In order to evaluate the therapeutic advantages of various autologous platelet concentrates (APC) as a single biomaterial during alveolar ridge preservation (ARP), a systematic review with meta‐analyses was conducted. PubMed, EMBASE, Web of Science, and Scopus were screened for randomized controlled trials (RCTs) that were released prior to 2024. The selected papers compared an APC with either unassisted healing (blood clot) or another biomaterial during ARP (third molars were not included). The outcome parameters included alveolar bone dimension alterations, soft tissue healing, and post‐op pain intensity. The search yielded 35 papers (33 studies), one applying platelet‐rich plasma (PRP), six using plasma rich in growth factors (PRGF), and 28 using leukocyte‐ and platelet‐rich fibrin (L‐PRF). These studies showed a large heterogeneity (e.g., outcome parameters, timing, surgical approach, and inclusion criteria), which hindered drawing strong conclusions. In most studies, however, ARP with PRP, PRGF, and L‐PRF alone produced faster soft tissue healing, less post‐extraction pain, less alveolar ridge resorption, more socket bone fill, and a higher bone density when compared to unassisted (spontaneous) healing. The ultimate benefit appears to be significantly influenced by the surgical approach. Limited literature exists comparing APC with other biomaterials for ARP, resulting in inconclusive data. APC application for ARP is a promising strategy to improve soft and hard tissue healing and reduce post‐extraction pain.

中文翻译：

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自体血小板浓缩物在牙槽嵴保存中的应用：荟萃分析的系统评价


为了评估各种自体血小板浓缩物（APC）作为单一生物材料在肺泡嵴保存（ARP）过程中的治疗优势，进行了荟萃分析的系统评价。 PubMed、EMBASE、Web of Science 和 Scopus 筛选了 2024 年之前发布的随机对照试验 (RCT)。选定的论文将 APC 与 ARP 期间的无辅助愈合（血凝块）或另一种生物材料（第三磨牙未植入）进行了比较。包括）。结果参数包括牙槽骨尺寸改变、软组织愈合和术后疼痛强度。检索产生了 35 篇论文（33 项研究），其中一篇使用富含血小板血浆 (PRP)，六篇使用富含生长因子的血浆 (PRGF)，28 篇使用富含白细胞和血小板的纤维蛋白 (L-PRF)。这些研究显示出很大的异质性（例如，结果参数、时机、手术方法和纳入标准），这阻碍了得出强有力的结论。然而，在大多数研究中，与无辅助（自发）相比，单独使用 ARP 联合 PRP、PRGF 和 L-PRF 可以产生更快的软组织愈合、更少的拔牙后疼痛、更少的牙槽嵴吸收、更多的牙槽骨填充以及更高的骨密度。 ） 康复。最终的益处似乎受到手术方法的显着影响。将 APC 与其他生物材料进行 ARP 比较的文献有限，导致数据不确定。 APC 应用 ARP 是一种有前景的策略，可改善软组织和硬组织愈合并减少拔牙后疼痛。