Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's esthetic awareness rises. However, adults may already have periodontal tissue abnormalities, rendering orthodontic treatment inefficient because a healthy periodontium is essential for success. Numerous risk factors have been linked to periodontal lesions, with orthodontic tooth movement possibly playing a minimal influence. Although such tissue damages are mostly of esthetic rather than functional concern for patients, restoration frequently requires invasive procedures. Autologous cells for the treatment of periodontal complications have grown in popularity as a less intrusive alternative. The present review analyzed the literature on the use of mesenchymal stem cells and oral tissue‐derived fibroblasts for the healing of periodontal defects that may be related to orthodontic tooth movement. Furthermore, the advantages and challenges of the two cell types have been examined. Although the number of clinical studies is currently limited, our study demonstrates that oral fibroblasts have the potential to be the next emergent frontrunners for tissue engineering in the periodontium.

中文翻译：

---

回顾口腔成纤维细胞相对于间充质干细胞在正畸牙齿移动期间或之后修复牙周缺损的益处和临床结果


正畸治疗对牙齿施加力，引起牙周膜炎症反应。这是通过牙周组织重塑来修复的，从而允许牙齿移位。尽管正畸治疗大多在儿童和青少年时期开始，但随着社会审美意识的提高，寻求这种治疗的成年人数量也在增加。然而，成年人可能已经存在牙周组织异常，导致正畸治疗效率低下，因为健康的牙周组织对于成功至关重要。许多危险因素与牙周病变有关，其中正畸牙齿移动的影响可能很小。尽管这种组织损伤对患者来说主要是美观而非功能问题，但修复通常需要侵入性手术。作为一种侵入性较小的替代方案，用于治疗牙周并发症的自体细胞越来越受欢迎。本综述分析了有关使用间充质干细胞和口腔组织来源的成纤维细胞治疗可能与正畸牙齿移动相关的牙周缺损的文献。此外，还研究了两种细胞类型的优点和挑战。尽管目前临床研究的数量有限，但我们的研究表明口腔成纤维细胞有潜力成为牙周组织工程的下一个新兴领跑者。