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Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-05-24 , DOI: 10.1016/j.addr.2024.115342
Kevin Las Heras 1 , Itxaso Garcia-Orue 2 , Fiorenza Rancan 3 , Manoli Igartua 2 , Edorta Santos-Vizcaino 2 , Rosa Maria Hernandez 2
Affiliation  

Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, the recognition of the immune system integral role in wound healing has significantly grown, instigating an approach shift towards immunological processes. Thus, this review explores the wound healing process, highlighting the engagement of the immune system, and delving into the behaviors of innate and adaptive immune cells in chronic wound scenarios. Moreover, the article investigates biomaterial-based strategies for the modulation of the immune system, elucidating how the adjustment of their physicochemical properties or their synergistic combination with other agents such as drugs, proteins or mesenchymal stromal cells can effectively modulate the behaviors of different immune cells. Finally this review explores various strategies based on synthetic and biological nanostructures, including extracellular vesicles, to finely tune the immune system as natural immunomodulators or therapeutic nanocarriers with promising biophysical properties.

中文翻译:


调节免疫系统以实现功能性慢性伤口愈合:生物材料和纳米医学的视角



受衰老、糖尿病和肥胖等因素的影响,慢性不愈合伤口持续成为医疗保健系统的沉重负担。与传统上强调促再生的治疗相反,人们对免疫系统在伤口愈合中不可或缺的作用的认识显着增强,从而引发了向免疫过程的转变。因此,这篇综述探讨了伤口愈合过程,强调了免疫系统的参与,并深入研究了慢性伤口情况下先天性和适应性免疫细胞的行为。此外,文章还研究了基于生物材料的免疫系统调节策略,阐明了其理化性质的调整或与药物、蛋白质或间充质基质细胞等其他药物的协同组合如何有效调节不同免疫细胞的行为。最后,本综述探讨了基于合成和生物纳米结构(包括细胞外囊泡)的各种策略,以微调免疫系统作为天然免疫调节剂或具有有前途的生物物理特性的治疗性纳米载体。
更新日期:2024-05-24
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