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Subcellular targeting strategies for protein and peptide delivery
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-07-02 , DOI: 10.1016/j.addr.2024.115387 Hao Su 1 , Guangyu Rong 2 , Longjie Li 1 , Yiyun Cheng 3
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-07-02 , DOI: 10.1016/j.addr.2024.115387 Hao Su 1 , Guangyu Rong 2 , Longjie Li 1 , Yiyun Cheng 3
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Cytosolic delivery of proteins and peptides provides opportunities for effective disease treatment, as they can specifically modulate intracellular processes. However, most of protein-based therapeutics only have extracellular targets and are cell-membrane impermeable due to relatively large size and hydrophilicity. The use of organelle-targeting strategy offers great potential to overcome extracellular and cell membrane barriers, and enables localization of protein and peptide therapeutics in the organelles. Although progresses have been made in the recent years, organelle-targeted protein and peptide delivery is still challenging and under exploration. We reviewed recent advances in subcellular targeted delivery of proteins/peptides with a focus on targeting mechanisms and strategies, and highlight recent examples of active and passive organelle-specific protein and peptide delivery systems. This emerging platform could open a new avenue to develop more effective protein and peptide therapeutics.
中文翻译：
蛋白质和肽递送的亚细胞靶向策略
蛋白质和肽的胞质递送为有效的疾病治疗提供了机会，因为它们可以特异性调节细胞内过程。然而，大多数基于蛋白质的疗法仅具有细胞外靶标，并且由于相对较大的尺寸和亲水性而无法渗透细胞膜。细胞器靶向策略的使用为克服细胞外和细胞膜屏障提供了巨大的潜力，并使蛋白质和肽疗法能够在细胞器中定位。尽管近年来取得了进展，但细胞器靶向的蛋白质和肽递送仍然具有挑战性并正在探索中。我们回顾了蛋白质/肽亚细胞靶向递送的最新进展，重点关注靶向机制和策略，并重点介绍了主动和被动细胞器特异性蛋白质和肽递送系统的最新示例。这个新兴平台可以开辟一条开发更有效的蛋白质和肽疗法的新途径。
更新日期：2024-07-02
中文翻译：
蛋白质和肽递送的亚细胞靶向策略
蛋白质和肽的胞质递送为有效的疾病治疗提供了机会，因为它们可以特异性调节细胞内过程。然而，大多数基于蛋白质的疗法仅具有细胞外靶标，并且由于相对较大的尺寸和亲水性而无法渗透细胞膜。细胞器靶向策略的使用为克服细胞外和细胞膜屏障提供了巨大的潜力，并使蛋白质和肽疗法能够在细胞器中定位。尽管近年来取得了进展，但细胞器靶向的蛋白质和肽递送仍然具有挑战性并正在探索中。我们回顾了蛋白质/肽亚细胞靶向递送的最新进展，重点关注靶向机制和策略，并重点介绍了主动和被动细胞器特异性蛋白质和肽递送系统的最新示例。这个新兴平台可以开辟一条开发更有效的蛋白质和肽疗法的新途径。
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