The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing tissues in agents or by topical application of those agents , their diffusion properties can be evaluated by kinetic collimated transmittance or diffuse reflectance spectroscopy. Using this method, recent studies were able to discriminate the diffusion properties of agents between healthy and diseased tissues, especially in the cases of cancer and diabetes mellitus. In the case of cancer, it was also possible to evaluate an increase of 5% in the mobile water content from the healthy to the cancerous colorectal and kidney tissues. Considering the application of some agents to living organisms or food products to protect them from deterioration during low temperature preservation (cryopreservation), and knowing that such agent inclusion may be reversed, some studies in these fields are also discussed. Considering the broadband application of the optical spectroscopy evaluation of the diffusion properties of agents in tissues and the physiological diagnostic data that such method can acquire, further studies concerning the optimization of fruit sweetness or evaluation of poison diffusion in tissues or antidote application for treatment optimization purposes are indicated as future perspectives.

中文翻译：

---

光评估组织中的分子扩散：病理的区分


组织中不同分子的扩散特性的评估是皮肤病学/美容学、临床医学、种植学和食品保鲜等各个领域都非常感兴趣的课题。在这篇综述中，讨论了最近使用动力学光谱测量来评估各种组织中的扩散特性的研究。通过将组织浸入试剂中或局部应用这些试剂，可以通过动力学准直透射率或漫反射光谱来评估它们的扩散特性。使用这种方法，最近的研究能够区分健康组织和患病组织之间的药物扩散特性，特别是在癌症和糖尿病的情况下。就癌症而言，从健康的结直肠和肾组织到癌变的结直肠和肾组织，流动水含量也增加了 5%。考虑到将某些试剂应用于活体或食品以保护它们在低温保存（冷冻保存）过程中免于变质，并且知道此类试剂的添加可能会逆转，因此还讨论了这些领域的一些研究。考虑到光谱学评估药物在组织中扩散特性的宽带应用以及该方法可以获得的生理诊断数据，进一步研究水果甜度的​​优化或毒物在组织中扩散的评估或解毒剂应用以达到治疗优化的目的表示为未来的观点。