This narrative review evaluates the existing literature on the clinical efficacy and safety of platelet‐rich plasma (PRP) and plasma rich in growth factors (PRGFs) in extra‐oral wound care, considering their potential benefits and drawbacks. The review specifically focuses on the impact of these treatments on patients' quality of life, pain management, treatment costs, recurrence rates, and potential complications. Given the extensive literature and diverse range of extra‐oral wound types in which these autologous platelet concentrates have been applied, this narrative review focuses on the most frequently described wound types, including diabetic foot ulcers, venous leg ulcers, pressure ulcers, surgical wounds, and burns. The use of PRP has been reported in various medical specialties, with a low risk of adverse events. While there is a growing interest in the use of PRGF with promising results, the available literature on this topic is still limited. Only a few studies evaluated patients' perception of the treatment and the relationship between treatment costs and clinical outcomes. Data on recurrence rates and complications also vary across studies. In conclusion, PRP and PRGF show promise as alternatives or as adjunctive therapies to conventional treatments for various extra‐oral wounds and ulcers, leading to reduced wound size and accelerated healing time but should be considered on a case‐by‐case basis, taking into account the type and severity of the wound.

中文翻译：

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富含血小板的血浆和富含生长因子的血浆在口外伤口护理中的应用


本叙述性综述评估了有关富含血小板血浆（PRP）和富含生长因子血浆（PRGF）在口外伤口护理中的临床疗效和安全性的现有文献，考虑了它们的潜在优点和缺点。该综述特别关注这些治疗对患者生活质量、疼痛管理、治疗费用、复发率和潜在并发症的影响。鉴于应用这些自体血小板浓缩物的大量文献和各种口腔外伤口类型，本文的叙述性综述重点关注最常描述的伤口类型，包括糖尿病足溃疡、静脉性腿部溃疡、压疮、手术伤口、和烧伤。 PRP 的使用已在多个医学专业中得到报道，不良事件的风险较低。尽管人们对使用 PRGF 并取得有希望的结果越来越感兴趣，但有关该主题的现有文献仍然有限。只有少数研究评估了患者对治疗的看法以及治疗费用和临床结果之间的关系。不同研究的复发率和并发症数据也有所不同。总之，PRP 和 PRGF 有希望作为各种口腔外伤口和溃疡的常规治疗的替代疗法或辅助疗法，从而缩小伤口大小并加速愈合时间，但应根据具体情况进行考虑，并考虑到考虑伤口的类型和严重程度。