Pharmacological research has expanded to the nanoscale level with advanced imaging technologies, enabling the analysis of drug distribution at the cellular organelle level. These advances in research techniques have contributed to the targeting of cellular organelles to address the fundamental causes of diseases. Beyond navigating the hurdles of reaching lesion tissues upon administration and identifying target cells within these tissues, controlling drug accumulation at the organelle level is the most refined method of disease management. This approach opens new avenues for the development of more potent therapeutic strategies by delving into the intricate roles and interplay of cellular organelles. Thus, organelle-targeted approaches help overcome the limitations of conventional therapies by precisely regulating functionally compartmentalized spaces based on their environment. This review discusses the basic concepts of organelle targeting research and proposes strategies to target diseases arising from organelle dysfunction. We also address the current challenges faced by organelle targeting and explore future research directions.

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细胞器相关疾病的精确亚细胞靶向方法


通过先进的成像技术，药理学研究已扩展到纳米级水平，从而能够在细胞器水平上分析药物分布。研究技术的这些进步有助于靶向细胞器来解决疾病的根本原因。除了克服给药后到达病变组织并识别这些组织内的靶细胞的障碍之外，在细胞器水平上控制药物积累是最精细的疾病管理方法。这种方法通过深入研究细胞细胞器的复杂作用和相互作用，为开发更有效的治疗策略开辟了新途径。因此，针对细胞器的方法通过根据环境精确调节功能划分的空间，有助于克服传统疗法的局限性。这篇综述讨论了细胞器靶向研究的基本概念，并提出了针对细胞器功能障碍引起的疾病的策略。我们还解决当前细胞器靶向面临的挑战并探索未来的研究方向。