Medication‐related osteonecrosis of the jaw (MRONJ) is an infectious side effect associated with bisphosphonates and monoclonal antibodies (denosumab, immune modulators, and antiangiogenic medications). Adjunctive therapies for the surgical management of MRONJ include autologous platelet concentrates (APCs). These APCs serve as a source of various cells and growth factors that aid tissue healing and regeneration. This review evaluated the use of platelet‐rich plasma (PRP), plasma‐rich in growth factors (PRGF), and leukocyte‐ and platelet‐rich fibrin (L‐PRF) as adjuvant therapies for the surgical management of MRONJ by conducting analyses on the results of 58 articles. Compared to surgical treatment alone, the application of PRP and L‐PRF after surgery appears to increase healing in the management of patients with MRONJ. No studies have reported unhealed lesions as a result of surgical treatment of MRONJ with PRGF application or compared it with surgical treatment alone. The overall results of this review have shown favorable healing rates of MRONJ lesions managed with the application of APCs after surgical treatment; however, significant methodological limitations may limit the scientific evidence supporting their use. Further randomized controlled trials with strict criteria are needed to establish the extent to which APCs can improve wound healing and quality of life in patients with MRONJ requiring surgical treatment.

中文翻译：

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自体血小板浓缩物作为药物相关颌骨坏死手术治疗的佐剂


药物相关性颌骨坏死 (MRONJ) 是一种与双磷酸盐和单克隆抗体（狄诺塞麦、免疫调节剂和抗血管生成药物）相关的感染性副作用。 MRONJ 手术治疗的辅助疗法包括自体浓缩血小板 (APC)。这些 APC 作为各种细胞和生长因子的来源，有助于组织愈合和再生。本综述通过对以下因素进行分析，评估了富含血小板血浆（PRP）、富含生长因子血浆（PRGF）以及富含白细胞和富含血小板纤维蛋白（L-PRF）作为辅助疗法用于 MRONJ 手术治疗的情况。 58篇文章的结果。与单独的手术治疗相比，手术后应用 PRP 和 L-PRF 似乎可以提高 MRONJ 患者的治愈率。尚无研究报告应用 PRGF 进行 MRONJ 手术治疗后出现未愈合的病变，也没有研究将其与单独手术治疗进行比较。本次综述的总体结果显示，手术治疗后应用 APC 治疗的 MRONJ 病变具有良好的治愈率；然而，重大的方法学局限性可能会限制支持其使用的科学证据。需要进一步采用严格标准的随机对照试验来确定 APC 在多大程度上可以改善需要手术治疗的 MRONJ 患者的伤口愈合和生活质量。