Autologous platelet concentrates (APCs) have demonstrated clear benefits across various clinical applications, including alveolar ridge preservation, guided tissue regeneration, guided bone regeneration, sinus floor elevation (both lateral window approach and transcrestal technique), endodontic surgery, the treatment of medication‐related osteonecrosis of the jaw bones, and periodontal plastic surgery. To ensure an optimal clinical outcome, clinicians must adhere strictly to the protocol to prepare the APCs and, especially follow evidence‐based surgical guidelines, often simple but crucial, to minimize the likelihood of errors. The majority of clinical trials reported on second‐generation APCs [the leukocyte‐ and platelet‐rich fibrin (L‐PRF) family, including its modifications (A‐PRF, A‐PRF+, CGF, T‐PRF, H‐PRF, etc.)]. These second‐generation APCs offer additional benefits compared to the first‐generation APCs, making them the preferred choice for the development of clinical recommendations. These recommendations have been formulated through a meticulous examination of the available clinical data and the clinical experience of the authors of this paper.

中文翻译：

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L-PRF在不同临床适应症中的使用说明


自体血小板浓缩物（APC）在各种临床应用中已显示出明显的益处，包括牙槽嵴保存、引导组织再生、引导骨再生、上颌窦底抬高（侧窗入路和牙槽嵴顶技术）、牙髓手术、药物相关疾病的治疗颌骨骨坏死和牙周整形手术。为了确保最佳的临床结果，临床医生必须严格遵守准备 APC 的方案，特别是遵循循证手术指南（通常简单但至关重要），以最大限度地减少错误的可能性。大多数临床试验报告了第二代 APC [富含白细胞和血小板的纤维蛋白 (L-PRF) 家族，包括其修饰形式（A-PRF、A-PRF+、CGF、T-PRF、H-PRF 等） .)]。与第一代 APC 相比，这些第二代 APC 具有额外的优势，使其成为制定临床建议的首选。这些建议是通过对现有临床数据和本文作者的临床经验进行仔细检查而制定的。