Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art,Advanced Drug Delivery Reviews

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Integrating microneedles and sensing strategies for diagnostic and monitoring applications: The state of the art
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-05-24 , DOI: 10.1016/j.addr.2024.115341
Shihao Pei ₁ , Samuel Babity ₁ , Ana Sara Cordeiro ₂ , Davide Brambilla ₁

Affiliation

Microneedles (MNs) offer minimally-invasive access to interstitial fluid (ISF) — a potent alternative to blood in terms of monitoring physiological analytes. This property is particularly advantageous for the painless detection and monitoring of drugs and biomolecules. However, the complexity of the skin environment, coupled with the inherent nature of the analytes being detected and the inherent physical properties of MNs, pose challenges when conducting physiological monitoring using this fluid. In this review, we discuss different sensing mechanisms and highlight advancements in monitoring different targets, with a particular focus on drug monitoring. We further list the current challenges facing the field and conclude by discussing aspects of MN design which serve to enhance their performance when monitoring different classes of analytes.

中文翻译：

集成微针和传感策略用于诊断和监测应用：最先进的技术

微针（MN）提供了对间质液（ISF）的微创访问——在监测生理分析物方面是血液的有效替代品。这一特性对于药物和生物分子的无痛检测和监测特别有利。然而，皮肤环境的复杂性，加上被检测分析物的固有性质以及 MN 的固有物理特性，给使用这种液体进行生理监测带来了挑战。在这篇综述中，我们讨论了不同的传感机制，并强调了监测不同目标的进展，特别关注药物监测。我们进一步列出了该领域当前面临的挑战，并通过讨论 MN 设计的各个方面进行总结，这些方面有助于提高其在监测不同类别分析物时的性能。

更新日期：2024-05-24

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