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Biopharmaceutical drug delivery and phototherapy using protein crystals
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-11-28 , DOI: 10.1016/j.addr.2024.115480
Renbin Zhou, Jinghan Qu, Xuejiao Liu, Fangrui Lin, Tymish Y. Ohulchanskyy, Nuernisha Alifu, Junle Qu, Da-Chuan Yin

Biopharmaceutical drugs, including proteins, peptides, and antibodies, are renowned for their high specificity and efficacy, fundamentally transforming disease treatment paradigms. However, their structural complexity presents challenges for their formulation and delivery. Protein crystals, characterized by high purity, high stability and a porous structure for biopharmaceutical drug encapsulation, providing a potential avenue for formulating and delivering biopharmaceutical drugs. There is increasing interest in engineering protein crystals to delivery biopharmaceutical drugs for biomedical applications. This review summarizes the recent advances in biopharmaceutical drug delivery and phototherapy using protein crystals. First, we evaluate the advantages of using protein crystals for biopharmaceutical drugs delivery. Next, we outline the strategies for in vitro and in vivo crystallization to prepare protein crystals. Importantly, the review highlights the advanced applications of protein crystals in biopharmaceutical drug delivery, tumor phototherapy, and other optical fields. Finally, it provides insights into future perspectives of biopharmaceutical drug delivery using protein crystals. This comprehensive review aims to provide effective insights into design of protein crystals to simplify biopharmaceutical drug delivery and improve disease treatment.

中文翻译:


使用蛋白质晶体的生物制药药物递送和光疗



生物制药药物,包括蛋白质、肽和抗体,以其高特异性和有效性而闻名,从根本上改变了疾病治疗模式。然而,它们的结构复杂性对其配方和递送提出了挑战。蛋白质晶体具有高纯度、高稳定性和多孔结构的特点,适用于生物制药药物的封装,为生物制药药物的配制和递送提供了潜在的途径。人们对工程蛋白质晶体以为生物医学应用提供生物制药药物的兴趣日益浓厚。本文总结了生物制药药物递送和利用蛋白质晶体进行光疗的最新进展。首先,我们评估了使用蛋白质晶体进行生物制药药物递送的优势。接下来,我们概述了体外和体内结晶制备蛋白质晶体的策略。重要的是,该综述强调了蛋白质晶体在生物制药药物递送、肿瘤光疗和其他光学领域的高级应用。最后,它为使用蛋白质晶体的生物制药药物递送的未来前景提供了见解。本综述旨在为蛋白质晶体的设计提供有效的见解,以简化生物制药药物递送并改善疾病治疗。
更新日期:2024-11-28
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