The survival of an organism relies on its ability to repair the damage caused by trauma, toxic agents, and inflammation. This process involving cell proliferation and differentiation is driven by several growth factors and is critically dependent on the organization of the extracellular matrix. Since autologous platelet concentrates (APCs) are fibrin matrices in which cells, growth factors, and cytokines are trapped and delivered over time, they are able to influence that response at different levels. The present review thoroughly describes the molecular components present in one of these APCs, leukocyte‐ and platelet‐rich fibrin (L‐PRF), and summarizes the level of evidence regarding the influence of L‐PRF on anti‐inflammatory reactions, analgesia, hemostasis, antimicrobial capacity, and its biological mechanisms on bone/soft tissue regeneration.

中文翻译：

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如何解释富含白细胞和血小板的纤维蛋白的有益作用


生物体的生存依赖于其修复由创伤、有毒物质和炎症造成的损伤的能力。这一涉及细胞增殖和分化的过程由多种生长因子驱动，并且很大程度上取决于细胞外基质的组织。由于自体血小板浓缩物 (APC) 是纤维蛋白基质，其中细胞、生长因子和细胞因子随着时间的推移被捕获和输送，因此它们能够在不同水平上影响这种反应。本综述全面描述了其中一种 APC 中存在的分子成分，即富含白细胞和血小板的纤维蛋白 (L-PRF)，并总结了有关 L-PRF 对抗炎反应、镇痛、止血影响的证据水平、抗菌能力及其对骨/软组织再生的生物学机制。