The aim of this narrative review is to relate the contribution of European researchers to the complex topic of the host immune system in periodontal disease, focusing on acquired immunity. Other chapters in this volume will address the genetics and autoantibody responses and other forms of immunity to periodontal disease. While the contribution of European authors is the focus, global literature is included in this descriptive narrative for contextual clarity, albeit many with European co‐authors. The topic is relatively intense and is thus broken down into sections outlined below, tackled as descriptive narratives to enhance understanding. Any attempt at a systematic or scoping review was quickly abandoned given the descriptive nature and marked variation of approach in almost all publications. Even the most uniform area of this acquired periodontal immunology literature, antibody responses to putative pathogens in periodontal diseases, falls short of common structures and common primary outcome variables one would need and expect in clinical studies, where randomized controlled clinical trials (RCTs) abound. Addressing ‘the host's role’ in immunity immediately requires a discussion of host susceptibility, which necessitates consideration of genetic studies (covered elsewhere in the volume and superficially covered here).

中文翻译：

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获得性宿主免疫在牙周病中的作用


这篇叙述性综述的目的是将欧洲研究人员的贡献与牙周病宿主免疫系统的复杂主题联系起来，重点关注获得性免疫。本卷的其他章节将讨论遗传学和自身抗体反应以及牙周病的其他形式的免疫。虽然欧洲作者的贡献是焦点，但为了上下文清晰，全球文学也包含在这个描述性叙述中，尽管其中许多是欧洲的合著者。该主题相对激烈，因此分为以下几个部分，以描述性叙述的形式进行处理，以增强理解。鉴于几乎所有出版物的描述性性质和方法的显着变化，任何系统或范围审查的尝试都很快被放弃。即使是牙周免疫学文献中最统一的领域，即对牙周疾病中假定病原体的抗体反应，也达不到人们在临床研究中需要和期望的共同结构和共同主要结果变量，其中随机对照临床试验（RCT）比比皆是。解决“宿主在免疫中的作用”立即需要讨论宿主的易感性，这需要考虑遗传研究（在本卷的其他地方介绍并在这里进行了粗略介绍）。