Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if individualization is desired. In this review article the authors systematically researched literature published during the last 5 years (2019 – spring 2024) on the topic of 3D printed dosage forms. Besides all kinds of oral dosage forms ranging from tablets and capsules to films, pellets, etc., numerous reports were also identified on parenteral and cutaneous dosage forms and also rectal, vaginal, dental, intravesical, and ophthalmic preparations. In total, more than 500 publications were identified and grouped according to the site of administration, and an overview of the manuscripts is presented here. Furthermore, selected publications are described and discussed in more detail. The review highlights the very different approaches that are currently used in order to develop 3D printed dosage forms but also addresses remaining challenges.

中文翻译：

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药物剂型 3D 打印：最新进展和应用


3D （3D） 打印，也称为增材制造，在许多行业中被认为是一种改变游戏规则的技术，也被认为在制药中具有潜在的用例，尤其是在需要个性化的情况下。在这篇综述文章中，作者系统研究了过去 5 年（2019 年至 2024 年春季）发表的关于 3D 打印剂型主题的文献。除了从片剂和胶囊到薄膜、丸剂等各种口服剂型外，还发现了大量关于肠胃外和皮肤剂型以及直肠、阴道、牙科、膀胱内和眼用制剂的报告。总共确定了 500 多篇出版物，并根据管理地点进行了分组，此处介绍了手稿的概述。此外，还更详细地描述和讨论了选定的出版物。该评论强调了目前用于开发 3D 打印剂型的截然不同的方法，但也解决了仍然存在的挑战。