Emerging studies have disclosed the pivotal role of cancer-associated microbiota in supporting cancer development, progression and dissemination, with the in-depth comprehending of tumor microenvironment. In particular, certain invasive bacteria that hide in various cells within the tumor tissues can render assistance to tumor growth and invasion through intricate mechanisms implicated in multiple branches of cancer biology. Thus, tumor-resident intracellular microbes are anticipated as next-generation targets for oncotherapy. This review is intended to delve into these internalized bacteria-driven cancer-promoting mechanisms and explore diversified antimicrobial therapeutic strategies to counteract the detrimental impact caused by these intruders, thereby improving therapeutic benefit of antineoplastic therapy.

中文翻译：

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肿瘤驻留细胞内细菌用于癌症治疗的研究进展


随着对肿瘤微环境的深入了解，新兴研究揭示了癌症相关微生物群在支持癌症发生、进展和传播方面的关键作用。特别是，隐藏在肿瘤组织内各种细胞中的某些侵袭性细菌可以通过涉及癌症生物学多个分支的复杂机制为肿瘤生长和侵袭提供帮助。因此，肿瘤驻留细胞内微生物有望成为肿瘤治疗的下一代靶点。本综述旨在深入研究这些内化的细菌驱动的促癌机制，并探索多样化的抗菌治疗策略，以抵消这些入侵者造成的不利影响，从而提高抗肿瘤治疗的治疗效果。