递送至线粒体甚至线粒体DNA操纵的关键突破。

更新日期：2024-06-05

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南