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Navigating cancer therapy induced cardiotoxicity: From pathophysiology to treatment innovations
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-06-18 , DOI: 10.1016/j.addr.2024.115361 Jessica Tetterton-Kellner 1 , Brian C Jensen 2 , Juliane Nguyen 3
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-06-18 , DOI: 10.1016/j.addr.2024.115361 Jessica Tetterton-Kellner 1 , Brian C Jensen 2 , Juliane Nguyen 3
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Every year, more than a million people in the United States undergo chemotherapy or radiation therapy for cancer, as estimated by the CDC. While chemotherapy has been an instrumental tool for treating cancer, it also causes severe adverse effects. The more commonly acknowledged adverse effects include hair loss, fatigue, and nausea, but a more severe and longer lasting side effect is cardiotoxicity. Cardiotoxicity, or heart damage, is a common complication of cancer treatments. It can range from mild to severe, and it can affect some patients temporarily or others permanently, even after they are cured of cancer. Dexrazoxane is the only FDA-approved drug for treating anthracycline induced cardiotoxicity, but it also has drawbacks and adverse effects. There is no other type of chemotherapy induced cardiotoxicity that has an approved treatment option. In this review, we discuss the pathophysiology of chemotherapeutic-induced cardiotoxicity, methods and guidelines of diagnosis, methods of treatment and mitigation, and current drug delivery approaches in therapeutic development.
中文翻译：
驾驭癌症治疗引起的心脏毒性：从病理生理学到治疗创新
据 CDC 估计，每年美国有超过 100 万人因癌症接受化疗或放疗。虽然化疗一直是治疗癌症的工具，但它也会引起严重的不良反应。更常见的不良反应包括脱发、疲劳和恶心，但更严重和更持久的副作用是心脏毒性。心脏毒性或心脏损伤是癌症治疗的常见并发症。它的范围从轻微到严重，并且可能会暂时或永久影响一些患者，即使他们的癌症治愈后也是如此。右雷佐生是 FDA 批准的唯一用于治疗蒽环类药物诱导的心脏毒性的药物，但它也有缺点和不良反应。没有其他类型的化疗引起的心脏毒性具有批准的治疗选择。在这篇综述中，我们讨论了化疗诱导的心脏毒性的病理生理学、诊断方法和指南、治疗和缓解方法以及当前治疗开发中的药物递送方法。
更新日期：2024-06-18
中文翻译：
驾驭癌症治疗引起的心脏毒性：从病理生理学到治疗创新
据 CDC 估计，每年美国有超过 100 万人因癌症接受化疗或放疗。虽然化疗一直是治疗癌症的工具，但它也会引起严重的不良反应。更常见的不良反应包括脱发、疲劳和恶心，但更严重和更持久的副作用是心脏毒性。心脏毒性或心脏损伤是癌症治疗的常见并发症。它的范围从轻微到严重，并且可能会暂时或永久影响一些患者，即使他们的癌症治愈后也是如此。右雷佐生是 FDA 批准的唯一用于治疗蒽环类药物诱导的心脏毒性的药物，但它也有缺点和不良反应。没有其他类型的化疗引起的心脏毒性具有批准的治疗选择。在这篇综述中，我们讨论了化疗诱导的心脏毒性的病理生理学、诊断方法和指南、治疗和缓解方法以及当前治疗开发中的药物递送方法。
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