This narrative review summarizes current knowledge on the use of autologous platelet concentrates (APCs) in esthetic medicine, with the goal of providing clinicians with reliable information for clinical practice. APCs contain platelets that release various growth factors with potential applications in facial and dermatologic treatments. This review examines several facial esthetic applications of APCs, including acne scarring, skin rejuvenation, melasma, vitiligo, stretchmarks, peri‐orbital rejuvenation, peri‐oral rejuvenation, hair regeneration and the volumizing effects of APC gels. A systematic review of literature databases (PubMed/MEDLINE) was conducted up to October 2023 to identify randomized controlled trials (RCTs) in the English language on APCs for facial rejuvenation and dermatology. A total of 96 articles were selected including those on platelet rich plasma (PRP), plasma‐rich in growth factors (PRGF), and platelet‐rich fibrin (PRF). Clinical recommendations gained from the reviews are provided. In summary, the use of APCs in facial esthetics is a promising yet relatively recent treatment approach. Overall, the majority of studies have focused on the use of PRP with positive outcomes. Only few studies have compared PRP versus PRF with all demonstrating superior outcomes using PRF. The existing studies have limitations including small sample sizes and lack of standardized assessment criteria. Future research should utilize well‐designed RCTs, incorporating appropriate controls, such as split‐face comparisons, and standardized protocols for APC usage, including optimal number of sessions, interval between sessions, and objective improvement scores. Nevertheless, the most recent formulations of platelet concentrates offer clinicians an ability to improve various clinical parameters and esthetic concerns.

中文翻译：

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自体浓缩血小板在美容医学中的应用


这篇叙述性综述总结了目前自体浓缩血小板 (APC) 在美容医学中的应用知识，旨在为临床医生的临床实践提供可靠的信息。 APC 含有可释放各种生长因子的血小板，具有在面部和皮肤科治疗中的潜在应用。这篇综述探讨了 APC 的几种面部美容应用，包括痤疮疤痕、皮肤年轻化、黄褐斑、白癜风、妊娠纹、眼眶周围年轻化、口周年轻化、头发再生和 APC 凝胶的丰盈效果。截至 2023 年 10 月，对文献数据库 (PubMed/MEDLINE) 进行了系统回顾，以确定关于面部年轻化和皮肤科 APC 的英文随机对照试验 (RCT)。总共选择了 96 篇文章，包括富含血小板血浆 (PRP)、富含生长因子血浆 (PRGF) 和富含血小板纤维蛋白 (PRF) 的文章。提供了从评论中获得的临床建议。总之，在面部美容中使用 APC 是一种很有前景但相对较新的治疗方法。总体而言，大多数研究都集中在 PRP 的使用上，并取得了积极的成果。只有少数研究比较了 PRP 与 PRF，所有研究都证明使用 PRF 具有更好的结果。现有研究存在样本量小、缺乏标准化评估标准等局限性。未来的研究应该利用精心设计的随机对照试验，结合适当的对照，例如分面比较，以及 APC 使用的标准化协议，包括最佳会话次数、会话间隔和客观改进分数。 然而，最新的浓缩血小板配方为临床医生提供了改善各种临床参数和美学问题的能力。