There is a postulated association of periodontitis with a number of human cancers. This narrative review provides current epidemiological evidence on the association between periodontitis and cancer. A PubMed search with the relevant keywords (periodontal disease, periodontitis, cancer, and malignancy) was completed to identify relevent articles. We present a narrative review on the association between periodontal disease and a range of cancers, including oral cancer, stomach and esophageal cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, hematological malignancies, liver cancer, breast cancer, and ovarian cancer. While there is a considerable body of epidemiological evidence that supports the association between periodontal disease and cancer, this is largely from cohort and case–control studies and the association may therefore be circumstantial as little evidence exists in the form of treatment trials that would validate the role of periodontal disease in the process of cancer initiation and development.

中文翻译：

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牙周炎与癌症的流行病学关联


据推测，牙周炎与许多人类癌症之间存在关联。本叙述性综述提供了有关牙周炎与癌症之间关联的当前流行病学证据。使用相关关键词 （牙周病、牙周炎、癌症和恶性肿瘤） 完成了 PubMed 搜索，以确定相关文章。我们介绍了牙周病与一系列癌症之间的关联，包括口腔癌、胃癌和食管癌、结直肠癌、肺癌、胰腺癌、前列腺癌、血液系统恶性肿瘤、肝癌、乳腺癌和卵巢癌。虽然有大量流行病学证据支持牙周病与癌症之间的关联，但这主要来自队列和病例对照研究，因此这种关联可能是间接的，因为几乎没有治疗试验形式的证据可以验证牙周病在癌症发生和发展过程中的作用。