Leukocyte‐ and platelet‐rich fibrin (L‐PRF), a by‐product of centrifuged autologous whole blood, contains high concentrations of platelets, leukocytes, and fibrin (the latter spontaneously creating a strong 3‐D network (a membrane)). L‐PRF membranes possess several characteristics essential in wound healing, including a barrier function, an antibacterial and analgesic activity, and the release of growth factors enhancing tissue regeneration and neo‐vasculogenesis. This review investigated the role of L‐PRF in treating non‐responding chronic wounds such as diabetic foot, venous leg ulcers, pressure ulcers, complex wounds, leprosy ulcers (Hansen's Disease), and other demanding wounds. Chronic wounds affect millions worldwide, negatively impacting their quality of life, productivity, and life expectancy while incurring high treatment costs for themselves and private and public health systems. L‐PRF has demonstrated clear adjunctive advantages in treating chronic skin wounds, shortening the time to complete wound closure, and improving patient‐reported outcome measures (including reducing pain and minimizing the need for analgesics). Also, in other demanding wounds, L‐PRF facilitates healing. To help clinicians, this article also proposes recommendations for the use of L‐PRF in the treatment of extra‐oral wounds.

中文翻译：

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L-PRF 在口外伤口护理中的应用


富含白细胞和血小板的纤维蛋白 (L-PRF) 是离心自体全血的副产品，含有高浓度的血小板、白细胞和纤维蛋白（后者自发地形成强大的 3D 网络（膜））。 L-PRF膜具有伤口愈合所必需的几个特性，包括屏障功能、抗菌和镇痛活性，以及​​促进组织再生和新血管生成的生长因子的释放。本综述调查了 L-PRF 在治疗无反应慢性伤口（如糖尿病足、静脉性腿部溃疡、压疮、复杂伤口、麻风溃疡（汉森病）和其他要求较高的伤口）中的作用。慢性伤口影响着全世界数百万人，对他们的生活质量、生产力和预期寿命产生负面影响，同时给他们自己以及私人和公共卫生系统带来高昂的治疗费用。 L-PRF 在治疗慢性皮肤伤口、缩短伤口完全闭合的时间和改善患者报告的结果指标（包括减轻疼痛和最大限度地减少镇痛药的需求）方面表现出明显的辅助优势。此外，对于其他要求较高的伤口，L-PRF 也能促进愈合。为了帮助临床医生，本文还提出了使用 L-PRF 治疗口外伤口的建议。