Increasing evidence suggests a significant association between periodontal disease and the occurrence of various cancers. The carcinogenic potential of several periodontal pathogens has been substantiated in vitro and in vivo. This review provides a comprehensive overview of the diverse mechanisms employed by different periodontal pathogens in the development of cancer. These mechanisms induce chronic inflammation, inhibit the host's immune system, activate cell invasion and proliferation, possess anti‐apoptotic activity, and produce carcinogenic substances. Elucidating these mechanisms might provide new insights for developing novel approaches for tumor prevention, therapeutic purposes, and survival improvement.

中文翻译：

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牙周病原体和癌症发展


越来越多的证据表明牙周病与各种癌症的发生之间存在显着关联。几种牙周病原体的致癌潜力已在体外和体内得到证实。本综述全面概述了不同牙周病原体在癌症发展中采用的不同机制。这些机制会诱导慢性炎症，抑制宿主的免疫系统，激活细胞侵袭和增殖，具有抗凋亡活性，并产生致癌物质。阐明这些机制可能为开发用于肿瘤预防、治疗目的和提高生存率的新方法提供新的见解。