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Targeting bacterial metabolites in tumor for cancer therapy: An alternative approach for targeting tumor-associated bacteria
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-06-02 , DOI: 10.1016/j.addr.2024.115345 Guofeng Ji 1 , Jingjing Zhao 2 , Xinghui Si 3 , Wantong Song 3
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-06-02 , DOI: 10.1016/j.addr.2024.115345 Guofeng Ji 1 , Jingjing Zhao 2 , Xinghui Si 3 , Wantong Song 3
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Emerging evidence reveal that tumor-associated bacteria (TAB) can facilitate the initiation and progression of multiple types of cancer. Recent work has emphasized the significant role of intestinal microbiota, particularly bacteria, plays in affecting responses to chemo- and immuno-therapies. Hence, it seems feasible to improve cancer treatment outcomes by targeting intestinal bacteria. While considering variable richness of the intestinal microbiota and diverse components among individuals, direct manipulating the gut microbiota is complicated in clinic. Tumor initiation and progression requires the gut microbiota-derived metabolites to contact and reprogram neoplastic cells. Hence, directly targeting tumor-associated bacteria metabolites may have the potential to provide alternative and innovative strategies to bypass the gut microbiota for cancer therapy. As such, there are great opportunities to explore holistic approaches that incorporates TAB-derived metabolites and related metabolic signals modulation for cancer therapy. In this review, we will focus on key opportunistic areas by targeting TAB-derived metabolites and related metabolic signals, but not bacteria itself, for cancer treatment, and elucidate future challenges that need to be addressed in this emerging field.
中文翻译：
靶向肿瘤中的细菌代谢物进行癌症治疗：靶向肿瘤相关细菌的另一种方法
新的证据表明，肿瘤相关细菌（TAB）可以促进多种癌症的发生和进展。最近的研究强调了肠道微生物群，特别是细菌，在影响化疗和免疫疗法反应方面的重要作用。因此，通过针对肠道细菌来改善癌症治疗结果似乎是可行的。考虑到肠道微生物群丰富度的差异以及个体间成分的多样性，直接调控肠道微生物群在临床上是很复杂的。肿瘤的发生和进展需要肠道微生物群衍生的代谢物接触并重新编程肿瘤细胞。因此，直接靶向肿瘤相关细菌代谢物可能有可能提供替代和创新策略来绕过肠道微生物群进行癌症治疗。因此，我们有很好的机会探索将 TAB 衍生代谢物和相关代谢信号调节结合起来进行癌症治疗的整体方法。在这篇综述中，我们将通过针对 TAB 衍生代谢物和相关代谢信号而非细菌本身来重点关注癌症治疗的关键机会领域，并阐明这一新兴领域需要解决的未来挑战。
更新日期：2024-06-02
中文翻译：
靶向肿瘤中的细菌代谢物进行癌症治疗：靶向肿瘤相关细菌的另一种方法
新的证据表明，肿瘤相关细菌（TAB）可以促进多种癌症的发生和进展。最近的研究强调了肠道微生物群，特别是细菌，在影响化疗和免疫疗法反应方面的重要作用。因此，通过针对肠道细菌来改善癌症治疗结果似乎是可行的。考虑到肠道微生物群丰富度的差异以及个体间成分的多样性，直接调控肠道微生物群在临床上是很复杂的。肿瘤的发生和进展需要肠道微生物群衍生的代谢物接触并重新编程肿瘤细胞。因此，直接靶向肿瘤相关细菌代谢物可能有可能提供替代和创新策略来绕过肠道微生物群进行癌症治疗。因此，我们有很好的机会探索将 TAB 衍生代谢物和相关代谢信号调节结合起来进行癌症治疗的整体方法。在这篇综述中，我们将通过针对 TAB 衍生代谢物和相关代谢信号而非细菌本身来重点关注癌症治疗的关键机会领域，并阐明这一新兴领域需要解决的未来挑战。
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