In the past two decades, quantitative mathematical modelling approaches have emerged as a paradigm to improve new drug research productivity, especially the application of pharmacokinetic-pharmacodynamic and quantitative systems pharmacology modelling. These approaches have largely made use of deterministic, differential equation-based models, however there is a growing use of agent-based models. In this review, the current applications and practices of agent-based model development are reviewed via relevant case studies from the literature. Gaps in the implementation of these models are identified and a future perspective on the priorities for further agent-based model development is given.

中文翻译：

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药物开发中的综合药代动力学-药效学和基于药物的建模：现状和未来前景


在过去的二十年里，定量数学建模方法已成为提高新药研究生产力的范式，尤其是药代动力学-药效学和定量系统药理学建模的应用。这些方法主要利用了确定性的、基于微分方程的模型，但越来越多地使用基于智能体的模型。在这篇综述中，通过文献中的相关案例研究回顾了基于智能体的模型开发的当前应用和实践。确定了这些模型实施中的差距，并给出了进一步基于智能体的模型开发优先事项的未来观点。